Temat: "Tryptophan Synthase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Tryptophan production by catalysis of a putative tryptophan synthase protein.
Autorzy:: Cao L; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.
Zhang J; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
Chen J; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.
Li M; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.
Chen H; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.
Wang C; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.
Gong C; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China. .; Pokaż więcej
Źródło:: Archives of microbiology [Arch Microbiol] 2024 Sep 02; Vol. 206 (9), pp. 390. Date of Electronic Publication: 2024 Sep 02.
Typ publikacji:: Journal Article
MeSH Terms:: Tryptophan Synthase*/metabolism
Tryptophan Synthase*/genetics
Tryptophan Synthase*/chemistry
Tryptophan*/metabolism
Escherichia coli*/genetics
Escherichia coli*/metabolism
Mutagenesis, Site-Directed*
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bacterial Proteins/chemistry ; Sphingomonadaceae/enzymology ; Sphingomonadaceae/genetics ; Sphingomonadaceae/metabolism ; Recombinant Proteins/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/chemistry ; Catalytic Domain ; Cloning, Molecular ; Hydrogen-Ion Concentration ; Indoles/metabolism ; Catalysis ; Serine/metabolism

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Tytuł:: Fungi Tryptophan Synthases: What Is the Role of the Linker Connecting the α and β Structural Domains in Hemileia vastatrix TRPS? A Molecular Dynamics Investigation.
Autorzy:: Martins NF; EMBRAPA Agroindústria Tropical, Planalto do Pici, Fortaleza 60511-110, CE, Brazil.
Viana MJA; EMBRAPA Agroindústria Tropical, Planalto do Pici, Fortaleza 60511-110, CE, Brazil.
Maigret B; LORIA, UMR 7504 CNRS, Université de Lorraine, 54000 Vandoeuvre les Nancy, France.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 06; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:: Journal Article
MeSH Terms:: Molecular Dynamics Simulation*
Tryptophan Synthase*/chemistry
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Basidiomycota*
Tryptophan ; Fungi/metabolism
SCR Organism:: Hemileia vastatrix

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Skocz do pozycji: 3.

Tytuł:: A Molecular Dynamics Simulation Study of the Effects of βGln114 Mutation on the Dynamic Behavior of the Catalytic Site of the Tryptophan Synthase.
Autorzy:: Roy A; Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A5B7, Canada.
Karttunen M; Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A5B7, Canada.; Department of Physics and Astronomy, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A3K7, Canada.; The Centre of Advanced Materials and Biomaterials Research, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A5B7, Canada.; Pokaż więcej
Źródło:: Journal of chemical information and modeling [J Chem Inf Model] 2024 Feb 12; Vol. 64 (3), pp. 983-1003. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Tryptophan Synthase*/genetics
Tryptophan Synthase*/chemistry
Tryptophan Synthase*/metabolism
Cryptosporidiosis*
Cryptosporidium*/metabolism
Humans ; Catalytic Domain ; Molecular Dynamics Simulation ; Salmonella typhimurium/genetics ; Protein Conformation ; Amino Acids ; Mutation ; Water ; Kinetics

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Skocz do pozycji: 4.

Tytuł:: Improving the Activity of Tryptophan Synthetase via a Nucleic Acid Scaffold.
Autorzy:: Wang Y; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China.
Wang X; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China.
Niu S; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China.
Cheng W; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China.
Liu X; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.
Min Y; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.
Qiu Y; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.
Ma L; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China.
Rao B; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.
Zhu L; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Oct 26; Vol. 28 (21). Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:: Journal Article
MeSH Terms:: Tryptophan Synthase*/chemistry
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Nucleic Acids*
Escherichia coli/metabolism ; Amino Acids
SCR Organism:: Trapa

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Skocz do pozycji: 5.

Tytuł:: Allostery, engineering and inhibition of tryptophan synthase.
Autorzy:: D'Amico RN; Department of Chemistry, Pennsylvania State University, University Park, PA, USA, 16802.
Boehr DD; Department of Chemistry, Pennsylvania State University, University Park, PA, USA, 16802. Electronic address: .; Pokaż więcej
Źródło:: Current opinion in structural biology [Curr Opin Struct Biol] 2023 Oct; Vol. 82, pp. 102657. Date of Electronic Publication: 2023 Jul 17.
Typ publikacji:: Journal Article; Review; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Tryptophan Synthase*/chemistry
Tryptophan Synthase*/metabolism
Models, Molecular ; Catalysis ; Allosteric Regulation

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Tytuł:: Tryptophan-synthesizing bacteria enhance colonic motility.
Autorzy:: Legan TB; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.
Lavoie B; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.
Norberg E; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.
Ley IC; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.
Tack S; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.
Tompkins TA; Lallemand Bio Ingredients, Montreal, Quebec, Canada.
Wargo MJ; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA.
Mawe GM; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.; Pokaż więcej
Źródło:: Neurogastroenterology and motility [Neurogastroenterol Motil] 2023 Oct; Vol. 35 (10), pp. e14629. Date of Electronic Publication: 2023 Jun 25.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Tryptophan*/pharmacology
Tryptophan Synthase*/pharmacology
Mice ; Animals ; Serotonin/metabolism ; Hydroxyindoleacetic Acid ; Gastrointestinal Motility ; Mice, Knockout ; Bacteria

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Skocz do pozycji: 7.

Tytuł:: Evidence from Co-expression Analysis for the Involvement of Amidase and INS in the Tryptophan-Independent Pathway of IAA Synthesis in Arabidopsis.
Autorzy:: Abu-Zaitoon YM; Department of Biology, Al-Hussein Bin Talal University, Maan, Jordan. .
Abu-Zaiton A; Department of Biology, Faculty of Science, Al-Albayt University, Mafraq, Jordan.
Tawaha ARA; Department of Biology, Faculty of Science, Al-Albayt University, Mafraq, Jordan.
Fandi KG; Department of Biology, Al-Hussein Bin Talal University, Maan, Jordan.
Alnaimat SM; Department of Biology, Al-Hussein Bin Talal University, Maan, Jordan.
Pati S; NatNov Bioscience Private Limited, Balasore, 756001, India.
Almomani FA; Department of Applied Biology, Jordan University of Science and Technology, Irbid, Jordan.; Pokaż więcej
Źródło:: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2022 Oct; Vol. 194 (10), pp. 4673-4682. Date of Electronic Publication: 2022 Jul 08.
Typ publikacji:: Journal Article
MeSH Terms:: Arabidopsis*/genetics
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Amidohydrolases/genetics ; Amidohydrolases/metabolism ; Hormones/metabolism ; Indoleacetic Acids/metabolism ; Indoles/metabolism ; Tryptophan/metabolism

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Skocz do pozycji: 8.

Tytuł:: Estimating conformational heterogeneity of tryptophan synthase with a template-based Alphafold2 approach.
Autorzy:: Casadevall G; CompBioLab Group, Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.
Duran C; CompBioLab Group, Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.
Estévez-Gay M; CompBioLab Group, Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.
Osuna S; CompBioLab Group, Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.; ICREA, Barcelona, Spain.; Pokaż więcej
Źródło:: Protein science : a publication of the Protein Society [Protein Sci] 2022 Oct; Vol. 31 (10), pp. e4426.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Tryptophan Synthase*/chemistry
Catalysis ; Catalytic Domain ; Protein Conformation ; Proteins

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Tytuł:: Human gut-associated Bifidobacterium species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan.
Autorzy:: Yong CC; Innovative Research Institute, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan.
Sakurai T; Innovative Research Institute, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan.
Kaneko H; Innovative Research Institute, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan.
Horigome A; Innovative Research Institute, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan.
Mitsuyama E; Innovative Research Institute, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan.
Nakajima A; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Katoh T; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Sakanaka M; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Abe T; Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Xiao JZ; Innovative Research Institute, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan.
Tanaka M; Innovative Research Institute, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan.
Odamaki T; Innovative Research Institute, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan.; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Katayama T; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.; Pokaż więcej
Źródło:: Gut microbes [Gut Microbes] 2024 Jan-Dec; Vol. 16 (1), pp. 2347728. Date of Electronic Publication: 2024 May 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Tryptophan*/metabolism
Indoles*/metabolism
Gastrointestinal Microbiome*
Bifidobacterium*/metabolism
Bifidobacterium*/genetics
Humans ; Tryptophan Synthase/metabolism ; Tryptophan Synthase/genetics ; Gastrointestinal Tract/microbiology ; Gastrointestinal Tract/metabolism

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Tytuł:: Similarities of P1-Like Phage Plasmids and Their Role in the Dissemination of bla CTX-M-55 .
Autorzy:: Wang M; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
Jiang L; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
Wei J; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
Zhu H; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
Zhang J; College of Veterinary Medicine, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, Guangzhou, China.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, Guangzhou, China.
Liu Z; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
Zhang W; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
He X; College of Veterinary Medicine, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, Guangzhou, China.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, Guangzhou, China.
Liu Y; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
Li R; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
Xiao X; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.
Sun Y; College of Veterinary Medicine, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, Guangzhou, China.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Zeng Z; College of Veterinary Medicine, South China Agricultural Universitygrid.20561.30, Guangzhou, China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, Guangzhou, China.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, Guangzhou, China.; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Wang Z; College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.; Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, China.; International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou, China.; Pokaż więcej
Źródło:: Microbiology spectrum [Microbiol Spectr] 2022 Oct 26; Vol. 10 (5), pp. e0141022. Date of Electronic Publication: 2022 Sep 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Bacteriophages*/genetics
Tryptophan Synthase*/genetics
beta-Lactamases/genetics ; Plasmids/genetics ; Escherichia coli ; Indoles ; Anti-Bacterial Agents/pharmacology

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Skocz do pozycji: 11.

Tytuł:: Fermentative Indole Production via Bacterial Tryptophan Synthase Alpha Subunit and Plant Indole-3-Glycerol Phosphate Lyase Enzymes.
Autorzy:: Ferrer L; Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, 33615 Bielefeld, Germany.
Mindt M; Wageningen Plant Research, Wageningen University & Research, 6708PB Wageningen, The Netherlands.; Axxence Aromatic GmbH, 46446 Emmerich am Rhein, Germany.
Suarez-Diez M; Laboratory of Systems and Synthetic Biology, Wageningen University & Research, 6708WE Wageningen, The Netherlands.
Jilg T; Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, 33615 Bielefeld, Germany.
Zagorščak M; Department of Biotechnology and Systems Biology, National Institute of Biology, 1000 Ljubljana, Slovenia.
Lee JH; Department of Food Science & Biotechnology, Kyungsung University, 608-736 Busan, Republic of Korea.
Gruden K; Department of Biotechnology and Systems Biology, National Institute of Biology, 1000 Ljubljana, Slovenia.
Wendisch VF; Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, 33615 Bielefeld, Germany.
Cankar K; Wageningen Plant Research, Wageningen University & Research, 6708PB Wageningen, The Netherlands.; Pokaż więcej
Źródło:: Journal of agricultural and food chemistry [J Agric Food Chem] 2022 May 11; Vol. 70 (18), pp. 5634-5645. Date of Electronic Publication: 2022 May 02.
Typ publikacji:: Journal Article
MeSH Terms:: Lyases*
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Animals ; Fermentation ; Glycerophosphates ; Indoles

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Skocz do pozycji: 12.

Tytuł:: Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase N -Dimethylallyl-l-tryptophan Synthase from Fusarium fujikuroi .
Autorzy:: Eaton SA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Ronnebaum TA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Roose BW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Pokaż więcej
Źródło:: Biochemistry [Biochemistry] 2022 Sep 20; Vol. 61 (18), pp. 2025-2035. Date of Electronic Publication: 2022 Sep 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Biological Products*
Dimethylallyltranstransferase*/chemistry
Tryptophan Synthase*/metabolism
Catalysis ; Fusarium ; Hemiterpenes ; Indoles ; Neoprene ; Nitrogen ; Organophosphorus Compounds ; Prenylation ; Substrate Specificity ; Tryptophan/chemistry
SCR Organism:: Fusarium fujikuroi

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Tytuł:: The role of tryptophan in Chlamydia trachomatis persistence.
Autorzy:: Wang L; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Hou Y; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Yuan H; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Chen H; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.; Pokaż więcej
Źródło:: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Aug 02; Vol. 12, pp. 931653. Date of Electronic Publication: 2022 Aug 02 (Print Publication: 2022).
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Chlamydia Infections*/microbiology
Tryptophan Synthase*/genetics
Chlamydia trachomatis ; Humans ; Indoles/metabolism ; Interferon-gamma/metabolism ; Tryptophan/metabolism

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Skocz do pozycji: 14.

Tytuł:: Computational Analysis on the Allostery of Tryptophan Synthase: Relationship between α/β-Ligand Binding and Distal Domain Closure.
Autorzy:: Ito S; Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Yagi K; Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Sugita Y; Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.; Computational Biophysics Research Team, RIKEN Center for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.; Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, 1-6-5 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.; Pokaż więcej
Źródło:: The journal of physical chemistry. B [J Phys Chem B] 2022 May 05; Vol. 126 (17), pp. 3300-3308. Date of Electronic Publication: 2022 Apr 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Tryptophan Synthase*/chemistry
Tryptophan Synthase*/metabolism
Allosteric Regulation ; Binding Sites ; Indoles/metabolism ; Kinetics ; Ligands ; Phosphates ; Protein Conformation

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Tytuł:: Discovery of antimicrobial agent targeting tryptophan synthase.
Autorzy:: Bosken YK; Department of Chemistry, University of California at Riverside, Riverside, California.
Ai R; Department of Chemistry, University of California at Riverside, Riverside, California.
Hilario E; Department of Chemistry, University of California at Riverside, Riverside, California.
Ghosh RK; Department of Biochemistry, University of California at Riverside, Riverside, California.
Dunn MF; Department of Biochemistry, University of California at Riverside, Riverside, California.
Kan SH; Department of Chemistry, University of California at Riverside, Riverside, California.
Niks D; Department of Biochemistry, University of California at Riverside, Riverside, California.
Zhou H; Department of Microbiology and Plant Pathology, University of California at Riverside, Riverside, California.
Ma W; Department of Microbiology and Plant Pathology, University of California at Riverside, Riverside, California.
Mueller LJ; Department of Chemistry, University of California at Riverside, Riverside, California.
Fan L; Department of Biochemistry, University of California at Riverside, Riverside, California.
Chang CA; Department of Chemistry, University of California at Riverside, Riverside, California.; Pokaż więcej
Źródło:: Protein science : a publication of the Protein Society [Protein Sci] 2022 Feb; Vol. 31 (2), pp. 432-442. Date of Electronic Publication: 2021 Nov 26.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/pharmacology
Tryptophan Synthase*/antagonists & inhibitors
Tryptophan Synthase*/chemistry
Binding Sites ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Dynamics Simulation

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Skocz do pozycji: 16.

Tytuł:: Directed Evolution Improves the Enzymatic Synthesis of L-5-Hydroxytryptophan by an Engineered Tryptophan Synthase.
Autorzy:: Xu L; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China. .
Li T; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Huo Z; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Chen Q; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Xia Q; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Jiang B; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.; Pokaż więcej
Źródło:: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2021 Oct; Vol. 193 (10), pp. 3407-3417. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji:: Journal Article
MeSH Terms:: Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Tryptophan Synthase*/chemistry
Directed Molecular Evolution*
Escherichia coli*/genetics
5-Hydroxytryptophan*/biosynthesis
Protein Engineering/methods

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Skocz do pozycji: 17.

Tytuł:: Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB.
Autorzy:: Michalska K; Center for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, Illinois, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, Illinois, USA.
Wellington S; Department of Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Maltseva N; Center for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, Illinois, USA.
Jedrzejczak R; Center for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, Illinois, USA.
Selem-Mojica N; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav, Mexico.
Rosas-Becerra LR; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav, Mexico.
Barona-Gómez F; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav, Mexico.
Hung DT; Department of Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Joachimiak A; Center for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, Illinois, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, Illinois, USA.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.; Pokaż więcej
Źródło:: Protein science : a publication of the Protein Society [Protein Sci] 2021 Sep; Vol. 30 (9), pp. 1904-1918. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Bacterial Proteins/*chemistry
Chlamydia trachomatis/*enzymology
Protein Subunits/*chemistry
Pyridoxal Phosphate/*chemistry
Tryptophan/*chemistry
Tryptophan Synthase/*chemistry
Allosteric Regulation ; Amino Acid Sequence ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites ; Biocatalysis ; Catalytic Domain ; Chlamydia trachomatis/chemistry ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Kinetics ; Models, Molecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Pyridoxal Phosphate/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Substrate Specificity ; Tryptophan/biosynthesis ; Tryptophan Synthase/genetics ; Tryptophan Synthase/metabolism

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Skocz do pozycji: 18.

Tytuł:: Mutation of βGln114 to Ala Alters the Stabilities of Allosteric States in Tryptophan Synthase Catalysis.
Autorzy:: Ghosh RK; Department of Biochemistry, University of California, Riverside, California 92521, United States.
Hilario E; Department of Chemistry, University of California, Riverside, California 92521, United States.
Liu V; Department of Chemistry, University of California, Riverside, California 92521, United States.
Wang Y; Department of Chemistry, University of California, Riverside, California 92521, United States.
Niks D; Department of Biochemistry, University of California, Riverside, California 92521, United States.
Holmes JB; Department of Chemistry, University of California, Riverside, California 92521, United States.
Sakhrani VV; Department of Chemistry, University of California, Riverside, California 92521, United States.
Mueller LJ; Department of Chemistry, University of California, Riverside, California 92521, United States.
Dunn MF; Department of Biochemistry, University of California, Riverside, California 92521, United States.; Pokaż więcej
Źródło:: Biochemistry [Biochemistry] 2021 Oct 26; Vol. 60 (42), pp. 3173-3186. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Bacterial Proteins/*chemistry
Tryptophan Synthase/*chemistry
Allosteric Regulation/genetics ; Bacterial Proteins/genetics ; Biocatalysis ; Kinetics ; Mutagenesis, Site-Directed ; Mutation ; Salmonella typhimurium/enzymology ; Tryptophan Synthase/genetics

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Skocz do pozycji: 19.

Tytuł:: Distinct conformational dynamics and allosteric networks in alpha tryptophan synthase during active catalysis.
Autorzy:: O'Rourke KF; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA.
D'Amico RN; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA.
Sahu D; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA.
Boehr DD; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA.; Pokaż więcej
Źródło:: Protein science : a publication of the Protein Society [Protein Sci] 2021 Mar; Vol. 30 (3), pp. 543-557. Date of Electronic Publication: 2020 Dec 19.
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Tryptophan Synthase*/chemistry
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Allosteric Regulation/genetics ; Catalysis ; Catalytic Domain/genetics ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Glycerophosphates/chemistry ; Glycerophosphates/metabolism ; Indoles/chemistry ; Indoles/metabolism ; Protein Conformation

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Skocz do pozycji: 20.

Tytuł:: Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB.
Autorzy:: Watkins-Dulaney EJ; Division of Biology and Biological Engineering, California Institute of Technology, MC 210-41, 1200 E. California Boulevard, Pasadena, CA, 91125, USA.
Dunham NP; Division of Chemistry and Chemical Engineering, California Institute of Technology, MC 210-41, 1200 E. California Boulevard, Pasadena, CA, 91125, USA.
Straathof S; Division of Chemistry and Chemical Engineering, California Institute of Technology, MC 210-41, 1200 E. California Boulevard, Pasadena, CA, 91125, USA.
Turi S; Division of Chemistry and Chemical Engineering, California Institute of Technology, MC 210-41, 1200 E. California Boulevard, Pasadena, CA, 91125, USA.
Arnold FH; Division of Biology and Biological Engineering, California Institute of Technology, MC 210-41, 1200 E. California Boulevard, Pasadena, CA, 91125, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, MC 210-41, 1200 E. California Boulevard, Pasadena, CA, 91125, USA.
Buller AR; Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, 53706, USA.; Pokaż więcej
Źródło:: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Sep 20; Vol. 60 (39), pp. 21412-21417. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein Engineering*
Ketones/*metabolism
Tryptophan Synthase/*metabolism
Alkylation ; Biocatalysis ; Ketones/chemistry ; Molecular Structure ; Tryptophan Synthase/chemistry

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