- Tytuł :
- Preparation of RGD4C fused anti-TNFα nanobody and inhibitory activity on triple-negative breast cancer in vivo.
- Autorzy :
- Źródło :
- Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118274. Date of Electronic Publication: 2020 Aug 19.
- Typ publikacji :
- Journal Article
- MeSH Terms :
-
Antineoplastic Agents, Immunological/*therapeutic use
Oligopeptides/*metabolism
Recombinant Fusion Proteins/*therapeutic use
Single-Domain Antibodies/*therapeutic use
Triple Negative Breast Neoplasms/*drug therapyTumor Necrosis Factor -alpha /*immunology
Animals ; Cell Line ; Cell Line,Tumor ; Cell Proliferation/drug effects ; Female ; Fibroblasts/drug effects ; Gene Expression ; Humans ; Integrin alphaVbeta3/metabolism ; Mice ; Mice, Inbred BALB C ; Neoplasm Metastasis/prevention & control ; Oligopeptides/chemistry ; Oligopeptides/genetics ; Pichia/metabolism ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/chemistry ; Single-Domain Antibodies/genetics ; Triple Negative Breast Neoplasms/pathology ;Tumor Necrosis Factor -alpha /antagonists & inhibitors ;Tumor Necrosis Factor -alpha /pharmacology ; Xenograft Model Antitumor Assays -
Czasopismo naukowe