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Wyszukujesz frazę ""Tumor Microenvironment"" wg kryterium: Temat


Tytuł :
Tumor-Associated Macrophages as Multifaceted Regulators of Breast Tumor Growth.
Autorzy :
Munir MT; Nutritional Sciences, Texas Tech University, Lubbock, TX 79409, USA.; Obesity Research Institute, Texas Tech University, Lubbock, TX 79409, USA.
Kay MK; Texas A&M University Health Sciences Center, College Station, TX 77843, USA.
Kang MH; Cancer Center, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Rahman MM; Department of Biological and Environmental Sciences, Qatar University, Doha 2713, Qatar.
Al-Harrasi A; Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al-Mouz 616, Oman.
Choudhury M; Texas A&M University Health Sciences Center, College Station, TX 77843, USA.
Moustaid-Moussa N; Nutritional Sciences, Texas Tech University, Lubbock, TX 79409, USA.; Obesity Research Institute, Texas Tech University, Lubbock, TX 79409, USA.
Hussain F; Mechanical Engineering, Texas Tech University, Lubbock, TX 79409, USA.
Rahman SM; Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al-Mouz 616, Oman.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 18; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Tumor Microenvironment*
Breast Neoplasms/*etiology
Breast Neoplasms/*metabolism
Tumor-Associated Macrophages/*immunology
Tumor-Associated Macrophages/*metabolism
Animals ; Biomarkers, Tumor ; Breast Neoplasms/mortality ; Breast Neoplasms/therapy ; Cell Communication ; Disease Progression ; Disease Susceptibility ; Exosomes/metabolism ; Female ; Gene Expression Regulation ; Humans ; Immunomodulation ; Macrophage Activation/immunology ; MicroRNAs/genetics ; Neoplasm Metastasis ; Neoplasm Staging ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/metabolism ; Tumor Burden ; Tumor-Associated Macrophages/pathology
Czasopismo naukowe
Tytuł :
The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression.
Autorzy :
Wang H; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Yung MMH; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Ngan HYS; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Chan KKL; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Chan DW; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 18; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Tumor Microenvironment*
Neoplasms/*pathology
Tumor-Associated Macrophages/*immunology
Animals ; Cell Differentiation ; Humans ; Immunotherapy/methods ; Neoplasm Metastasis ; Neoplasms/immunology ; Neoplasms/therapy ; Tumor-Associated Macrophages/pathology
Czasopismo naukowe
Tytuł :
Identification of microenvironment related potential biomarkers of biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma.
Autorzy :
Sun X; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Wang L; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Li H; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Jin C; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Yu Y; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Hou L; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Liu X; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Yu Y; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Yan R; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Xue F; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.; Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 Jun 16; Vol. 13 (12), pp. 16024-16042. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Prostatectomy*
Tumor Microenvironment*/genetics
Adenocarcinoma/*pathology
Adenocarcinoma/*surgery
Biomarkers, Tumor/*metabolism
Neoplasm Recurrence, Local/*pathology
Prostatic Neoplasms/*pathology
Prostatic Neoplasms/*surgery
Adenocarcinoma/genetics ; Adenocarcinoma/immunology ; Confounding Factors, Epidemiologic ; Databases, Genetic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Genome, Human ; Humans ; Male ; Middle Aged ; Prognosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/immunology ; Receptors, Androgen/metabolism ; Reproducibility of Results ; Stromal Cells/metabolism
Czasopismo naukowe
Tytuł :
Vulnerabilities in the tumor and microenvironment in follicular lymphoma.
Autorzy :
Araujo-Ayala F; Department of Hematology-Oncology, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
Pérez-Galán P; Department of Hematology-Oncology, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.; Hematological Neoplasms Program, Centro de Investigación Biomédica en Red-Oncología (CIBERONC), Madrid, Spain.
Campo E; Department of Hematology-Oncology, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.; Hematological Neoplasms Program, Centro de Investigación Biomédica en Red-Oncología (CIBERONC), Madrid, Spain.; Hematopathology Unit, Pathology Department, Hospital Clínic of Barcelona, Barcelona, Spain.; Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain.
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Źródło :
Hematological oncology [Hematol Oncol] 2021 Jun; Vol. 39 Suppl 1, pp. 83-87.
Typ publikacji :
Journal Article; Review
MeSH Terms :
B-Lymphocytes*/immunology
B-Lymphocytes*/pathology
Cell Proliferation*
Lymphoma, Follicular*/genetics
Lymphoma, Follicular*/immunology
Lymphoma, Follicular*/pathology
Lymphoma, Follicular*/therapy
Mutation*
Tumor Microenvironment*/genetics
Tumor Microenvironment*/immunology
Cell Survival/genetics ; Cell Survival/immunology ; Humans
Czasopismo naukowe
Tytuł :
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape.
Autorzy :
de Jong MME; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Kellermayer Z; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Papazian N; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Tahri S; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Hofste Op Bruinink D; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Hoogenboezem R; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Sanders MA; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
van de Woestijne PC; Department of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Bos PK; Department of Orthopedic Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Khandanpour C; Medical Department A, University Hospital Münster, Münster, Germany.
Vermeulen J; Janssen Research & Development LLC, Leiden, the Netherlands.
Moreau P; Nantes University Hospital Hotel-Dieu, Nantes, France.
van Duin M; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Broijl A; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Sonneveld P; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands. .
Cupedo T; Department of Hematology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands. .
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Źródło :
Nature immunology [Nat Immunol] 2021 Jun; Vol. 22 (6), pp. 769-780. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Mesenchymal Stem Cells/*immunology
Multiple Myeloma/*immunology
Neoplasm Recurrence, Local/*immunology
Tumor Microenvironment/*immunology
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Bone Marrow/drug effects ; Bone Marrow/immunology ; Bone Marrow/pathology ; Cell Line, Tumor ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Male ; Mesenchymal Stem Cells/pathology ; Middle Aged ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control ; Primary Cell Culture ; Prospective Studies ; RNA-Seq ; Single-Cell Analysis ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
Spontaneous Fusion of MSC with Breast Cancer Cells Can Generate Tumor Dormancy.
Autorzy :
Melzer C; Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, 30625 Hannover, Germany.
Ohe JV; Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, 30625 Hannover, Germany.
Luo T; Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, 30625 Hannover, Germany.
Hass R; Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, 30625 Hannover, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 31; Vol. 22 (11). Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis*
Cell Transformation, Neoplastic*
Mesenchymal Stem Cells*
Tumor Microenvironment*
Breast Neoplasms/*pathology
Animals ; Cell Communication ; Cell Division ; Cell Fusion ; Cell Line ; Coculture Techniques ; Female ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID
Czasopismo naukowe
Tytuł :
Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes.
Autorzy :
Chirivì M; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.; Department of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, C.so della Repubblica 79, 04100 Latina, Italy.
Maiullari F; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
Milan M; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.; Institute of Biochemistry and Cell Biology, National Research Council of Italy (IBBC-CNR), Via Ercole Ramarini, 32, Monterotondo, 00015 Rome, Italy.
Presutti D; Institute of Physical Chemistry Polish Academy of Sciences, Marcina Kasprzaka 44/52, 01-224 Warszawa, Poland.
Cordiglieri C; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.
Crosti M; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.
Sarnicola ML; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.
Soluri A; Institute of Biochemistry and Cell Biology, National Research Council of Italy (IBBC-CNR), Via Ercole Ramarini, 32, Monterotondo, 00015 Rome, Italy.; Unit of Molecular Neurosciences, University Campus Bio-Medico, Rome, 00128 Roma, Italy.
Volpi M; Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland.
Święszkowski W; Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland.
Prati D; Department of Transfusion Medicine and Hematology, IRCCS Ca 'Granda Hospital Maggiore Policlinico Foundation, Via Francesco Sforza 35, 20122 Milan, Italy.
Rizzi M; Ufficio Programmazione e Grant Office, National Research Council of Italy (UPGO-CNR), Piazzale Aldo Moro 7, 00185 Rome, Italy.
Costantini M; Institute of Physical Chemistry Polish Academy of Sciences, Marcina Kasprzaka 44/52, 01-224 Warszawa, Poland.
Seliktar D; Department of Biomedical Engineering, Technion Institute, Haifa 32000, Israel.
Parisi C; Institute of Biochemistry and Cell Biology, National Research Council of Italy (IBBC-CNR), Via Ercole Ramarini, 32, Monterotondo, 00015 Rome, Italy.
Bearzi C; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.; Institute of Genetic and Biomedical Research, UOS of Milan, National Research Council (IRGB-CNR), Via Gaudenzio Fantoli 16/15, 20138 Milan, Italy.
Rizzi R; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.; Institute of Biomedical Technologies, National Research Council (ITB-CNR), Via Fratelli Cervi, 93, Segrate, 20090 Milan, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 30; Vol. 22 (11). Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Tumor Escape*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Extracellular Matrix/*immunology
Gene Expression Regulation, Neoplastic/*immunology
Tumor Microenvironment/*immunology
5'-Nucleotidase/genetics ; 5'-Nucleotidase/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; Cancer-Associated Fibroblasts/immunology ; Cancer-Associated Fibroblasts/pathology ; Cell Culture Techniques ; Elastic Modulus ; Extracellular Matrix/chemistry ; Female ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/immunology ; Humans ; Hydrogels/chemistry ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Lymphocyte Activation ; Mechanotransduction, Cellular ; Models, Biological ; NF-kappa B/genetics ; NF-kappa B/immunology ; Phenotype ; Primary Cell Culture ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Rheology ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/immunology ; Transcription Factor RelA/genetics ; Transcription Factor RelA/immunology ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/pathology ; Tumor Microenvironment/genetics ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/pathology
Czasopismo naukowe
Tytuł :
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Autorzy :
Oura K; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Morishita A; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Tani J; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Masaki T; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 28; Vol. 22 (11). Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinoma, Hepatocellular/*therapy
Immune Checkpoint Inhibitors/*therapeutic use
Immunotherapy, Adoptive/*methods
Liver/*drug effects
Liver Neoplasms/*therapy
Tumor Microenvironment/*drug effects
Animals ; Carcinoma, Hepatocellular/immunology ; Humans ; Liver/immunology ; Liver/pathology ; Liver Neoplasms/immunology ; Neoplasm Recurrence, Local ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
The Acidic Brain-Glycolytic Switch in the Microenvironment of Malignant Glioma.
Autorzy :
Reuss AM; Laboratory for Translational Cell Biology and Neurooncology, Department of Neurosurgery, University Hospital Erlangen-Nürnberg, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Groos D; Institute of Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Buchfelder M; Laboratory for Translational Cell Biology and Neurooncology, Department of Neurosurgery, University Hospital Erlangen-Nürnberg, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Savaskan N; Laboratory for Translational Cell Biology and Neurooncology, Department of Neurosurgery, University Hospital Erlangen-Nürnberg, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 24; Vol. 22 (11). Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Glycolysis*
Tumor Microenvironment*
Brain/*metabolism
Brain Neoplasms/*metabolism
Glioma/*metabolism
Lactic Acid/*metabolism
Animals ; Brain Chemistry ; Brain Neoplasms/physiopathology ; Carbonic Anhydrases ; Glioma/physiopathology ; Humans ; Hydrogen-Ion Concentration ; Neovascularization, Pathologic
Czasopismo naukowe
Tytuł :
Heterogeneity of Colorectal Cancer Progression: Molecular Gas and Brakes.
Autorzy :
Gaiani F; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.; Gastroenterology and Endoscopy Unit, University-Hospital of Parma, via Gramsci 14, 43126 Parma, Italy.
Marchesi F; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, 20132 Milan, Italy.
Negri F; Medical Oncology Unit, University Hospital of Parma, 43126 Parma, Italy.
Greco L; Laboratory of Molecular Gastroenterology, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Italy.
Malesci A; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Italy.
de'Angelis GL; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.; Gastroenterology and Endoscopy Unit, University-Hospital of Parma, via Gramsci 14, 43126 Parma, Italy.
Laghi L; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.; Laboratory of Molecular Gastroenterology, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 15; Vol. 22 (10). Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Colorectal Neoplasms/*etiology
Colorectal Neoplasms/*prevention & control
Tumor Microenvironment/*immunology
Anticarcinogenic Agents/pharmacology ; Biomarkers, Tumor/analysis ; Colorectal Neoplasms/pathology ; DNA Methylation ; Drug Resistance, Neoplasm ; Fusobacterium nucleatum/metabolism ; Gastrointestinal Microbiome ; High-Throughput Nucleotide Sequencing ; Humans ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/pathology ; Micronutrients/pharmacology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/physiology
Czasopismo naukowe
Tytuł :
A pan-cancer analysis of the HER family gene and their association with prognosis, tumor microenvironment, and therapeutic targets.
Autorzy :
Yang X; Department of Otorhinolaryngology Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou City, Gansu Province, PR China.
Miao Y; The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, PR China. Electronic address: .
Wang J; The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, PR China.
Mi D; The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, PR China; Gansu Academy of Traditional Chinese Medicine, Lanzhou City, Gansu Province, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 May 15; Vol. 273, pp. 119307. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Tumor Microenvironment*
Antineoplastic Agents/*therapeutic use
Biomarkers, Tumor/*metabolism
Neoplasms/*pathology
Receptor Protein-Tyrosine Kinases/*metabolism
Biomarkers, Tumor/genetics ; Computational Biology ; Gene Expression Profiling ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Prognosis ; Receptor Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Tytuł :
Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems.
Autorzy :
Sun Y; Department of Oncology, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200120, China.
Li Y; Department of Pharmacy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Shi S; Department of Oncology, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200120, China.
Dong C; Department of Oncology, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200120, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 05; Vol. 26 (9). Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Delivery Systems*
Tumor Microenvironment*
Nanoparticles/*chemistry
Animals ; Extracellular Matrix/metabolism ; Humans ; Hydrogen-Ion Concentration ; Nanotechnology
Czasopismo naukowe
Tytuł :
Identification of immune-related genes with prognostic significance in the microenvironment of cutaneous melanoma.
Autorzy :
Qu Y; Department of Dermatology, Yantai Yuhuangding Hospital, No. 20, Yuhuangding East Road, Zhifu District, Yantai City, 264099, China. .
Zhang S; Department of Dermatology, Yantai Yuhuangding Hospital Laishan Branch, Yantai, China.
Zhang Y; Department of Dermatology, Zoucheng People's Hospital, Zoucheng, China.
Feng X; Department of Dermatology, Yantai Yuhuangding Hospital, No. 20, Yuhuangding East Road, Zhifu District, Yantai City, 264099, China.
Wang F; Department of Dermatology, Dongying District People's Hospital of Dongying City, No. 333 Jinan Road, Dongying District, Dongying, 257000, China. .
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 May; Vol. 478 (5), pp. 943-959. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Transcriptome*
Tumor Microenvironment*
Biomarkers, Tumor/*genetics
Melanoma/*genetics
Skin Neoplasms/*genetics
Databases, Genetic ; GTP-Binding Proteins/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Lectins, C-Type/genetics ; Melanoma/immunology ; Melanoma/mortality ; Melanoma/pathology ; Membrane Glycoproteins/genetics ; Neoplasm Staging ; Predictive Value of Tests ; Receptors, Immunologic/genetics ; Receptors, KIR2DL4/genetics ; Risk Assessment ; Risk Factors ; Skin Neoplasms/immunology ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Involvement of Galectin-1 Tumor Microenvironment in Radiosensitivity.
Autorzy :
Chen YF; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.
Wang CC; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.
Hsu CY; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.
Huang EY; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.; .; School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan, R.O.C.
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Źródło :
Anticancer research [Anticancer Res] 2021 May; Vol. 41 (5), pp. 2321-2331.
Typ publikacji :
Journal Article
MeSH Terms :
Galectin 1/*genetics
Neoplasms, Experimental/*radiotherapy
Radiation Tolerance/*genetics
Tumor Microenvironment/*radiation effects
Animals ; Cell Line, Tumor ; Galectin 1/metabolism ; Mice ; Mice, Knockout ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Survival Analysis ; Tumor Burden/genetics ; Tumor Burden/radiation effects ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
The Role of Hypoxic Bone Marrow Microenvironment in Acute Myeloid Leukemia and Future Therapeutic Opportunities.
Autorzy :
Bruno S; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Mancini M; Istituto di Ematologia 'Seràgnoli', IRCCS Azienda Ospedaliero, Universitaria di Bologna, 40138 Bologna, Italy.
De Santis S; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Monaldi C; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Cavo M; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.; Istituto di Ematologia 'Seràgnoli', IRCCS Azienda Ospedaliero, Universitaria di Bologna, 40138 Bologna, Italy.
Soverini S; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 25; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Tumor Microenvironment*
Bone Marrow/*metabolism
Bone Marrow/*pathology
Hypoxia/*metabolism
Leukemia, Myeloid, Acute/*etiology
Leukemia, Myeloid, Acute/*metabolism
Animals ; Cell Line, Tumor ; Cellular Reprogramming ; Disease Management ; Disease Susceptibility ; Energy Metabolism ; Epigenesis, Genetic ; Gene Expression Regulation, Leukemic ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Molecular Targeted Therapy ; Neoplastic Stem Cells/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma.
Autorzy :
Ho DW; Department of Pathology, The University of Hong Kong, Hong Kong, China. .; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China. .
Tsui YM; Department of Pathology, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Chan LK; Department of Pathology, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Sze KM; Department of Pathology, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Zhang X; Department of Pathology, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Cheu JW; Department of Pathology, The University of Hong Kong, Hong Kong, China.
Chiu YT; Department of Pathology, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Lee JM; Department of Pathology, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Chan AC; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.; Department of Surgery, The University of Hong Kong, Hong Kong, China.
Cheung ET; Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
Yau DT; Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
Chia NH; Department of Surgery, Queen Elizabeth Hospital, Hong Kong, China.
Lo IL; Department of Surgery, Queen Elizabeth Hospital, Hong Kong, China.
Sham PC; Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
Cheung TT; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.; Department of Surgery, The University of Hong Kong, Hong Kong, China.
Wong CC; Department of Pathology, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Ng IO; Department of Pathology, The University of Hong Kong, Hong Kong, China. .; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 17; Vol. 12 (1), pp. 3684. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*immunology
Gene Expression Regulation/*immunology
Liver Neoplasms/*immunology
Macrophages/*immunology
Tumor Microenvironment/*immunology
Algorithms ; Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/virology ; Cell Proliferation ; Gene Expression Regulation/genetics ; Hepatitis B virus/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/virology ; Macrophages/cytology ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nectins/genetics ; Nectins/metabolism ; Principal Component Analysis ; Prognosis ; RNA-Seq ; Receptors, Immunologic/metabolism ; Single-Cell Analysis ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
Inter-Metastatic Heterogeneity of Tumor Marker Expression and Microenvironment Architecture in a Preclinical Cancer Model.
Autorzy :
Kalra J; Experimental Therapeutics, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.; Applied Research Centre, Langara, Vancouver, BC V5Y 2Z6, Canada.; Department Anesthesia Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Baker J; Integrative Oncology, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.
Song J; Chemical and Biomolecular Engineering Department, Vanderbilt University, Nashville, TN 37235, USA.
Kyle A; Integrative Oncology, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.
Minchinton A; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Integrative Oncology, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.
Bally M; Experimental Therapeutics, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Nanomedicine Innovation Network, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 13; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Tumor Microenvironment*
Biomarkers, Tumor/*metabolism
Animals ; Brain/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Lung/pathology ; Mice, Nude ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
Role of Nitric Oxide in Gene Expression Regulation during Cancer: Epigenetic Modifications and Non-Coding RNAs.
Autorzy :
de la Cruz-Ojeda P; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, 41013 Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Institute of Health Carlos III, 28029 Madrid, Spain.; Department of Medical Physiology and Biophysics, University of Seville, 41009 Seville, Spain.
Flores-Campos R; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, 41013 Seville, Spain.
Dios-Barbeito S; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, 41013 Seville, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/University of Seville/IBiS, 41013 Seville, Spain.
Navarro-Villarán E; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, 41013 Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Institute of Health Carlos III, 28029 Madrid, Spain.; Department of Medical Physiology and Biophysics, University of Seville, 41009 Seville, Spain.
Muntané J; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, 41013 Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Institute of Health Carlos III, 28029 Madrid, Spain.; Department of Medical Physiology and Biophysics, University of Seville, 41009 Seville, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 10; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Epigenesis, Genetic*
Gene Expression Regulation, Neoplastic*
Tumor Microenvironment*
Neoplasms/*pathology
Neoplastic Stem Cells/*pathology
Nitric Oxide/*metabolism
RNA, Long Noncoding/*genetics
Animals ; Cancer-Associated Fibroblasts/pathology ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplastic Stem Cells/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution.
Autorzy :
Lima LG; Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Ham S; Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Shin H; Department of Bio-convergence Engineering, Korea University, Seoul, South Korea.
Chai EPZ; Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
Lek ESH; Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; School of Chemistry and Molecular Biosciences, Faculty of Science, University of Queensland, Brisbane, QLD, Australia.
Lobb RJ; Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; Centre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD, Australia.
Müller AF; Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Mathivanan S; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Yeo B; Olivia Newton-John Cancer Research Institute, Austin Hospital, Heidelberg, Melbourne, VIC, Australia.
Choi Y; Department of Bio-convergence Engineering, Korea University, Seoul, South Korea.; School of Biomedical Engineering, Korea University, Seoul, South Korea.; Department of Bioengineering, Korea University, Seoul, South Korea.
Parker BS; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.
Möller A; Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. .; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia. .; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 10; Vol. 12 (1), pp. 3543. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tumor Microenvironment*/immunology
Breast Neoplasms/*blood
Chemokine CCL2/*metabolism
Exosomes/*metabolism
Receptors, CCR2/*metabolism
Animals ; Breast Neoplasms/pathology ; Cytokines/metabolism ; Exosomes/immunology ; Exosomes/pathology ; Female ; Glycosaminoglycans/metabolism ; Humans ; Killer Cells, Natural/immunology ; Liver/immunology ; Liver/metabolism ; Liver/pathology ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis ; Proteoglycans/metabolism ; Receptors, Cytokine/metabolism ; Spleen/immunology ; Spleen/metabolism ; Spleen/pathology ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment.
Autorzy :
Frank AC; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Raue R; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Fuhrmann DC; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Sirait-Fischer E; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Reuse C; Department for Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, Rebenring 56, 38106 Braunschweig, Germany.
Weigert A; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt, 60590 Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany.
Lütjohann D; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.
Hiller K; Department for Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, Rebenring 56, 38106 Braunschweig, Germany.; Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
Syed SN; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Brüne B; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt, 60590 Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany.
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Źródło :
Theranostics [Theranostics] 2021 Jun 04; Vol. 11 (15), pp. 7570-7588. Date of Electronic Publication: 2021 Jun 04 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tumor Microenvironment*
Breast Neoplasms/*metabolism
L-Lactate Dehydrogenase/*metabolism
Macrophages/*enzymology
Mammary Neoplasms, Animal/*metabolism
Animals ; Breast Neoplasms/pathology ; Female ; Humans ; Isoenzymes/metabolism ; MCF-7 Cells ; Mammary Neoplasms, Animal/pathology
Czasopismo naukowe

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