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Tytuł:
Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript.
Autorzy:
Dunn DM; Department of Human Genetics, Rm 308 BPRB, 20 South 2030 East, University of Utah, Salt Lake City, UT 84112, USA.
Ishigami T
Pankow J
von Niederhausern A
Alder J
Hunt SC
Leppert MF
Lalouel JM
Weiss RB
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Źródło:
Journal of human genetics [J Hum Genet] 2002; Vol. 47 (12), pp. 665-76.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Alternative Splicing*
Frameshift Mutation*
Polymorphism, Genetic*
Ubiquitin-Protein Ligases*
Calcium-Binding Proteins/*genetics
Chromosomes, Human, Pair 18/*genetics
Hypertension/*genetics
Ligases/*genetics
Amino Acid Sequence ; Endosomal Sorting Complexes Required for Transport ; Exons ; Humans ; Hypertension/physiopathology ; Introns/genetics ; Kidney/metabolism ; Molecular Sequence Data ; Nedd4 Ubiquitin Protein Ligases ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.
Autorzy:
Maspero E; Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
Valentini E
Mari S
Cecatiello V
Soffientini P
Pasqualato S
Polo S
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2013 Jun; Vol. 20 (6), pp. 696-701. Date of Electronic Publication: 2013 May 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endosomal Sorting Complexes Required for Transport/*chemistry
Endosomal Sorting Complexes Required for Transport/*metabolism
Ubiquitin/*chemistry
Ubiquitin/*metabolism
Ubiquitin-Protein Ligases/*chemistry
Ubiquitin-Protein Ligases/*metabolism
Crystallography, X-Ray ; Humans ; Models, Molecular ; Nedd4 Ubiquitin Protein Ligases ; Protein Binding ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31.
Autorzy:
Ishige T; Department of Molecular Diagnosis and Graduate School of Medicine, Chiba University, Chiba, Japan.
Sawai S
Itoga S
Sato K
Utsuno E
Beppu M
Kanai K
Nishimura M
Matsushita K
Kuwabara S
Nomura F
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Źródło:
Journal of human genetics [J Hum Genet] 2012 Dec; Vol. 57 (12), pp. 807-8. Date of Electronic Publication: 2012 Sep 20.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Endosomal Sorting Complexes Required for Transport/*genetics
Microsatellite Repeats/*genetics
Mutagenesis, Insertional/*genetics
Spinocerebellar Ataxias/*genetics
Ubiquitin-Protein Ligases/*genetics
Case-Control Studies ; DNA/analysis ; DNA/genetics ; Genetic Testing ; Humans ; Nedd4 Ubiquitin Protein Ligases ; Polymerase Chain Reaction ; Sequence Analysis, DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Physiological functions of the HECT family of ubiquitin ligases.
Autorzy:
Rotin D; Program in Cell Biology, The Hospital for Sick Children, Ontario, Canada. />Kumar S
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Źródło:
Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2009 Jun; Vol. 10 (6), pp. 398-409. Date of Electronic Publication: 2009 May 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Protein Isoforms/*metabolism
Ubiquitin/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Endosomal Sorting Complexes Required for Transport ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Humans ; Models, Molecular ; Nedd4 Ubiquitin Protein Ligases ; Protein Conformation ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Signal Transduction/physiology ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases.
Autorzy:
Kong L; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Cheng J; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Zhu Y; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Ding Y; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Meng J; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Chen Z; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Xie Q; State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Guo Y; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.; National Center for Plant Gene Research, Beijing, 100193, China.
Li J; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Yang S; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.; National Center for Plant Gene Research, Beijing, 100193, China.
Gong Z; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.; National Center for Plant Gene Research, Beijing, 100193, China.
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Źródło:
Nature communications [Nat Commun] 2015 Oct 20; Vol. 6, pp. 8630. Date of Electronic Publication: 2015 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arabidopsis/*enzymology
Arabidopsis Proteins/*metabolism
Phosphoprotein Phosphatases/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Abscisic Acid/metabolism ; Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Mutation ; Phosphoprotein Phosphatases/genetics ; Proteasome Endopeptidase Complex/metabolism ; Signal Transduction ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Protein degradation: Prime time for PROTACs.
Autorzy:
Deshaies RJ; Howard Hughes Medical Institute and Division of Biology and Biological Engineering, Caltech, Pasadena, California, USA.
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Źródło:
Nature chemical biology [Nat Chem Biol] 2015 Sep; Vol. 11 (9), pp. 634-5.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Targeted Therapy*
Proteasome Endopeptidase Complex/*chemistry
Small Molecule Libraries/*chemical synthesis
Ubiquitin-Protein Ligases/*chemistry
Ubiquitinated Proteins/*chemistry
Animals ; Binding Sites ; Humans ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; Proteolysis ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitinated Proteins/metabolism ; Ubiquitination/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
Autorzy:
Tan D; Department of Biological Sciences, Columbia University, New York, New York, USA.
Zhou M; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA.
Kiledjian M; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA.
Tong L; Department of Biological Sciences, Columbia University, New York, New York, USA.
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2014 Aug; Vol. 21 (8), pp. 679-85. Date of Electronic Publication: 2014 Jul 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
RNA Interference*
RNA, Messenger/*chemistry
RNA-Binding Proteins/*chemistry
Ubiquitin-Protein Ligases/*chemistry
Amino Acid Substitution ; Base Pairing ; Base Sequence ; Binding Sites ; Crystallography, X-Ray ; HEK293 Cells ; HMGB Proteins/genetics ; HMGB Proteins/metabolism ; Humans ; Hydrogen Bonding ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Models, Molecular ; Mutagenesis, Site-Directed ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Autorzy:
Schlundt A; 1] Biomolecular NMR Spectroscopy, Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany. [2] Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany. [3].
Heinz GA; 1] Institute of Molecular Immunology, Research Unit Molecular Immune Regulation, Helmholtz Zentrum München, Germany. [2] Institute for Immunology, Ludwig-Maximilians-Universität München, Munich, Germany. [3].
Janowski R; 1] Group Intracellular Transport and RNA Biology, Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany. [2].
Geerlof A; Biomolecular NMR Spectroscopy, Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.
Stehle R; Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany.
Heissmeyer V; 1] Institute of Molecular Immunology, Research Unit Molecular Immune Regulation, Helmholtz Zentrum München, Germany. [2] Institute for Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.
Niessing D; Group Intracellular Transport and RNA Biology, Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.
Sattler M; 1] Biomolecular NMR Spectroscopy, Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany. [2] Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany.
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2014 Aug; Vol. 21 (8), pp. 671-8. Date of Electronic Publication: 2014 Jul 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
RNA Interference*
RNA, Messenger/*chemistry
Ubiquitin-Protein Ligases/*chemistry
Amino Acid Substitution ; Animals ; Base Pairing ; Base Sequence ; Binding Sites ; Consensus Sequence ; Crystallography, X-Ray ; Mice ; Models, Molecular ; Mutagenesis, Site-Directed ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; RNA Stability ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.
Autorzy:
Mattiroli F; 1] Division of Biochemistry, Cancer Genomics Center, Netherlands Cancer Institute, Amsterdam, The Netherlands. [2].
Sixma TK; Division of Biochemistry, Cancer Genomics Center, Netherlands Cancer Institute, Amsterdam, The Netherlands.
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2014 Apr; Vol. 21 (4), pp. 308-16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Models, Biological*
Lysine/*metabolism
Ubiquitin/*metabolism
Ubiquitin-Protein Ligases/*physiology
Humans ; Lysine/chemistry ; Signal Transduction ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Small Ubiquitin-Related Modifier Proteins/physiology ; Substrate Specificity ; Ubiquitin/chemistry ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
New insights into ubiquitin E3 ligase mechanism.
Autorzy:
Berndsen CE; Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, Virginia, USA.
Wolberger C; 1] Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2014 Apr; Vol. 21 (4), pp. 301-7.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
Models, Biological*
Ubiquitin-Protein Ligases/*physiology
Ubiquitination/*physiology
Catalysis ; Lysine/chemistry ; Lysine/metabolism ; Signal Transduction ; Substrate Specificity ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Plant ubiquitin ligases as signaling hubs.
Autorzy:
Shabek N; Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.
Zheng N; Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2014 Apr; Vol. 21 (4), pp. 293-6.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
Models, Biological*
Signal Transduction*
Arabidopsis Proteins/*physiology
Proteasome Endopeptidase Complex/*physiology
Ubiquitin-Protein Ligases/*physiology
Arabidopsis/metabolism ; Arabidopsis/physiology ; Arabidopsis Proteins/metabolism ; Ligases/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Centromeric histone H2B monoubiquitination promotes noncoding transcription and chromatin integrity.
Autorzy:
Sadeghi L; 1] Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden. [2].
Siggens L; 1] Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden. [2].
Svensson JP; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Ekwall K; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2014 Mar; Vol. 21 (3), pp. 236-43. Date of Electronic Publication: 2014 Feb 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Centromere/*ultrastructure
Chromatin/*chemistry
Histones/*chemistry
Membrane Proteins/*metabolism
Nuclear Proteins/*metabolism
Schizosaccharomyces pombe Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Cell Cycle ; Chromatin Immunoprecipitation ; Chromosome Segregation ; Chromosomes/ultrastructure ; Epigenesis, Genetic ; Gene Silencing ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Proteins/genetics ; Micronucleus Tests ; Microscopy, Fluorescence ; Nuclear Proteins/genetics ; Oligonucleotide Array Sequence Analysis ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Transcription, Genetic ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The roles of Pellino E3 ubiquitin ligases in immunity.
Autorzy:
Moynagh PN; 1] Institute of Immunology, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland. [2] Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast BT9 7AE, Northern Ireland, United Kingdom.
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Źródło:
Nature reviews. Immunology [Nat Rev Immunol] 2014 Feb; Vol. 14 (2), pp. 122-31. Date of Electronic Publication: 2014 Jan 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Nuclear Proteins/*physiology
Ubiquitin-Protein Ligases/*physiology
Animals ; Humans ; Immunity, Innate ; Nod2 Signaling Adaptor Protein/physiology ; Nuclear Proteins/chemistry ; Protein Processing, Post-Translational ; Signal Transduction ; Toll-Like Receptors/physiology ; Ubiquitin-Protein Ligases/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio.
Autorzy:
Schleinitz D; Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Leipzig, Leipzig, Germany.
Klöting N; 1] Department of Internal Medicine, Neurology, and Dermatology, Clinic for Endocrinology and Nephrology, University Clinic of Leipzig, Leipzig, Germany [2] IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Breitfeld J; Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Leipzig, Leipzig, Germany.
Dietrich A; 1] Department of Internal Medicine, Neurology, and Dermatology, Clinic for Endocrinology and Nephrology, University Clinic of Leipzig, Leipzig, Germany [2] IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
Schön MR; Municipal Clinic Karlsruhe, Clinic of Visceral Surgery, Karlsruhe, Germany.
Lohmann T; Municipal Clinic, Dresden, Germany.
Dreßler M; Municipal Clinic, Dresden, Germany.
Stumvoll M; 1] Department of Internal Medicine, Neurology, and Dermatology, Clinic for Endocrinology and Nephrology, University Clinic of Leipzig, Leipzig, Germany [2] IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
McCarthy MI; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK [3] Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Blüher M; Department of Internal Medicine, Neurology, and Dermatology, Clinic for Endocrinology and Nephrology, University Clinic of Leipzig, Leipzig, Germany.
Kovacs P; Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Leipzig, Leipzig, Germany.
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Źródło:
International journal of obesity (2005) [Int J Obes (Lond)] 2014 Jan; Vol. 38 (1), pp. 120-5. Date of Electronic Publication: 2013 Apr 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Body Composition*
Body Fat Distribution*
Adaptor Proteins, Signal Transducing/*metabolism
Adipose Tissue/*metabolism
Cell Adhesion Molecules, Neuronal/*metabolism
Hexosyltransferases/*metabolism
Membrane Proteins/*metabolism
Obesity/*metabolism
Receptors, Lymphocyte Homing/*metabolism
Subcutaneous Fat/*metabolism
T-Box Domain Proteins/*metabolism
Tryptophan-tRNA Ligase/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adult ; Body Mass Index ; Cell Adhesion Molecules, Neuronal/genetics ; Female ; Genotype ; Hexosyltransferases/genetics ; Humans ; Male ; Membrane Proteins/genetics ; Middle Aged ; Phenotype ; Polymorphism, Single Nucleotide ; RNA, Messenger/metabolism ; Receptors, Lymphocyte Homing/genetics ; T-Box Domain Proteins/genetics ; Tryptophan-tRNA Ligase/genetics ; Ubiquitin-Protein Ligases/genetics ; Waist-Hip Ratio
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.
Autorzy:
Rai R; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Li JM
Zheng H
Lok GT
Deng Y
Huen MS
Chen J
Jin J
Chang S
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2011 Nov 20; Vol. 18 (12), pp. 1400-7. Date of Electronic Publication: 2011 Nov 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Telomere/*chemistry
Ubiquitin-Protein Ligases/*physiology
Animals ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosomes, Mammalian/metabolism ; DNA Damage ; DNA-Binding Proteins/metabolism ; Histones/metabolism ; Mice ; Protein Interaction Mapping ; Protein Stability ; Telomere-Binding Proteins ; Tumor Suppressor p53-Binding Protein 1 ; Ubiquitin-Protein Ligases/analysis ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis.
Autorzy:
Lipkowitz S; Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. />Weissman AM
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Źródło:
Nature reviews. Cancer [Nat Rev Cancer] 2011 Aug 24; Vol. 11 (9), pp. 629-43. Date of Electronic Publication: 2011 Aug 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
RING Finger Domains*
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Neoplasms/*physiopathology
Gene Expression Regulation, Neoplastic ; Humans ; Molecular Structure ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chfr and RNF8 synergistically regulate ATM activation.
Autorzy:
Wu J; Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Chen Y
Lu LY
Wu Y
Paulsen MT
Ljungman M
Ferguson DO
Yu X
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2011 Jun 26; Vol. 18 (7), pp. 761-8. Date of Electronic Publication: 2011 Jun 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Tumor Suppressor Proteins/*metabolism
Tumor Suppressor Proteins/*physiology
Ubiquitin-Protein Ligases/*physiology
Acetylation ; Animals ; Ataxia Telangiectasia Mutated Proteins ; Cells, Cultured ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosome Aberrations ; DNA Damage ; DNA Repair ; Enzyme Activation ; Genomic Instability ; Histones/metabolism ; Lymphoma, T-Cell/genetics ; Mice ; Mice, Knockout ; Poly-ADP-Ribose Binding Proteins ; Radiation, Ionizing ; Trans-Activators/metabolism ; Tumor Suppressor Proteins/chemistry ; Tumor Suppressor Proteins/genetics ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structural basis of substrate recognition and specificity in the N-end rule pathway.
Autorzy:
Matta-Camacho E; Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Kozlov G
Li FF
Gehring K
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2010 Oct; Vol. 17 (10), pp. 1182-7. Date of Electronic Publication: 2010 Sep 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Oligopeptides/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Acetylation ; Amino Acid Sequence ; Amino Acids/chemistry ; Binding Sites ; Crystallography, X-Ray ; Exocrine Pancreatic Insufficiency/genetics ; Humans ; Models, Molecular ; Molecular Sequence Data ; Mutation, Missense ; Oligopeptides/chemistry ; Protein Binding ; Protein Conformation ; Protein Folding ; Protein Interaction Mapping ; Protein Processing, Post-Translational ; Protein Stability ; Protein Structure, Tertiary ; Structure-Activity Relationship ; Substrate Specificity ; Syndrome ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/genetics ; Zinc Fingers/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
Autorzy:
Vandenabeele P; Department for Molecular Biomedical Research, VIB, B-9052 Ghent, Belgium. />Bertrand MJ
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Źródło:
Nature reviews. Immunology [Nat Rev Immunol] 2012 Dec; Vol. 12 (12), pp. 833-44. Date of Electronic Publication: 2012 Nov 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Inhibitor of Apoptosis Proteins/*metabolism
Receptors, Pattern Recognition/*metabolism
Signal Transduction/*physiology
Ubiquitin-Protein Ligases/*metabolism
Animals ; Apoptosis/immunology ; Drosophila melanogaster/enzymology ; Drosophila melanogaster/immunology ; Humans ; Immunity, Innate ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Inhibitor of Apoptosis Proteins/immunology ; Mice ; Receptors, Pattern Recognition/immunology ; Signal Transduction/immunology ; Toll-Like Receptors/immunology ; Toll-Like Receptors/metabolism ; Ubiquitin-Protein Ligases/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.
Autorzy:
Elgazzar S; Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Zembutsu H
Takahashi A
Kubo M
Aki F
Hirata K
Takatsuka Y
Okazaki M
Ohsumi S
Yamakawa T
Sasa M
Katagiri T
Miki Y
Nakamura Y
Pokaż więcej
Źródło:
Journal of human genetics [J Hum Genet] 2012 Dec; Vol. 57 (12), pp. 766-71. Date of Electronic Publication: 2012 Sep 06.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Asian People/*genetics
Breast Neoplasms/*genetics
Carcinoma, Intraductal, Noninfiltrating/*genetics
Neoplasms, Hormone-Dependent/*genetics
Nuclear Proteins/*genetics
Polymorphism, Single Nucleotide/*genetics
Receptors, Estrogen/*metabolism
Ubiquitin-Protein Ligases/*genetics
Aged ; Breast Neoplasms/metabolism ; Carcinoma, Intraductal, Noninfiltrating/metabolism ; Case-Control Studies ; Chromosomes, Human, Pair 3/genetics ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Middle Aged ; Neoplasms, Hormone-Dependent/metabolism ; Nuclear Proteins/metabolism ; Receptor, Fibroblast Growth Factor, Type 2/genetics ; Risk Factors ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
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