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Tytuł :
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Autorzy :
Sadeghi-Amiri L; Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Islamic Republic of Iran.
Barzegar A; Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Islamic Republic of Iran. Electronic address: .
Nikbakhsh-Zati N; Department of Surgery, Faculty of Medicine, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.
Mehraban P; Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Islamic Republic of Iran.
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Źródło :
Gene [Gene] 2021 Feb 15; Vol. 769, pp. 145216. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Up-Regulation*
Adenocarcinoma/*genetics
Cytochrome P-450 CYP1A1/*genetics
Stomach Neoplasms/*genetics
Cell Line, Tumor ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease.
Autorzy :
Ding Q; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA.
Shults NV; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA.
Gychka SG; Department of Pathological Anatomy N2, Bogomolets National Medical University, 01601 Kiev, Ukraine.
Harris BT; Departments of Neurology and Pathology, Georgetown University Medical Center, Washington, DC 20007, USA.
Suzuki YJ; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 08; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Pandemics*
Up-Regulation*
Alzheimer Disease/*metabolism
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*epidemiology
COVID-19/*metabolism
Hippocampus/*metabolism
Receptors, Virus/*metabolism
SARS-CoV-2/*metabolism
Alzheimer Disease/complications ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Autopsy ; COVID-19/complications ; COVID-19/virology ; Hippocampus/pathology ; Humans ; Oxidation-Reduction ; Oxidative Stress ; Peroxiredoxin VI/metabolism ; Plaque, Amyloid/metabolism ; Protein Carbonylation ; Severity of Illness Index ; Virus Internalization
Czasopismo naukowe
Tytuł :
Differentially expressed circulating microRNAs associated with idiopathic recurrent pregnancy loss.
Autorzy :
Jairajpuri DS; Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain. Electronic address: .
Malalla ZH; Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.
Mahmood N; Department of Obstetrics and Gynecology, Salmaniya Medical Complex, Manama, Bahrain.
Khan F; Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.
Almawi WY; College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates; Faculty of Sciences, El Manar University, Tunis, Tunisia.
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Źródło :
Gene [Gene] 2021 Feb 05; Vol. 768, pp. 145334. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Abortion, Habitual/*genetics
Circulating MicroRNA/*genetics
MicroRNAs/*blood
Adult ; Case-Control Studies ; Female ; Gene Expression Regulation ; Genetic Association Studies ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Oligonucleotide Array Sequence Analysis ; Pregnancy
Czasopismo naukowe
Tytuł :
Clinical Applicability of the Proliferation Marker Thymidine Kinase 1 in Head and Neck Cancer Patients.
Autorzy :
Meirovitz A; Department of Oncology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Gross M; Department of Otolaryngology-Head and Neck Surgery, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Leibovici V; Department of Dermatology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Sheva K; Department of Oncology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Popovzer A; Department of Oncology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Barak V; Department of Oncology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel .
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 1083-1087.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*/radiation effects
Biomarkers, Tumor/*blood
Head and Neck Neoplasms/*pathology
Head and Neck Neoplasms/*radiotherapy
Thymidine Kinase/*blood
Case-Control Studies ; Female ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/enzymology ; Humans ; Lymphatic Metastasis ; Male ; Neoplasm Staging ; Prognosis ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Prognostic Influence of Cytoplasmic/Nuclear Hepatoma-derived Growth Factor in Head and Neck Cancer.
Autorzy :
Lee HP; Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.; Department of Nursing, Meiho University, Pingtung, Taiwan, R.O.C.
Tsai KW; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan, R.O.C.
Lee CC; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.; .; Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan, R.O.C.; School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.; School of Medicine, National Defense Medical Center, Taipei, Taiwan, R.O.C.; Department of Otolaryngology, Head and Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan, R.O.C.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 803-810.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Head and Neck Neoplasms/*pathology
Intercellular Signaling Peptides and Proteins/*metabolism
Tumor Suppressor Protein p53/*metabolism
Aged ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/mortality ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Survival Analysis ; Tissue Array Analysis
Czasopismo naukowe
Tytuł :
Association Between CD133 Expression and Prognosis in Human Lung Adenocarcinoma.
Autorzy :
Yamashita N; Laboratory of Cell and Gene Therapy, Hyogo College of Medicine, Nishinomiya, Japan; .; Department of Thoracic Surgery, Shinkomonji Hospital, Kitakyushu, Japan.
Oyama T; Laboratory of Cell and Gene Therapy, Hyogo College of Medicine, Nishinomiya, Japan.; Imamitsu Home Care Clinic, Kitakyushu, Japan.
So T; Department of Thoracic Surgery, Shinkomonji Hospital, Kitakyushu, Japan.
Miyata T; Department of Thoracic Surgery, Shinkuki General Hospital, Kuki, Japan.
Yoshimatsu T; Department of Thoracic Surgery, Fukuoka-Wajiro Hospital, Fukuoka, Japan.
Nakano R; Department of Pathology, Fukuoka-Wajiro Hospital, Fukuoka, Japan.
Matsunaga W; Laboratory of Cell and Gene Therapy, Hyogo College of Medicine, Nishinomiya, Japan.
Gotoh A; Laboratory of Cell and Gene Therapy, Hyogo College of Medicine, Nishinomiya, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 905-910.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
AC133 Antigen/*metabolism
Adenocarcinoma of Lung/*pathology
Biomarkers, Tumor/*metabolism
Lung Neoplasms/*pathology
Adenocarcinoma of Lung/metabolism ; Adult ; Aged ; Aged, 80 and over ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/metabolism ; Male ; Middle Aged ; Neoplasm Staging ; Neoplastic Stem Cells/metabolism ; Prognosis ; Survival Analysis
Czasopismo naukowe
Tytuł :
FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role.
Autorzy :
Tat V; Department of Medicine, Firestone Institute for Respiratory Health, and.
Ayaub EA; Department of Medicine, Firestone Institute for Respiratory Health, and.
Ayoub A; Department of Medicine, Firestone Institute for Respiratory Health, and.
Vierhout M; Department of Medicine, Firestone Institute for Respiratory Health, and.
Naiel S; Department of Medicine, Firestone Institute for Respiratory Health, and.
Padwal MK; Department of Medicine, Firestone Institute for Respiratory Health, and.
Abed S; Department of Medicine, Firestone Institute for Respiratory Health, and.
Mekhael O; Department of Medicine, Firestone Institute for Respiratory Health, and.
Tandon K; Department of Medicine, Firestone Institute for Respiratory Health, and.; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
Revill SD; Department of Medicine, Firestone Institute for Respiratory Health, and.
Yousof T; Department of Medicine, Firestone Institute for Respiratory Health, and.
Bellaye PS; Department of Medicine, Firestone Institute for Respiratory Health, and.; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
Kolb PS; Department of Medicine, Firestone Institute for Respiratory Health, and.; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
Dvorkin-Gheva A; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
Naqvi A; Department of Medicine, Firestone Institute for Respiratory Health, and.; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
Cutz JC; Department of Medicine, Firestone Institute for Respiratory Health, and.; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
Hambly N; Department of Medicine, Firestone Institute for Respiratory Health, and.; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
Kato J; Pulmonary Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Vaughan M; Pulmonary Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Moss J; Pulmonary Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Kolb MRJ; Department of Medicine, Firestone Institute for Respiratory Health, and.; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
Ask K; Department of Medicine, Firestone Institute for Respiratory Health, and.; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; and.
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Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2021 Feb; Vol. 64 (2), pp. 235-246.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Diseases, Interstitial/*metabolism
Lung Diseases, Interstitial/*pathology
Tacrolimus Binding Proteins/*metabolism
Up-Regulation/*physiology
Animals ; Biomarkers/metabolism ; Biopsy/methods ; Bleomycin/adverse effects ; Cytokines/metabolism ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Female ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Idiopathic Pulmonary Fibrosis/pathology ; Inflammation/metabolism ; Inflammation/pathology ; Lung ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Severity of Illness Index ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Elevated Free Triiodothyronine Is Associated With Increased Proliferative Activity in Triple-negative Breast Cancer.
Autorzy :
Nisman B; Department of Oncology, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel; .
Allweis TM; Department of Surgery and Breast Health Center, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel.; Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Carmon E; Departmentt of Surgery, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel.
Kadouri L; Department of Oncology, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel.; Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Maly B; Department of Pathology, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel.
Maimon O; Department of Oncology, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel.
Meirovitz A; Department of Oncology, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel.
Peretz T; Department of Oncology, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel.; Faculty of Medicine, Hebrew University, Jerusalem, Israel.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 949-954.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Thymidine Kinase/*blood
Triiodothyronine/*blood
Triple Negative Breast Neoplasms/*blood
Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Thyrotropin/blood ; Thyroxine/blood
Czasopismo naukowe
Tytuł :
IL-8/CXCR2 Signalling Promotes Cell Proliferation in Oesophageal Squamous Cell Carcinoma and Correlates With Poor Prognosis.
Autorzy :
Inoue M; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
Takeuchi H; Department of Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan .
Matsuda S; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
Nishi T; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
Fukuda K; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
Nakamura R; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
Takahashi T; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
Wada N; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
Kawakubo H; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
Kitagawa Y; Department of Surgery, Keio University, School of Medicine, Tokyo, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 783-794.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Esophageal Neoplasms/*surgery
Esophageal Squamous Cell Carcinoma/*surgery
Interleukin-8/*metabolism
Receptors, Interleukin-8B/*metabolism
Aged ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Interleukin-8/antagonists & inhibitors ; Interleukin-8/genetics ; Male ; Mice ; Middle Aged ; Neoplasm Transplantation ; Phenylurea Compounds/pharmacology ; Prognosis ; RNA, Small Interfering/pharmacology ; Receptors, Interleukin-8B/antagonists & inhibitors ; Receptors, Interleukin-8B/genetics ; Signal Transduction/drug effects ; Survival Analysis
Czasopismo naukowe
Tytuł :
Salivary CPLANE1 Levels as a Biomarker of Oral Squamous Cell Carcinoma.
Autorzy :
Ueda S; Department of Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.; Department of Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.
Goto M; Department of Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.
Hashimoto K; Department of Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.; Department of Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.
Imazawa M; Department of Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.
Takahashi M; Department of Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.
Oh-Iwa I; Department of Maxillofacial Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan.
Shimozato K; Department of Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.
Nagao T; Department of Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan.
Nomoto S; Department of Surgery, School of Dentistry, Aichi Gakuin University Graduate School of Medicine, Nagoya, Japan; .
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 765-772.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Biomarkers, Tumor/*genetics
Carcinoma, Squamous Cell/*diagnosis
Membrane Proteins/*genetics
Mouth Neoplasms/*diagnosis
Saliva/*chemistry
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Case-Control Studies ; Early Detection of Cancer ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Leukoplakia, Oral/genetics ; Lichen Planus, Oral/genetics ; Male ; Middle Aged ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Neoplasm Staging ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
5-Aminolevulinic acid combined with sodium ferrous citrate (5-ALA/SFC) ameliorated liver injury in a murine acute graft-versus-host disease model by reducing inflammation responses through PGC1-α activation.
Autorzy :
Wang Z; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.; Laboratory of Functional Morphology Graduate School of Human Health Sciences Tokyo Metropolitan University, Tokyo, Japan.
Ma K; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Liu C; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Hu X; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Que W; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Ito H; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Takahashi K; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Nakajima M; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Tanaka T; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Ren K; Project Division for Healthcare Innovation, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Guo WZ; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yi SQ; Laboratory of Functional Morphology Graduate School of Human Health Sciences Tokyo Metropolitan University, Tokyo, Japan.
Li XK; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.; Project Division for Healthcare Innovation, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
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Źródło :
Drug discoveries & therapeutics [Drug Discov Ther] 2021 Jan 23; Vol. 14 (6), pp. 304-312. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Cytokines/*genetics
Ferrous Compounds/*administration & dosage
Graft vs Host Disease/*drug therapy
Levulinic Acids/*administration & dosage
Liver/*drug effects
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*genetics
Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Disease Models, Animal ; Drug Therapy, Combination ; Ferrous Compounds/chemistry ; Ferrous Compounds/pharmacology ; Gene Expression Regulation/drug effects ; Graft vs Host Disease/etiology ; Graft vs Host Disease/genetics ; Levulinic Acids/pharmacology ; Liver/immunology ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Sodium Citrate/chemistry ; T-Lymphocytes/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Up-Regulation of Nfat5 mRNA and Fzd4 mRNA as a Marker of Poor Outcome in Neonatal Hypoxic-Ischemic Encephalopathy.
Autorzy :
O'Sullivan MP; INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; National Children's Research Centre, Crumlin, Dublin, Ireland. Electronic address: .
Casey S; INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Finder M; Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; Neonatal Department, Karolinska University Hospital, Stockholm, Sweden.
Ahearne C; INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Clarke G; INFANT Research Centre, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland; APC Microbiome, Ireland, University College Cork, Cork, Ireland.
Hallberg B; Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; Neonatal Department, Karolinska University Hospital, Stockholm, Sweden.
Boylan GB; INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Murray DM; INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; National Children's Research Centre, Crumlin, Dublin, Ireland.
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Źródło :
The Journal of pediatrics [J Pediatr] 2021 Jan; Vol. 228, pp. 74-81.e2. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Asphyxia Neonatorum/*genetics
Frizzled Receptors/*genetics
Hypoxia-Ischemia, Brain/*genetics
RNA, Messenger/*genetics
Transcription Factors/*genetics
Asphyxia Neonatorum/blood ; Asphyxia Neonatorum/diagnosis ; Biomarkers/blood ; Electroencephalography ; Female ; Follow-Up Studies ; Frizzled Receptors/metabolism ; Humans ; Hypoxia-Ischemia, Brain/blood ; Infant, Newborn ; Male ; Prognosis ; RNA, Messenger/blood ; Retrospective Studies ; Severity of Illness Index ; Transcription Factors/blood
Czasopismo naukowe
Tytuł :
Paeonol inhibits apoptosis of vascular smooth muscle cells via up-regulation of autophagy by activating class III PI3K/Beclin-1 signaling pathway.
Autorzy :
Liu Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China; Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei, Anhui 230038, China; Anhui Key Laboratory for Research and Development of Traditional Chinese Medicine, Hefei, Anhui 230012, China.
Song A; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.
Wu H; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China; Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei, Anhui 230038, China; Anhui Key Laboratory for Research and Development of Traditional Chinese Medicine, Hefei, Anhui 230012, China.
Sun Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.
Dai M; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China; Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei, Anhui 230038, China; Anhui Key Laboratory for Research and Development of Traditional Chinese Medicine, Hefei, Anhui 230012, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118714. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*/drug effects
Up-Regulation*/drug effects
Acetophenones/*pharmacology
Apoptosis/*drug effects
Beclin-1/*metabolism
Muscle, Smooth, Vascular/*cytology
Myocytes, Smooth Muscle/*cytology
Phosphatidylinositol 3-Kinases/*metabolism
Animals ; Aorta/metabolism ; Apolipoproteins E/deficiency ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Caspase 3/metabolism ; Lipoproteins, LDL ; Male ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/metabolism ; Models, Biological ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/ultrastructure ; Sequestosome-1 Protein/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
[Chinese medicine Buyang Huanwu decoction promotes neurogenesis and angiogenesis in ischemic stroke rats by upregulating miR-199a-5p expression].
Autorzy :
Zhuge L; College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Fang Y; College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Jin H; College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Li L; College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yang Y; College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Hu X; College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Chu L; College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
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Źródło :
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2020 Dec 25; Vol. 49 (6), pp. 687-696.
Typ publikacji :
Journal Article
MeSH Terms :
Drugs, Chinese Herbal*/pharmacology
Drugs, Chinese Herbal*/therapeutic use
Ischemic Stroke*/drug therapy
MicroRNAs*/genetics
Neurogenesis*/drug effects
Up-Regulation*/drug effects
Animals ; Brain Ischemia/drug therapy ; Male ; Rats ; Rats, Sprague-Dawley ; Vascular Endothelial Growth Factor A/genetics
Czasopismo naukowe
Tytuł :
Shear stress-exposed pulmonary artery endothelial cells fail to upregulate HSP70 in chronic thromboembolic pulmonary hypertension.
Autorzy :
Salibe-Filho W; Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Araujo TLS; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
G Melo E; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
B C T Coimbra L; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Lapa MS; Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Acencio MMP; Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Freitas-Filho O; Cardiovascular Surgery Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Capelozzi VL; Department of Pathology, Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Teixeira LR; Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Fernandes CJCS; Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Jatene FB; Cardiovascular Surgery Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Laurindo FRM; Vascular Biology Laboratory, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
Terra-Filho M; Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo, Brazil.
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Źródło :
PloS one [PLoS One] 2020 Dec 03; Vol. 15 (12), pp. e0242960. Date of Electronic Publication: 2020 Dec 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Stress, Mechanical*
Up-Regulation*
Endothelial Cells/*pathology
HSP70 Heat-Shock Proteins/*metabolism
Hypertension, Pulmonary/*pathology
Pulmonary Artery/*pathology
Thromboembolism/*complications
Biomechanical Phenomena ; Chronic Disease ; Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/metabolism ; Shear Strength
Czasopismo naukowe
Tytuł :
Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.
Autorzy :
Matsumoto T; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Chino H; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Akiya M; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Hashimura M; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Yokoi A; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Tochimoto M; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Nakagawa M; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Jiang Z; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Saegusa M; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Dec; Vol. 59 (12), pp. 1409-1419. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Brain Neoplasms/*metabolism
Glioblastoma/*metabolism
Left-Right Determination Factors/*metabolism
Nodal Protein/*metabolism
Adolescent ; Adult ; Aged ; Brain Neoplasms/genetics ; Cell Hypoxia ; Cell Line, Tumor ; Cell Survival ; Cobalt/adverse effects ; Epithelial-Mesenchymal Transition ; Female ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Humans ; Left-Right Determination Factors/genetics ; Male ; Middle Aged ; Nodal Protein/genetics ; Phosphorylation ; Signal Transduction ; Young Adult
Czasopismo naukowe
Tytuł :
MYBL2 amplification in breast cancer: Molecular mechanisms and therapeutic potential.
Autorzy :
Bayley R; Institute of Cancer and Genomic Science, College of Medical and Dental Sciences, University of Birmingham, UK.
Ward C; Institute of Cancer and Genomic Science, College of Medical and Dental Sciences, University of Birmingham, UK.
Garcia P; Institute of Cancer and Genomic Science, College of Medical and Dental Sciences, University of Birmingham, UK. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2020 Dec; Vol. 1874 (2), pp. 188407. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Amplification*
Up-Regulation*
Breast Neoplasms/*genetics
Cell Cycle Proteins/*genetics
Trans-Activators/*genetics
Biomarkers, Tumor/genetics ; Female ; Gene Expression Regulation ; Humans ; Polymorphism, Single Nucleotide ; Prognosis ; Survival Analysis
Czasopismo naukowe
Tytuł :
Transplantation of brown adipose tissue up-regulates miR-99a to ameliorate liver metabolic disorders in diabetic mice by targeting NOX4.
Autorzy :
Li P; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.; Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Fan C; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.; Department of Endocrinology and Metabolism, Hainan General Hospital, Haikou, Hainan, China.
Cai Y; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.; Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Fang S; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zeng Y; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhang Y; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Lin X; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhang H; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Xue Y; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Guan M; Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
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Źródło :
Adipocyte [Adipocyte] 2020 Dec; Vol. 9 (1), pp. 57-67.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Adipose Tissue, Brown/*metabolism
Diabetes Mellitus, Experimental/*metabolism
Liver Diseases/*metabolism
Metabolic Diseases/*metabolism
MicroRNAs/*metabolism
NADPH Oxidase 4/*metabolism
Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/chemically induced ; Diet, High-Fat ; Disease Models, Animal ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; NADPH Oxidase 4/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Streptozocin
Czasopismo naukowe
Tytuł :
Silencing hsa_circ_PVT1 (circPVT1) suppresses the growth and metastasis of glioblastoma multiforme cells by up-regulation of miR-199a-5p.
Autorzy :
Chi G; Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Yang F; Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Xu D; Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Liu W; Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 188-196.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Gene Expression Regulation*
Gene Silencing*
Glioblastoma*/genetics
Glioblastoma*/metabolism
Glioblastoma*/pathology
MicroRNAs*/biosynthesis
MicroRNAs*/genetics
RNA, Circular*/biosynthesis
RNA, Circular*/genetics
RNA, Neoplasm*/biosynthesis
RNA, Neoplasm*/genetics
Up-Regulation*
Cell Line, Tumor ; Female ; Humans ; Male ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
Upregulation of S100A10 in metastasized breast cancer stem cells.
Autorzy :
Yanagi H; Department of Biochemistry, Fujita Health University School of Medicine, Toyoake, Japan.; Department of Medical Oncology, Fujita Health University School of Medicine, Toyoake, Japan.
Watanabe T; Department of Biochemistry, Fujita Health University School of Medicine, Toyoake, Japan.
Nishimura T; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Hayashi T; Department of Biochemistry, Fujita Health University School of Medicine, Toyoake, Japan.
Kono S; Division of Breast and Endocrine Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Tsuchida H; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Hirata M; Department of Breast Surgery, Fujita Health University School of Medicine, Toyoake, Japan.
Kijima Y; Department of Breast Surgery, Fujita Health University School of Medicine, Toyoake, Japan.
Takao S; Division of Breast and Endocrine Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Okada S; Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Suzuki M; Department of Molecular Oncology, Fujita Health University School of Medicine, Toyoake, Japan.
Imaizumi K; Department of Respiratory Medicine, Fujita Health University School of Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Kawada K; Department of Medical Oncology, Fujita Health University School of Medicine, Toyoake, Japan.
Minami H; Division of Medical Oncology/Hematology, Kobe University Graduate School of Medicine, Kobe, Japan.
Gotoh N; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Shimono Y; Department of Biochemistry, Fujita Health University School of Medicine, Toyoake, Japan.; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Division of Medical Oncology/Hematology, Kobe University Graduate School of Medicine, Kobe, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Dec; Vol. 111 (12), pp. 4359-4370. Date of Electronic Publication: 2020 Oct 11.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Annexin A2/*metabolism
Breast Neoplasms/*metabolism
Neoplastic Stem Cells/*metabolism
S100 Proteins/*metabolism
Animals ; Annexin A2/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Disease Progression ; Female ; Gene Expression Profiling ; Gene Knockout Techniques ; Humans ; Hyaluronan Receptors/metabolism ; Lentivirus/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Matrix Metalloproteinases/metabolism ; Mice ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplastic Stem Cells/pathology ; Organoids ; Reverse Transcriptase Polymerase Chain Reaction ; S100 Proteins/genetics
Czasopismo naukowe

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