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Wyszukujesz frazę ""Ubiquitination"" wg kryterium: Temat


Tytuł :
TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination.
Autorzy :
Zhang J; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Qiu Q; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Wang H; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Chen C; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Luo D; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Oct 15; Vol. 407 (2), pp. 112800. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ferroptosis*
Ubiquitination*
Endothelium, Vascular/*pathology
Glucose/*adverse effects
Growth Inhibitors/*adverse effects
Phospholipid Hydroperoxide Glutathione Peroxidase/*metabolism
Retina/*pathology
Tripartite Motif Proteins/*metabolism
Cell Death ; Cell Proliferation ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Humans ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Reactive Oxygen Species ; Retina/drug effects ; Retina/metabolism ; Sweetening Agents/adverse effects
Czasopismo naukowe
Tytuł :
Aberrant FBXW7-mediated ubiquitination and degradation of ZMYND8 enhances tumor progression and stemness in bladder cancer.
Autorzy :
Qiu F; Department of Urology, The First Affiliated Hospital of Soochow University, China.
Jin Y; Department of Urology, The First Affiliated Hospital of Soochow University, China.
Pu J; Department of Urology, The First Affiliated Hospital of Soochow University, China.
Huang Y; Department of Urology, The First Affiliated Hospital of Soochow University, China.
Hou J; Department of Urology, The First Affiliated Hospital of Soochow University, China.
Zhao X; Department of Urology, The First Affiliated Hospital of Soochow University, China.
Lu Y; Department of Urology, The First Affiliated Hospital of Soochow University, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Oct 15; Vol. 407 (2), pp. 112807. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Ubiquitination*
Biomarkers, Tumor/*metabolism
F-Box-WD Repeat-Containing Protein 7/*metabolism
Neoplastic Stem Cells/*pathology
Tumor Suppressor Proteins/*metabolism
Urinary Bladder Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; F-Box-WD Repeat-Containing Protein 7/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplastic Stem Cells/metabolism ; Prognosis ; Proteolysis ; Survival Rate ; Tumor Cells, Cultured ; Tumor Suppressor Proteins/genetics ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Ubiquitination in T-Cell Activation and Checkpoint Inhibition: New Avenues for Targeted Cancer Immunotherapy.
Autorzy :
Gavali S; Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, 17176 Solna, Sweden.
Liu J; Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, 17176 Solna, Sweden.
Li X; Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, 17176 Solna, Sweden.
Paolino M; Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, 17176 Solna, Sweden.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 06; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Ubiquitination*
Immune Checkpoint Inhibitors/*therapeutic use
Immunotherapy/*methods
Lymphocyte Activation/*immunology
Neoplasms/*drug therapy
T-Lymphocytes/*immunology
Animals ; Humans ; Neoplasms/immunology ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
RNF31 mediated ubiquitination of A20 aggravates inflammation and hepatocyte apoptosis through the TLR4/MyD88/NF-κB signaling pathway.
Autorzy :
Li S; Department of laboratory medicine, Zhumadian Central Hospital, Zhumadian, 463000, Henan, China. Electronic address: .
Zheng X; Department of laboratory medicine, Zhumadian Central Hospital, Zhumadian, 463000, Henan, China.
Hu Y; Department of laboratory medicine, Zhumadian Central Hospital, Zhumadian, 463000, Henan, China.
You K; Department of Hepatobiliary Surgery, First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, Henan, China.
Wang J; Department of Hepatobiliary Surgery, First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, Henan, China.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Oct 01; Vol. 348, pp. 109623. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Signal Transduction*
Ubiquitination*
Hepatocytes/*pathology
Tumor Necrosis Factor alpha-Induced Protein 3/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Cell Line ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2.
Autorzy :
Li B; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Ye J; Trauma Medicine Center, Peking University People's Hospital; Key Laboratory of Trauma and Neural Regeneration (Peking University), National Center for Trauma Medicine, Beijing 100044, P.R. China; Department of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing 100044, P.R. China.
Liu R; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Weng L; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Cao Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Jia S; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Xu C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Liu Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Yan S; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Zheng M; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119918. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Resistance*
Ubiquitination*
Apoptosis Regulatory Proteins/*physiology
Insulin Receptor Substrate Proteins/*metabolism
Neoplasm Proteins/*physiology
Proto-Oncogene Proteins c-mdm2/*metabolism
Animals ; Apoptosis Regulatory Proteins/genetics ; Cell Differentiation ; Cell Line ; Diet, High-Fat ; Disease Models, Animal ; Enzyme Stability ; Gene Knockdown Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Fibers, Skeletal/cytology ; Myoblasts/cytology ; Myoblasts/drug effects ; Neoplasm Proteins/genetics ; Obesity/genetics ; Obesity/metabolism ; Palmitates/pharmacology ; Proteolysis/drug effects
Czasopismo naukowe
Tytuł :
USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates.
Autorzy :
Zhang F; Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Zhao Y; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Center, Zhejiang University, Hangzhou, China. Electronic address: .
Sun Y; Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China; Cancer Center, Zhejiang University, Hangzhou, China. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101109. Date of Electronic Publication: 2021 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ubiquitination*
S-Phase Kinase-Associated Proteins/*metabolism
Ubiquitin Thiolesterase/*metabolism
Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Enzyme Stability ; Humans ; Protein Domains ; S-Phase Kinase-Associated Proteins/genetics ; Ubiquitin Thiolesterase/genetics
Czasopismo naukowe
Tytuł :
HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages.
Autorzy :
Petrova T; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life sciences, University of Dundee, UK.
Zhang J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life sciences, University of Dundee, UK.
Nanda SK; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life sciences, University of Dundee, UK.
Figueras-Vadillo C; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life sciences, University of Dundee, UK.
Cohen P; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life sciences, University of Dundee, UK.
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Źródło :
The FEBS journal [FEBS J] 2021 Oct; Vol. 288 (20), pp. 5909-5924. Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ubiquitination*
Esters/*chemistry
Interleukin-18/*metabolism
Macrophages/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Toll-Like Receptors/*metabolism
Ubiquitin/*chemistry
Ubiquitin-Protein Ligases/*physiology
Animals ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction
Czasopismo naukowe
Tytuł :
KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.
Autorzy :
Ge W; Foot and Ankle Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan, China.
Chen Y; Center of Traumatic Orthopedics, People's Liberation Army 990 Hospital, Xinyang, Henan, China.
Guo Y; Foot and Ankle Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan, China.
Zhao D; Foot and Ankle Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan, China.
Mu L; Foot and Ankle Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan, China.
Zhang K; Foot and Ankle Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan, China.
Zhuo W; Department of Orthopedics and Traumatology, 960 Hospital of PLA, Jinan, Shandong, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 17; Vol. 570, pp. 117-124. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Ubiquitination*
Chromosomal Proteins, Non-Histone/*metabolism
Kinesin/*genetics
Leiomyosarcoma/*genetics
Leiomyosarcoma/*pathology
Oncogene Proteins/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
Ubiquitin-Specific Proteases/*metabolism
Up-Regulation/*genetics
Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; Kinesin/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; Protein Stability ; Proteolysis
Czasopismo naukowe
Tytuł :
ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation.
Autorzy :
Tian M; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Hao F; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Jin X; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Sun X; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Jiang Y; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Wang Y; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Li D; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chang T; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Zou Y; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Peng P; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Xia C; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Liu J; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Li Y; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Wang P; Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Feng Y; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Wei M; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
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Źródło :
ELife [Elife] 2021 Sep 07; Vol. 10. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ubiquitination*
ATP Citrate (pro-S)-Lyase/*metabolism
Acyltransferases/*metabolism
Antineoplastic Agents/*pharmacology
Cell Differentiation/*drug effects
Cullin Proteins/*metabolism
Fatty Acids/*metabolism
ATP Citrate (pro-S)-Lyase/genetics ; Acyltransferases/genetics ; Amino Acid Sequence ; Animals ; Cell Line, Tumor ; Cellular Reprogramming Techniques ; Colitis/pathology ; Cullin Proteins/genetics ; Fatty Acids/genetics ; Female ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
The Ubiquitin System: An Emerging Therapeutic Target for Lung Cancer.
Autorzy :
Jin JO; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China.; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea.
Puranik N; Biological Sciences Department, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.
Bui QT; Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Yadav D; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea.
Lee PC; Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 06; Vol. 22 (17). Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Ubiquitination*
Bortezomib/*therapeutic use
Lung Neoplasms/*drug therapy
Signal Transduction/*drug effects
Ubiquitin/*metabolism
Ubiquitin-Protein Ligases/*antagonists & inhibitors
Animals ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Proteasome Inhibitors/therapeutic use ; Protein Processing, Post-Translational/drug effects ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO.
Autorzy :
Zhou Y; State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, 130112, Changchun, China.
Bu Z; Military Veterinary Institute, Academy of Military Medical Sciences, 130112, Changchun, China.
Qian J; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, 210014, Nanjing, China.
Cheng Y; State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, 130112, Changchun, China.
Qiao L; State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, 130112, Changchun, China.
Yang S; State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, 130112, Changchun, China.
Cheng S; State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, 130112, Changchun, China.
Wang X; Military Veterinary Institute, Academy of Military Medical Sciences, 130112, Changchun, China.
Ren L; College of Animal Sciences, Jilin University, 130062, Changchun, China. .
Yang Y; State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, 130112, Changchun, China. .
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Źródło :
BMC veterinary research [BMC Vet Res] 2021 Aug 30; Vol. 17 (1), pp. 289. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article
MeSH Terms :
Ubiquitination*
Brucella melitensis/*metabolism
I-kappa B Kinase/*metabolism
NF-kappa B/*metabolism
UTP-Glucose-1-Phosphate Uridylyltransferase/*genetics
Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Brucella melitensis/genetics ; Brucellosis/metabolism ; Brucellosis/microbiology ; Gene Expression Regulation ; Mice ; RAW 264.7 Cells ; Signal Transduction ; Ubiquitin/genetics ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.
Autorzy :
Lee J; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.
Kim J; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.; Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Korea.
Shin J; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.
Kang Y; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.
Choi J; Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Korea.
Cheong H; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.; Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 25; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Ubiquitination*
Autophagy-Related Proteins/*metabolism
Neoplasms/*metabolism
Tumor Suppressor Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Vesicular Transport Proteins/*metabolism
Autophagy-Related Proteins/genetics ; Cell Survival ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Proteins/metabolism ; Phosphate-Binding Proteins/metabolism ; Vesicular Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons.
Autorzy :
Mele M; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.
De Luca P; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.
Santos AR; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Vieira M; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Salazar IL; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.
Pinheiro PS; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.
Duarte CB; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Aug; Vol. 35 (8), pp. e21763.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*
Gene Expression Regulation*
Ubiquitination*
Golgi Matrix Proteins/*metabolism
Hippocampus/*metabolism
Neurons/*metabolism
Receptors, AMPA/*biosynthesis
Animals ; Golgi Matrix Proteins/genetics ; HEK293 Cells ; Humans ; Rats ; Receptors, AMPA/genetics
Czasopismo naukowe
Tytuł :
T-2 Toxin Induces Oxidative Stress at Low Doses via Atf3ΔZip2a/2b-Mediated Ubiquitination and Degradation of Nrf2.
Autorzy :
Chen X; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Tianhe District, Guangzhou 510642, China.; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China.; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China.
Mu P; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Tianhe District, Guangzhou 510642, China.; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China.; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China.
Zhu L; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Tianhe District, Guangzhou 510642, China.; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China.; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China.
Mao X; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Tianhe District, Guangzhou 510642, China.; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China.; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China.
Chen S; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Tianhe District, Guangzhou 510642, China.; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China.; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China.
Zhong H; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Tianhe District, Guangzhou 510642, China.; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China.; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China.
Deng Y; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Tianhe District, Guangzhou 510642, China.; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China.; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 25; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress*
Ubiquitination*
Activating Transcription Factor 3/*metabolism
Cation Transport Proteins/*metabolism
NF-E2-Related Factor 2/*metabolism
T-2 Toxin/*pharmacology
Female ; Humans ; MCF-7 Cells ; Signal Transduction ; T-2 Toxin/toxicity
Czasopismo naukowe
Tytuł :
Ubiquitination-dependent and -independent repression of target genes by SETDB1 reveal a context-dependent role for its methyltransferase activity during adipogenesis.
Autorzy :
Zhang J; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.; Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan.
Matsumura Y; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.
Kano Y; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.; Laboratory of Molecular Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Yoshida A; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.; Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Kawamura T; Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.; Proteomics Laboratory, Isotope Science Center, University of Tokyo, Tokyo, Japan.
Hirakawa H; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.; Department of Physiology and Cell Biology, Tokyo Medical and Dental University (TMDU), Graduate School, Tokyo, Japan.
Inagaki T; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.
Tanaka T; Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.
Kimura H; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.
Yanagi S; Laboratory of Molecular Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Fukami K; Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Doi T; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Osborne TF; Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, and Medicine in the Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, St. Petersburg, FL, USA.
Kodama T; Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.
Aburatani H; Genome Science Division, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.
Sakai J; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.; Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan.
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Źródło :
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2021 Jul; Vol. 26 (7), pp. 513-529. Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Adipogenesis*
Epigenesis, Genetic*
Ubiquitination*
Histone-Lysine N-Methyltransferase/*metabolism
3T3-L1 Cells ; Animals ; CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; HEK293 Cells ; Histone Code ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mutation, Missense
Czasopismo naukowe
Tytuł :
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way.
Autorzy :
Chauhan AK; Department of Radiology, The Ohio State University, Columbus, OH, 43210, United States.
Sun Y; Department of Radiology, The Ohio State University, Columbus, OH, 43210, United States.
Zhu Q; Department of Radiology, The Ohio State University, Columbus, OH, 43210, United States. Electronic address: .
Wani AA; Department of Radiology, The Ohio State University, Columbus, OH, 43210, United States; Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, 43210, United States; James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, 43210, United States. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Jul; Vol. 103, pp. 103128. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
DNA Repair*
Ubiquitination*
Proteasome Endopeptidase Complex/*metabolism
Animals ; DNA/metabolism ; DNA Damage ; DNA Helicases/metabolism ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/metabolism ; Humans ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Polymerase II/metabolism ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
A single mutation weakens symbiont-induced reproductive manipulation through reductions in deubiquitylation efficiency.
Autorzy :
Beckmann JF; Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849; .
Van Vaerenberghe K; Division of Biological Sciences, University of Montana, Missoula, MT 59801.
Akwa DE; Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849.
Cooper BS; Division of Biological Sciences, University of Montana, Missoula, MT 59801 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 28; Vol. 118 (39).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Symbiosis*
Ubiquitination*
Cytoplasm/*pathology
Drosophila melanogaster/*microbiology
Embryo, Nonmammalian/*microbiology
Wolbachia/*physiology
Animals ; Cytoplasm/microbiology ; Deubiquitinating Enzymes/metabolism ; Drosophila melanogaster/genetics ; Embryo, Nonmammalian/metabolism ; Female ; Male
Czasopismo naukowe
Tytuł :
Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale.
Autorzy :
Steger M; Evotec München GmbH, Am Klopferspitz 19a, Martinsried, Germany. .
Demichev V; Charité - Universitätsmedizin Berlin, Department of Biochemistry, Berlin, Germany.; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK.; The University of Cambridge, Department of Biochemistry and Cambridge Centre for Proteomics, Cambridge, UK.
Backman M; Evotec München GmbH, Am Klopferspitz 19a, Martinsried, Germany.
Ohmayer U; Evotec München GmbH, Am Klopferspitz 19a, Martinsried, Germany.
Ihmor P; Evotec München GmbH, Am Klopferspitz 19a, Martinsried, Germany.
Müller S; Evotec München GmbH, Am Klopferspitz 19a, Martinsried, Germany.
Ralser M; Charité - Universitätsmedizin Berlin, Department of Biochemistry, Berlin, Germany.; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK.
Daub H; Evotec München GmbH, Am Klopferspitz 19a, Martinsried, Germany.
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Źródło :
Nature communications [Nat Commun] 2021 Sep 13; Vol. 12 (1), pp. 5399. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article
MeSH Terms :
Neural Networks, Computer*
Ubiquitination*
Proteome/*metabolism
Proteomics/*methods
Tandem Mass Spectrometry/*methods
Ubiquitin-Specific Peptidase 7/*metabolism
Cell Line, Tumor ; HCT116 Cells ; Humans ; Jurkat Cells ; Signal Transduction ; Substrate Specificity ; Time Factors ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
Structural and Biochemical Basis for Higher-Order Assembly between A20-Binding Inhibitor of NF-κB 1 (ABIN1) and M1-Linked Ubiquitins.
Autorzy :
Hong JY; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan.
Lin SC; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Kuo BJ; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan.
Lo YC; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Sep 03; Vol. 433 (18), pp. 167116. Date of Electronic Publication: 2021 Jun 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ubiquitination*
DNA-Binding Proteins/*chemistry
DNA-Binding Proteins/*metabolism
Multiprotein Complexes/*chemistry
Multiprotein Complexes/*metabolism
NF-kappa B/*metabolism
Ubiquitins/*metabolism
Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation ; Sequence Homology ; Ubiquitins/chemistry
Czasopismo naukowe
Tytuł :
Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity.
Autorzy :
Ramachandran P; Biocatalysts Laboratory, Department of Agricultural Microbiology, Directorate of Natural Resource Management, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India.
J BJ; Department of Plant Biotechnology, Centre for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India.
Maupin-Furlow JA; Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA; Genetics Institute, University of Florida, Gainesville, FL, USA.
Uthandi S; Biocatalysts Laboratory, Department of Agricultural Microbiology, Directorate of Natural Resource Management, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India. Electronic address: .
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Źródło :
Microbiological research [Microbiol Res] 2021 Sep; Vol. 250, pp. 126810. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Host-Pathogen Interactions*
Plant Immunity*
Bacteria/*metabolism
Bacterial Proteins/*metabolism
Plants/*microbiology
Proteasome Endopeptidase Complex/*immunology
Ubiquitination/*immunology
Bacteria/genetics ; Bacterial Proteins/genetics ; Plant Proteins/metabolism ; Proteasome Endopeptidase Complex/genetics ; Ubiquitination/genetics
Czasopismo naukowe

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