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Title:
The TAM Subfamily of Receptor Tyrosine Kinases: The Early Years.
Authors:
Prieto AL; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.
Lai C; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.; Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405, USA.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 16; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 16.
Publication Type:
Journal Article; Review
MeSH Terms:
Axl Receptor Tyrosine Kinase*
Proto-Oncogene Proteins*/genetics
c-Mer Tyrosine Kinase/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/chemistry ; Tamoxifen ; Tyrosine
Academic Journal
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Title:
Landscape of FLT3 Variations Associated with Structural and Functional Impact on Acute Myeloid Leukemia: A Computational Study.
Authors:
Mirza Z; King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Al-Saedi DA; Department of Biochemistry, Faculty of Sciences, University of Tabuk, Tabuk 48322, Saudi Arabia.
Alganmi N; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Computer Science Department, Faculty of Computing and Information Technology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Karim S; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 18; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 18.
Publication Type:
Journal Article
MeSH Terms:
fms-Like Tyrosine Kinase 3*/genetics
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
Humans ; Molecular Docking Simulation ; Sorafenib/pharmacology ; Mutation ; Protein-Tyrosine Kinases/genetics
Academic Journal
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Title:
The Configuration of GRB2 in Protein Interaction and Signal Transduction.
Authors:
Wang D; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Liu G; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.; School of Life Science, Tianjin University, Tianjin 200072, China.
Meng Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Chen H; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Ye Z; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.; Zhejiang Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Hangzhou 310022, China.
Jing J; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China.; Zhejiang Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Hangzhou 310022, China.
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Source:
Biomolecules [Biomolecules] 2024 Feb 22; Vol. 14 (3). Date of Electronic Publication: 2024 Feb 22.
Publication Type:
Journal Article; Review
MeSH Terms:
Signal Transduction*
Receptor Protein-Tyrosine Kinases*/metabolism
GRB2 Adaptor Protein/metabolism ; Tyrosine/metabolism ; Receptors, Cell Surface/metabolism ; Son of Sevenless Proteins ; Protein Binding ; Phosphorylation
Academic Journal
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Title:
Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma.
Authors:
Repici A; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, 98166 Messina, Italy.
Ardizzone A; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, 98166 Messina, Italy.
De Luca F; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, 98166 Messina, Italy.
Colarossi L; Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy.
Prestifilippo A; Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy.
Pizzino G; Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy.
Paterniti I; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, 98166 Messina, Italy.
Esposito E; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, 98166 Messina, Italy.
Capra AP; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, 98166 Messina, Italy.
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Source:
Cells [Cells] 2024 Feb 19; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 19.
Publication Type:
Journal Article; Review
MeSH Terms:
Axl Receptor Tyrosine Kinase*/metabolism
Glioblastoma*/metabolism
Humans ; Proto-Oncogene Proteins/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction
Academic Journal
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Title:
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Authors:
Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Katis VL; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Du Y; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Sikdar A; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Wang D; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Bradshaw WJ; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Rygiel KA; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Leisner TM; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Chalk R; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Mishra S; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Williams CA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Gileadi O; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Brennan PE; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Wiley JC; Sage Bionetworks, Seattle, WA, United States of America.
Gockley J; Sage Bionetworks, Seattle, WA, United States of America.
Cary GA; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America.
Carter GW; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America.
Young JE; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Pearce KH; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Fu H; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
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Corporate Authors:
Emory-Sage-SGC TREAT-AD Center
Source:
PloS one [PLoS One] 2024 Feb 15; Vol. 19 (2), pp. e0293548. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).
Publication Type:
Journal Article
MeSH Terms:
src Homology Domains*
Protein-Tyrosine Kinases*/metabolism
Humans ; Immunoreceptor Tyrosine-Based Activation Motif ; Intracellular Signaling Peptides and Proteins/metabolism ; Syk Kinase/metabolism ; Phosphorylation ; Receptors, Fc/metabolism ; Enzyme Precursors/metabolism
Academic Journal
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Title:
Intrinsic resistance to ROS1 inhibition in a patient with CD74-ROS1 mediated by AXL overexpression.
Authors:
Peters TL; Enliven Therapeutics, Inc., Boulder, Colorado, USA.
Chen N; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Tyler LC; OnKure Therapeutics, Inc., Boulder, Colorado, USA.
Le AT; Cell Technologies Shared Resources, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Dimou A; Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Doebele RC; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
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Source:
Thoracic cancer [Thorac Cancer] 2023 Nov; Vol. 14 (33), pp. 3259-3265. Date of Electronic Publication: 2023 Sep 19.
Publication Type:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Axl Receptor Tyrosine Kinase*/genetics
Axl Receptor Tyrosine Kinase*/metabolism
Humans ; Drug Resistance, Neoplasm/genetics ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Oncogene Proteins, Fusion/metabolism ; Tyrosine Kinase Inhibitors/pharmacology ; Tyrosine Kinase Inhibitors/therapeutic use
Academic Journal
Full Text  Link opens in a new windowDetails
Title:
Molecular Characterization of the Recombinant Ig1 Axl Receptor Domain: An Intriguing Bait for Screening in Drug Discovery.
Authors:
Di Stasi R; Istituto di Biostrutture e Bioimmagini, CNR-Consiglio Nazionale delle Ricerche, Via Pietro Castellino 111, 80131 Napoli, Italy.
De Rosa L; Istituto di Biostrutture e Bioimmagini, CNR-Consiglio Nazionale delle Ricerche, Via Pietro Castellino 111, 80131 Napoli, Italy.
Izzi G; Istituto di Biostrutture e Bioimmagini, CNR-Consiglio Nazionale delle Ricerche, Via Pietro Castellino 111, 80131 Napoli, Italy.
D'Andrea LD; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta', CNR-Consiglio Nazionale delle Ricerche, Via Mario Bianco 9, 20131 Milano, Italy.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2024 Jan 20; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 20.
Publication Type:
Journal Article
MeSH Terms:
Axl Receptor Tyrosine Kinase*
Neoplasms*
Humans ; Receptor Protein-Tyrosine Kinases/chemistry ; Proto-Oncogene Proteins/metabolism ; Ligands ; Drug Discovery
Academic Journal
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Title:
A Comprehensive Review of Small-Molecule Inhibitors Targeting Bruton Tyrosine Kinase: Synthetic Approaches and Clinical Applications.
Authors:
Zhang Q; Nanyang Central Hospital, Nanyang 473000, China.
Wen C; Nanyang Central Hospital, Nanyang 473000, China.
Zhao L; The Rogel Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Wang Y; First People's Hospital of Shangqiu, Shangqiu 476100, China.; Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2023 Dec 11; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 11.
Publication Type:
Journal Article; Review
MeSH Terms:
Protein-Tyrosine Kinases*
Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Humans ; Adult ; Agammaglobulinaemia Tyrosine Kinase/metabolism ; B-Lymphocytes/metabolism ; Signal Transduction
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Effect of High-Fat Food on the Pharmacokinetic Profile and Safety of SAF-189s, an ALK/ROS1 Inhibitor, in Healthy Chinese Adults.
Authors:
Qin H; Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Tan Y; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Diao L; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Hui AM; EnCureGen Pharma, 9 Yayingshi Road, Huangpu District, Guangzhou, 510700, China.
Wu Z; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Zhou Y; Wanbang Biopharmaceuticals, 6 Yangshan Road, Economic Zone, Xuzhou, 221004, Jiangsu, China.
Sun J; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Xiang X; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Qiu J; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Hu W; Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. .
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Source:
Drugs in R&D [Drugs R D] 2023 Dec; Vol. 23 (4), pp. 465-473. Date of Electronic Publication: 2023 Nov 07.
Publication Type:
Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article
MeSH Terms:
East Asian People*
Protein-Tyrosine Kinases*/pharmacokinetics
Diet, High-Fat*
Adult ; Humans ; Administration, Oral ; Area Under Curve ; Biological Availability ; Cross-Over Studies ; Fasting ; Food-Drug Interactions ; Healthy Volunteers ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases
Academic Journal
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Title:
Expression Patterns and Functional Analysis of Three SmTAT Genes Encoding Tyrosine Aminotransferases in Salvia miltiorrhiza .
Authors:
Dong S; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Science, Shaanxi Normal University, Xi'an 710062, China.
Wang L; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Science, Shaanxi Normal University, Xi'an 710062, China.
Qin H; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Science, Shaanxi Normal University, Xi'an 710062, China.
Zhan H; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Science, Shaanxi Normal University, Xi'an 710062, China.
Wang D; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Science, Shaanxi Normal University, Xi'an 710062, China.
Cao X; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Science, Shaanxi Normal University, Xi'an 710062, China.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 25; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 25.
Publication Type:
Journal Article
MeSH Terms:
Tyrosine Transaminase*/genetics
Tyrosine Transaminase*/metabolism
Salvia miltiorrhiza*/metabolism
Transaminases/genetics ; Transaminases/metabolism ; Tyrosine/genetics ; Tyrosine/metabolism ; Gene Expression Regulation, Plant ; Plant Proteins/genetics ; Plant Proteins/metabolism
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis.
Authors:
Gao L; Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, National Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
He C; Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, National Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Yang A; Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, National Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China. .
Zhou H; Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Lu Q; Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, 40202, USA.
Birge RB; Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School Cancer Center, Rutgers University, Newark, NJ, USA. .
Wu Y; Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, National Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China. .; Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA. .
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Source:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Aug 03; Vol. 21 (1), pp. 195. Date of Electronic Publication: 2023 Aug 03.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:
Arthritis*
Axl Receptor Tyrosine Kinase*/metabolism
c-Mer Tyrosine Kinase*/metabolism
Receptor Protein-Tyrosine Kinases*/metabolism
Receptors, IgG*/metabolism
Animals ; Mice ; Antibodies ; Carrier Proteins ; Cytokines/metabolism ; Inflammation ; Proto-Oncogene Proteins/metabolism ; Tyrosine
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
[Tyro3 and CDK9 as biomarkers for drug resistance to breast cancer anti-PD-1 therapies].
Authors:
Zhang JF; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China.
Liu T; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China.
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Source:
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2023 Aug 23; Vol. 45 (8), pp. 651-656.
Publication Type:
English Abstract; Journal Article
MeSH Terms:
Receptor Protein-Tyrosine Kinases*/genetics
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Humans ; Animals ; Mice ; c-Mer Tyrosine Kinase/genetics ; c-Mer Tyrosine Kinase/metabolism ; Axl Receptor Tyrosine Kinase ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; B7-H1 Antigen/genetics ; Drug Resistance, Neoplasm ; Biomarkers ; Cell Line, Tumor ; Cyclin-Dependent Kinase 9
Academic Journal
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Title:
AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.
Authors:
Mohammadzadeh P; Department of Biomedical Sciences, Colorado State University, 1617 Campus Delivery, Fort Collins, CO, 80523, USA.
Roueinfar M; Department of Biomedical Sciences, Colorado State University, 1617 Campus Delivery, Fort Collins, CO, 80523, USA.
Amberg GC; Department of Biomedical Sciences, Colorado State University, 1617 Campus Delivery, Fort Collins, CO, 80523, USA. .
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Source:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Oct 12; Vol. 21 (1), pp. 284. Date of Electronic Publication: 2023 Oct 12.
Publication Type:
Video-Audio Media; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, LHRH*/metabolism
Axl Receptor Tyrosine Kinase*
Mice ; Humans ; Animals ; Matrix Metalloproteinase 9/metabolism ; Signal Transduction ; Gonadotropin-Releasing Hormone/metabolism ; Gonadotropin-Releasing Hormone/pharmacology ; Receptor Protein-Tyrosine Kinases/metabolism
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
AXL in cancer: a modulator of drug resistance and therapeutic target.
Authors:
Tang Y; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Zang H; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Wen Q; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. .
Fan S; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. .
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Source:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Jun 16; Vol. 42 (1), pp. 148. Date of Electronic Publication: 2023 Jun 16.
Publication Type:
Journal Article; Review
MeSH Terms:
Axl Receptor Tyrosine Kinase*
Neoplasms*/drug therapy
Neoplasms*/genetics
Humans ; c-Mer Tyrosine Kinase/metabolism ; Drug Resistance, Neoplasm ; Proto-Oncogene Proteins/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Protein Tyrosine Phosphatase Receptor Zeta 1 as a Potential Target in Cancer Therapy and Diagnosis.
Authors:
Papadimitriou E; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Kanellopoulou VK; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 30; Vol. 24 (9). Date of Electronic Publication: 2023 Apr 30.
Publication Type:
Journal Article; Review
MeSH Terms:
Tyrosine*
Glioma*
Humans ; Signal Transduction ; Carrier Proteins/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Tumor Microenvironment ; Receptor-Like Protein Tyrosine Phosphatases, Class 5/genetics ; Receptor-Like Protein Tyrosine Phosphatases, Class 5/metabolism
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Axl contributes to efficient migration and invasion of melanoma cells.
Authors:
Shao H; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Pittsburgh VA Health System, Pittsburgh, Pennsylvania, United States of America.
Teramae D; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Pittsburgh VA Health System, Pittsburgh, Pennsylvania, United States of America.
Wells A; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Pittsburgh VA Health System, Pittsburgh, Pennsylvania, United States of America.
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Source:
PloS one [PLoS One] 2023 Mar 29; Vol. 18 (3), pp. e0283749. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).
Publication Type:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Melanoma*/genetics
Melanoma*/pathology
Skin Neoplasms*/genetics
Skin Neoplasms*/pathology
Axl Receptor Tyrosine Kinase*/genetics
Cell Line, Tumor ; Humans ; Neoplasm Invasiveness ; Recombinant Proteins ; Receptor Protein-Tyrosine Kinases ; c-Mer Tyrosine Kinase ; Signal Transduction ; Phosphorylation
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
Authors:
Kan Y; Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Paung Y; Department of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Seeliger MA; Department of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Miller WT; Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.; Department of Veterans Affairs Medical Center, Northport, NY 11768-2200, USA.
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Source:
Cells [Cells] 2023 Mar 15; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 15.
Publication Type:
Journal Article; Review; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
ErbB Receptors*/metabolism
Protein-Tyrosine Kinases*/chemistry
Protein-Tyrosine Kinases*/metabolism
Protein-Tyrosine Kinases*/physiology
Protein Domains ; Receptor Protein-Tyrosine Kinases/metabolism ; src Homology Domains
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Bruton's Tyrosine Kinase Inhibitors (BTKIs): Review of Preclinical Studies and Evaluation of Clinical Trials.
Authors:
Rozkiewicz D; Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Hermanowicz JM; Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.; Department of Clinical Pharmacy, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Kwiatkowska I; Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Krupa A; Department of Internal Medicine and Metabolic, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland.
Pawlak D; Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2023 Mar 06; Vol. 28 (5). Date of Electronic Publication: 2023 Mar 06.
Publication Type:
Journal Article; Review
MeSH Terms:
Autoimmune Diseases*/drug therapy
Tyrosine Kinase Inhibitors*/pharmacology
Neoplasms*/drug therapy
Humans ; Agammaglobulinaemia Tyrosine Kinase/metabolism ; Signal Transduction
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis.
Authors:
She Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xu X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yu Q; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yang X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
He J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. .
Tang XX; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. .; Guangzhou Laboratory, Bio-Island, Guangzhou, China. .
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Source:
Respiratory research [Respir Res] 2023 Apr 29; Vol. 24 (1), pp. 118. Date of Electronic Publication: 2023 Apr 29.
Publication Type:
Journal Article
MeSH Terms:
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/genetics
Pulmonary Fibrosis*/metabolism
Receptor Protein-Tyrosine Kinases*/genetics
Animals ; Mice ; Apoptosis ; c-Mer Tyrosine Kinase/genetics ; c-Mer Tyrosine Kinase/metabolism ; Macrophages/metabolism ; Phagocytosis
Academic Journal
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Title:
Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics.
Authors:
Kozaki R; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Yasuhiro T; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Kato H; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Murai J; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Hotta S; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Ariza Y; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Sakai S; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Fujikawa R; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Yoshida T; Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
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Source:
PloS one [PLoS One] 2023 Mar 10; Vol. 18 (3), pp. e0282166. Date of Electronic Publication: 2023 Mar 10 (Print Publication: 2023).
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tyrosine Kinase Inhibitors*
Lymphoma, Large B-Cell, Diffuse*/pathology
Humans ; Agammaglobulinaemia Tyrosine Kinase ; Transcriptome ; Proto-Oncogene Proteins c-akt/metabolism ; Leukocytes, Mononuclear/metabolism ; Protein Kinase Inhibitors/pharmacology
Academic Journal
Full Text  Link opens in a new window Full TextDetails
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