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Tytuł:
Escherichia coli DNA repair helicase Lhr is also a uracil-DNA glycosylase.
Autorzy:
Buckley RJ; School of Life Sciences, University of Nottingham, Nottingham, UK.
Lou-Hing A; School of Life Sciences, University of Nottingham, Nottingham, UK.
Hanson KM; School of Biological and Geographical Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
Ahmed NR; School of Biological and Geographical Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
Cooper CDO; School of Biological and Geographical Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.; CHARM Therapeutics Ltd, B900 Babraham Research Campus, Cambridge, UK.
Bolt EL; School of Life Sciences, University of Nottingham, Nottingham, UK.
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Źródło:
Molecular microbiology [Mol Microbiol] 2023 Aug; Vol. 120 (2), pp. 298-306. Date of Electronic Publication: 2023 Jul 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Uracil-DNA Glycosidase*/genetics
Uracil-DNA Glycosidase*/metabolism
Escherichia coli*/genetics
Escherichia coli*/metabolism
Amino Acid Sequence ; DNA/metabolism ; Uracil/chemistry ; DNA Repair ; DNA Helicases/metabolism ; Bacterial Proteins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity.
Autorzy:
Mu Y; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Zelazowska MA; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Chen Z; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Plummer JB; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Dong Q; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY 11794, USA; Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, NY 11794, USA.
Krug LT; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY 11794, USA; HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
McBride KM; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: .
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Źródło:
DNA repair [DNA Repair (Amst)] 2023 Aug; Vol. 128, pp. 103515. Date of Electronic Publication: 2023 Jun 08.
Typ publikacji:
Journal Article
MeSH Terms:
Uracil-DNA Glycosidase*/metabolism
Epstein-Barr Virus Infections*
Animals ; Mice ; Humans ; Leucine/genetics ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/metabolism ; DNA/metabolism ; Uracil ; DNA Repair ; Mammals/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Mutational and structural analyses of UdgX: insights into the active site pocket architecture and its evolution.
Autorzy:
Aroli S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Woo EJ; Korea Research Institute of Bioscience and Biotechnology 125 Gwahak-ro,Yuseong-gu, Daejeon 34141, Republic of Korea.; Department of life science, UST-KRIBB School, University of Science & Technology, Daejeon 34113, Korea.
Gopal B; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
Varshney U; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.; Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Jul 21; Vol. 51 (13), pp. 6554-6565.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Uracil-DNA Glycosidase*/chemistry
Uracil-DNA Glycosidase*/genetics
Catalytic Domain ; DNA/chemistry ; DNA Repair ; Mutation ; Uracil
Czasopismo naukowe
Szczegóły
Tytuł:
Register-Shifted Structures in Base-Flipped Uracil-Damaged DNA.
Autorzy:
Orndorff PB; Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, CHE 205, Tampa, Florida 33620, United States.
van der Vaart A; Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, CHE 205, Tampa, Florida 33620, United States.
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2023 Aug 02; Vol. 145 (30), pp. 16350-16354. Date of Electronic Publication: 2023 Jul 21.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Uracil*/chemistry
Thymine*/chemistry
Uracil-DNA Glycosidase/chemistry ; DNA Damage ; DNA Repair ; DNA/chemistry
Czasopismo naukowe
Szczegóły
Tytuł:
Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment.
Autorzy:
Kesharwani S; Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India.
Raj P; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.
Paul A; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.
Roy K; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Bhanot A; Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India.
Mehta A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Gopal A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Varshney U; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India; Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India.
Gopal B; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.
Sundriyal S; Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Oct 05; Vol. 258, pp. 115604. Date of Electronic Publication: 2023 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
Uracil-DNA Glycosidase*/chemistry
Uracil-DNA Glycosidase*/metabolism
Mycobacterium tuberculosis*
Uracil/pharmacology ; Barbiturates/pharmacology ; DNA Repair
Czasopismo naukowe
Szczegóły
Tytuł:
Correlated Target Search by Vaccinia Virus Uracil-DNA Glycosylase, a DNA Repair Enzyme and a Processivity Factor of Viral Replication Machinery.
Autorzy:
Diatlova EA; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia.
Mechetin GV; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia.
Yudkina AV; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia.
Zharkov VD; Biology Department, Tomsk State University, 634050 Tomsk, Russia.
Torgasheva NA; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia.
Endutkin AV; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia.
Shulenina OV; NRC 'Kurchatov Institute'-B. P. Konstantinov Petersburg Nuclear Physics Institute, Leningrad Region, 188300 Gatchina, Russia.
Konevega AL; NRC 'Kurchatov Institute'-B. P. Konstantinov Petersburg Nuclear Physics Institute, Leningrad Region, 188300 Gatchina, Russia.
Gileva IP; State Research Center of Virology and Biotechnology Vector, Novosibirsk Region, 630559 Koltsovo, Russia.
Shchelkunov SN; State Research Center of Virology and Biotechnology Vector, Novosibirsk Region, 630559 Koltsovo, Russia.
Zharkov DO; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 23; Vol. 24 (11). Date of Electronic Publication: 2023 May 23.
Typ publikacji:
Journal Article
MeSH Terms:
Uracil-DNA Glycosidase*/genetics
Uracil-DNA Glycosidase*/metabolism
Vaccinia virus*/genetics
DNA/metabolism ; Virus Replication ; DNA Repair ; Uracil/metabolism ; DNA, Viral/genetics ; DNA, Viral/metabolism ; DNA Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Replication Protein A Enhances Kinetics of Uracil DNA Glycosylase on ssDNA and Across DNA Junctions: Explored with a DNA Repair Complex Produced with SpyCatcher/SpyTag Ligation.
Autorzy:
Greenwood SN; Department of Molecular Biology, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA.
Kulkarni RS; Department of Molecular Biology, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA.
Mikhail M; Department of Molecular Biology, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA.; Department of Internal Medicine, Newark Beth Israel Medical Center, Newark, NJ 07112, USA.
Weiser BP; Department of Molecular Biology, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA.
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Źródło:
Chembiochem : a European journal of chemical biology [Chembiochem] 2023 May 16; Vol. 24 (10), pp. e202200765. Date of Electronic Publication: 2023 Apr 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Repair*
Replication Protein A*/genetics
Replication Protein A*/metabolism
Uracil-DNA Glycosidase*/genetics
Humans ; DNA/metabolism ; DNA Replication ; DNA, Single-Stranded ; Kinetics ; Uracil/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Enzymatic Cleavage-Mediated Extension Stalling Enables Accurate Recognition and Quantification of Locus-Specific Uracil Modification in DNA.
Autorzy:
Ji TT; College of Chemistry and Molecular Sciences, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.
Xie NB; College of Chemistry and Molecular Sciences, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.; School of Public Health, Research Center of Public Health, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, China.
Ding JH; College of Chemistry and Molecular Sciences, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.
Wang M; College of Chemistry and Molecular Sciences, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.
Guo X; College of Chemistry and Molecular Sciences, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.
Chen YY; College of Chemistry and Molecular Sciences, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.
Yu SY; School of Public Health, Research Center of Public Health, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, China.
Feng YQ; College of Chemistry and Molecular Sciences, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.; School of Public Health, Research Center of Public Health, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, China.
Yuan BF; College of Chemistry and Molecular Sciences, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.; School of Public Health, Research Center of Public Health, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430060, China.; Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan Research Center for Infectious Diseases and Cancer, Zhongnan Hospital of Wuhan University, Chinese Academy of Medical Sciences, Wuhan, Hubei 430071, China.
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Źródło:
Analytical chemistry [Anal Chem] 2023 May 30; Vol. 95 (21), pp. 8384-8392. Date of Electronic Publication: 2023 May 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Uracil*/chemistry
DNA*/genetics
DNA*/chemistry
Uracil-DNA Glycosidase/metabolism ; Nucleotides ; DNA, Single-Stranded
Czasopismo naukowe
Szczegóły
Tytuł:
Biochemical characterization and mechanistic insight of the family IV uracil DNA glycosylase from Sulfolobus islandicus REY15A.
Autorzy:
Wu M; College of Environmental Science and Engineering, Yangzhou University, China.
Lin T; College of Environmental Science and Engineering, Yangzhou University, China.
Dong K; College of Environmental Science and Engineering, Yangzhou University, China.
Gong Y; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China.
Liu X; Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, China.
Zhang L; College of Environmental Science and Engineering, Yangzhou University, China; Guangling College, Yangzhou University, China. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2023 Mar 01; Vol. 230, pp. 123222. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Uracil-DNA Glycosidase*/chemistry
Sulfolobus*/genetics
Amino Acid Sequence ; DNA/metabolism ; DNA Repair ; Archaea/metabolism ; Uracil/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Uracil-DNA glycosylase efficiency is modulated by substrate rigidity.
Autorzy:
Orndorff PB; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA.
Poddar S; School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.; The Biodesign Institute Center for Single Molecule Biophysics, Arizona State University, Tempe, AZ, 85287, USA.
Owens AM; School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.; The Biodesign Institute Virginia G. Piper Center for Personalized Diagnostics, Arizona State University, Tempe, AZ, 85287, USA.
Kumari N; School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.; The Biodesign Institute Center for Single Molecule Biophysics, Arizona State University, Tempe, AZ, 85287, USA.
Ugaz BT; School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.; The Biodesign Institute Center for Single Molecule Biophysics, Arizona State University, Tempe, AZ, 85287, USA.
Amin S; Magnetic Resonance Research Center, Arizona State University, Tempe, AZ, 85287, USA.
Van Horn WD; School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA. .; The Biodesign Institute Virginia G. Piper Center for Personalized Diagnostics, Arizona State University, Tempe, AZ, 85287, USA. .
van der Vaart A; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA. .
Levitus M; School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA. .; The Biodesign Institute Center for Single Molecule Biophysics, Arizona State University, Tempe, AZ, 85287, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 08; Vol. 13 (1), pp. 3915. Date of Electronic Publication: 2023 Mar 08.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
Uracil-DNA Glycosidase*/chemistry
DNA/chemistry ; DNA Repair ; Mutagenesis ; Uracil ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of a new and diverse set of Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) inhibitors using structure-based virtual screening: Experimental validation and molecular dynamics studies.
Autorzy:
Raj P; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
Selvam K; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
Roy K; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Mani Tripathi S; Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India.
Kesharwani S; Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India.
Gopal B; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
Varshney U; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India; Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India.
Sundriyal S; Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Nov 15; Vol. 76, pp. 129008. Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Uracil-DNA Glycosidase*/chemistry
Uracil-DNA Glycosidase*/genetics
Uracil-DNA Glycosidase*/metabolism
Mycobacterium tuberculosis*
Molecular Dynamics Simulation ; Uracil/pharmacology ; Uracil/metabolism ; Anti-Bacterial Agents
Czasopismo naukowe
Szczegóły
Tytuł:
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A.
Autorzy:
Wu M; College of Environmental Science and Engineering, Yangzhou University, China.
Zhang L; College of Environmental Science and Engineering, Yangzhou University, China; Guangling College, Yangzhou University, China. Electronic address: .
Dong K; College of Environmental Science and Engineering, Yangzhou University, China.
Gong Y; Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China. Electronic address: .
Liu X; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China.
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Źródło:
DNA repair [DNA Repair (Amst)] 2022 Dec; Vol. 120, pp. 103420. Date of Electronic Publication: 2022 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Uracil-DNA Glycosidase*/metabolism
Sulfolobus*/genetics
Sulfolobus*/metabolism
Uracil ; DNA Repair ; DNA
Czasopismo naukowe
Szczegóły
Tytuł:
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase.
Autorzy:
Chang C; Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Yang Y; Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Li J; Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Park SH; Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Fang GC; Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Liang C; Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Cao W; Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA. Electronic address: .
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Źródło:
DNA repair [DNA Repair (Amst)] 2022 Nov; Vol. 119, pp. 103408. Date of Electronic Publication: 2022 Sep 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Thymine DNA Glycosylase*/genetics
Uracil-DNA Glycosidase*/metabolism
5-Methylcytosine ; Cytosine ; DNA/metabolism ; DNA Repair ; Humans ; Oxidative Stress ; Pedobacter ; Thymine ; Uracil
SCR Organism:
Pedobacter heparinus
Czasopismo naukowe
Szczegóły
Tytuł:
Catalytic single-molecule Förster resonance energy transfer biosensor for uracil-DNA glycosylase detection and cellular imaging.
Autorzy:
Zhang Q; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, 250014, China.
Li CC; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
Ma F; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. Electronic address: .
Luo X; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China. Electronic address: .
Zhang CY; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, 250014, China. Electronic address: .
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Źródło:
Biosensors & bioelectronics [Biosens Bioelectron] 2022 Oct 01; Vol. 213, pp. 114447. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Biosensing Techniques*
Uracil-DNA Glycosidase*/metabolism
DNA/chemistry ; DNA Repair ; Fluorescence Resonance Energy Transfer ; Uracil/chemistry
Czasopismo naukowe
Szczegóły
Tytuł:
DR0022 from Deinococcus radiodurans is an acid uracil-DNA glycosylase.
Autorzy:
Li J; Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.
Yang Y; Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.
Chang C; Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.
Cao W; Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.
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Źródło:
The FEBS journal [FEBS J] 2022 Oct; Vol. 289 (20), pp. 6420-6434. Date of Electronic Publication: 2022 Jun 22.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deinococcus*/genetics
Uracil-DNA Glycosidase*/chemistry
Amino Acid Sequence ; Animals ; DNA Repair ; Humans ; Mammals/metabolism ; Models, Molecular ; Uracil/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Design of Uracil-Modified DNA Nanotubes for Targeted Drug Release via DNA-Modifying Enzyme Reactions.
Autorzy:
Deng Y; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Tan Y; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Zhang Y; College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Zhang L; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Zhang C; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Ke Y; Wallance H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322, United States.
Su X; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
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Źródło:
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2022 Aug 03; Vol. 14 (30), pp. 34470-34479. Date of Electronic Publication: 2022 Jul 22.
Typ publikacji:
Journal Article
MeSH Terms:
Nanotubes*
Uracil-DNA Glycosidase*
Animals ; DNA/chemistry ; DNA Repair ; DNA-(Apurinic or Apyrimidinic Site) Lyase ; Drug Liberation ; Humans ; Mice ; Uracil/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Electro-organic synthesis of C-5 sulfenylated amino uracils: Optimization and exploring topoisomerase-I based anti-cancer profile.
Autorzy:
Rani P; Department of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar 125004, India.
Chahal S; Department of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar 125004, India.
Kumar R; Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda 151401, India.
Mayank; Institut interdisciplinaire d'innovation technologique - 3IT USherbrooke, Sherbrooke, Quebec, Canada.
Kumar P; Department of Chemistry, Kurukshetra University, Kurukshetra 136119, India.
Negi A; Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Espoo 02150, Finland.
Singh R; Department of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar 125004, India.
Kumar S; Department of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar 125004, India; Department of Bioinformatics and Computational Biology, College of Biotechnology, CCS Haryana Agricultural University, Hisar 125004, India.
Kataria R; Department of Chemistry & Centre for Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India.
Joshi G; Department of Pharmaceutical Science, Hemvati Nandan Bahuguna Garhwal (A Central) University, Srinagar-246174, Dist. Garhwal, (Uttarakhand), India; Department of Biotechnology, Graphic Era (Deemed to be University), Bell Road, Clement Town Dehradun, Uttarakhand- 248002. Electronic address: .
Sindhu J; Department of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar 125004, India. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2023 Sep; Vol. 138, pp. 106660. Date of Electronic Publication: 2023 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Uracil*/pharmacology
Antineoplastic Agents*/chemistry
Humans ; Molecular Structure ; Structure-Activity Relationship ; Cell Proliferation ; Chemistry Techniques, Synthetic ; DNA ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Cell Line, Tumor ; Dose-Response Relationship, Drug
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis and Biological Evaluation of Novel Uracil Derivatives as Thymidylate Synthase Inhibitors.
Autorzy:
Lone MN; Department of Chemistry, School of Physical & Chemical Sciences, Central University of Kashmir, Ganderbal, J&K, India.
Gul S; Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, J&K, India.
Mehraj U; Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, J&K, India.
Sofi S; Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, J&K, India.
Dar AH; Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, J&K, India.
Ganie SA; Division of Basic Sciences and Humanities FoA, SKUAST-K, Srinagar, J&K, India.
Wani NA; Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, J&K, India. .
Mir MA; Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, J&K, India. .
Zargar MA; Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, J&K, India. .
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Źródło:
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2023 Oct; Vol. 195 (10), pp. 6212-6231. Date of Electronic Publication: 2023 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Uracil*/pharmacology
Breast Neoplasms*/drug therapy
Humans ; Female ; Thymidylate Synthase/genetics ; Thymidylate Synthase/metabolism ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Enzyme Inhibitors/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
A Multimodal Approach towards Genomic Identification of Protein Inhibitors of Uracil-DNA Glycosylase.
Autorzy:
Muselmani W; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
Kashif-Khan N; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
Bagnéris C; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
Santangelo R; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
Williams MA; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
Savva R; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
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Źródło:
Viruses [Viruses] 2023 Jun 10; Vol. 15 (6). Date of Electronic Publication: 2023 Jun 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA*
Uracil-DNA Glycosidase*/antagonists & inhibitors
Uracil-DNA Glycosidase*/chemistry
Genome, Viral ; Genomics ; Viral Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ultra-sensitive biosensor based on CRISPR-Cas12a and Endo IV coupled DNA hybridization reaction for uracil DNA glycosylase detection and intracellular imaging.
Autorzy:
Dong K; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Shu W; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhang J; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Cheng S; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhang J; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhao R; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Hua T; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhang W; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: .
Wang H; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Clinical Research Center of Cancer Immunotherapy of Hubei, Wuhan, 430000, China. Electronic address: hb_.
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Źródło:
Biosensors & bioelectronics [Biosens Bioelectron] 2023 Apr 15; Vol. 226, pp. 115118. Date of Electronic Publication: 2023 Feb 03.
Typ publikacji:
Journal Article
MeSH Terms:
Uracil-DNA Glycosidase*
Biosensing Techniques*
CRISPR-Cas Systems ; Limit of Detection ; DNA, Single-Stranded
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 15981

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