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Tytuł:
Design, synthesis, and biological activity evaluation of novel tubulin polymerization inhibitors based on pyrimidine ring skeletons.
Autorzy:
Kang Y; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Pei Y; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Qin J; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Zhang Y; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Duan Y; Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China.
Yang H; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Yao Y; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China. Electronic address: .
Sun M; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Mar 15; Vol. 84, pp. 129195. Date of Electronic Publication: 2023 Feb 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin Modulators*/pharmacology
Antineoplastic Agents*/pharmacology
Structure-Activity Relationship ; Tubulin/metabolism ; Cell Proliferation ; Drug Design ; Pyrimidines/pharmacology ; Drug Screening Assays, Antitumor ; Polymerization ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis.
Autorzy:
Deng S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States.
Banerjee S; Department of Chemistry, Middle Tennessee State University, 1301 E. Main Street, Murfreesboro, TN, 37132, United States; Molecular Biosciences Program, Middle Tennessee State University, 1301 E. Main Street, Murfreesboro, TN, 37132, United States.
Chen H; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States.
Pochampally S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States.
Wang Y; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yun MK; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, United States.
White SW; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, United States.
Parmar K; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States.
Meibohm B; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States.
Hartman KL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States.
Wu Z; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States.
Miller DD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States. Electronic address: .
Li W; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2023 Feb 28; Vol. 555, pp. 216046. Date of Electronic Publication: 2022 Dec 31.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Melanoma*/drug therapy
Tubulin Modulators*/chemistry
Tubulin Modulators*/pharmacology
Tubulin Modulators*/therapeutic use
Animals ; Humans ; Male ; Mice ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation ; Colchicine/pharmacology ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Polymerization/drug effects ; Tubulin/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of pyrazole-carbohydrazide with indole moiety as tubulin polymerization inhibitors and anti-tumor candidates.
Autorzy:
Man RJ; Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning, China.
Lu T; Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning, China.; Agro-Food Science and Technology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.; College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Zheng CC; Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning, China.; Agro-Food Science and Technology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.; College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Li T; Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning, China.; Agro-Food Science and Technology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.; College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Wu MK; Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning, China.; Agro-Food Science and Technology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.; College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Li DD; College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
He XM; Agro-Food Science and Technology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.; Guangxi Key Laboratory of Fruits and Vegetables Storage-processing Technology, Nanning, China.
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Źródło:
Drug development research [Drug Dev Res] 2023 Feb; Vol. 84 (1), pp. 110-120. Date of Electronic Publication: 2022 Nov 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin Modulators*/pharmacology
Tubulin Modulators*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/metabolism
Tubulin/metabolism ; Cell Line, Tumor ; Molecular Docking Simulation ; Colchicine/pharmacology ; Indoles/pharmacology ; Pyrazoles/pharmacology ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction.
Autorzy:
Foroutan A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Corazzari M; Department of Health Science (DSS), Center for Translational Research on Autoimmune and Allergic Disease (CAAD) & Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), Università del Piemonte Orientale 'Amedeo Avogadro,', 28100, Novara, Italy.
Grolla AA; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Colombo G; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Travelli C; Department of Drug Sciences, Università degli Studi di Pavia, 27100, Pavia, Italy.
Genazzani AA; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Theeramunkong S; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University Research Unit in Drug, Health Product Development and Application (DHP-DA), Thammasat University, Klong Luang, 12120, Pathum Thani, Thailand.
Galli U; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy. Electronic address: .
Tron GC; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114895. Date of Electronic Publication: 2022 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Tubulin Modulators*/chemical synthesis
Tubulin Modulators*/chemistry
Tubulin Modulators*/pharmacology
Pyrrolidinones*/chemical synthesis
Pyrrolidinones*/chemistry
Pyrrolidinones*/pharmacology
Child ; Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Microtubules/drug effects ; Structure-Activity Relationship ; Tubulin/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Design, synthesis and biological evaluation of novel tubulin inhibitors targeting colchicine sites.
Autorzy:
Yuan M; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Su J; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Zhang Y; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Qin J; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Yang H; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Duan Y; Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China.
Yao Y; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China. Electronic address: .
Sun M; School of Pharmaceutical Sciences, and Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Mar 01; Vol. 83, pp. 129166. Date of Electronic Publication: 2023 Jan 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin Modulators*/chemistry
Antineoplastic Agents*/chemistry
Colchicine/chemistry ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Tubulin/metabolism ; Binding Sites ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Identification of Inhibitors of Tubulin Polymerization Using a CRISPR-Edited Cell Line with Endogenous Fluorescent Tagging of β-Tubulin and Histone H1.
Autorzy:
Khachatryan H; Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA.
Olszowy B; Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA.
Barrero CA; Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA.
Gordon J; Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA.
Perez-Leal O; Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Jan 29; Vol. 13 (2). Date of Electronic Publication: 2023 Jan 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Tubulin*/metabolism
Antineoplastic Agents*/pharmacology
Humans ; Tubulin Modulators/chemistry ; Histones/metabolism ; Polymerization ; Clustered Regularly Interspaced Short Palindromic Repeats ; Cell Line ; Cell Proliferation ; Cell Line, Tumor ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects.
Autorzy:
Peng X; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Jiangxi Province Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering, College of Pharmacy, Gannan Medical University, Ganzhou 314000, China.
Ren Y; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 516000, China.
Pan W; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Jiangxi Province Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering, College of Pharmacy, Gannan Medical University, Ganzhou 314000, China.
Liu J; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 516000, China.
Chen J; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 516000, China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 627-640. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin Modulators*/pharmacology
Tubulin Modulators*/therapeutic use
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Molecular Structure ; Structure-Activity Relationship ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Tubulin/metabolism ; Polymerization
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of potent microtubule-destabilizing agents targeting for colchicine site by virtual screening, biological evaluation, and molecular dynamics simulation.
Autorzy:
Zhang H; College of Life Science, Northwest Normal University, Lanzhou, Gansu 730070, PR China; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: .
Luo QQ; College of Life Science, Northwest Normal University, Lanzhou, Gansu 730070, PR China.
Hu ML; College of Life Science, Northwest Normal University, Lanzhou, Gansu 730070, PR China.
Wang N; College of Life Science, Northwest Normal University, Lanzhou, Gansu 730070, PR China.
Qi HZ; College of Life Science, Northwest Normal University, Lanzhou, Gansu 730070, PR China.
Zhang HR; College of Life Science, Northwest Normal University, Lanzhou, Gansu 730070, PR China.
Ding L; College of Life Science, Northwest Normal University, Lanzhou, Gansu 730070, PR China.
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Źródło:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2023 Jan 01; Vol. 180, pp. 106340. Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Colchicine*/chemistry
Colchicine*/pharmacology
Microtubules*/chemistry
Microtubules*/drug effects
Tubulin Modulators*/pharmacology
Tubulin Modulators*/chemistry
Humans ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Tubulin/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones.
Autorzy:
Argirova M; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Guncheva M; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Momekov G; Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.
Cherneva E; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.; Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.
Mihaylova R; Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.
Rangelov M; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Todorova N; Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Denev P; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Anichina K; Department of Organic Synthesis, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria.
Mavrova A; Department of Organic Synthesis, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria.
Yancheva D; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 29; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:
Journal Article
MeSH Terms:
Tubulin*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Humans ; Animals ; Swine ; Antioxidants/pharmacology ; Structure-Activity Relationship ; Tubulin Modulators/pharmacology ; Tubulin Modulators/chemistry ; Hydrazones/pharmacology ; Molecular Docking Simulation ; Polymerization ; Drug Screening Assays, Antitumor ; Benzimidazoles ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy.
Autorzy:
Hawash M; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus P.O. Box 7, Palestine.
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Źródło:
Biomolecules [Biomolecules] 2022 Dec 10; Vol. 12 (12). Date of Electronic Publication: 2022 Dec 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Antineoplastic Agents*/chemistry
Colchicine*/chemistry
Colchicine*/pharmacology
Neoplasms*/drug therapy
Tubulin*/metabolism
Molecular Targeted Therapy*
Humans ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation ; Microtubules/metabolism ; Tubulin Modulators/pharmacology ; Tubulin Modulators/therapeutic use ; Tubulin Modulators/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anticancer 5-arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones as tubulin inhibitors.
Autorzy:
Rehulka J; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Subtelna I; Department of Pharmaceutical, Organic, and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Kryshchyshyn-Dylevych A; Department of Pharmaceutical, Organic, and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Cherniienko A; Department of Pharmaceutical, Organic, and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Ivanova A; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Matveieva M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Polishchuk P; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Gurska S; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Hajduch M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Zagrijtschuk O; MyeloPro Diagnostics and Research GmbH, Vienna, Austria.
Dzubak P; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Lesyk R; Department of Pharmaceutical, Organic, and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.; Department of Biotechnology and Cell Biology, Medical College, Faculty of Medicine, University of Information Technology and Management in Rzeszow, Rzeszow, Poland.
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Źródło:
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 Dec; Vol. 355 (12), pp. e2200419. Date of Electronic Publication: 2022 Sep 15.
Typ publikacji:
Journal Article
MeSH Terms:
Tubulin Modulators*/pharmacology
Tubulin Modulators*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Cell Line, Tumor ; Structure-Activity Relationship ; Tubulin/metabolism ; Apoptosis ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Binding Sites
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors.
Autorzy:
Li X; Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Wu H; Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China; Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Feng KW; Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Xu J; Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Wu S; Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: .
Zhou ZZ; Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China; Pharmacy Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: .
Li XF; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Nov 01; Vol. 73, pp. 117007. Date of Electronic Publication: 2022 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Tubulin Modulators*/chemistry
Tubulin Modulators*/pharmacology
Aniline Compounds/pharmacology ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation ; Colchicine/chemistry ; Colchicine/pharmacology ; Drug Screening Assays, Antitumor ; Molecular Structure ; Pyridines/pharmacology ; Structure-Activity Relationship ; Tubulin/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of Simple Diacylhydrazine-Functionalized Cinnamic Acid Derivatives as Potential Microtubule Stabilizers.
Autorzy:
Zhou X; State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals, Guizhou University, Guiyang 550025, China.
Fu YH; Science and Technology College, Hubei University of Arts and Science, Xiangyang 441025, China.
Zou YY; College of Pharmacy, Guizhou University, Guiyang 550025, China.
Meng J; State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals, Guizhou University, Guiyang 550025, China.
Ou-Yang GP; College of Pharmacy, Guizhou University, Guiyang 550025, China.
Ge QS; College of Pharmacy, Guizhou University, Guiyang 550025, China.
Wang ZC; State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals, Guizhou University, Guiyang 550025, China.; College of Pharmacy, Guizhou University, Guiyang 550025, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 15; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 15.
Typ publikacji:
Journal Article
MeSH Terms:
Tubulin*/metabolism
Antineoplastic Agents*/chemistry
Tubulin Modulators/pharmacology ; Tubulin Modulators/chemistry ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Microtubules/metabolism ; Hydrazines/pharmacology ; Molecular Structure ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.
Autorzy:
Lin S; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.
Du T; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.
Zhang J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.
Wu D; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.
Tian H; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhang K; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.
Jiang L; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Lu D; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Sheng L; Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Li Y; Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Ji M; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.
Chen X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.
Xu H; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2022 Dec 22; Vol. 65 (24), pp. 16372-16391. Date of Electronic Publication: 2022 Dec 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin Modulators*/pharmacology
Tubulin Modulators*/therapeutic use
Tubulin Modulators*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Antineoplastic Agents*/chemistry
Humans ; Colchicine/metabolism ; Tubulin/metabolism ; Cell Line, Tumor ; Binding Sites ; Structure-Activity Relationship ; Cell Proliferation ; Drug Screening Assays, Antitumor
Czasopismo naukowe
Szczegóły
Tytuł:
Targeting the tubulin C-terminal tail by charged small molecules.
Autorzy:
Li S; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & MHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China. .
Mori M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, Siena 53100, Italy.
Yang M; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & MHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China. .
Elfazazi S; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, Madrid 28040, Spain.
Hortigüela R; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, Madrid 28040, Spain.
Chan P; Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Feng X; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang 524088, China.
Risinger A; Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Yang Z; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang 524088, China.
Oliva MÁ; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, Madrid 28040, Spain.
Fernando Díaz J; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, Madrid 28040, Spain.
Fang WS; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & MHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Dec 21; Vol. 21 (1), pp. 153-162. Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin*/metabolism
Antineoplastic Agents*/pharmacology
Microtubules/metabolism ; Binding Sites ; Tubulin Modulators/pharmacology ; Tubulin Modulators/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA).
Autorzy:
Prudhomme V; Université Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF, 63000, Clermont-Ferrand, France.
Cucca M; Université Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF, 63000, Clermont-Ferrand, France.
Nauton L; Université Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF, 63000, Clermont-Ferrand, France.
Andrieu E; Université Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF, 63000, Clermont-Ferrand, France.
Fereyrolles M; Université Clermont Auvergne, INSERM, NEURODOL, 63000, Clermont-Ferrand, France.
Lamoine S; Université Clermont Auvergne, INSERM, NEURODOL, 63000, Clermont-Ferrand, France.
Michelin C; Université Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF, 63000, Clermont-Ferrand, France.
Bennis K; Université Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF, 63000, Clermont-Ferrand, France.
Collin A; Université Clermont Auvergne, INSERM, NEURODOL, 63000, Clermont-Ferrand, France.
De Ceuninck F; Center for Therapeutic Innovation, Immuno-inflammatory Disease, Institut de Recherches Servier, 78290, Croissy-sur-Seine, France.
Botez I; Drug Design Small Molecules Unit, Institut de Recherches Servier, 78290, Croissy-sur-Seine, France.
Mallet C; Université Clermont Auvergne, INSERM, NEURODOL, 63000, Clermont-Ferrand, France.
Ducki S; Université Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF, 63000, Clermont-Ferrand, France. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 15; Vol. 244, pp. 114809. Date of Electronic Publication: 2022 Oct 01.
Typ publikacji:
Journal Article
MeSH Terms:
Tubulin*/metabolism
Antineoplastic Agents*/pharmacology
Cell Line, Tumor ; Tubulin Modulators ; Indoles/pharmacology ; Angiogenesis Inhibitors/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors.
Autorzy:
Chen L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Ji TY; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Huo XS; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Zeng ZY; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Ye WX; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Dai CC; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Zhang YQ; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
You WW; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Zhao PL; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 15; Vol. 244, pp. 114864. Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:
Journal Article
MeSH Terms:
Tubulin Modulators*/pharmacology
Antineoplastic Agents*/pharmacology
Humans ; Pyrimidines/pharmacology ; Drug Screening Assays, Antitumor ; Apoptosis ; HeLa Cells ; HEK293 Cells ; Drug Design ; Structure-Activity Relationship ; Cell Line, Tumor ; Molecular Structure ; Cell Proliferation ; G2 Phase Cell Cycle Checkpoints ; Tubulin/metabolism ; Polymerization
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy.
Autorzy:
Qin J; School of Pharmaceutical Sciences, And Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Li H; School of Pharmaceutical Sciences, And Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Wang X; School of Pharmaceutical Sciences, And Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Zhang Y; School of Pharmaceutical Sciences, And Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Duan Y; Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, 450018, China.
Yao Y; School of Pharmaceutical Sciences, And Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: .
Yang H; School of Pharmaceutical Sciences, And Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: .
Sun M; School of Pharmaceutical Sciences, And Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 05; Vol. 243, pp. 114738. Date of Electronic Publication: 2022 Sep 17.
Typ publikacji:
Journal Article
MeSH Terms:
Tubulin*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/metabolism
Animals ; Humans ; Polymerization ; Zebrafish/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Apoptosis ; Tubulin Modulators/pharmacology ; Tubulin Modulators/metabolism ; Microtubules ; Drug Screening Assays, Antitumor
Czasopismo naukowe
Szczegóły
Tytuł:
Design, synthesis and biological evaluation of novel diarylpyridine derivatives as tubulin polymerisation inhibitors.
Autorzy:
Yang S; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Wang C; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Shi L; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Chang J; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Zhang Y; The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao University, Qingdao, China.
Meng J; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Liu W; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Zeng J; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Zhang R; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Shao Y; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.
Xing D; The Affiliated Hospital of Qingdao University, Cancer Institute, School of Basic Medicine, Qingdao University, Qingdao, China.; Qingdao Cancer Institute, Qingdao, China.; School of Life Sciences, Tsinghua University, Beijing, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 2755-2764.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Tubulin Modulators*
Cell Line, Tumor ; Cell Proliferation ; Colchicine/metabolism ; Colchicine/pharmacology ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Pyridines/pharmacology ; Structure-Activity Relationship ; Tubulin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis and screening of novel 4-N-heterocyclic-2-aryl-6,7,8-trimethoxyquinazolines as antiproliferative and tubulin polymerization inhibitors.
Autorzy:
Dwivedi AR; Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab 151401, India; Laboratory of Organic and Medicinal Chemistry, Department of Chemistry, Central University of Punjab, Bathinda, Punjab 151401, India.
Rawat SS; School of Basic Sciences, Indian Institute of Technology, Mandi, HP 175005, India.
Kumar V; Laboratory of Organic and Medicinal Chemistry, Department of Chemistry, Central University of Punjab, Bathinda, Punjab 151401, India.
Kumar N; Laboratory of Organic and Medicinal Chemistry, Department of Chemistry, Central University of Punjab, Bathinda, Punjab 151401, India.
Anand P; Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab 151401, India; Laboratory of Organic and Medicinal Chemistry, Department of Chemistry, Central University of Punjab, Bathinda, Punjab 151401, India.
Yadav RP; Department of Microbiology, School of Biological Sciences, Central University of Punjab, Bathinda, Punjab 151401, India.
Baranwal S; Department of Microbiology, School of Biological Sciences, Central University of Punjab, Bathinda, Punjab 151401, India.
Prasad A; School of Basic Sciences, Indian Institute of Technology, Mandi, HP 175005, India. Electronic address: .
Kumar V; Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab 151401, India; Laboratory of Organic and Medicinal Chemistry, Department of Chemistry, Central University of Punjab, Bathinda, Punjab 151401, India. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Oct 15; Vol. 72, pp. 116976. Date of Electronic Publication: 2022 Aug 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Quinazolines*/chemistry
Tubulin Modulators*/chemistry
Cell Line, Tumor ; Cell Proliferation ; Colchicine/pharmacology ; Drug Screening Assays, Antitumor ; HEK293 Cells ; Humans ; Molecular Docking Simulation ; Polymerization ; Structure-Activity Relationship ; Tubulin/metabolism
Czasopismo naukowe
Szczegóły
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