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Wyświetlanie 1-5 z 5
Tytuł:
Methylophiopogonanone A is a naturally occurring broad-spectrum inhibitor against human UDP-glucuronosyltransferases: Inhibition behaviours and implication in herb-drug interactions.
Autorzy:
Zhou QH; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhu GH; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Song YQ; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Que YF; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
He QQ; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Tu DZ; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zeng HR; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qin WW; Department of Pharmacy and Worldwide Medical Center, Huashan Hospital, Fudan University, Shanghai, China.
Ai CZ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, China.
Ge GB; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Dec; Vol. 129 (6), pp. 437-449. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Herb-Drug Interactions*
Benzodioxoles/*pharmacology
Enzyme Inhibitors/*pharmacology
Glucuronosyltransferase/*antagonists & inhibitors
Isoflavones/*pharmacology
Benzodioxoles/administration & dosage ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/administration & dosage ; HeLa Cells ; Humans ; Inhibitory Concentration 50 ; Isoflavones/administration & dosage ; Microsomes, Liver/enzymology
Czasopismo naukowe
Tytuł:
A broad-spectrum substrate for the human UDP-glucuronosyltransferases and its use for investigating glucuronidation inhibitors.
Autorzy:
Zhou QH; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Qin WW; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040, China.
Finel M; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 00014, Finland.
He QQ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Tu DZ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wang CR; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Ge GB; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 01; Vol. 180, pp. 252-261. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji:
Journal Article
MeSH Terms:
Benzodioxoles/*metabolism
Enzyme Inhibitors/*pharmacology
Glucuronosyltransferase/*antagonists & inhibitors
Glucuronosyltransferase/*metabolism
Isoflavones/*metabolism
Animals ; Benzodioxoles/chemistry ; Dogs ; Drug Evaluation, Preclinical/methods ; Drug Interactions ; Enzyme Inhibitors/metabolism ; Female ; Glucuronides/chemistry ; Glucuronides/metabolism ; Glucuronosyltransferase/chemistry ; Humans ; Isoflavones/chemistry ; Kinetics ; Macaca fascicularis ; Male ; Mice ; Microsomes, Liver/metabolism ; Rabbits ; Rats ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł:
Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors.
Autorzy:
Huo PC; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hu Q; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shu S; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhou QH; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
He RJ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hou J; Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Guan XQ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Tu DZ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hou XD; Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Liu P; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhang N; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address: .
Liu ZG; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: .
Ge GB; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jan 01; Vol. 29, pp. 115853. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Design*
Chalcone/*pharmacology
Enzyme Inhibitors/*pharmacology
Lipase/*antagonists & inhibitors
Animals ; Chalcone/chemical synthesis ; Chalcone/chemistry ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Lipase/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Pancreas/enzymology ; Structure-Activity Relationship ; Swine
Czasopismo naukowe
Tytuł:
Fast HPLC-DAD quantification of nine polyphenols in honey by using second-order calibration method based on trilinear decomposition algorithm.
Autorzy:
Zhang XH; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Wu HL
Wang JY
Tu DZ
Kang C
Zhao J
Chen Y
Miu XX
Yu RQ
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Źródło:
Food chemistry [Food Chem] 2013 May 01; Vol. 138 (1), pp. 62-9. Date of Electronic Publication: 2012 Nov 06.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromatography, High Pressure Liquid/*methods
Honey/*analysis
Polyphenols/*analysis
Algorithms ; Calibration ; Chromatography, High Pressure Liquid/instrumentation ; Chromatography, High Pressure Liquid/standards ; Models, Theoretical
Czasopismo naukowe
Tytuł:
Second-order calibration applied to quantification of two active components of Schisandra chinensis in complex matrix.
Autorzy:
Zhang XH; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Wu HL; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Wang JY; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Chen Y; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Yu YJ; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Nie CC; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Kang C; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Tu DZ; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Yu RQ; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
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Źródło:
Journal of pharmaceutical analysis [J Pharm Anal] 2012 Aug; Vol. 2 (4), pp. 241-248. Date of Electronic Publication: 2012 Apr 25.
Typ publikacji:
Journal Article
Czasopismo naukowe
    Wyświetlanie 1-5 z 5

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