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Wyszukujesz frazę ""Tumor Cells, Cultured"" wg kryterium: Temat


Tytuł:
Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL.
Autorzy:
Balandrán JC; Laboratorio de Oncoinmunología y Citómica, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social Delegación Puebla, Puebla, Mexico.; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico.
Dávila-Velderrain J; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology (MIT), Cambridge, MA, United States.; The Broad Institute of MIT and Harvard, Cambridge, MA, United States.
Sandoval-Cabrera A; Hospital para el Niño de Toluca, Instituto Materno Infantil del Estado de México (IMIEM), Toluca, Mexico.
Zamora-Herrera G; Laboratorio de Oncoinmunología y Citómica, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social Delegación Puebla, Puebla, Mexico.
Terán-Cerqueda V; Servicio de Hematología, Unidad Médica de Alta Especialidad, Hospital de Especialidades 'Manuel Ávila Camacho', Instituto Mexicano del Seguro Social, Puebla, Mexico.
García-Stivalet LA; Servicio de Hematología, Unidad Médica de Alta Especialidad, Hospital de Especialidades 'Manuel Ávila Camacho', Instituto Mexicano del Seguro Social, Puebla, Mexico.
Limón-Flores JA; Servicio de Hematología, Unidad Médica de Alta Especialidad, Hospital de Especialidades 'Manuel Ávila Camacho', Instituto Mexicano del Seguro Social, Puebla, Mexico.
Armenta-Castro E; Laboratorio de Oncoinmunología y Citómica, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social Delegación Puebla, Puebla, Mexico.
Rodríguez-Martínez A; Laboratorio de Oncoinmunología y Citómica, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social Delegación Puebla, Puebla, Mexico.; Posgrado en Ciencias Químicas, Area de Bioquímica y Biología Molecular, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Leon-Chavez BA; Posgrado en Ciencias Químicas, Area de Bioquímica y Biología Molecular, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Vallejo-Ruiz V; Laboratorio de Oncoinmunología y Citómica, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social Delegación Puebla, Puebla, Mexico.
Hassane DC; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Pérez-Tapia SM; Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI) and Unidad de Investigación, Desarrollo e Innovación Médica y Biotecnológica (UDIMEB), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
Ortiz-Navarrete V; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico.
Guzman ML; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Pelayo R; Laboratorio de Oncoinmunología y Citómica, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social Delegación Puebla, Puebla, Mexico.
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Źródło:
Frontiers in immunology [Front Immunol] 2021 Oct 19; Vol. 12, pp. 746492. Date of Electronic Publication: 2021 Oct 19 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Spheroids, Cellular*
Stem Cell Niche*
Tumor Cells, Cultured*
Neoplastic Stem Cells/*pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
Animals ; Bone Marrow/pathology ; Female ; Heterografts ; Humans ; Mesenchymal Stem Cells/pathology ; Mice ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
Protocol for photoactivation of YAP in cancer cell spheroids embedded in collagen gels.
Autorzy:
Illes B; Department of Chemistry and Center for NanoScience (CeNS), Ludwig-Maximilians-Universität München, Butenandtstr. 11, 81377 Munich, Germany.
Engelke H; Department of Chemistry and Center for NanoScience (CeNS), Ludwig-Maximilians-Universität München, Butenandtstr. 11, 81377 Munich, Germany.; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Humboldtstr. 46, 8010 Graz, Austria.
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Źródło:
STAR protocols [STAR Protoc] 2021 Jul 07; Vol. 2 (3), pp. 100657. Date of Electronic Publication: 2021 Jul 07 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Spheroids, Cellular*/cytology
Spheroids, Cellular*/metabolism
Tumor Cells, Cultured*/cytology
Tumor Cells, Cultured*/metabolism
YAP-Signaling Proteins*/genetics
YAP-Signaling Proteins*/metabolism
Cell Culture Techniques/*methods
Optogenetics/*methods
Collagen/chemistry ; Fluorescent Antibody Technique ; Gels/chemistry ; HeLa Cells ; Humans ; Plasmids/genetics
Czasopismo naukowe
Tytuł:
Cancer cell cycle dystopia: heterogeneity, plasticity, and therapy.
Autorzy:
Witkiewicz AK; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA. Electronic address: .
Kumarasamy V; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Sanidas I; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Knudsen ES; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA. Electronic address: .
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Źródło:
Trends in cancer [Trends Cancer] 2022 Sep; Vol. 8 (9), pp. 711-725. Date of Electronic Publication: 2022 May 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CDC2-CDC28 Kinases*
Neoplasms*/genetics
Neoplasms*/therapy
Animals ; Cell Cycle/genetics ; Cell Division ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Cyclins/genetics ; Cyclins/metabolism ; Humans ; Mammals/metabolism ; Microtubule-Associated Proteins/metabolism ; Protein Serine-Threonine Kinases ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
Autorzy:
Drosos Y; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Myers JA; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xu B; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mathias KM; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Beane EC; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Radko-Juettner S; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA; St. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mobley RJ; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Larsen ME; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Piccioni F; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ma X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Low J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hansen BS; Center for Advanced Genome Engineering, Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Peters ST; Center for Advanced Genome Engineering, Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Bhanu NV; Department of Biochemistry and Biophysics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dhanda SK; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Upadhyaya SA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pruett-Miller SM; Center for Advanced Genome Engineering, Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Root DE; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Garcia BA; Department of Biochemistry and Biophysics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Partridge JF; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Roberts CWM; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA; St. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2022 Jul 07; Vol. 82 (13), pp. 2472-2489.e8. Date of Electronic Publication: 2022 May 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Enhancer of Zeste Homolog 2 Protein*/antagonists & inhibitors
Enhancer of Zeste Homolog 2 Protein*/genetics
Enhancer of Zeste Homolog 2 Protein*/metabolism
F-Box Proteins*/genetics
F-Box Proteins*/metabolism
Histone-Lysine N-Methyltransferase*/genetics
Histone-Lysine N-Methyltransferase*/metabolism
Jumonji Domain-Containing Histone Demethylases*/genetics
Jumonji Domain-Containing Histone Demethylases*/metabolism
Polycomb-Group Proteins*/genetics
Polycomb-Group Proteins*/metabolism
SMARCB1 Protein*/genetics
SMARCB1 Protein*/metabolism
Chromatin/genetics ; Chromatin/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Rhabdoid Tumor/genetics ; Rhabdoid Tumor/metabolism ; Rhabdoid Tumor/pathology ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcriptional Activation/genetics ; Tumor Cells, Cultured/metabolism
Czasopismo naukowe
Tytuł:
hTERT Transduction Extends the Lifespan of Primary Pediatric Low-Grade Glioma Cells While Preserving the Biological Response to NGF.
Autorzy:
Franzese O; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Di Francesco AM; Institute of Internal Medicine, Periodic Fever and Rare Diseases Center, Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy.
Meco D; UOC di Oncologia Pediatrica, 'Fondazione Policlinico Universitario A. Gemelli', IRCCS, Rome, Italy.
Graziani G; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Cusano G; UOC di Oncologia Pediatrica, 'Fondazione Policlinico Universitario A. Gemelli', IRCCS, Rome, Italy.
Levati L; Molecular Oncology Laboratory, IDI-IRCCS, Rome, Italy.
Riccardi R; UOC di Oncologia Pediatrica, 'Fondazione Policlinico Universitario A. Gemelli', IRCCS, Rome, Italy.
Ruggiero A; UOC di Oncologia Pediatrica, 'Fondazione Policlinico Universitario A. Gemelli', IRCCS, Rome, Italy.
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Źródło:
Pathology oncology research : POR [Pathol Oncol Res] 2021 Apr 02; Vol. 27, pp. 612375. Date of Electronic Publication: 2021 Apr 02 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms*
Glioma*
Tumor Cells, Cultured*
Nerve Growth Factor/*metabolism
Telomerase/*genetics
Transduction, Genetic/*methods
Cell Culture Techniques/methods ; Humans
Czasopismo naukowe
Tytuł:
2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights.
Autorzy:
Elbadawi MM; Department of Chemistry, Graduate School of Science, Hiroshima University, Hiroshima, Japan.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Abd El-Hafeez AA; Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Somaa WR; Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Albohy A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, Egypt.
Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Agama KK; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Ghosh P; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Comprehensive Cancer Center, University of California San Diego, La Jolla, CA, USA.; Veterans Affairs Medical Center, La Jolla, CA, USA.
Pommier Y; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Abe M; Department of Chemistry, Graduate School of Science, Hiroshima University, Hiroshima, Japan.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 349-372.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Focal Adhesion Kinase 1/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Quinolines/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Focal Adhesion Kinase 1/metabolism ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Inhibitory effect of roburic acid in combination with docetaxel on human prostate cancer cells.
Autorzy:
Wang X; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.
Xuetao X; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Wu M; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.
Wu P; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Sheng Z; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Liu W; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Ma YY; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Zhao DG; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Zhang K; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Li D; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Zheng X; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Goodin S; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 542-553.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Docetaxel/*pharmacology
Prostatic Neoplasms/*drug therapy
Antineoplastic Combined Chemotherapy Protocols/chemical synthesis ; Antineoplastic Combined Chemotherapy Protocols/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Docetaxel/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Esomeprazole/chemistry ; Esomeprazole/pharmacology ; Humans ; Male ; Molecular Structure ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Discovery of a novel Aurora B inhibitor GSK650394 with potent anticancer and anti- aspergillus fumigatus dual efficacies in vitro .
Autorzy:
He Y; College of Chemistry, Fuzhou University, Fuzhou, China.
Fu W; College of Chemistry, Fuzhou University, Fuzhou, China.
Du L; College of Chemistry, Fuzhou University, Fuzhou, China.
Yao H; College of Chemistry, Fuzhou University, Fuzhou, China.
Hua Z; College of Chemistry, Fuzhou University, Fuzhou, China.
Li J; College of Chemistry, Fuzhou University, Fuzhou, China.
Lin Z; College of Chemistry, Fuzhou University, Fuzhou, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 109-117.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*
Antifungal Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Aspergillus fumigatus/*drug effects
Aurora Kinase B/*antagonists & inhibitors
Benzoates/*pharmacology
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Antifungal Agents/chemistry ; Antineoplastic Agents/chemistry ; Aurora Kinase B/metabolism ; Benzoates/chemistry ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies.
Autorzy:
Khalifa MM; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Al-Karmalawy AA; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Nafie MS; Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Tantawy MA; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Egypt.; Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, Egypt.
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 299-314.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Molecular Docking Simulation*
Antineoplastic Agents/*pharmacology
DNA/*chemistry
DNA Topoisomerases, Type II/*metabolism
Phthalazines/*pharmacology
Topoisomerase II Inhibitors/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Phthalazines/chemical synthesis ; Phthalazines/chemistry ; Structure-Activity Relationship ; Topoisomerase II Inhibitors/chemical synthesis ; Topoisomerase II Inhibitors/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer.
Autorzy:
Halim PA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Hassan RA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Mohamed KO; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Hassanin SO; Biochemistry Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
Khalil MG; Pharmacology and Toxicology Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
Abdou AM; Department of Microbiology and Immunology, National Research Centre, Dokki, Egypt.
Osman EO; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 189-201.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Chalcones/*pharmacology
Cytotoxins/*pharmacology
Pyrazoles/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Cytotoxins/chemical synthesis ; Cytotoxins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Halogenation ; Humans ; MCF-7 Cells ; Molecular Docking Simulation ; Molecular Structure ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
Autorzy:
Benýšek J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.; First Faculty of Medicine, Charles University, Prague, Czech Republic.
Buša M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Rubešová P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Fanfrlík J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Lepšík M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Brynda J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Matoušková Z; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Bartz U; Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, Rheinbach, Germany.
Horn M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Gütschow M; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany.
Mareš M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 515-526.
Typ publikacji:
Journal Article
MeSH Terms:
Cathepsin K/*antagonists & inhibitors
Hydrazines/*pharmacology
Nitriles/*pharmacology
Protease Inhibitors/*pharmacology
Cathepsin K/metabolism ; Dose-Response Relationship, Drug ; Humans ; Hydrazines/chemistry ; Models, Molecular ; Molecular Structure ; Nitriles/chemistry ; Protease Inhibitors/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Osthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis.
Autorzy:
Lv X; Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Yang H; Department of Ophthalmology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Zhong H; Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
He L; Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Wang L; Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 417-426.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Coumarins/*pharmacology
MicroRNAs/*genetics
Retinoblastoma/*drug therapy
Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Apoptosis/drug effects ; Cell Line ; Cell Line, Tumor ; Cell Survival/drug effects ; Coumarins/administration & dosage ; Humans ; Male ; Mice ; Mice, Nude ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Retinoblastoma/genetics ; Retinoblastoma/pathology ; TOR Serine-Threonine Kinases/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition.
Autorzy:
Xu S; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Fan R; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Wang L; National Center of Colorectal Disease, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, P.R. China.
He W; Biology Department, Boston College, Brighton, MA, USA.
Ge H; School of Life Sciences, Huzhou University, Huzhou, P.R. China.
Chen H; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Xu W; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Zhang J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China.
Xu W; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Feng Y; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, P.R. China.
Fan Z; National Center of Colorectal Disease, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, P.R. China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 236-251.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Pentacyclic Triterpenes/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Pentacyclic Triterpenes/chemical synthesis ; Pentacyclic Triterpenes/chemistry ; STAT3 Transcription Factor/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity.
Autorzy:
Fioravanti R; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Rodriguez V; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Caroli J; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Chianese U; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Benedetti R; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Di Bello E; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Noce B; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Zwergel C; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Corinti D; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Viña D; Center for Research in Molecular Medicine and Chronic Disease (CIMUS), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Altucci L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.; Biogem Institute of Molecular and Genetic Biology, Ariano Irpino, Italy.
Mattevi A; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Valente S; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Mai A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 973-985.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Heterocyclic Compounds/*pharmacology
Histone Demethylases/*antagonists & inhibitors
Tranylcypromine/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Histone Demethylases/metabolism ; Humans ; Molecular Structure ; Monoamine Oxidase/metabolism ; Structure-Activity Relationship ; Tranylcypromine/chemical synthesis ; Tranylcypromine/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation.
Autorzy:
Chaudhary CL; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Lim D; Innovo Therapeutics Inc, Daejeon, Republic of Korea.
Chaudhary P; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Guragain D; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Awasthi BP; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Park HD; Innovo Therapeutics Inc, Daejeon, Republic of Korea.
Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Jeong BS; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 844-856.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Pyridines/*pharmacology
Pyrimidines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Chickens ; Dose-Response Relationship, Drug ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/pathology ; Models, Molecular ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines.
Autorzy:
Mussi S; Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Rezzola S; Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Chiodelli P; Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Nocentini A; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Sesto Fiorentino, Florence, Italy.
Supuran CT; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Sesto Fiorentino, Florence, Italy.
Ronca R; Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 280-286.
Typ publikacji:
Journal Article
MeSH Terms:
Acetazolamide/*pharmacology
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Sulfonamides/*pharmacology
Acetazolamide/chemical synthesis ; Acetazolamide/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Purification of differentiated tumor cells from medulloblastoma for transplantation into mouse cerebellum.
Autorzy:
Yang Y; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA.
Qu Y; Pediatric Cancer Center, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Cheng Y; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA.
Guo D; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA.; Pediatric Cancer Center, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Fan Q; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA.; Pediatric Cancer Center, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Yang ZJ; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA.
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Źródło:
STAR protocols [STAR Protoc] 2021 Mar 26; Vol. 2 (2), pp. 100409. Date of Electronic Publication: 2021 Mar 26 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tumor Cells, Cultured*/cytology
Tumor Cells, Cultured*/pathology
Tumor Cells, Cultured*/transplantation
Cell Separation/*methods
Cerebellar Neoplasms/*pathology
Cerebellum/*surgery
Medulloblastoma/*pathology
Animals ; Cell Culture Techniques/methods ; Cell Differentiation ; Cell Transplantation ; Mice
Czasopismo naukowe
Tytuł:
A survey of electrokinetically-driven microfluidics for cancer cells manipulation.
Autorzy:
Romero-Soto FO; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Nuevo Leon, México.
Polanco-Oliva MI; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Nuevo Leon, México.
Gallo-Villanueva RC; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Nuevo Leon, México.
Martinez-Chapa SO; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Nuevo Leon, México.
Perez-Gonzalez VH; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Nuevo Leon, México.
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Źródło:
Electrophoresis [Electrophoresis] 2021 Mar; Vol. 42 (5), pp. 605-625. Date of Electronic Publication: 2020 Dec 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Biomarkers, Tumor*/analysis
Biomarkers, Tumor*/metabolism
Electrophoresis*
Microfluidic Analytical Techniques*
Neoplastic Cells, Circulating*/chemistry
Neoplastic Cells, Circulating*/metabolism
Tumor Cells, Cultured*/chemistry
Tumor Cells, Cultured*/cytology
Tumor Cells, Cultured*/metabolism
Humans ; Lab-On-A-Chip Devices ; Neoplasms/diagnosis ; Neoplasms/pathology ; Neoplasms/therapy
Czasopismo naukowe
Tytuł:
Stimulatory role of nectin-4 and p95-ErbB2 in multilayered T47D cell proliferation.
Autorzy:
Kedashiro S; From the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Kameyama T; From the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Mizutani K; From the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Takai Y; From the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2022 Jun; Vol. 27 (6), pp. 451-464. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/pathology
Cadherins*/metabolism
Cell Adhesion Molecules*/metabolism
Cell Adhesion Molecules*/pharmacology
Phosphatidylinositol 3-Kinases*/metabolism
Receptor, ErbB-2*/metabolism
Adherens Junctions/drug effects ; Cell Adhesion/drug effects ; Cell Proliferation/drug effects ; Female ; Humans ; Nectins/pharmacology ; Tumor Cells, Cultured
Czasopismo naukowe

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