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Wyszukujesz frazę ""Tryptophan"" wg kryterium: Temat


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Tytuł:
Tryptophan and its metabolites in normal physiology and cancer etiology.
Autorzy:
Perez-Castro L; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Garcia R; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Venkateswaran N; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Barnes S; Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Conacci-Sorrell M; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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Źródło:
The FEBS journal [FEBS J] 2023 Jan; Vol. 290 (1), pp. 7-27. Date of Electronic Publication: 2021 Nov 07.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Tryptophan*/metabolism
Neoplasms*/genetics
Neoplasms*/therapy
Humans ; Kynurenine/metabolism ; Tryptophan Oxygenase/genetics ; T-Lymphocytes/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism
Czasopismo naukowe
Tytuł:
The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression.
Autorzy:
Nguyen DT; Department of Medicine, Division of Renal Diseases and Hypertension.
Kleczko EK; Department of Medicine, Division of Renal Diseases and Hypertension.
Dwivedi N; Department of Medicine, Division of Renal Diseases and Hypertension.
Monaghan MT; Department of Medicine, Division of Renal Diseases and Hypertension.
Gitomer BY; Department of Medicine, Division of Renal Diseases and Hypertension.
Chonchol MB; Department of Medicine, Division of Renal Diseases and Hypertension.; Consortium for Fibrosis Research and Translation, and.
Clambey ET; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Nemenoff RA; Department of Medicine, Division of Renal Diseases and Hypertension.; Consortium for Fibrosis Research and Translation, and.
Klawitter J; Department of Medicine, Division of Renal Diseases and Hypertension.; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Hopp K; Department of Medicine, Division of Renal Diseases and Hypertension.; Consortium for Fibrosis Research and Translation, and.
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Źródło:
JCI insight [JCI Insight] 2023 Jan 10; Vol. 8 (1). Date of Electronic Publication: 2023 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan*
Polycystic Kidney, Autosomal Dominant*/genetics
Polycystic Kidney, Autosomal Dominant*/metabolism
Animals ; Mice ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Mice, Inbred C57BL ; Kynurenine ; Mice, Knockout ; Tryptophan Oxygenase/genetics
Czasopismo naukowe
Tytuł:
Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism.
Autorzy:
Ge PY; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Qu SY; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Ni SJ; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Yao ZY; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Qi YY; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Zhao X; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Guo R; School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Yang NY; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Zhang QC; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Zhu HX; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
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Źródło:
Phytotherapy research : PTR [Phytother Res] 2023 Jan; Vol. 37 (1), pp. 342-357. Date of Electronic Publication: 2022 Sep 11.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan*/metabolism
Berberine*/pharmacology
Mice ; Animals ; Depression/drug therapy ; Depression/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Neurotransmitter Agents ; Stress, Psychological/drug therapy ; Disease Models, Animal ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Tryptophan Hydroxylase
Czasopismo naukowe
Tytuł:
Label-free tumor cell screening based on IDO1-mediated tryptophan metabolism at single cell level.
Autorzy:
Zhou H; Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, PR China.
Wen H; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, 30 Puzhu South Road, Nanjing, 211816, PR China.
Wang L; Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, PR China.
Xu M; Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, PR China.
Jia Y; Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, PR China.
Duan S; China National Narcotics Control Commission, China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, No. 24 Tongjiaxiang Road, Nanjing, 210009, PR China.
Di B; China National Narcotics Control Commission, China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, No. 24 Tongjiaxiang Road, Nanjing, 210009, PR China.
Yu Z; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, 30 Puzhu South Road, Nanjing, 211816, PR China. Electronic address: .
Hu C; Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: .
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Źródło:
Analytical biochemistry [Anal Biochem] 2022 Dec 15; Vol. 659, pp. 114936. Date of Electronic Publication: 2022 Oct 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tryptophan*/metabolism
Neoplasms*/diagnosis
Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/analysis ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Tryptophan Oxygenase ; Oxidation-Reduction ; Kynurenine/metabolism
Czasopismo naukowe
Tytuł:
Evidence from Co-expression Analysis for the Involvement of Amidase and INS in the Tryptophan-Independent Pathway of IAA Synthesis in Arabidopsis.
Autorzy:
Abu-Zaitoon YM; Department of Biology, Al-Hussein Bin Talal University, Maan, Jordan. .
Abu-Zaiton A; Department of Biology, Faculty of Science, Al-Albayt University, Mafraq, Jordan.
Tawaha ARA; Department of Biology, Faculty of Science, Al-Albayt University, Mafraq, Jordan.
Fandi KG; Department of Biology, Al-Hussein Bin Talal University, Maan, Jordan.
Alnaimat SM; Department of Biology, Al-Hussein Bin Talal University, Maan, Jordan.
Pati S; NatNov Bioscience Private Limited, Balasore, 756001, India.
Almomani FA; Department of Applied Biology, Jordan University of Science and Technology, Irbid, Jordan.
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Źródło:
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2022 Oct; Vol. 194 (10), pp. 4673-4682. Date of Electronic Publication: 2022 Jul 08.
Typ publikacji:
Journal Article
MeSH Terms:
Arabidopsis*/genetics
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Amidohydrolases/genetics ; Amidohydrolases/metabolism ; Benzopyrans ; Hormones/metabolism ; Indoleacetic Acids/metabolism ; Indoles/metabolism ; Phenols ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Tryptophan degradation enzymes and Angiotensin (1-7) expression in human placenta.
Autorzy:
Silvano A; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Seravalli V; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Strambi N; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Tartarotti E; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Tofani L; Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy.
Calosi L; Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy.
Parenti A; Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Italy. Electronic address: .
Di Tommaso M; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy. Electronic address: .
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Źródło:
Journal of reproductive immunology [J Reprod Immunol] 2022 Sep; Vol. 153, pp. 103692. Date of Electronic Publication: 2022 Aug 06.
Typ publikacji:
Journal Article; Observational Study
MeSH Terms:
Angiotensin I*/genetics
Angiotensin I*/immunology
Immune Tolerance*/genetics
Immune Tolerance*/immunology
Indoleamine-Pyrrole 2,3,-Dioxygenase*/biosynthesis
Indoleamine-Pyrrole 2,3,-Dioxygenase*/genetics
Indoleamine-Pyrrole 2,3,-Dioxygenase*/immunology
Peptide Fragments*/genetics
Peptide Fragments*/immunology
Placenta*/enzymology
Placenta*/immunology
Tryptophan Hydroxylase*/genetics
Tryptophan Hydroxylase*/immunology
Angiotensin II/immunology ; Female ; Humans ; Infant, Newborn ; Kynurenine/analysis ; Kynurenine/genetics ; Kynurenine/immunology ; Pregnancy ; RNA, Messenger ; Tryptophan/analysis ; Tryptophan/genetics ; Tryptophan/immunology ; Tryptophan Oxygenase/genetics ; Tryptophan Oxygenase/immunology
Czasopismo naukowe
Tytuł:
Pancancer Analysis of Revealed TDO2 as a Biomarker of Prognosis and Immunotherapy.
Autorzy:
Cui J; Department of Oral and Maxillofacial Surgery, Jinan Stamotological Hospital, Jinan, 101 Jinglv Road, Shandong 250001, China.; Central Laboratory of Jinan Stamotological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Jinan, 101 Jinglv Road, Shandong 250001, China.
Tian Y; Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
Liu T; Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
Lin X; Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
Li L; Department of Gynecology, Central Hospital Affiliated to Shandong First Medical University, 105.jiefang road, Jinan, Shandong 250013, China.
Li Z; Department of Gynecology, Meihekou City Central Hospital, 2688 Kangmei Avenue, Meihekou city, Jilin 135000, China.
Shen L; Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
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Źródło:
Disease markers [Dis Markers] 2022 Sep 09; Vol. 2022, pp. 5447017. Date of Electronic Publication: 2022 Sep 09 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasms*/genetics
Neoplasms*/therapy
Tryptophan Oxygenase*/genetics
Tryptophan Oxygenase*/metabolism
B7 Antigens/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; DNA ; Humans ; Immunotherapy ; Kynurenine/genetics ; Kynurenine/metabolism ; Methyltransferases/genetics ; Microsatellite Instability ; Prognosis ; Tryptophan/genetics ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase N -Dimethylallyl-l-tryptophan Synthase from Fusarium fujikuroi .
Autorzy:
Eaton SA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Ronnebaum TA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Roose BW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
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Źródło:
Biochemistry [Biochemistry] 2022 Sep 20; Vol. 61 (18), pp. 2025-2035. Date of Electronic Publication: 2022 Sep 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Biological Products*
Dimethylallyltranstransferase*/chemistry
Tryptophan Synthase*/metabolism
Catalysis ; Fusarium ; Hemiterpenes ; Indoles ; Neoprene ; Nitrogen ; Organophosphorus Compounds ; Prenylation ; Substrate Specificity ; Tryptophan/chemistry
SCR Organism:
Fusarium fujikuroi
Czasopismo naukowe
Tytuł:
Coordination of plant growth and abiotic stress responses by tryptophan synthase β subunit 1 through modulation of tryptophan and ABA homeostasis in Arabidopsis.
Autorzy:
Liu WC; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China; State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng 475004, China.
Song RF; State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng 475004, China.
Zheng SQ; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.
Li TT; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.
Zhang BL; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.
Gao X; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.
Lu YT; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China. Electronic address: .
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Źródło:
Molecular plant [Mol Plant] 2022 Jun 06; Vol. 15 (6), pp. 973-990. Date of Electronic Publication: 2022 Apr 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arabidopsis*/metabolism
Arabidopsis Proteins*/genetics
Arabidopsis Proteins*/metabolism
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Abscisic Acid/metabolism ; Droughts ; Gene Expression Regulation, Plant ; Homeostasis ; Hormones/metabolism ; Hydrogen Peroxide/metabolism ; Indoleacetic Acids/metabolism ; Plants, Genetically Modified/metabolism ; Stress, Physiological/genetics ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges.
Autorzy:
Peng X; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
Zhao Z; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
Liu L; Department of Obstetrics and Gynecology, Fengrun District People's Hospital, Tangshan, Hebei, 063000, People's Republic of China.
Bai L; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
Tong R; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
Yang H; POWERCHINA Chengdu Engineering Corporation Limited, Chengdu, Sichuan, 610072, People's Republic of China.
Zhong L; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
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Źródło:
Drug design, development and therapy [Drug Des Devel Ther] 2022 Aug 08; Vol. 16, pp. 2639-2657. Date of Electronic Publication: 2022 Aug 08 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/drug therapy
Tryptophan*
Humans ; Immunotherapy ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Tryptophan Oxygenase/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
The role of tryptophan in Chlamydia trachomatis persistence.
Autorzy:
Wang L; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Hou Y; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Yuan H; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Chen H; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
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Źródło:
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Aug 02; Vol. 12, pp. 931653. Date of Electronic Publication: 2022 Aug 02 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Chlamydia Infections*/microbiology
Tryptophan Synthase*/genetics
Chlamydia trachomatis ; Humans ; Indoles/metabolism ; Interferon-gamma/metabolism ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Structural and biochemical basis for the substrate specificity of Pad-1, an indole-3-pyruvic acid aminotransferase in auxin homeostasis.
Autorzy:
Choi M; Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Rhee S; Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea. Electronic address: .
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Źródło:
Journal of structural biology [J Struct Biol] 2022 Jun; Vol. 214 (2), pp. 107857. Date of Electronic Publication: 2022 Apr 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transaminases*/genetics
Transaminases*/metabolism
Tryptophan*
Glutamine ; Homeostasis/physiology ; Indoleacetic Acids/chemistry ; Indoles ; Kinetics ; Substrate Specificity ; Tryptophan Transaminase/metabolism
Czasopismo naukowe
Tytuł:
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.
Autorzy:
Pataskar A; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Champagne J; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nagel R; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kenski J; Division of Molecular Oncology and Immunology, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Laos M; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Michaux J; Lausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Pak HS; Lausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Bleijerveld OB; NKI Proteomics facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Mordente K; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Navarro JM; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Blommaert N; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nielsen MM; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Lovecchio D; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Stone E; Department of Molecular Biosciences, University of Texas, Austin, TX, USA.
Georgiou G; Department of Molecular Biosciences, University of Texas, Austin, TX, USA.
de Gooijer MC; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
van Tellingen O; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Altelaar M; NKI Proteomics facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht Institute for Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre, Utrecht, The Netherlands.
Joosten RP; Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Perrakis A; Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Olweus J; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Bassani-Sternberg M; Lausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Peeper DS; Division of Molecular Oncology and Immunology, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Agami R; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. .; Erasmus MC, Department of Genetics, Rotterdam University, Rotterdam, The Netherlands. .
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Źródło:
Nature [Nature] 2022 Mar; Vol. 603 (7902), pp. 721-727. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan*/metabolism
Tryptophan-tRNA Ligase*/genetics
Tryptophan-tRNA Ligase*/metabolism
Codon/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Interferon-gamma ; Neoplasms/immunology ; Phenylalanine ; T-Lymphocytes ; Tryptophan Oxygenase/genetics ; Tryptophan Oxygenase/metabolism
Czasopismo naukowe
Tytuł:
Construction of cell factory capable of efficiently converting L-tryptophan into 5-hydroxytryptamine.
Autorzy:
Wang Y; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen X; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen Q; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhou N; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Wang X; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhang A; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen K; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China. .; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China. .
Ouyang P; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
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Źródło:
Microbial cell factories [Microb Cell Fact] 2022 Mar 24; Vol. 21 (1), pp. 47. Date of Electronic Publication: 2022 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Serotonin*/metabolism
Tryptophan*/metabolism
5-Hydroxytryptophan/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Tytuł:
Effect of process parameters and surfactant additives on the obtained activity of recombinant tryptophan hydroxylase (TPH1) for enzymatic synthesis of 5-hydroxytryptophan (5-HTP).
Autorzy:
Vargas MA; Laboratorio de Tecnología Enzimática para Bioprocesos, Departamento de Ingeniería en Alimentos, Universidad de La Serena, Chile.
Deive FJ; Departamento de Ingeniería Química, Campus As Lagoas-Marcosende, Universidade de Vigo, Vigo, Spain; CINTECX - Universidad de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain.
Álvarez MS; Departamento de Ingeniería Química, Campus As Lagoas-Marcosende, Universidade de Vigo, Vigo, Spain; CINTECX - Universidad de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain.
Longo MA; Departamento de Ingeniería Química, Campus As Lagoas-Marcosende, Universidade de Vigo, Vigo, Spain; CINTECX - Universidad de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain.
Rodríguez A; Departamento de Ingeniería Química, Campus As Lagoas-Marcosende, Universidade de Vigo, Vigo, Spain.
Bernal C; Laboratorio de Tecnología Enzimática para Bioprocesos, Departamento de Ingeniería en Alimentos, Universidad de La Serena, Chile; Instituto de Investigación Multidisciplinario en Ciencia y Tecnología, Universidad de La Serena, Benavente 980, 1720010 La Serena, Chile.
Martínez R; Laboratorio de Tecnología Enzimática para Bioprocesos, Departamento de Ingeniería en Alimentos, Universidad de La Serena, Chile. Electronic address: .
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Źródło:
Enzyme and microbial technology [Enzyme Microb Technol] 2022 Mar; Vol. 154, pp. 109975. Date of Electronic Publication: 2021 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
5-Hydroxytryptophan*
Tryptophan Hydroxylase*/genetics
Humans ; Serotonin ; Surface-Active Agents ; Tryptophan
Czasopismo naukowe
Tytuł:
Loss of Pleckstrin homology like domain, family A, member 1 promotes type Ⅱ alveolar epithelial cell apoptosis in chronic obstructive pulmonary disease emphysematous phenotype via interaction with tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon.
Autorzy:
Bai S; Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Ye R; Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Wang C; Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Sun P; Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Wang D; Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Yue Y; Department of Radiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Wang H; Department of Radiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Wu S; Department of Biobank, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Yu M; Department of Biobank, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China.
Xi S; Department of Environmental and Occupational Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New District, Shenyang City, China. Electronic address: .
Zhao L; Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, China. Electronic address: .
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Źródło:
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2022 Oct; Vol. 151, pp. 106297. Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pulmonary Disease, Chronic Obstructive*
Tryptophan*/genetics
Tryptophan Hydroxylase/*metabolism
Alveolar Epithelial Cells ; Apoptosis/genetics ; Blood Proteins ; Humans ; Phenotype ; Phosphoproteins ; Tyrosine 3-Monooxygenase/genetics
Czasopismo naukowe
Tytuł:
Impact of IDO1 and IDO2 on the B Cell Immune Response.
Autorzy:
Merlo LMF; Lankenau Institute for Medical Research, Wynnewood, PA, United States.
Peng W; Lankenau Institute for Medical Research, Wynnewood, PA, United States.
Mandik-Nayak L; Lankenau Institute for Medical Research, Wynnewood, PA, United States.
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Źródło:
Frontiers in immunology [Front Immunol] 2022 Apr 13; Vol. 13, pp. 886225. Date of Electronic Publication: 2022 Apr 13 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Indoleamine-Pyrrole 2,3,-Dioxygenase*
Tryptophan Oxygenase*
Immunity ; Tryptophan/pharmacology
Czasopismo naukowe
Tytuł:
A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.
Autorzy:
Li S; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Li S; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Zhao Y; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Zhang B; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Wang X; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Yang X; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Wang Y; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Jia C; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Chang Y; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China. .
Wei W; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China. .
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Źródło:
Transgenic research [Transgenic Res] 2021 Dec; Vol. 30 (6), pp. 781-797. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Kynurenine*/genetics
Kynurenine*/metabolism
Tryptophan Oxygenase*/genetics
Tryptophan Oxygenase*/metabolism
Animals ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Mice ; Mice, Inbred DBA ; Mice, Knockout ; Phenotype ; Tryptophan/genetics ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH- and Hsp90-dependent control of their heme levels.
Autorzy:
Biswas P; Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA.
Dai Y; Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA.
Stuehr DJ; Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA. Electronic address: .
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Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2022 Feb 20; Vol. 180, pp. 179-190. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Heme*
Tryptophan*/metabolism
Enzyme Inhibitors ; HEK293 Cells ; HeLa Cells ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Tryptophan Oxygenase/genetics ; Tryptophan Oxygenase/metabolism
Czasopismo naukowe
Tytuł:
Directed Evolution Improves the Enzymatic Synthesis of L-5-Hydroxytryptophan by an Engineered Tryptophan Synthase.
Autorzy:
Xu L; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China. .
Li T; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Huo Z; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Chen Q; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Xia Q; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Jiang B; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
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Źródło:
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2021 Oct; Vol. 193 (10), pp. 3407-3417. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan Synthase*
5-Hydroxytryptophan ; Escherichia coli ; Tryptophan
Czasopismo naukowe

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