The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment.
Autorzy:
Iorio M; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.; Center for Applied Biomedical Research, University of Bologna, 40138 Bologna, Italy.; Centro Studi e Ricerca sulle Neoplasie Ginecologiche (CSR), University of Bologna, 40138 Bologna, Italy. UmeshGaneshN; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.; Center for Applied Biomedical Research, University of Bologna, 40138 Bologna, Italy.; Centro Studi e Ricerca sulle Neoplasie Ginecologiche (CSR), University of Bologna, 40138 Bologna, Italy. De Luise M; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.; Center for Applied Biomedical Research, University of Bologna, 40138 Bologna, Italy.; Centro Studi e Ricerca sulle Neoplasie Ginecologiche (CSR), University of Bologna, 40138 Bologna, Italy. Porcelli AM; Center for Applied Biomedical Research, University of Bologna, 40138 Bologna, Italy.; Centro Studi e Ricerca sulle Neoplasie Ginecologiche (CSR), University of Bologna, 40138 Bologna, Italy.; Department of Pharmacy and Biotechnology (FABIT), University of Bologna, 40126 Bologna, Italy.; Interdepartmental Center of Industrial Research (CIRI) Life Science and Health Technologies, University of Bologna, 40064 Ozzano dell'Emilia, Italy. Gasparre G; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.; Center for Applied Biomedical Research, University of Bologna, 40138 Bologna, Italy.; Centro Studi e Ricerca sulle Neoplasie Ginecologiche (CSR), University of Bologna, 40138 Bologna, Italy. Kurelac I; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.; Center for Applied Biomedical Research, University of Bologna, 40138 Bologna, Italy.; Centro Studi e Ricerca sulle Neoplasie Ginecologiche (CSR), University of Bologna, 40138 Bologna, Italy.
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Źródło:
Cancers [Cancers (Basel)] 2021 Oct 29; Vol. 13 (21). Date of Electronic Publication: 2021 Oct 29.
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target.
Autorzy:
Gampala S; Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Shah F; Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Lu X; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Biohealth Informatics, IUPUI, Indianapolis, IN, 46202, USA. Moon HR; School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47906, USA. Babb O; Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. UmeshGaneshN; Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA. Sandusky G; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine , Indianapolis, IN, 46202, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W Walnut St. R4-321, Indianapolis, IN, 46202, USA. Hulsey E; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine , Indianapolis, IN, 46202, USA. Armstrong L; Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Mosely AL; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W Walnut St. R4-321, Indianapolis, IN, 46202, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Han B; School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47906, USA.; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA. Ivan M; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W Walnut St. R4-321, Indianapolis, IN, 46202, USA.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Yeh JJ; Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA. Kelley MR; Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W Walnut St. R4-321, Indianapolis, IN, 46202, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Zhang C; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. .; Department of Biohealth Informatics, IUPUI, Indianapolis, IN, 46202, USA. .; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W Walnut St. R4-321, Indianapolis, IN, 46202, USA. . Fishel ML; Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. .; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W Walnut St. R4-321, Indianapolis, IN, 46202, USA. .; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. .
A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma.
Autorzy:
Kurelac I; Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Via Massarenti 9, 40138 Bologna, Italy.; Tumor-Host Interaction Lab, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, UK. Abarrategi A; Hematopoietic Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Regenerative Medicine Lab, CICbiomaGUNE, Paseo Miramón 182, 20014 Donostia, Spain.; Ikerbasque, Basque Foundation of Science, Maria Diaz de Haro 3, 48013 Bilbao, Spain. Ragazzi M; Anatomia Patologica, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, Italy. Iommarini L; Dipartimento di Farmacia e Biotecnologie, Università di Bologna, Via Selmi 3, 40126 Bologna, Italy. UmeshGaneshN; Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Via Massarenti 9, 40138 Bologna, Italy. Snoeks T; In Vivo Imaging Operations, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Bonnet D; Hematopoietic Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Porcelli AM; Dipartimento di Farmacia e Biotecnologie, Università di Bologna, Via Selmi 3, 40126 Bologna, Italy.; Centro Interdipartimentale di Ricerca Industriale Scienze della Vita e Tecnologie per la Salute, Università di Bologna, Via Tolara di Sopra 41/E, 40064 Ozzano dell'Emilia, Italy. Malanchi I; Tumor-Host Interaction Lab, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, UK. Gasparre G; Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Via Massarenti 9, 40138 Bologna, Italy.; Centro di Ricerca Biomedica Applicata (CRBA), Università di Bologna, Via Massarenti 9, 40138 Bologna, Italy.
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Źródło:
Journal of clinical medicine [J Clin Med] 2019 Dec 11; Vol. 8 (12). Date of Electronic Publication: 2019 Dec 11.
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