Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""Tryptophan"" wg kryterium: Temat


Starter badań:

Tytuł:
Engineering of human tryptophan hydroxylase 2 for efficient synthesis of 5-hydroxytryptophan.
Autorzy:
Wang B; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800# Lihu Road, WuXi 214122, People's Republic of China.
Xu JZ; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800# Lihu Road, WuXi 214122, People's Republic of China.
Liu S; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800# Lihu Road, WuXi 214122, People's Republic of China.
Rao ZM; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800# Lihu Road, WuXi 214122, People's Republic of China; National Engineering Laboratory for Cereal Fermentation Technology, School of Biotechnology, Jiangnan University, 1800# Lihu Road, WuXi 214122, People's Republic of China. Electronic address: .
Zhang WG; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800# Lihu Road, WuXi 214122, People's Republic of China. Electronic address: .
Pokaż więcej
Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 260 (Pt 1), pp. 129484. Date of Electronic Publication: 2024 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
5-Hydroxytryptophan*/metabolism
Tryptophan Hydroxylase*/genetics
Tryptophan Hydroxylase*/chemistry
Tryptophan Hydroxylase*/metabolism
Humans ; Tryptophan/chemistry ; Catalytic Domain ; Hydroxylation
Czasopismo naukowe
Tytuł:
Fungi Tryptophan Synthases: What Is the Role of the Linker Connecting the α and β Structural Domains in Hemileia vastatrix TRPS? A Molecular Dynamics Investigation.
Autorzy:
Martins NF; EMBRAPA Agroindústria Tropical, Planalto do Pici, Fortaleza 60511-110, CE, Brazil.
Viana MJA; EMBRAPA Agroindústria Tropical, Planalto do Pici, Fortaleza 60511-110, CE, Brazil.
Maigret B; LORIA, UMR 7504 CNRS, Université de Lorraine, 54000 Vandoeuvre les Nancy, France.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 06; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Tryptophan Synthase*/chemistry
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Basidiomycota*
Tryptophan ; Fungi/metabolism
SCR Organism:
Hemileia vastatrix
Czasopismo naukowe
Tytuł:
A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis.
Autorzy:
Zelante T; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy. .; Interuniversity Consortium for Biotechnology, (CIB), 34149, Trieste, Italy. .
Paolicelli G; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Fallarino F; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Gargaro M; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Vascelli G; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
De Zuani M; International Clinical Research Centre, St. Anne's University Hospital Brno, Brno, Czech Republic.
Fric J; International Clinical Research Centre, St. Anne's University Hospital Brno, Brno, Czech Republic.; Institute of Hematology and Blood Transfusion, U Nemocnice 2094/1, 128 20, Prague, Czech Republic.; International Clinical Research Centre, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Laznickova P; International Clinical Research Centre, St. Anne's University Hospital Brno, Brno, Czech Republic.; International Clinical Research Centre, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Kohoutkova MH; International Clinical Research Centre, St. Anne's University Hospital Brno, Brno, Czech Republic.; International Clinical Research Centre, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Macchiarulo A; Department of Pharmaceutical Science, University of Perugia, 06132, Perugia, Italy.
Dolciami D; Department of Pharmaceutical Science, University of Perugia, 06132, Perugia, Italy.
Pieraccini G; Mass Spectrometry Center (CISM), University of Florence, 50139, Florence, Italy.
Gaetani L; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Scalisi G; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Trevisan C; Department of Medical and Biological Science, University of Udine, 33100, Udine, Italy.
Frossi B; Department of Medical and Biological Science, University of Udine, 33100, Udine, Italy.
Pucillo C; Department of Medical and Biological Science, University of Udine, 33100, Udine, Italy.
De Luca A; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Nunzi E; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.; Center of Functional Genomics, C.U.R.Ge.F, University of Perugia, 06132, Perugia, Italy.
Spaccapelo R; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.; Center of Functional Genomics, C.U.R.Ge.F, University of Perugia, 06132, Perugia, Italy.; Interuniversity Consortium for Biotechnology, (CIB), 34149, Trieste, Italy.
Pariano M; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Borghi M; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Boscaro F; Mass Spectrometry Center (CISM), University of Florence, 50139, Florence, Italy.
Romoli R; Mass Spectrometry Center (CISM), University of Florence, 50139, Florence, Italy.
Mancini A; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Gentili L; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Renga G; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Costantini C; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Puccetti M; Department of Pharmaceutical Science, University of Perugia, 06132, Perugia, Italy.
Giovagnoli S; Department of Pharmaceutical Science, University of Perugia, 06132, Perugia, Italy.
Ricci M; Department of Pharmaceutical Science, University of Perugia, 06132, Perugia, Italy.
Antonini M; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Calabresi P; Unità di Neurologia, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Puccetti P; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.; Center of Functional Genomics, C.U.R.Ge.F, University of Perugia, 06132, Perugia, Italy.
Di Filippo M; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.
Romani L; Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, 1, 06132, Perugia, Italy.; Center of Functional Genomics, C.U.R.Ge.F, University of Perugia, 06132, Perugia, Italy.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2024 Mar 20; Vol. 14 (1), pp. 6651. Date of Electronic Publication: 2024 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
Multiple Sclerosis*
Tryptophan*/metabolism
Humans ; Kynurenine/metabolism ; Ligands ; Receptors, Aryl Hydrocarbon/metabolism ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Tytuł:
Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression.
Autorzy:
Crump LS; Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Floyd JL; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Kuo LW; Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Post MD; Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Bickerdike M; Antido Therapeutics, Melbourne, Australia.; BioTarget Consulting, Auckland, New Zealand.
O'Neill K; Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Sompel K; Division of Reproductive Sciences Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Jordan KR; Department of Immunology and Microbiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Corr BR; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Marjon N; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Woodruff ER; Division of Reproductive Sciences Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Richer JK; Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Bitler BG; Division of Reproductive Sciences Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Pokaż więcej
Źródło:
Cancer research communications [Cancer Res Commun] 2024 Mar 18; Vol. 4 (3), pp. 822-833.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan Oxygenase*/genetics
Ovarian Neoplasms*/drug therapy
Female ; Humans ; Tryptophan/metabolism ; B7-H1 Antigen ; Interleukin-6 ; Kynurenine/metabolism ; Enzyme Inhibitors/pharmacology ; Macrophages/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
Clinical Significance of Tryptophanyl-tRNA Synthetase 1 Gene Expression in Patients With Locally Advanced Gastric Cancer.
Autorzy:
Oshima T; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan; .
Hashimoto I; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.; Department of Surgery, Yokohama City University, Yokohama, Japan.
Hiroshima Y; Kanagawa Cancer Center Research Institute, Yokohama, Japan.
Kimura Y; Advanced Medical Research Center, Yokohama City University, Yokohama, Japan.
Tanabe M; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.; Department of Surgery, Yokohama City University, Yokohama, Japan.
Onuma S; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.; Department of Surgery, Yokohama City University, Yokohama, Japan.
Morita J; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.; Department of Surgery, Yokohama City University, Yokohama, Japan.
Nagasawa S; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.; Department of Surgery, Yokohama City University, Yokohama, Japan.
Kanematsu K; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Aoyama T; Department of Surgery, Yokohama City University, Yokohama, Japan.
Yamada T; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.; Department of Surgery, Yokohama City University, Yokohama, Japan.
Ogata T; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Rino Y; Department of Surgery, Yokohama City University, Yokohama, Japan.
Saito A; Department of Surgery, Yokohama City University, Yokohama, Japan.
Miyagi Y; Kanagawa Cancer Center Research Institute, Yokohama, Japan.
Pokaż więcej
Źródło:
Anticancer research [Anticancer Res] 2024 Feb; Vol. 44 (2), pp. 673-678.
Typ publikacji:
Journal Article
MeSH Terms:
Stomach Neoplasms*/genetics
Stomach Neoplasms*/surgery
Stomach Neoplasms*/pathology
Tryptophan-tRNA Ligase*/genetics
Humans ; Clinical Relevance ; Tryptophan ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/analysis ; Gene Expression ; Prognosis ; Neoplasm Staging
Czasopismo naukowe
Tytuł:
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics.
Autorzy:
Villani S; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.
Fallarini S; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.
Rezzi SJ; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.
Di Martino RMC; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.
Aprile S; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.
Del Grosso E; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy. Electronic address: .
Pokaż więcej
Źródło:
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Jan 05; Vol. 237, pp. 115750. Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan*/metabolism
Breast Neoplasms*
Humans ; Female ; Kynurenine/metabolism ; Chromatography, Liquid/methods ; Tryptophan Oxygenase ; Tandem Mass Spectrometry/methods ; Cell Line ; Indoleamine-Pyrrole 2,3,-Dioxygenase
Czasopismo naukowe
Tytuł:
Tryptophan metabolism enzymes are potential targets in ovarian clear cell carcinoma.
Autorzy:
Zhang S; Clinical Biobank, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.; Department of Medical Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Gao Y; Department of Pathology, Molecular Pathology Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Wang P; Department of Pathology, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China.
Wang S; Department of Obstetrics and Gynaecology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.; National Clinical Research Centre for Obstetric & Gynaecologic Diseases, Beijing, China.
Wang Y; Department of Pathology, Molecular Pathology Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Li M; Department of Pathology, Molecular Pathology Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Wang A; Clinical Biobank, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.; Department of Medical Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhao K; Clinical Biobank, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.; Department of Medical Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhang Z; Clinical Biobank, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.; Department of Medical Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Sun J; Department of Pathology, Molecular Pathology Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Guo D; Clinical Biobank, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.; Department of Medical Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Liang Z; Department of Pathology, Molecular Pathology Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Pokaż więcej
Źródło:
Cancer medicine [Cancer Med] 2023 Dec; Vol. 12 (24), pp. 21996-22005. Date of Electronic Publication: 2023 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tryptophan*/metabolism
Ovarian Neoplasms*/pathology
Female ; Humans ; Tryptophan Oxygenase ; Carcinoma, Ovarian Epithelial ; L-Amino Acid Oxidase
Czasopismo naukowe
Tytuł:
A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men.
Autorzy:
Liu C; School of Psychology, Xinxiang Medical University, Xinxiang, PR China; The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, PR China; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China. Electronic address: .
Li K; The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, PR China; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China; School of Psychology and Cognitive Science, East China Normal University, Shanghai, PR China.
Fu M; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China.
Zhang Y; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China.
Sindermann C; Department of Molecular Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany; Interchange Forum for Reflecting on Intelligent Systems, University of Stuttgart, Stuttgart, Germany.
Montag C; Department of Molecular Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Zheng X; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China; Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China.
Zhang H; School of Psychology, Xinxiang Medical University, Xinxiang, PR China.
Yao S; The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, PR China; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China.
Wang Z; School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, IDG/McGovern Institute for Brain Research, Peking. Tsinghua Center for Life Sciences, Peking University, Beijing, PR China.
Zhou B; The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, PR China.
Kendrick KM; The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, PR China; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China.
Becker B; The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, PR China; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, PR China; Department of Psychology, The University of Hong Kong, Hong Kong, PR China. Electronic address: .
Pokaż więcej
Źródło:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2023 Dec; Vol. 77, pp. 24-34. Date of Electronic Publication: 2023 Sep 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tryptophan*
Serotonin*
Male ; Humans ; Anxiety/genetics ; Anxiety/psychology ; Prefrontal Cortex/diagnostic imaging ; Polymorphism, Genetic ; Tryptophan Hydroxylase/genetics
Czasopismo naukowe
Tytuł:
Advances in the microbial synthesis of the neurotransmitter serotonin.
Autorzy:
Wang Y; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Chen Y; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Zhang A; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Chen K; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China. .
Ouyang P; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Pokaż więcej
Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2023 Aug; Vol. 107 (15), pp. 4717-4725. Date of Electronic Publication: 2023 Jun 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Serotonin*/metabolism
Tryptophan Hydroxylase*/metabolism
Tryptophan/metabolism ; Hydroxylation ; Neurotransmitter Agents
Czasopismo naukowe
Tytuł:
Rational design of tryptophan hydroxylation 1 for improving 5-Hydroxytryptophan production.
Autorzy:
Song F; Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China.
Gu T; Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China.
Zhang L; Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China.
Zhang J; Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China.
You S; Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China; Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin 300072, PR China. Electronic address: .
Qi W; Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China; State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300350, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, PR China; Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin 300072, PR China. Electronic address: .
Su R; Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China; State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300350, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, PR China; Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin 300072, PR China.
Pokaż więcej
Źródło:
Enzyme and microbial technology [Enzyme Microb Technol] 2023 Apr; Vol. 165, pp. 110198. Date of Electronic Publication: 2023 Jan 16.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan*
5-Hydroxytryptophan*/metabolism
Animals ; Serotonin/metabolism ; Hydroxylation ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/chemistry ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Tytuł:
Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through control of cell heme allocation by nitric oxide.
Autorzy:
Biswas P; Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, USA.
Stuehr DJ; Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, USA. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Jun; Vol. 299 (6), pp. 104753. Date of Electronic Publication: 2023 Apr 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Indoleamine-Pyrrole 2,3,-Dioxygenase*/chemistry
Indoleamine-Pyrrole 2,3,-Dioxygenase*/metabolism
Nitric Oxide*
Tryptophan Oxygenase*/chemistry
Tryptophan Oxygenase*/metabolism
Animals ; Heme/metabolism ; Mammals/metabolism ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Autorzy:
Xiang M; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery and Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong510006, China.
Xia K; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery and Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong510006, China.
Chen B; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery and Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong510006, China.
Luo Z; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery and Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong510006, China.
Yu Y; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery and Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong510006, China.
Jiang L; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery and Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong510006, China.
Zhou H; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery and Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong510006, China.
Pokaż więcej
Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 May 22; Vol. 51 (9), pp. 4637-4649.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Infective Agents*
Tryptophan-tRNA Ligase*/genetics
Escherichia coli*/enzymology
Escherichia coli*/genetics
Escherichia coli Proteins*/genetics
Binding Sites ; Catalytic Domain ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV).
Autorzy:
Pawlowski T; Department of Psychiatry, Wrocław Medical University, 50-367 Wrocław, Poland.
Malyszczak K; Department of Psychiatry, Wrocław Medical University, 50-367 Wrocław, Poland.
Pawlak D; Department of Pharmacodynamics, Medical University of Bialystok, 15-089 Białystok, Poland.
Inglot M; Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiency, Wroclaw Medical University, 50-367 Wrocław, Poland.
Zalewska M; Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiency, Wroclaw Medical University, 50-367 Wrocław, Poland.
Grzywacz A; Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Radkowski M; Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, 02-091 Warsaw, Poland.
Laskus T; Department of Adult Infectious Diseases, Medical University of Warsaw, 02-091 Warsaw, Poland.
Janocha-Litwin J; Department of Infectious Diseases and Hepatology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Frydecka D; Department of Psychiatry, Wrocław Medical University, 50-367 Wrocław, Poland.
Pokaż więcej
Źródło:
Cells [Cells] 2023 Mar 22; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Depression*/genetics
Depression*/metabolism
Hepatitis C, Chronic*/complications
Hepatitis C, Chronic*/drug therapy
Hepatitis C, Chronic*/genetics
Interferon alpha-2*/adverse effects
Interferon alpha-2*/pharmacology
Interferon alpha-2*/therapeutic use
Tryptophan*/drug effects
Tryptophan*/metabolism
Adult ; Humans ; Antiviral Agents/therapeutic use ; Kynurenine ; Polyethylene Glycols/pharmacology ; Polymorphism, Genetic ; Prospective Studies ; Receptor, Serotonin, 5-HT1A/genetics ; Ribavirin/adverse effects ; Ribavirin/pharmacology ; Ribavirin/therapeutic use ; Tryptophan Hydroxylase/genetics ; Tryptophan Oxygenase/genetics
Czasopismo naukowe
Tytuł:
Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State.
Autorzy:
Sinenko SA; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.
Kuzmin AA; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.
Skvortsova EV; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.
Ponomartsev SV; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.
Efimova EV; Institute of Translational Biomedicine, St-Petersburg State University, 7-9 Universitetskaya Emb, 199034 St. Petersburg, Russia.
Bader M; Max-Delbruck Center for Molecular Medicine, 13125 Berlin-Buch, Germany.
Alenina N; Max-Delbruck Center for Molecular Medicine, 13125 Berlin-Buch, Germany.
Tomilin AN; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.; Institute of Translational Biomedicine, St-Petersburg State University, 7-9 Universitetskaya Emb, 199034 St. Petersburg, Russia.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 02; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 02.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Reprogramming*
Serotonin*/biosynthesis
Tryptophan Hydroxylase*/metabolism
Pluripotent Stem Cells*
Animals ; Mice ; Fibroblasts/metabolism ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Tryptophan degradation enzymes expression in the placenta and the Kynurenine/Tryptophan ratio in maternal plasma after elective cesarean section.
Autorzy:
Silvano A; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Seravalli V; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Strambi N; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Vallario A; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Tofani L; Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy.
Parenti A; Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy. Electronic address: .
Di Tommaso M; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy. Electronic address: .
Pokaż więcej
Źródło:
Journal of reproductive immunology [J Reprod Immunol] 2023 Mar; Vol. 156, pp. 103823. Date of Electronic Publication: 2023 Feb 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tryptophan*/metabolism
Kynurenine*/metabolism
Humans ; Pregnancy ; Female ; Cesarean Section ; Tryptophan Oxygenase/genetics ; Placenta/metabolism ; RNA, Messenger ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism
Czasopismo naukowe
Tytuł:
Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses.
Autorzy:
Nguyen TTT; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea.
Choi YH; Department of Microbiology, College of Medicine, Gachon University, Incheon 21999, Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.
Lee WK; New Drug Development Center, Osong Medical Innovation Foundation, Cheongju 28160, Korea.
Ji Y; Department of Microbiology, College of Medicine, Gachon University, Incheon 21999, Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.
Chun E; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea.
Kim YH; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea.
Lee JE; Department of Biochemistry, Kangwon National University, Chuncheon 24341, Korea.
Jung HS; Department of Biochemistry, Kangwon National University, Chuncheon 24341, Korea.
Suh JH; Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon 21983, Korea.
Kim S; Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon 21983, Korea.
Jin M; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea; Department of Microbiology, College of Medicine, Gachon University, Incheon 21999, Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea. Electronic address: .
Pokaż więcej
Źródło:
Cell reports [Cell Rep] 2023 Jan 31; Vol. 42 (1), pp. 111905. Date of Electronic Publication: 2022 Dec 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tryptophan-tRNA Ligase*/genetics
Humans ; Tryptophan/metabolism ; Inflammation
Czasopismo naukowe
Tytuł:
Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells.
Autorzy:
Pham QT; Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.; Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Taniyama D; Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Akabane S; Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Takashima T; Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Maruyama R; Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Sekino Y; Department of Urology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Sentani K; Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Yasui W; Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Oue N; Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Pokaż więcej
Źródło:
Pathobiology : journal of immunopathology, molecular and cellular biology [Pathobiology] 2023; Vol. 90 (1), pp. 44-55. Date of Electronic Publication: 2022 Jun 09.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan Oxygenase*/genetics
Tryptophan Oxygenase*/metabolism
Stomach Neoplasms*/genetics
Humans ; Tryptophan/metabolism ; B7-H1 Antigen/genetics ; Neoplastic Stem Cells/metabolism
Czasopismo naukowe
Tytuł:
Tryptophan and its metabolites in normal physiology and cancer etiology.
Autorzy:
Perez-Castro L; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Garcia R; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Venkateswaran N; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Barnes S; Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Conacci-Sorrell M; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Pokaż więcej
Źródło:
The FEBS journal [FEBS J] 2023 Jan; Vol. 290 (1), pp. 7-27. Date of Electronic Publication: 2021 Nov 07.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Tryptophan*/metabolism
Neoplasms*/genetics
Neoplasms*/therapy
Humans ; Kynurenine/metabolism ; Tryptophan Oxygenase/genetics ; T-Lymphocytes/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism
Czasopismo naukowe
Tytuł:
The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression.
Autorzy:
Nguyen DT; Department of Medicine, Division of Renal Diseases and Hypertension.
Kleczko EK; Department of Medicine, Division of Renal Diseases and Hypertension.
Dwivedi N; Department of Medicine, Division of Renal Diseases and Hypertension.
Monaghan MT; Department of Medicine, Division of Renal Diseases and Hypertension.
Gitomer BY; Department of Medicine, Division of Renal Diseases and Hypertension.
Chonchol MB; Department of Medicine, Division of Renal Diseases and Hypertension.; Consortium for Fibrosis Research and Translation, and.
Clambey ET; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Nemenoff RA; Department of Medicine, Division of Renal Diseases and Hypertension.; Consortium for Fibrosis Research and Translation, and.
Klawitter J; Department of Medicine, Division of Renal Diseases and Hypertension.; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Hopp K; Department of Medicine, Division of Renal Diseases and Hypertension.; Consortium for Fibrosis Research and Translation, and.
Pokaż więcej
Źródło:
JCI insight [JCI Insight] 2023 Jan 10; Vol. 8 (1). Date of Electronic Publication: 2023 Jan 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Tryptophan*
Polycystic Kidney, Autosomal Dominant*/genetics
Polycystic Kidney, Autosomal Dominant*/metabolism
Animals ; Mice ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Mice, Inbred C57BL ; Kynurenine ; Mice, Knockout ; Tryptophan Oxygenase/genetics
Czasopismo naukowe
Tytuł:
Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism.
Autorzy:
Ge PY; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Qu SY; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Ni SJ; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Yao ZY; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Qi YY; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Zhao X; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Guo R; School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Yang NY; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Zhang QC; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Zhu HX; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Pokaż więcej
Źródło:
Phytotherapy research : PTR [Phytother Res] 2023 Jan; Vol. 37 (1), pp. 342-357. Date of Electronic Publication: 2022 Sep 11.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan*/metabolism
Berberine*/pharmacology
Mice ; Animals ; Depression/drug therapy ; Depression/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Neurotransmitter Agents ; Stress, Psychological/drug therapy ; Disease Models, Animal ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Tryptophan Hydroxylase
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies