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Wyszukujesz frazę ""Tumor Suppressor Protein p53"" wg kryterium: Temat


Tytuł :
A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs.
Autorzy :
Zhang Y; Livestock Biotechnology, School of Life Science, Technische Universität München, Germany. Electronic address: .
Niu G; Livestock Biotechnology, School of Life Science, Technische Universität München, Germany. Electronic address: .
Flisikowska T; Livestock Biotechnology, School of Life Science, Technische Universität München, Germany. Electronic address: .
Schnieke A; Livestock Biotechnology, School of Life Science, Technische Universität München, Germany. Electronic address: .
Flisikowski K; Livestock Biotechnology, School of Life Science, Technische Universität München, Germany. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 14; Vol. 553, pp. 25-29. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Organ Specificity*
Sex Characteristics*
Angiotensin-Converting Enzyme 2/*metabolism
Sus scrofa/*metabolism
Tumor Suppressor Protein p53/*metabolism
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; Base Sequence ; Binding Sites ; COVID-19/metabolism ; COVID-19/virology ; Disease Models, Animal ; Female ; Fibroblasts ; Gene Deletion ; Male ; Promoter Regions, Genetic/genetics ; Tumor Suppressor Protein p53/deficiency ; Tumor Suppressor Protein p53/genetics ; X Chromosome/genetics
Czasopismo naukowe
Tytuł :
Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis.
Autorzy :
Wei H; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qu L; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Dai S; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Li Y; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wang H; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Feng Y; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen X; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jiang L; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guo M; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Li J; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen Z; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen L; Molecular and Computational Biology Program, Department of Biological Sciences and Department of Chemistry, University of Southern California, Los Angeles, CA, USA.
Zhang Y; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China. .
Chen Y; Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 16; Vol. 12 (1), pp. 2280. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Mitochondria/*physiology
Tumor Suppressor Protein p53/*ultrastructure
bcl-X Protein/*ultrastructure
Cell Line, Tumor ; Crystallography, X-Ray ; Humans ; Molecular Docking Simulation ; Mutation ; Protein Binding/genetics ; Protein Multimerization/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/isolation & purification ; Tumor Suppressor Protein p53/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/isolation & purification ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Guardian of genome on the tract: Wild type p53-mdm2 complex inhibition in healing the breast cancer.
Autorzy :
S K J; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, India.
S P D; Department of Pharmacognosy and Phytopharmacy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, India. Electronic address: .
R S; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, India.
Sai Surya NU; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, India.
Chenmala K; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, India.
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Źródło :
Gene [Gene] 2021 Jun 20; Vol. 786, pp. 145616. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Breast Neoplasms/*metabolism
Proto-Oncogene Proteins c-mdm2/*metabolism
Tumor Suppressor Protein p53/*metabolism
Breast Neoplasms/genetics ; Disease Progression ; Female ; Humans ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Key proteins of proteome underlying sperm malformation of rats exposed to low fenvalerate doses are highly related to P53.
Autorzy :
Huang S; Department of Histology and Embryology, Medical School, Southeast University, Nanjing, China.; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
Lu Y; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.; Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
Li S; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.; Reproductive Center of Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhou T; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.; Central Laboratory, Wuxi Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Wuxi, China.
Wang J; Zhong Da Hospital, Southeast University, Nanjing, China.
Xia J; Zhong Da Hospital, Southeast University, Nanjing, China.
Zhang X; Department of Histology and Embryology, Medical School, Southeast University, Nanjing, China.
Zhou Z; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Jun; Vol. 36 (6), pp. 1181-1194. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Proteome*
Tumor Suppressor Protein p53*
Animals ; HSP90 Heat-Shock Proteins ; Male ; Nitriles ; Proteomics ; Pyrethrins ; Rats ; Rats, Sprague-Dawley ; Spermatozoa
Czasopismo naukowe
Tytuł :
UVB Inhibits Proliferation, Cell Cycle and Induces Apoptosis via p53, E2F1 and Microtubules System in Cervical Cancer Cell Lines.
Autorzy :
Granados-López AJ; Laboratorio de microRNAs y Cáncer, Unidad Académica de Ciencias Biológicas, Campus II, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Zacatecas 98068, Mexico.; Unidad Académica de Estudios Nucleares, Campus II, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Zacatecas 98068, Mexico.
Manzanares-Acuña E; Unidad Académica de Estudios Nucleares, Campus II, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Zacatecas 98068, Mexico.
López-Hernández Y; CONACYT, Laboratorio de Metabolómica y Proteómica, Unidad Académica de Ciencias Biológicas, Campus II, Universidad Autónoma de Zacatecas, Av. Preparatoria No.301, Zacatecas 98068, Mexico.
Castañeda-Delgado JE; Catedrático-CONACYT, Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, Mexico.
Fraire-Soto I; Laboratorio de microRNAs y Cáncer, Unidad Académica de Ciencias Biológicas, Campus II, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Zacatecas 98068, Mexico.
Reyes-Estrada CA; Laboratorio de Inmunohistoquímica y EOx, MCS de la Unidad Académica de Medicina Humana, Campus Siglo XXI, Universidad Autónoma de Zacatecas, Kilómetro 6, Ejido la Escondida, Zacatecas 98160, Mexico.
Gutiérrez-Hernández R; Laboratorio de Etnofarmacología Nutrición, Unidad Académica de Enfermería, Campus Siglo XXI, Universidad Autónoma de Zacatecas, Kilómetro 6, Ejido la Escondida, Zacatecas 98160, Mexico.
López JA; Laboratorio de microRNAs y Cáncer, Unidad Académica de Ciencias Biológicas, Campus II, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Zacatecas 98068, Mexico.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 14; Vol. 22 (10). Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Ultraviolet Rays*
E2F1 Transcription Factor/*metabolism
Gene Expression Regulation, Neoplastic/*radiation effects
Microtubules/*radiation effects
Tumor Suppressor Protein p53/*metabolism
Uterine Cervical Neoplasms/*pathology
Apoptosis ; Cell Cycle ; Cell Proliferation ; E2F1 Transcription Factor/genetics ; Female ; Humans ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/genetics ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/radiotherapy
Czasopismo naukowe
Tytuł :
Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers.
Autorzy :
Peng DH; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Perlmutter Cancer Center, NYU Langone Health, 550 First Avenue, Smilow Building 10th Floor, Suite 1010, New York, NY, USA.
Rodriguez BL; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Diao L; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gaudreau PO; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Thoracic & Upper GI Cancer Research Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Padhye A; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA.
Konen JM; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ochieng JK; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Class CA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Fradette JJ; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gibson L; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chen L; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wang J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Byers LA; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gibbons DL; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 10; Vol. 12 (1), pp. 2606. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antineoplastic Agents, Immunological/*pharmacology
B7-H1 Antigen/*metabolism
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors
Proto-Oncogene Proteins p21(ras)/*genetics
Th17 Cells/*metabolism
Tumor Suppressor Protein p53/*genetics
Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; B7-H1 Antigen/immunology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Drug Resistance, Neoplasm/immunology ; Drug Synergism ; Female ; Humans ; Immune Checkpoint Inhibitors/immunology ; Immunohistochemistry ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Male ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/immunology ; Neoplasm Metastasis ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins p21(ras)/metabolism ; Th17 Cells/immunology ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Impact of tumor heterogeneity and microenvironment in identifying neoantigens in a patient with ovarian cancer.
Autorzy :
Dao T; Molecular Pharmacology Program, SKI, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Klatt MG; Molecular Pharmacology Program, SKI, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Korontsvit T; Molecular Pharmacology Program, SKI, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mun SS; Molecular Pharmacology Program, SKI, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Guzman S; Molecular Pharmacology Program, SKI, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mattar M; Molecular Pharmacology Program, SKI, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zivanovic O; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA.
Kyi CK; Gynecological Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Socci ND; Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
O'Cearbhaill RE; Gynecological Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. .; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. .; National University of Ireland, Galway, Ireland. .
Scheinberg DA; Molecular Pharmacology Program, SKI, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Gynecological Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. .; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. .; Experimental Therapeutics Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 May; Vol. 70 (5), pp. 1189-1202. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Neoplasm/*metabolism
Epitopes, T-Lymphocyte/*metabolism
HLA-A2 Antigen/*metabolism
Immunotherapy, Adoptive/*methods
Mutation/*genetics
Ovarian Neoplasms/*immunology
T-Lymphocytes/*immunology
Tumor Suppressor Protein p53/*metabolism
Antigens, Neoplasm/genetics ; Cells, Cultured ; Epitopes, T-Lymphocyte/genetics ; Female ; HLA-A2 Antigen/genetics ; Humans ; Middle Aged ; Neoplasm Staging ; Tumor Microenvironment ; Tumor Suppressor Protein p53/genetics ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Cyclopiazonic acid induced p53-dependent apoptosis in the testis of mice: Another male related risk factor of infertility.
Autorzy :
Bonyadi F; Department of Basic Science, Histology section, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Hasanzadeh S; Department of Basic Science, Histology section, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Malekinejad H; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.; Experimental and Applied Pharmaceutical Research Center, Urmia University of Medical Sciences, Urmia, Iran.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 May; Vol. 36 (5), pp. 903-913. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Testis*/metabolism
Tumor Suppressor Protein p53*/metabolism
Animals ; Apoptosis ; Humans ; Indoles/metabolism ; Male ; Mice ; Oxidative Stress ; Risk Factors ; Spermatogenesis
Czasopismo naukowe
Tytuł :
6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
Autorzy :
Choi YJ; Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea.
Lee J; Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea.
Ha SH; Division of Biotechnology, Jeonbuk National University, Iksan, South Korea.
Lee HK; Department of Biological Science, Gachon University, Seongnam, South Korea.
Lim HM; Department of Biological Science, Gachon University, Seongnam, South Korea.
Yu SH; Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea.
Lee CM; Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea.
Nam MJ; Department of Biological Science, Gachon University, Seongnam, South Korea.
Yang YH; Department of Biological Engineering, Konkuk University, Seoul, South Korea.
Park K; Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea.
Choi YS; Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea.; Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea.
Jang KY; Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea.; Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea.; Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea.
Park SH; Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 May; Vol. 36 (5), pp. 914-925. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Colonic Neoplasms*/drug therapy
Tumor Suppressor Protein p53*
Apoptosis ; Cell Line, Tumor ; Cell Survival ; Humans ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer.
Autorzy :
Manzano RG; Molecular Genetics and Genomics Laboratory, Unidad de Consejo Genetico, Plataforma de Oncologia, Hospital Quironsalud Torrevieja, Pda. La Loma s/n, 03184, Torrevieja (Alicante), Spain. .
Catalan-Latorre A; Unidad de Farmacocinetica y Farmacoterapia Personalizada, Plataforma de Oncologia, Hospital Quironsalud Torrevieja, Pda. La Loma s/n, 03184, Torrevieja (Alicante), Spain.
Brugarolas A; Medical Oncology Department, Plataforma de Oncologia, Hospital Quironsalud Torrevieja, Pda. La Loma s/n, 03184, Torrevieja (Alicante), Spain.
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Źródło :
BMC cancer [BMC Cancer] 2021 Apr 20; Vol. 21 (1), pp. 432. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor*
Mutation*
Immune Checkpoint Inhibitors/*therapeutic use
Retinoblastoma Binding Proteins/*genetics
Tumor Suppressor Protein p53/*genetics
Ubiquitin-Protein Ligases/*genetics
Urinary Bladder Neoplasms/*drug therapy
Urinary Bladder Neoplasms/*etiology
Adult ; Aged ; DNA Damage ; Female ; Genomics/methods ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Staging ; Polymorphism, Single Nucleotide ; Prognosis ; Proportional Hazards Models ; Retinoblastoma Binding Proteins/metabolism ; Treatment Outcome ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Tumor Suppressor Protein p53/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/mortality
Czasopismo naukowe
Tytuł :
Microvesicles mediate sorafenib resistance in liver cancer cells through attenuating p53 and enhancing FOXM1 expression.
Autorzy :
Jaffar Ali D; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, Jiangsu 210096, China.
He C; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China.
Xu H; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China.
Kumaravel S; Department of Medical Physiology, College of Medicine, Texas A & M Health Science Center, College Station, TX 77843, United States of America.
Sun B; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China.
Zhou Y; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Liu R; Department of Genetic Engineering, College of Natural Science, University of Suwon, Kyunggi-Do 445-743, Republic of Korea.
Xiao Z; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119149. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cell-Derived Microparticles/*metabolism
Drug Resistance, Neoplasm/*physiology
Forkhead Box Protein M1/*biosynthesis
Liver Neoplasms/*metabolism
Sorafenib/*pharmacology
Tumor Suppressor Protein p53/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Sorafenib/therapeutic use ; Tumor Suppressor Protein p53/antagonists & inhibitors ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Expression of p53 and Ki-67 proteins in patients with increasing severity and duration of pterygium.
Autorzy :
Mahesh M; All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Mittal SK; All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Kishore S; All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Singh A; All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Gupta N; All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Rana R; All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
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Źródło :
Indian journal of ophthalmology [Indian J Ophthalmol] 2021 Apr; Vol. 69 (4), pp. 847-850.
Typ publikacji :
Journal Article
MeSH Terms :
Ki-67 Antigen*/metabolism
Pterygium*/diagnosis
Tumor Suppressor Protein p53*/metabolism
Conjunctiva/metabolism ; Humans ; Immunohistochemistry ; India
Czasopismo naukowe
Tytuł :
Commentary: Expression of p53 and Ki-67 proteins in patients with increasing severity and duration of pterygium.
Autorzy :
Arora R; Guru Nanak Eye Center, Maulana Azad Medical College, New Delhi, India.
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Źródło :
Indian journal of ophthalmology [Indian J Ophthalmol] 2021 Apr; Vol. 69 (4), pp. 851.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Pterygium*/diagnosis
Tumor Suppressor Protein p53*/genetics
Conjunctiva/metabolism ; Humans ; Ki-67 Antigen/metabolism
Czasopismo naukowe
Tytuł :
Targeting a neoantigen derived from a common TP53 mutation.
Autorzy :
Hsiue EH; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Wright KM; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Douglass J; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Hwang MS; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Mog BJ; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Pearlman AH; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Paul S; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
DiNapoli SR; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Konig MF; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Wang Q; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Complete Omics, Baltimore, MD 21227, USA.
Schaefer A; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Miller MS; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Skora AD; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Azurmendi PA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Murphy MB; Cytiva, Marlborough, MA 01752, USA.
Liu Q; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Watson E; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Li Y; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pardoll DM; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Bettegowda C; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine, MD 21205, USA.
Papadopoulos N; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kinzler KW; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Vogelstein B; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Gabelli SB; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. .; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Zhou S; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. .; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Mar 05; Vol. 371 (6533). Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*immunology
Antibodies, Neoplasm/*immunology
Antigens, Neoplasm/*immunology
HLA-A2 Antigen/*immunology
Neoplasms/*therapy
Tumor Suppressor Protein p53/*immunology
Alleles ; Animals ; Antibodies, Bispecific/chemistry ; Antibodies, Bispecific/therapeutic use ; Antibodies, Neoplasm/chemistry ; Antibodies, Neoplasm/therapeutic use ; Arginine/genetics ; COS Cells ; Chlorocebus aethiops ; Female ; HEK293 Cells ; HLA-A2 Antigen/chemistry ; HLA-A2 Antigen/genetics ; Histidine/genetics ; Humans ; Immunization, Passive ; Jurkat Cells ; Lymphocyte Activation ; Mice, Inbred NOD ; Mutation ; T-Lymphocytes/immunology ; Tumor Suppressor Protein p53/chemistry ; Tumor Suppressor Protein p53/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
Autorzy :
Magnussen HM; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Huang DT; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Mar 05; Vol. 433 (5), pp. 166807. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Proto-Oncogene Proteins c-mdm2/*chemistry
Tumor Suppressor Protein p53/*chemistry
Ubiquitin/*chemistry
Ubiquitin-Conjugating Enzymes/*chemistry
Amino Acid Sequence ; Animals ; Biocatalysis ; Catalytic Domain ; Conserved Sequence ; Crystallography, X-Ray ; Gene Expression ; Humans ; Mammals ; Models, Molecular ; Protein Aggregates ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Domains ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitination ; Xenopus ; Zebrafish
Czasopismo naukowe
Tytuł :
Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function.
Autorzy :
Kon N; Institute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York.
Churchill M; Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York.
Li H; Institute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York.
Mukherjee S; Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York.
Manfredi JJ; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Gu W; Institute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York. .
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Źródło :
Cancer research [Cancer Res] 2021 Feb 15; Vol. 81 (4), pp. 935-944. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Tumor Suppressor Protein p53/*metabolism
Tumor Suppressor Protein p53/*physiology
Acetylation ; Animals ; Apoptosis/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cells, Cultured ; DNA Damage/genetics ; Genes, Tumor Suppressor/physiology ; Lysine/metabolism ; Mice ; Mice, Transgenic ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Mutant Proteins/physiology ; Mutation ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Protein Processing, Post-Translational/genetics ; Protein Stability ; Transcriptional Activation/genetics ; Tumor Suppressor Protein p53/chemistry
Czasopismo naukowe
Tytuł :
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction.
Autorzy :
Zhao J; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Blayney A; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Liu X; Department of Chemistry, University of Massachusetts, Amherst, MA, USA.
Gandy L; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Jin W; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Yan L; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Ha JH; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Canning AJ; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Connelly M; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Yang C; Department of Chemistry, New York University, New York, NY, USA.
Liu X; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Xiao Y; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Cosgrove MS; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Solmaz SR; Department of Chemistry, State University of New York at Binghamton, Binghamton, NY, USA.
Zhang Y; Department of Chemistry, New York University, New York, NY, USA.; NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai, China.
Ban D; Merck Research Laboratories, Mass Spectrometry and Biophysics, Kenilworth, NJ, USA.
Chen J; Department of Chemistry, University of Massachusetts, Amherst, MA, USA.; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, USA.
Loh SN; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Wang C; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 12; Vol. 12 (1), pp. 986. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Apoptosis/*drug effects
Catechin/*analogs & derivatives
Catechin/*pharmacology
Proto-Oncogene Proteins c-mdm2/*chemistry
Tumor Suppressor Protein p53/*chemistry
Binding Sites ; Cell Line, Tumor ; Epitopes ; Humans ; Protein Binding ; Proto-Oncogene Proteins c-mdm2/metabolism ; Scattering, Small Angle ; Tea ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
Ligustrazine induces the colorectal cancer cells apoptosis via p53-dependent mitochondrial pathway and cell cycle arrest at the G0/G1 phase.
Autorzy :
Bian Y; School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China; TCM Nursing Intervention Laboratory of Chronic Disease Key Laboratory, Nanjing, China.
Yang L; School of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China; 4 Jingwen Library, Nanjing University of Chinese Medicine, Nanjing, China.
Sheng W; Department of Cardiology, Nantong Hospital of Traditional Chinese Medicine, Nantong, China.
Li Z; College of Health Economics Management, Nanjing University of Chinese Medicine, Nanjing, China.
Xu Y; School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China; TCM Nursing Intervention Laboratory of Chronic Disease Key Laboratory, Nanjing, China.
Li W; Jingwen Library, Nanjing University of Chinese Medicine, Nanjing, China.
Zeng L; School of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Jingwen Library, Nanjing University of Chinese Medicine, Nanjing, China. .
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Źródło :
Annals of palliative medicine [Ann Palliat Med] 2021 Feb; Vol. 10 (2), pp. 1578-1588. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms*/drug therapy
Tumor Suppressor Protein p53*/genetics
Tumor Suppressor Protein p53*/metabolism
Apoptosis ; Cell Cycle Checkpoints ; Cell Proliferation ; G1 Phase ; Humans ; Pyrazines ; Signal Transduction
Czasopismo naukowe
Tytuł :
Up-regulation of miRNA-151-3p enhanced the neuroprotective effect of dexmedetomidine against β-amyloid by targeting DAPK-1 and TP53.
Autorzy :
Guo Y; Department of Anesthesiology, Changzhi Medical College, No.271, Taihang East Street, Changzhi City, Shanxi Province 046011, China.
Wu Y; Department of Anesthesiology, Changzhi Medical College, No.271, Taihang East Street, Changzhi City, Shanxi Province 046011, China.
Li N; Department of Ophthalmology, Changzhi people's Hospital, No.053, Yingbin West Street, Changzhi County, Changzhi City, Shanxi Province 046000, China.
Wang Z; Department of Anesthesiology, Changzhi Medical College, No.271, Taihang East Street, Changzhi City, Shanxi Province 046011, China. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2021 Feb; Vol. 118, pp. 104587. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*chemistry
Death-Associated Protein Kinases/*antagonists & inhibitors
Dexmedetomidine/*pharmacology
MicroRNAs/*genetics
Neuroblastoma/*drug therapy
Neuroprotective Agents/*pharmacology
Tumor Suppressor Protein p53/*antagonists & inhibitors
Adrenergic alpha-2 Receptor Agonists/pharmacology ; Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Death-Associated Protein Kinases/genetics ; Death-Associated Protein Kinases/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; PC12 Cells ; Rats ; Reactive Oxygen Species/metabolism ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe

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