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Tytuł :
Determination of the molecular reach of the protein tyrosine phosphatase SHP-1.
Autorzy :
Clemens L; Center for Complex Biological Systems, University of California Irvine, Irvine, California.
Kutuzov M; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Bayer KV; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Goyette J; EMBL Australia Node in Single Molecule Science, School of Medical Sciences University of New South Wales, Sydney, Australia; ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, Sydney, Australia.
Allard J; Center for Complex Biological Systems, University of California Irvine, Irvine, California. Electronic address: .
Dushek O; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 May 18; Vol. 120 (10), pp. 2054-2066. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Tyrosine Phosphatase, Non-Receptor Type 11*
Tyrosine*/metabolism
Phosphorylation ; Protein Phosphatase 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism ; SH2 Domain-Containing Protein Tyrosine Phosphatases
Czasopismo naukowe
Tytuł :
Novel phospho-specific monoclonal antibodies reveal differential regulation of tyrosine phosphorylation within the immunoreceptor tyrosine-based activation motif of the Fc receptor γ subunit leading to fine tuning of Syk activation.
Autorzy :
Yamashita Y; Department of Immunology, School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan.
Yamashita T; Department of Immunology, School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Apr 02; Vol. 547, pp. 89-95. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Immunoreceptor Tyrosine-Based Activation Motif*
Antibodies, Monoclonal/*metabolism
Antibodies, Phospho-Specific/*metabolism
Mast Cells/*immunology
Receptors, IgG/*metabolism
Syk Kinase/*metabolism
Tyrosine/*metabolism
Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Phospho-Specific/immunology ; Cells, Cultured ; Mast Cells/metabolism ; Mice, Inbred C57BL ; Phosphorylation ; Receptors, IgG/chemistry ; Signal Transduction ; Tyrosine/chemistry
Czasopismo naukowe
Tytuł :
Noncanonical Gene Fusions Detected at the DNA Level Necessitate Orthogonal Diagnosis Methods Before Targeted Therapy.
Autorzy :
Song Z; Department of Clinical Trial, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China; Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, People's Republic of China.
Lu C; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, People's Republic of China; Biotechnology and Health Centre, City University of Hong Kong Shenzhen Research Institute, Shenzhen, People's Republic of China.
Xu CW; Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Zheng Z; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, People's Republic of China; Biotechnology and Health Centre, City University of Hong Kong Shenzhen Research Institute, Shenzhen, People's Republic of China; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, People's Republic of China. Electronic address: .
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Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2021 Mar; Vol. 16 (3), pp. 344-348.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Lung Neoplasms*/diagnosis
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Protein-Tyrosine Kinases*
DNA/genetics ; Gene Fusion ; Genomics ; Humans ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-ret ; Receptor Protein-Tyrosine Kinases
Raport
Tytuł :
The Multifaceted Roles of TAM Receptors during Viral Infection.
Autorzy :
Wang ZY; Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Wang PG; Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. .
An J; Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. .; Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, 100093, China. .
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Źródło :
Virologica Sinica [Virol Sin] 2021 Feb; Vol. 36 (1), pp. 1-12. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Receptor Protein-Tyrosine Kinases*/metabolism
Virus Diseases*
Animals ; Mice ; Proto-Oncogene Proteins/metabolism ; Signal Transduction ; c-Mer Tyrosine Kinase/metabolism
Czasopismo naukowe
Tytuł :
Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
Autorzy :
Vinette V; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Aubry I; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Insull H; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Uetani N; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Hardy S; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Tremblay ML; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Jul; Vol. 35 (7), pp. e21708.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism/*physiology
Mitochondrial Dynamics/*physiology
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*metabolism
Tyrosine/*metabolism
Cell Line ; Cell Line, Tumor ; Cell Proliferation/physiology ; HCT116 Cells ; HEK293 Cells ; Humans ; Phosphorylation/physiology ; Protein-Tyrosine Kinases/metabolism ; RNA, Small Interfering/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study.
Autorzy :
Rocha S; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Lucas M; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Silva VLM; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Gomes PMO; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Silva AMS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Araújo AN; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Aniceto N; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Guedes RC; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Corvo ML; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Fernandes E; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: .
Freitas M; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 30; Vol. 181, pp. 1171-1182. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Enzyme Inhibitors/*pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*genetics
Pyrazoles/*pharmacology
Binding Sites/drug effects ; Computer Simulation ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Enzyme Inhibitors/chemistry ; Humans ; Insulin/chemistry ; Insulin/genetics ; Insulin/metabolism ; Insulin Resistance/genetics ; Molecular Docking Simulation ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy.
Autorzy :
McGee MC; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
August A; Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Huang W; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.; Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Jan; Vol. 109 (1), pp. 49-53. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors
Agammaglobulinaemia Tyrosine Kinase*/immunology
Agammaglobulinaemia Tyrosine Kinase*/metabolism
Lymphopenia*/drug therapy
Lymphopenia*/enzymology
Lymphopenia*/immunology
SARS-CoV-2*/immunology
SARS-CoV-2*/metabolism
Signal Transduction*/drug effects
Signal Transduction*/immunology
COVID-19/*drug therapy
COVID-19/enzymology ; COVID-19/immunology ; Cytokines/immunology ; Humans ; Immunity, Innate/drug effects ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/immunology ; Protein-Tyrosine Kinases/metabolism
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Regulation of glutamate receptors by striatal-enriched tyrosine phosphatase 61 (STEP 61 ).
Autorzy :
Won S; Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.
Roche KW; Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.
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Źródło :
The Journal of physiology [J Physiol] 2021 Jan; Vol. 599 (2), pp. 443-451. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Review
MeSH Terms :
Protein Tyrosine Phosphatases*/metabolism
Receptors, N-Methyl-D-Aspartate*/metabolism
Animals ; Corpus Striatum/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/metabolism ; Synapses/metabolism ; Tyrosine
Czasopismo naukowe
Tytuł :
Effects of novel Btk and Syk inhibitors on platelet functions alone and in combination in vitro and in vivo.
Autorzy :
Series J; Inserm, U1048, Université Toulouse 3, I2MC, Toulouse Cedex 04, France.; Laboratoire d'Hématologie CHU de Toulouse, Toulouse Cedex 04, France.
Ribes A; Inserm, U1048, Université Toulouse 3, I2MC, Toulouse Cedex 04, France.; Laboratoire d'Hématologie CHU de Toulouse, Toulouse Cedex 04, France.
Garcia C; Inserm, U1048, Université Toulouse 3, I2MC, Toulouse Cedex 04, France.; Laboratoire d'Hématologie CHU de Toulouse, Toulouse Cedex 04, France.
Souleyreau P; Laboratoire d'Hématologie CHU de Toulouse, Toulouse Cedex 04, France.
Bauters A; Institut d'hématologie-transfusion, Laboratoire d'hémostase, CHU Lille, Lille, France.
Morschhauser F; Université de Lille, CHU Lille, EA 7365 - GRITA, Lille, France.
Jürgensmeier JM; Gilead Sciences Inc., Foster City, CA, USA.
Sié P; Inserm, U1048, Université Toulouse 3, I2MC, Toulouse Cedex 04, France.; Laboratoire d'Hématologie CHU de Toulouse, Toulouse Cedex 04, France.
Ysebaert L; Service d'Hématologie IUCT-oncopôle, Toulouse Cedex 09, France.
Payrastre B; Inserm, U1048, Université Toulouse 3, I2MC, Toulouse Cedex 04, France.; Laboratoire d'Hématologie CHU de Toulouse, Toulouse Cedex 04, France.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Dec; Vol. 18 (12), pp. 3336-3351. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Platelet Aggregation*
Protein-Tyrosine Kinases*
Agammaglobulinaemia Tyrosine Kinase ; Hemostasis ; Humans ; Platelet Activation ; Syk Kinase
Czasopismo naukowe
Tytuł :
The molecular basis of regulation of bacterial capsule assembly by Wzc.
Autorzy :
Yang Y; Rosalind Franklin Institute, Harwell Campus, Harwell, UK.; Division of Structural Biology, The University of Oxford, Oxford, UK.; The Research Complex at Harwell, Harwell Campus, Harwell, UK.
Liu J; Rosalind Franklin Institute, Harwell Campus, Harwell, UK.; Division of Structural Biology, The University of Oxford, Oxford, UK.
Clarke BR; Department of Molecular and Cellular Biology, The University of Guelph, Guelph, ON, Canada.
Seidel L; Department of Molecular and Cellular Biology, The University of Guelph, Guelph, ON, Canada.
Bolla JR; Physical and Theoretical Chemistry Laboratory, Department of Chemistry, South Parks Road, The University of Oxford, Oxford, UK.; The Kavli Institute for Nanoscience Discovery, Oxford, UK.
Ward PN; Rosalind Franklin Institute, Harwell Campus, Harwell, UK.; Division of Structural Biology, The University of Oxford, Oxford, UK.; The Research Complex at Harwell, Harwell Campus, Harwell, UK.
Zhang P; Division of Structural Biology, The University of Oxford, Oxford, UK.; Electron Bio-Imaging Centre, Diamond Light Source, Harwell Science and Innovation Campus, Harwell, UK.
Robinson CV; Physical and Theoretical Chemistry Laboratory, Department of Chemistry, South Parks Road, The University of Oxford, Oxford, UK.; The Kavli Institute for Nanoscience Discovery, Oxford, UK.
Whitfield C; Department of Molecular and Cellular Biology, The University of Guelph, Guelph, ON, Canada. .
Naismith JH; Rosalind Franklin Institute, Harwell Campus, Harwell, UK. .; Division of Structural Biology, The University of Oxford, Oxford, UK. .; The Research Complex at Harwell, Harwell Campus, Harwell, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 16; Vol. 12 (1), pp. 4349. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Capsules/*chemistry
Bacterial Capsules/*metabolism
Escherichia coli/*metabolism
Escherichia coli Proteins/*chemistry
Membrane Proteins/*chemistry
Periplasm/*metabolism
Polysaccharides, Bacterial/*metabolism
Protein-Tyrosine Kinases/*chemistry
Amino Acid Motifs ; Catalytic Domain ; Cryoelectron Microscopy ; Cytoplasm/metabolism ; Escherichia coli/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Mass Spectrometry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Models, Molecular ; Periplasm/chemistry ; Phosphorylation ; Protein Conformation, alpha-Helical ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Tyrosine/chemistry ; Tyrosine/metabolism
Czasopismo naukowe
Tytuł :
Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective.
Autorzy :
Brullo C; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.
Villa C; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.
Tasso B; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.
Russo E; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.
Spallarossa A; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 16; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Agammaglobulinaemia Tyrosine Kinase/*antagonists & inhibitors
Protein Kinase Inhibitors/*administration & dosage
Adenine/administration & dosage ; Adenine/analogs & derivatives ; Agammaglobulinaemia Tyrosine Kinase/metabolism ; COVID-19/drug therapy ; Chemistry, Pharmaceutical/methods ; Drug Delivery Systems/methods ; Hematologic Neoplasms/drug therapy ; Humans ; Inflammation/drug therapy ; Neoplasms/drug therapy ; Piperidines/administration & dosage ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pyrimidines/administration & dosage ; SARS-CoV-2/drug effects
Czasopismo naukowe
Tytuł :
N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application.
Autorzy :
Song HE; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lee Y; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.; College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea.
Kim E; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Cho CY; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Jung O; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lee D; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lee EG; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Nam SH; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Kang M; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Macalino SJY; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
Kim JE; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Jung JW; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Kwon SW; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Choi S; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
Lee JW; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.; Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 08826, Republic of Korea.
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Źródło :
Theranostics [Theranostics] 2021 Jul 06; Vol. 11 (16), pp. 8092-8111. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CSK Tyrosine-Protein Kinase/*metabolism
Carcinoma, Hepatocellular/*metabolism
Membrane Proteins/*metabolism
CSK Tyrosine-Protein Kinase/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Movement/physiology ; Genes, src/genetics ; Genes, src/physiology ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Peptides/metabolism ; Phosphorylation ; Protein-Tyrosine Kinases/metabolism ; Signal Transduction ; Tetraspanins/genetics ; Tetraspanins/metabolism
Czasopismo naukowe
Tytuł :
Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion.
Autorzy :
Sevillano J; Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.
Sánchez-Alonso MG; Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.
Pizarro-Delgado J; Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.
Ramos-Álvarez MDP; Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 28; Vol. 22 (11). Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diabetes Mellitus, Type 2/*physiopathology
Insulin/*metabolism
Receptor-Like Protein Tyrosine Phosphatases, Class 2/*metabolism
Animals ; Humans ; Insulin Resistance ; Obesity ; Prevalence ; Protein Tyrosine Phosphatases/metabolism ; Receptor, Insulin/metabolism ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Breaking Oncogene Addiction: Getting RTK/RAS-Mutated Cancers off the SOS.
Autorzy :
Sheffels E; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, United States.
Kortum RL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 27; Vol. 64 (10), pp. 6566-6568. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Receptor Protein-Tyrosine Kinases/*metabolism
SOS1 Protein/*metabolism
ras Proteins/*metabolism
Drug Resistance, Neoplasm/drug effects ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/genetics ; SOS1 Protein/antagonists & inhibitors ; Signal Transduction/drug effects ; ras Proteins/antagonists & inhibitors ; ras Proteins/genetics
Czasopismo naukowe
Tytuł :
The protein tyrosine phosphatase PTP-PEST mediates hypoxia-induced endothelial autophagy and angiogenesis via AMPK activation.
Autorzy :
Chandel S; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras (IIT Madras), Chennai, Tamil Nadu 600036, India.
Manikandan A; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras (IIT Madras), Chennai, Tamil Nadu 600036, India.
Mehta N; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras (IIT Madras), Chennai, Tamil Nadu 600036, India.
Nathan AA; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras (IIT Madras), Chennai, Tamil Nadu 600036, India.
Tiwari RK; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras (IIT Madras), Chennai, Tamil Nadu 600036, India.
Mohapatra SB; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras (IIT Madras), Chennai, Tamil Nadu 600036, India.
Chandran M; Cardiovascular Disease and Diabetes Biology Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thyacaud Post, Thiruvananthpuram, Kerala 695014, India.
Jaleel A; Cardiovascular Disease and Diabetes Biology Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thyacaud Post, Thiruvananthpuram, Kerala 695014, India.
Manoj N; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras (IIT Madras), Chennai, Tamil Nadu 600036, India.
Dixit M; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras (IIT Madras), Chennai, Tamil Nadu 600036, India .
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Źródło :
Journal of cell science [J Cell Sci] 2021 Jan 11; Vol. 134 (1). Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AMP-Activated Protein Kinases*/genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 12*
Autophagy ; Endothelial Cells/metabolism ; Humans ; Hypoxia ; Phosphorylation ; Protein Tyrosine Phosphatases
Czasopismo naukowe
Tytuł :
Doubling up on function: dual-specificity tyrosine-regulated kinase 1A (DYRK1A) in B cell acute lymphoblastic leukemia.
Autorzy :
Kim JH; Department of Medicine, Division of Hematology.
Li L; Department of Medicine, Division of Hematology.
Resar LM; Department of Medicine, Division of Hematology.; Departments of Oncology and Pathology, and Institute of Cellular Engineering, and.; Pathobiology, Human Genetics, and Cellular and Molecular Medicine Graduate Programs, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Jan 04; Vol. 131 (1).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Protein-Tyrosine Kinases*/genetics
B-Lymphocytes ; Humans ; Protein-Serine-Threonine Kinases/genetics ; Tyrosine
Czasopismo naukowe
Tytuł :
Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma.
Autorzy :
Lamberti G; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Andrini E; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Sisi M; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Rizzo A; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Parisi C; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Di Federico A; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Gelsomino F; Oncologia Medica, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni - 15, Bologna, Italy. Electronic address: .
Ardizzoni A; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; Oncologia Medica, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni - 15, Bologna, Italy.
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Źródło :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2020 Dec; Vol. 156, pp. 103119. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Protein-Tyrosine Kinases*
Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Anaplastic Lymphoma Kinase ; ErbB Receptors/genetics ; Humans ; Mutation ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Tytuł :
Structural based study to identify new potential inhibitors for dual specificity tyrosine-phosphorylation- regulated kinase.
Autorzy :
Bhardwaj VK; Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh, 176061, India; Biotechnology division, CSIR-IHBT, Palampur, Himachal Pradesh, 176061, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-IHBT Campus, Palampur, Himachal Pradesh, 176061, India.
Singh R; Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh, 176061, India; Biotechnology division, CSIR-IHBT, Palampur, Himachal Pradesh, 176061, India.
Sharma J; Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh, 176061, India; Biotechnology division, CSIR-IHBT, Palampur, Himachal Pradesh, 176061, India.
Das P; Academy of Scientific & Innovative Research (AcSIR), CSIR-IHBT Campus, Palampur, Himachal Pradesh, 176061, India; Natural Product Chemistry and Process Development, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.
Purohit R; Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh, 176061, India; Biotechnology division, CSIR-IHBT, Palampur, Himachal Pradesh, 176061, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-IHBT Campus, Palampur, Himachal Pradesh, 176061, India. Electronic address: .
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Źródło :
Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2020 Oct; Vol. 194, pp. 105494. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Protein-Serine-Threonine Kinases*/metabolism
Protein-Tyrosine Kinases*/metabolism
Phosphorylation ; Tyrosine
Czasopismo naukowe
Tytuł :
GLASS: Global Lorlatinib for ALK(+) and ROS1(+) retrospective Study: real world data of 123 NSCLC patients.
Autorzy :
Peled N; The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center, Beer-Sheva, Israel; Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel. Electronic address: .
Gillis R; The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center, Beer-Sheva, Israel; Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.
Kilickap S; Department of Preventive Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Froesch P; Oncology Institute of the Southern Switzerland, Bellinzona, Switzerland.
Orlov S; Pavlov First Saint Petersburg State Medical University, St Petersburg, Russia.
Filippova E; Pavlov First Saint Petersburg State Medical University, St Petersburg, Russia.
Demirci U; Uskudar University, Faculty of Medicine, Department of Medical Oncology, Turkey.
Christopoulos P; Department of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital, and Translational Lung Research Heidelberg, Member of the German Center for Lung Research (DZL), Germany.
Cicin I; Trakya University, Faculty of Medicine, Department of Medical Oncology, Turkey.
Basal FB; University of Health Sciences, Dr. A.Y. Ankara Oncology Hospital, Department of Medical Oncology, Turkey.
Yilmaz C; Ege University, Faculty of Medicine, Department of Medical Oncology, İzmir, Turkey.
Fedor M; N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, 197798, Russian Federation; St. PetersburgClinical Research and Practical Center for Specialized Types of Medical Care (Oncologic), St. Petersburg, 197758, Russian Federation.
Korkmaz T; Acibadem MAA University Hospital, School of Medicine, Department of Medical Oncology, Maslak Hospital, İstanbul, Turkey.
Paydas S; Department of Oncology, Cukurova University Faculty of Medicine, Adana, Turkey.
Gautschi O; University of Berne and Cantonal Hospital of Lucerne, Switzerland.
Zirtiloglu A; Department of Medical Oncology, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Eralp Y; Acibadem MAA University Hospital, School of Medicine, Department of Medical Oncology, Maslak Hospital, İstanbul, Turkey.
Cinkir HY; Gaziantep University, Faculty of Medicine, Department of Medical Oncology, Gaziantep, Turkey.
Sezer A; Adana Baskent University, Faculty of Medicine, Department of Medical Oncology, Adana, Turkey.
Erman M; Department of Preventive Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Tural D; Department of Medical Oncology, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Turna H; Cerrahpasa University, Faculty of Medicine Department of Medical Oncology, Istanbul, Turkey.
Mazieres J; Centre Hospitalier Universitaire de Toulouse, Université Paul Sabatier, Toulouse, France.
Dudnik E; Thoracic Cancer Service, Davidoff Cancer Center, Rabin Medical Center, Beilinson Campus, Petah Tikva, 49100, Israel.
Reguart N; Division of Medical Oncology, Hospital Clínic, Barcelona,Spain; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
Camidge DR; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, 1665 North Aurora Court, Aurora, CO, 80045, USA.
Ng TL; Ankara University Faculty of Medicine, Department of Medical Oncology, Ankara, Turkey.
Şenler FÇ; Department of Medical Oncology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
Beypınar İ; Yildirim Beyazit University Faculty of Medicine, Department of Medical Oncology, Ankara, Turkey.
Yazılıtaş D; Dokuz Eylul University Faculty of Medicine, Department of Medical Oncology, Izmir, Turkey.
Demirkazık A; Department of Medical Oncology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
Karaoğlu A; Medicalpark Bahçelievler Hospital, Department of Medical Oncology, Istanbul, Turkey.
Okutur K; Akdeniz University Faculty of Medicine, Department of Medical Oncology, Antalya, Turkey.
Coşkun HŞ; Dicle University Faculty of Medicine, Department of Medical Oncology, Diyarbakir, Turkey.
Şendur MAN; Dokuz Eylul University Faculty of Medicine, Department of Medical Oncology, Izmir, Turkey.
Isikdogan A; Dicle University Faculty of Medicine, Department of Medical Oncology, Diyarbakir, Turkey.
Cabuk D; Kocaeli University, Division of Medical Oncology, Kocaeli, Turkey.
Yumuk PF; Marmara University Faculty of Medicine, Department of Medical Oncology, Istanbul, Turkey.
Yıldız I; Acibadem MAA University Hospital, School of Medicine, Department of Medical Oncology, Maslak Hospital, İstanbul, Turkey.
Kaplan MA; Dicle University Faculty of Medicine, Department of Medical Oncology, Diyarbakir, Turkey.
Özyılkan Ö; Adana Baskent University, Faculty of Medicine, Department of Medical Oncology, Adana, Turkey.
Öztop İ; Medicalpark Bahçelievler Hospital, Department of Medical Oncology, Istanbul, Turkey.
Olmez OF; Medipol University Faculty of Medicine, Department of Medical Oncology, Istanbul, Turkey.
Aydin K; Memorial Ankara Hospital, Ankara, Turkey.
Aydıner A; Istanbul University Institute of Cancer, Department of Medical Oncology, Istanbul, Turkey.
Meydan N; Adnan Menderes Univesity Faculty of Medicine, Turkey.
Grinberg RD; The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center, Beer-Sheva, Israel; Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.
Roisman LC; The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center, Beer-Sheva, Israel; Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.
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Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2020 Oct; Vol. 148, pp. 48-54. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Neoplasms*/drug therapy
Protein-Tyrosine Kinases*
Female ; Humans ; Lactams, Macrocyclic ; Male ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases/genetics ; Retrospective Studies
Czasopismo naukowe
Tytuł :
An International Real-World Analysis of the Efficacy and Safety of Lorlatinib Through Early or Expanded Access Programs in Patients With Tyrosine Kinase Inhibitor-Refractory ALK-Positive or ROS1-Positive NSCLC.
Autorzy :
Zhu VW; Chao Family Comprehensive Cancer Center, University of California, Irvine School of Medicine, Orange, California.
Lin YT; Department of Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University Cancer Center, National Taiwan University, Taipei, Taiwan, Republic of China; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China.
Kim DW; Department of Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Loong HH; Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Nagasaka M; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
To H; University of Nevada School of Medicine, Reno, Nevada.
Ang YL; Department of Hematology-Oncology, National University Cancer Institute, Singapore.
Ock CY; Department of Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Tchekmedyian N; Pacific Shores Medical Group, Long Beach, California.
Ou SI; Chao Family Comprehensive Cancer Center, University of California, Irvine School of Medicine, Orange, California. Electronic address: .
Syn NL; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Reungwetwattana T; Division of Medical Oncology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Lin CC; Department of Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University Cancer Center, National Taiwan University, Taipei, Taiwan, Republic of China; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China.
Soo RA; Department of Hematology-Oncology, National University Cancer Institute, Singapore.
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Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2020 Sep; Vol. 15 (9), pp. 1484-1496. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms*/drug therapy
Protein-Tyrosine Kinases*
Hong Kong ; Humans ; Lactams, Macrocyclic ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases ; Republic of Korea ; Taiwan
Czasopismo naukowe

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