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Tytuł:
TBK1 is part of a galectin 8 dependent membrane damage recognition complex and drives autophagy upon Adenovirus endosomal escape.
Autorzy:
Pied N; CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France.
Daussy CF; CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France.
Denis Z; CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France.
Ragues J; CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France.
Faure M; CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France.
Iggo R; INSERM U1218, Institut Bergonié, University of Bordeaux, Bordeaux, France.
Tschan MP; Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.
Roger B; CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France.
Rayne F; CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France.
Wodrich H; CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Jul 20; Vol. 18 (7), pp. e1010736. Date of Electronic Publication: 2022 Jul 20 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenoviridae Infections*/metabolism
Autophagy*
Endosomes*/metabolism
Protein Serine-Threonine Kinases*/genetics
Adenoviridae/metabolism ; Galectins/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Advanced Non-Small Cell Lung Cancer after Neoadjuvant Therapy.
Autorzy:
Losmanova T; Institute of Pathology, University of Bern, 3008 Bern, Switzerland.
Zens P; Institute of Pathology, University of Bern, 3008 Bern, Switzerland.; Graduate School for Health Science, University of Bern, 3012 Bern, Switzerland.
Scherz A; Department of Medical Oncology, Inselspital University Hospital Bern, 3010 Bern, Switzerland.
Schmid RA; Department of General Thoracic Surgery, Inselspital University Hospital Bern, 3010 Bern, Switzerland.
Tschan MP; Institute of Pathology, University of Bern, 3008 Bern, Switzerland.
Berezowska S; Institute of Pathology, University of Bern, 3008 Bern, Switzerland.; Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
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Źródło:
Cells [Cells] 2021 Oct 13; Vol. 10 (10). Date of Electronic Publication: 2021 Oct 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chaperone-Mediated Autophagy*
Neoadjuvant Therapy*
Biomarkers, Tumor/*metabolism
Carcinoma, Non-Small-Cell Lung/*metabolism
Carcinoma, Non-Small-Cell Lung/*therapy
HSC70 Heat-Shock Proteins/*metabolism
Lung Neoplasms/*metabolism
Lysosomal-Associated Membrane Protein 2/*metabolism
Aged ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Disease-Free Survival ; Female ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Multivariate Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment.
Autorzy:
Niklaus NJ; Institute of Pathology, University of Bern, CH-3008 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, CH-3012 Bern, Switzerland.
Tokarchuk I; Institute of Pathology, University of Bern, CH-3008 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, CH-3012 Bern, Switzerland.
Zbinden M; Institute of Pathology, University of Bern, CH-3008 Bern, Switzerland.
Schläfli AM; Institute of Pathology, University of Bern, CH-3008 Bern, Switzerland.
Maycotte P; Centro de Investigación Biomédica de Oriente (CIBIOR), Instituto Mexicano del Seguro Social (IMSS), Puebla 74360, Mexico.
Tschan MP; Institute of Pathology, University of Bern, CH-3008 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, CH-3012 Bern, Switzerland.
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Źródło:
Cells [Cells] 2021 Jun 09; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Autophagy*
Cell Transformation, Neoplastic*
Breast Neoplasms/*pathology
Carcinogenesis/*pathology
Animals ; Cell Line, Tumor ; Female ; Humans ; Neoplasm Recurrence, Local
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells.
Autorzy:
Schläfli AM; Institute of Pathology, University of Bern, Bern, Switzerland. .
Tokarchuk I; Institute of Pathology, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Parejo S; Institute of Pathology, University of Bern, Bern, Switzerland.
Jutzi S; Institute of Pathology, University of Bern, Bern, Switzerland.
Berezowska S; Institute of Pathology, University of Bern, Bern, Switzerland.; Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Engedal N; Centre for Molecular Medicine Norway (NCMM), University of Oslo, Oslo, Norway.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Tschan MP; Institute of Pathology, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
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Źródło:
Scientific reports [Sci Rep] 2021 Apr 27; Vol. 11 (1), pp. 9011. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anaplastic Lymphoma Kinase/*antagonists & inhibitors
Antineoplastic Agents/*pharmacology
Autophagy/*drug effects
Carcinoma, Non-Small-Cell Lung/*immunology
Lung Neoplasms/*immunology
Oncogene Proteins, Fusion/*metabolism
Pyrimidines/*pharmacology
Sulfones/*pharmacology
Autophagy-Related Protein-1 Homolog/metabolism ; Carcinoma, Non-Small-Cell Lung/enzymology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Class III Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Class III Phosphatidylinositol 3-Kinases/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Lung Neoplasms/enzymology ; Lung Neoplasms/metabolism ; Microtubule-Associated Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer.
Autorzy:
Dommann N; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Sánchez-Taltavull D; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Eggs L; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Birrer F; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Brodie T; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Salm L; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Baier FA; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Medová M; Department of Biomedical Research, Radiation Oncology, University of Bern, Bern University Hospital, 3008 Bern, Switzerland.
Humbert M; Institute of Pathology, University of Bern, 3008 Bern, Switzerland.
Tschan MP; Institute of Pathology, University of Bern, 3008 Bern, Switzerland.
Beldi G; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Candinas D; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
Stroka D; Department of Biomedical Research, Visceral and Transplantation Surgery, University of Bern, Clinic of Visceral Surgery and Medicine, Bern University Hospital, 3008 Bern, Switzerland.
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Źródło:
Cancers [Cancers (Basel)] 2020 Jul 15; Vol. 12 (7). Date of Electronic Publication: 2020 Jul 15.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.
Autorzy:
Adams O
Janser FA
Dislich B
Berezowska S
Humbert M
Seiler CA
Kröll D
Slotta-Huspenina J
Feith M
Ott K
Tschan MP
Langer R
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Źródło:
PloS one [PLoS One] 2019 Oct 30; Vol. 14 (10), pp. e0224832. Date of Electronic Publication: 2019 Oct 30 (Print Publication: 2019).
Typ publikacji:
Published Erratum
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma.
Autorzy:
Djavaheri-Mergny M; INSERM U1218, Université de Bordeaux, 33076 Bordeaux, France. .; INSERM U1138, 75006 Paris, France. .; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France. .; Université Pierre et Marie Curie, Sorbonne Université, 75006 Paris, France. .; Cell Biology and Metabolomics platforms, Gustave Roussy Cancer Campus, 94800 Villejuif, France. .; TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge, COST Action CA15138. .
Giuriato S; TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge, COST Action CA15138. .; INSERM, UMR1037 CRCT, F-31000 Toulouse, France. .; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000 Toulouse, France. .; CNRS, ERL5294 CRCT, F-31000 Toulouse, France. .; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. .; European Research Initiative on ALK-related malignancies (ERIA), F-31000 Toulouse, France. .
Tschan MP; TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge, COST Action CA15138. mario.tschan@pathology.unibe.ch.; Institute of Pathology, Division of Experimental Pathology, University of Bern, Murtenstrasse 31, CH-3008 Bern, Switzerland. mario.tschan@pathology.unibe.ch.
Humbert M; Institute of Pathology, Division of Experimental Pathology, University of Bern, Murtenstrasse 31, CH-3008 Bern, Switzerland. .
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Źródło:
Cells [Cells] 2019 Jan 30; Vol. 8 (2). Date of Electronic Publication: 2019 Jan 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Autophagy*
Leukemia/*pathology
Lymphoma/*pathology
Animals ; Clinical Trials as Topic ; Hematopoiesis ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells.
Autorzy:
Janser FA; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .; Graduate School for Cellular and Biomedical Sciences, University of Bern, Freiestr. 1, 3012 Bern, Switzerland. .
Adams O; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .; Graduate School for Cellular and Biomedical Sciences, University of Bern, Freiestr. 1, 3012 Bern, Switzerland. .
Bütler V; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .
Schläfli AM; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .
Dislich B; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .
Seiler CA; Department of Visceral Surgery and Medicine, University Hospital Bern, 3010 Bern, Switzerland. .
Kröll D; Department of Visceral Surgery and Medicine, University Hospital Bern, 3010 Bern, Switzerland. .
Langer R; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .
Tschan MP; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. mario.tschan@pathology.unibe.ch.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Freiestr. 1, 3012 Bern, Switzerland. mario.tschan@pathology.unibe.ch.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Oct 08; Vol. 19 (10). Date of Electronic Publication: 2018 Oct 08.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma/*drug therapy
Antineoplastic Agents/*pharmacology
Autophagy/*drug effects
Esophageal Neoplasms/*drug therapy
Lapatinib/*pharmacology
Adenocarcinoma/metabolism ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Esophageal Neoplasms/metabolism ; HEK293 Cells ; Humans ; Lapatinib/therapeutic use ; Receptor, ErbB-2/antagonists & inhibitors
SCR Disease Name:
Adenocarcinoma Of Esophagus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway.
Autorzy:
Graule J; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Uth K; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Freiestrasse 1, 3012, Bern, Switzerland.
Fischer E; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Centeno I; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Galván JA; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Eichmann M; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Rau TT; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Langer R; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Dawson H; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Nitsche U; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, Munich, 81675, Germany.
Traeger P; Careanesth AG, Nelkenstrasse 15, Zürich, 8006, Switzerland.
Berger MD; Department of Medical Oncology, University Hospital of Bern, 3010, Bern, Switzerland.; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, 90033, CA, USA.
Schnüriger B; Department of Visceral and Internal Medicine, University Hospital of Bern, 3008, Bern, Switzerland.
Hädrich M; Department of Visceral and Internal Medicine, University Hospital of Bern, 3008, Bern, Switzerland.
Studer P; Department of Visceral and Internal Medicine, University Hospital of Bern, 3008, Bern, Switzerland.
Inderbitzin D; University of Bern and Bürgerspital Solothurn, Schöngrünstrasse 42, 4500, Solothurn, Switzerland.
Lugli A; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.
Tschan MP; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Freiestrasse 1, 3012, Bern, Switzerland.
Zlobec I; Institute of Pathology, University of Bern, Murtenstrasse 31, Room L310, 3008, Bern, Switzerland. .
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2018 Sep 26; Vol. 10 (1), pp. 120. Date of Electronic Publication: 2018 Sep 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Methylation*
CDX2 Transcription Factor/*genetics
CDX2 Transcription Factor/*metabolism
Colorectal Neoplasms/*metabolism
Histones/*metabolism
Benzamides/pharmacology ; Caco-2 Cells ; Cell Line, Tumor ; Colorectal Neoplasms/genetics ; CpG Islands ; Decitabine/pharmacology ; Female ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; HT29 Cells ; Humans ; Hydroxamic Acids/pharmacology ; Male ; Prognosis ; Promoter Regions, Genetic ; Retrospective Studies ; Tissue Array Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expression Analysis of Autophagy Related Markers LC3B, p62 and HMGB1 Indicate an Autophagy-Independent Negative Prognostic Impact of High p62 Expression in Pulmonary Squamous Cell Carcinomas.
Autorzy:
Langer R; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .
Neppl C; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .
Keller MD; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .
Schmid RA; Division of General Thoracic Surgery, Inselspital University Hospital Bern, 3010 Bern, Switzerland. .; Department of Clinical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland. .
Tschan MP; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. mario.tschan@pathology.unibe.ch.
Berezowska S; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland. .
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Źródło:
Cancers [Cancers (Basel)] 2018 Aug 21; Vol. 10 (9). Date of Electronic Publication: 2018 Aug 21.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.
Autorzy:
Adams O; Institute of Pathology, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Janser FA; Institute of Pathology, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Dislich B; Institute of Pathology, University of Bern, Bern, Switzerland.
Berezowska S; Institute of Pathology, University of Bern, Bern, Switzerland.
Humbert M; Institute of Pathology, University of Bern, Bern, Switzerland.
Seiler CA; Department of Visceral Surgery and Medicine, Inselspital University Hospital Bern and University of Bern, Bern, Switzerland.
Kroell D; Department of Visceral Surgery and Medicine, Inselspital University Hospital Bern and University of Bern, Bern, Switzerland.
Slotta-Huspenina J; Institute of Pathology, Technische Universität München, München, Germany.
Feith M; Department of Surgery, Klinikum Rechts der Isar, Technische Universität München, München, Germany.
Ott K; Department of Surgery, RoMED Klinikum, Rosenheim, Germany.
Tschan MP; Institute of Pathology, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Langer R; Institute of Pathology, University of Bern, Bern, Switzerland.
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Źródło:
PloS one [PLoS One] 2018 Jun 13; Vol. 13 (6), pp. e0197610. Date of Electronic Publication: 2018 Jun 13 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenocarcinoma/*drug therapy
Esophageal Neoplasms/*drug therapy
Microtubule-Associated Proteins/*genetics
RNA-Binding Proteins/*genetics
Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adult ; Aged ; Autophagy/genetics ; Biopsy ; Disease-Free Survival ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoadjuvant Therapy/adverse effects ; Paclitaxel/administration & dosage ; Paclitaxel/adverse effects ; Transcription Factors
SCR Disease Name:
Adenocarcinoma Of Esophagus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells.
Autorzy:
Trocoli A; 1] INSERM U916 VINCO, Institut Bergonié, 229, cours de l'Argonne 33076 Bordeaux Cedex, France [2] Université Bordeaux, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.
Bensadoun P; 1] INSERM U916 VINCO, Institut Bergonié, 229, cours de l'Argonne 33076 Bordeaux Cedex, France [2] Université Bordeaux, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.
Richard E; 1] INSERM U916 VINCO, Institut Bergonié, 229, cours de l'Argonne 33076 Bordeaux Cedex, France [2] Université Bordeaux, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.
Labrunie G; 1] INSERM U916 VINCO, Institut Bergonié, 229, cours de l'Argonne 33076 Bordeaux Cedex, France [2] Université Bordeaux, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.
Merhi F; 1] INSERM U916 VINCO, Institut Bergonié, 229, cours de l'Argonne 33076 Bordeaux Cedex, France [2] Université Bordeaux, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.
Schläfli AM; Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.
Brigger D; Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.
Souquere S; UMR 8122, CNRS - IGR - Université Paris-XI, Villejuif, France.
Pierron G; UMR 8122, CNRS - IGR - Université Paris-XI, Villejuif, France.
Pasquet JM; INSERM U1035, Université Bordeaux, Bordeaux, France.
Soubeyran P; 1] INSERM U916 VINCO, Institut Bergonié, 229, cours de l'Argonne 33076 Bordeaux Cedex, France [2] Université Bordeaux, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.
Reiffers J; 1] INSERM U916 VINCO, Institut Bergonié, 229, cours de l'Argonne 33076 Bordeaux Cedex, France [2] Université Bordeaux, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.
Ségal-Bendirdjian E; INSERM UMR-S 1007, Cellular Homeostasis and Cancer, Université Paris Descartes, Sorbonne Paris Cité, 45 rue des Saints-Pères, 75006, Paris, France.
Tschan MP; Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.
Djavaheri-Mergny M; 1] INSERM U916 VINCO, Institut Bergonié, 229, cours de l'Argonne 33076 Bordeaux Cedex, France [2] Université Bordeaux, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.
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Źródło:
Cell death and differentiation [Cell Death Differ] 2014 Dec; Vol. 21 (12), pp. 1852-61. Date of Electronic Publication: 2014 Jul 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*metabolism
Cell Transformation, Neoplastic/*metabolism
Leukemia, Myeloid, Acute/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Cell Line, Tumor ; Cell Survival ; Cell Transformation, Neoplastic/genetics ; Gene Expression ; Gene Expression Regulation, Leukemic ; Granulocytes/metabolism ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Sequestosome-1 Protein ; Tretinoin/pharmacology ; Ubiquitination ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation.
Autorzy:
Federzoni EA; 1] Experimental Oncology/Hematology, Department of Clinical Research, University of Bern, Bern, Switzerland [2] Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA [4].
Humbert M; 1] Experimental Oncology/Hematology, Department of Clinical Research, University of Bern, Bern, Switzerland [2] Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland [3].
Torbett BE; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
Behre G; Department for Hematology and Oncology, University Hospital of Leipzig, Leipzig, Germany.
Fey MF; 1] Experimental Oncology/Hematology, Department of Clinical Research, University of Bern, Bern, Switzerland [2] Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland.
Tschan MP; 1] Experimental Oncology/Hematology, Department of Clinical Research, University of Bern, Bern, Switzerland [2] Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland [3] Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland [4] Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.
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Źródło:
Scientific reports [Sci Rep] 2014 Mar 03; Vol. 4, pp. 4261. Date of Electronic Publication: 2014 Mar 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CCAAT-Enhancer-Binding Proteins/*metabolism
Hexokinase/*metabolism
Kruppel-Like Transcription Factors/*metabolism
Leukemia, Myeloid, Acute/*metabolism
Leukemia, Myeloid, Acute/*pathology
Neutrophils/*metabolism
Neutrophils/*pathology
Cell Differentiation ; Cell Line, Tumor ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene.
Autorzy:
He Z; Institute of Pharmacology, University of Bern, Bern, Switzerland.
Liu H
Agostini M
Yousefi S
Perren A
Tschan MP
Mak TW
Melino G
Simon HU
Pokaż więcej
Źródło:
Cell death and differentiation [Cell Death Differ] 2013 Oct; Vol. 20 (10), pp. 1415-24. Date of Electronic Publication: 2013 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins/*metabolism
Liver/*physiology
Microtubule-Associated Proteins/*genetics
Microtubule-Associated Proteins/*metabolism
Nuclear Proteins/*metabolism
Tumor Suppressor Proteins/*metabolism
Animals ; Apoptosis/physiology ; Autophagy/physiology ; Autophagy-Related Protein 5 ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; HCT116 Cells ; Humans ; Lipid Metabolism/genetics ; Liver/cytology ; Liver/metabolism ; Mice ; Nuclear Proteins/genetics ; Transcriptional Activation ; Tumor Protein p73 ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 30

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