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Tytuł :
Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy.
Autorzy :
Liu YC; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Kwon J; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Fabiani E; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Xiao Z; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Liu YV; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Follo MY; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Liu J; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Huang H; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Gao C; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Liu J; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Falconi G; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Valentini L; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Gurnari C; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Finelli C; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Cocco L; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Liu JH; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Jones AI; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Yang J; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Yang H; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Thoms JAI; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Unnikrishnan A; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Pimanda JE; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Pan R; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Bassal MA; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Voso MT; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Tenen DG; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
Chai L; From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli' (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.
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Źródło :
The New England journal of medicine [N Engl J Med] 2022 May 26; Vol. 386 (21), pp. 1998-2010.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Demethylation*/drug effects
Myelodysplastic Syndromes*/drug therapy
Myelodysplastic Syndromes*/genetics
Oncogenes*/drug effects
Oncogenes*/physiology
Up-Regulation*/drug effects
Clustered Regularly Interspaced Short Palindromic Repeats ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Transcription Factors/biosynthesis ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
A comprehensive bioinformatic analysis of cyclin-dependent kinase 2 (CDK2) in glioma.
Autorzy :
Liu H; Biocomma Limited, Shenzhen, China. Electronic address: .
Weng J; Department of Pathology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong, China. Electronic address: .
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Źródło :
Gene [Gene] 2022 May 15; Vol. 822, pp. 146325. Date of Electronic Publication: 2022 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Brain Neoplasms/*pathology
Computational Biology/*methods
Cyclin-Dependent Kinase 2/*genetics
Glioma/*pathology
Adult ; Aged ; B-Lymphocytes/metabolism ; Brain Neoplasms/genetics ; Brain Neoplasms/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Case-Control Studies ; Databases, Genetic ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/immunology ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Nomograms ; Prognosis ; Survival Analysis
Czasopismo naukowe
Tytuł :
Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response.
Autorzy :
Kim GT; Department of Life Science, Gachon University, Sungnam, Korea.
Devi S; Department of Life Science, Gachon University, Sungnam, Korea.
Sharma A; Department of Life Science, Gachon University, Sungnam, Korea.
Cho KH; Department of Life Science, Gachon University, Sungnam, Korea.
Kim SJ; Biomedical Research Center, Asan Institute for Life Sciences, Seoul, Korea.
Kim BR; The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Kwon SH; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA. .
Park TS; Department of Life Science, Gachon University, Sungnam, Korea. .; Lipidomia Inc., Sungnam, Korea. .
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Źródło :
Experimental & molecular medicine [Exp Mol Med] 2022 May; Vol. 54 (5), pp. 573-584. Date of Electronic Publication: 2022 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Resistance*
Serine C-Palmitoyltransferase*/genetics
Serine C-Palmitoyltransferase*/metabolism
Up-Regulation*
Animals ; Ceramides/metabolism ; Endoplasmic Reticulum Stress ; Insulin/metabolism ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
CircPDE7B/miR-661 axis accelerates the progression of human keloid fibroblasts by upregulating fibroblast growth factor 2 (FGF2).
Autorzy :
Wu F; Department of Plastic Surgery, The First Hospital of Qinhuangdao, No. 258, Wenhua Road, Qinhuangdao, 066000, Hebei, China.
He H; Department of Plastic Surgery, The First Hospital of Qinhuangdao, No. 258, Wenhua Road, Qinhuangdao, 066000, Hebei, China.
Chen Y; Department of Pathology, The First Hospital of Qinhuangdao, Qinhuangdao, China.
Zhu D; Department of Plastic Surgery, The First Hospital of Qinhuangdao, Qinhuangdao, China.
Jiang T; Medical Department, The First Hospital of Qinhuangdao, Qinhuangdao, China.
Wang J; Department of Plastic Surgery, The First Hospital of Qinhuangdao, No. 258, Wenhua Road, Qinhuangdao, 066000, Hebei, China. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2022 Apr; Vol. 477 (4), pp. 1113-1126. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Up-Regulation*
Fibroblast Growth Factor 2/*biosynthesis
Fibroblasts/*metabolism
Keloid/*metabolism
MicroRNAs/*metabolism
RNA, Circular/*metabolism
Cell Line ; Fibroblast Growth Factor 2/genetics ; Humans ; Keloid/genetics ; MicroRNAs/genetics ; RNA, Circular/genetics
Czasopismo naukowe
Tytuł :
Identification of Key Genes Associated with Brain Metastasis from Breast Cancer: A Bioinformatics Analysis.
Autorzy :
Zeng C; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China (mainland).; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China (mainland).
Lin M; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China (mainland).; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China (mainland).
Jin Y; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China (mainland).; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China (mainland).
Zhang J; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China (mainland).; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China (mainland).
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Źródło :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2022 Mar 17; Vol. 28, pp. e935071. Date of Electronic Publication: 2022 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Neoplastic*
Up-Regulation*
Brain Neoplasms/*genetics
Breast Neoplasms/*genetics
Computational Biology/*methods
Oncogenes/*genetics
Brain Neoplasms/diagnosis ; Brain Neoplasms/secondary ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; Neoplasm Metastasis ; Prognosis ; RNA, Neoplasm/genetics
Czasopismo naukowe
Tytuł :
Up-Regulated Interleukin-10 Induced by E2F Transcription Factor 2-MicroRNA-17-5p Circuitry in Extrafollicular Effector B Cells Contributes to Autoantibody Production in Systemic Lupus Erythematosus.
Autorzy :
Xu L; Medical University of South Carolina, Charleston, and The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Wang L; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Shi Y; Medical University of South Carolina, Charleston, and The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Deng Y; Medical University of South Carolina, Charleston.
Oates JC; Medical University of South Carolina, Charleston, and Ralph H. Johnson VA Medical Center, Medical Service, Charleston, South Carolina.
Kamen DL; Medical University of South Carolina, Charleston.
Gilkeson GS; Medical University of South Carolina, Charleston, and Ralph H. Johnson VA Medical Center, Medical Service, Charleston, South Carolina.
Wang F; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Zhang M; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Tan W; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Tsao BP; Medical University of South Carolina, Charleston.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2022 Mar; Vol. 74 (3), pp. 496-507. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoantibodies*
Up-Regulation*
B-Lymphocyte Subsets/*metabolism
E2F Transcription Factors/*metabolism
Interleukin-10/*metabolism
Lupus Erythematosus, Systemic/*metabolism
Adolescent ; Adult ; Aged ; Female ; Humans ; Interleukin-10/genetics ; Leukocytes, Mononuclear/metabolism ; Lupus Erythematosus, Systemic/genetics ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł :
Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g.
Autorzy :
Thymiakou E; Laboratory of Biochemistry, University of Crete Medical School, Heraklion 71003, Greece; Gene Regulation and Epigenetics group, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology of Hellas, Heraklion 70013, Greece.
Xenikaki E; Laboratory of Biochemistry, University of Crete Medical School, Heraklion 71003, Greece.
Kardassis D; Laboratory of Biochemistry, University of Crete Medical School, Heraklion 71003, Greece; Gene Regulation and Epigenetics group, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology of Hellas, Heraklion 70013, Greece. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2022 Mar; Vol. 1867 (3), pp. 159108. Date of Electronic Publication: 2021 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Czasopismo naukowe
Tytuł :
MiR-34c-3p upregulates erastin-induced ferroptosis to inhibit proliferation in oral squamous cell carcinomas by targeting SLC7A11.
Autorzy :
Sun K; Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China; School of Stomatology of Qingdao University, Qingdao 266003, China.
Ren W; Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.
Li S; Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.
Zheng J; Department of Endodontics, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.
Huang Y; Department of Otolaryngology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.
Zhi K; Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China; School of Stomatology of Qingdao University, Qingdao 266003, China; Key Lab of Oral Clinical Medicine, the Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address: .
Gao L; Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China; Key Lab of Oral Clinical Medicine, the Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address: .
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Źródło :
Pathology, research and practice [Pathol Res Pract] 2022 Mar; Vol. 231, pp. 153778. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Transport System y+/*drug effects
Cell Proliferation/*drug effects
MicroRNAs/*pharmacology
Squamous Cell Carcinoma of Head and Neck/*drug therapy
Up-Regulation/*genetics
Aged ; Amino Acid Transport System y+/pharmacology ; Female ; Ferroptosis/drug effects ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/therapeutic use ; Middle Aged ; Piperazines/adverse effects ; Piperazines/therapeutic use ; Squamous Cell Carcinoma of Head and Neck/genetics ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.
Autorzy :
Wen YC; Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Urology and Kidney, Taipei medical university, Taipei, Taiwan.
Liu CL; Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
Yeh HL; General Education Development Center, Hsin Sheng Junior College of Medical Care and Management, Taoyuan, Taiwan.
Chen WH; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Jiang KC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Tram VTN; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Hsiao M; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Huang J; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Chen WY; Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. .; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. .
Liu YN; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. .
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Źródło :
British journal of cancer [Br J Cancer] 2022 Mar; Vol. 126 (5), pp. 778-790. Date of Electronic Publication: 2021 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Glucose/*metabolism
Intracellular Signaling Peptides and Proteins/*genetics
Leukemia Inhibitory Factor/*genetics
Phosphoenolpyruvate Carboxykinase (GTP)/*genetics
Prostatic Neoplasms, Castration-Resistant/*pathology
Transcription Factors/*genetics
Animals ; Cell Line, Tumor ; Cell Proliferation ; Feedback, Physiological ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; PC-3 Cells ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Deregulated Expression of miR-483-3p Serves as a Diagnostic Biomarker in Severe Pneumonia Children with Respiratory Failure and Its Predictive Value for the Clinical Outcome of Patients.
Autorzy :
Zhou J; Department of Pediatrics Medicine, Yidu Central Hospital of Weifang, Weifang, 262500, Shandong, China.
Lin J; Department of Pediatrics Medicine, Yidu Central Hospital of Weifang, Weifang, 262500, Shandong, China.
Zhao Y; Department of Geriatric Health, Yidu Central Hospital of Weifang, Weifang, 262500, Shandong, China.
Sun X; Department of Neurology, Yidu Central Hospital of Weifang, 4138 Linglongshan Road, Qingzhou, Weifang, 262500, Shandong, China. .
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Źródło :
Molecular biotechnology [Mol Biotechnol] 2022 Mar; Vol. 64 (3), pp. 311-319. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Biomarkers/*blood
Insulin-Like Growth Factor I/*genetics
MicroRNAs/*blood
Pneumonia/*diagnosis
Biobehavioral Sciences ; Case-Control Studies ; Cell Line ; Child, Preschool ; Early Diagnosis ; Female ; Gene Expression Regulation/drug effects ; Humans ; Infant ; Lipopolysaccharides/adverse effects ; Male ; Pneumonia/blood ; Pneumonia/genetics ; Predictive Value of Tests ; Survival Analysis
Czasopismo naukowe
Tytuł :
Circular RNA circ_0023404 serves as a miR-636 sponge to promote malignant behaviors in cervical cancer cells through upregulation of CYP2S1.
Autorzy :
Guo WW; Department of Gynecology and Obstetrics, Dalian Municipal Women and Children's Medical Center (Group), Dalian, China.
Feng MM; Department of Pathology, Dalian Liaoyu Hospital, Dalian, China.
Li SF; Department of Gynecology and Obstetrics, Dalian hospital of Shengjing Hospital Affiliated to China Medical University, Dalian, China.
Wei LH; Department of Gynecology and Obstetrics, Siping Maternal and Child Health Care Hospital, Siping, China.
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Źródło :
The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2022 Mar; Vol. 38 (3), pp. 218-229. Date of Electronic Publication: 2021 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Up-Regulation*
Cytochrome P-450 Enzyme System/*genetics
MicroRNAs/*genetics
RNA, Circular/*genetics
Uterine Cervical Neoplasms/*genetics
Female ; Humans
Czasopismo naukowe
Tytuł :
A single-domain i-body, AD-114, attenuates renal fibrosis through blockade of CXCR4.
Autorzy :
Cao Q; Renal Medicine, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Huang C; Renal Medicine, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Yi H; Renal Medicine, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Gill AJ; Department of Anatomical Pathology, NSW Health Pathology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Chou A; Department of Anatomical Pathology, NSW Health Pathology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Foley M; The Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.; AdAlta Limited, Melbourne, Victoria, Australia.
Hosking CG; The Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.; AdAlta Limited, Melbourne, Victoria, Australia.
Lim KK; The Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.; AdAlta Limited, Melbourne, Victoria, Australia.
Triffon CF; The Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.; AdAlta Limited, Melbourne, Victoria, Australia.
Shi Y; Renal Medicine, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Chen XM; Renal Medicine, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Pollock CA; Renal Medicine, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
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Źródło :
JCI insight [JCI Insight] 2022 Feb 22; Vol. 7 (4). Date of Electronic Publication: 2022 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Up-Regulation*
Kidney/*pathology
Kidney Diseases/*genetics
Receptors, CXCR4/*genetics
Animals ; Cell Line ; Disease Models, Animal ; Extracellular Matrix/metabolism ; Fibrosis/genetics ; Fibrosis/metabolism ; Fibrosis/pathology ; Humans ; Kidney/metabolism ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, CXCR4/biosynthesis ; Signal Transduction
Czasopismo naukowe
Tytuł :
ADP-ribosylation factor 6 expression increase in oesophageal adenocarcinoma suggests a potential biomarker role for it.
Autorzy :
Kanamarlapudi V; Institute of Life Science 1, School of Medicine, Swansea University, Singleton Park, Swansea, United Kingdom.
Tamaddon-Jahromi S; Institute of Life Science 1, School of Medicine, Swansea University, Singleton Park, Swansea, United Kingdom.
Murphy K; Cellular Pathology, Swansea Bay University Health Board, Singleton Hospital, Swansea, United Kingdom.
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Źródło :
PloS one [PLoS One] 2022 Feb 10; Vol. 17 (2), pp. e0263845. Date of Electronic Publication: 2022 Feb 10 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
ADP-Ribosylation Factor 6/*genetics
ADP-Ribosylation Factor 6/*metabolism
Adenocarcinoma/*pathology
Esophageal Neoplasms/*pathology
Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Case-Control Studies ; Disease Progression ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasm Grading ; Tissue Array Analysis
SCR Disease Name :
Adenocarcinoma Of Esophagus
Czasopismo naukowe
Tytuł :
The Neuronal Transcription Factor Creb3l1 Potential Upregulates Ntrk2 in the Hypertensive Microenvironment to Promote Vascular Smooth Muscle Cell-Neuron Interaction and Prevent Neurons from Ferroptosis: A Bioinformatic Research of scRNA-seq Data.
Autorzy :
Zhao X; Institute of Tradition Chinese Medicine, Shandong University of Traditional Chinese Medicine, China.
Yang J; Department of Cardiology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, China.
Yang C; Department of Cardiology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, China.
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Źródło :
Disease markers [Dis Markers] 2022 Feb 10; Vol. 2022, pp. 8339759. Date of Electronic Publication: 2022 Feb 10 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Computational Biology*
Ferroptosis*
Up-Regulation*
Cyclic AMP Response Element-Binding Protein/*physiology
Hypertension/*genetics
Muscle, Smooth, Vascular/*cytology
Nerve Tissue Proteins/*physiology
Neurons/*physiology
Receptor, trkB/*physiology
Animals ; Base Sequence ; Cell Communication ; Mice ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation.
Autorzy :
Bechara R; Université Paris-Saclay, CEA, INSERM UMR 1184, Center for Research in Immunology of Viral, Autoimmune, Hematological and Bacterial Diseases (IMVA-HB), Le Kremlin Bicêtre, France.; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Amatya N; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Majumder S; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zhou C; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Li Y; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Liu Q; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Tsinghua University, Beijing, China.
McGeachy MJ; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gaffen SL; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
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Źródło :
JCI insight [JCI Insight] 2022 Feb 08; Vol. 7 (3). Date of Electronic Publication: 2022 Feb 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Autoimmunity*
Gene Expression Regulation*
Up-Regulation*
Encephalomyelitis, Autoimmune, Experimental/*genetics
RNA-Binding Proteins/*genetics
Th17 Cells/*immunology
Animals ; Cells, Cultured ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/genetics ; RNA-Binding Proteins/biosynthesis ; Th17 Cells/pathology
Czasopismo naukowe
Tytuł :
Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma.
Autorzy :
Kiss F; Somogy County Kaposi Mór Teaching Hospital Kaposvár, H-7400 Kaposvár, Hungary.; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.
Kormos V; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.
Szőke É; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.
Kecskés A; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.
Tóth N; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.
Steib A; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.
Szállási Á; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Hungary.
Scheich B; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Hungary.
Gaszner B; Research Group for Mood Disorders, Department of Anatomy & Centre for Neuroscience & Szentágothai Research Centre, University of Pécs Medical School, H-7624 Pécs, Hungary.
Kun J; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.; Bioinformatics Research Group, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.
Fülöp G; Somogy County Kaposi Mór Teaching Hospital Kaposvár, H-7400 Kaposvár, Hungary.
Pohóczky K; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.; Department of Pharmacology, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary.
Helyes Z; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs János Szentágothai Research Centre, H-7624 Pécs, Hungary.; PharmInVivo Ltd., H-7629 Pécs, Hungary.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 08; Vol. 23 (3). Date of Electronic Publication: 2022 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*/drug effects
Carcinoma, Squamous Cell/*genetics
Mouth Neoplasms/*genetics
TRPA1 Cation Channel/*genetics
TRPV Cation Channels/*genetics
Aged ; Aged, 80 and over ; Calcium/metabolism ; Capsaicin/pharmacology ; Carcinoma, Squamous Cell/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; In Situ Hybridization ; Isothiocyanates/pharmacology ; Male ; Middle Aged ; Mouth Neoplasms/metabolism ; TRPA1 Cation Channel/metabolism ; TRPV Cation Channels/metabolism
Czasopismo naukowe
Tytuł :
PCGEM1 promotes proliferation, migration and invasion in prostate cancer by sponging miR-506 to upregulate TRIAP1.
Autorzy :
Liu H; Department of Urology, Heilongjiang Red Cross Sengong General Hospital, 32 Hexing Rd, Xiangfang District, Harbin, 150001, Heilongjiang Province, China.
He X; Department of General Surgery, Heilongjiang Red Cross Sengong General Hospital, Harbin, 150001, Heilongjiang Province, China.
Li T; Department of Urology, Heilongjiang Red Cross Sengong General Hospital, 32 Hexing Rd, Xiangfang District, Harbin, 150001, Heilongjiang Province, China.
Qu Y; Department of Urology, Heilongjiang Red Cross Sengong General Hospital, 32 Hexing Rd, Xiangfang District, Harbin, 150001, Heilongjiang Province, China.
Xu L; Department of Urology, Heilongjiang Red Cross Sengong General Hospital, 32 Hexing Rd, Xiangfang District, Harbin, 150001, Heilongjiang Province, China.
Hou Y; Department of Urology, Heilongjiang Red Cross Sengong General Hospital, 32 Hexing Rd, Xiangfang District, Harbin, 150001, Heilongjiang Province, China.
Fu Y; Department of Urology, Heilongjiang Red Cross Sengong General Hospital, 32 Hexing Rd, Xiangfang District, Harbin, 150001, Heilongjiang Province, China.
Wang H; Department of Urology, Heilongjiang Red Cross Sengong General Hospital, 32 Hexing Rd, Xiangfang District, Harbin, 150001, Heilongjiang Province, China. .
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Źródło :
BMC urology [BMC Urol] 2022 Feb 02; Vol. 22 (1), pp. 14. Date of Electronic Publication: 2022 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Up-Regulation*
Intracellular Signaling Peptides and Proteins/*genetics
MicroRNAs/*physiology
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*pathology
RNA, Long Noncoding/*genetics
Animals ; Cell Movement ; Cell Proliferation ; Humans ; Male ; Models, Animal ; Neoplasm Invasiveness ; Prognosis ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p.
Autorzy :
Bai K; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ma Y; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li J; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
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Źródło :
Bioengineered [Bioengineered] 2022 Feb; Vol. 13 (2), pp. 2099-2113.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Neoplastic*
Up-Regulation*
Alkaline Ceramidase/*biosynthesis
Carcinogenesis/*metabolism
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*biosynthesis
RNA, Neoplasm/*metabolism
Alkaline Ceramidase/genetics ; Carcinogenesis/genetics ; Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Humans ; Liver Neoplasms/genetics ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; RNA, Circular ; RNA, Neoplasm/genetics
Czasopismo naukowe
Tytuł :
CircMIIP Contributes to Non-Small Cell Lung Cancer Progression by Binding miR-766-5p to Upregulate FAM83A Expression.
Autorzy :
Wang T; Department of Thoracic Surgery, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yungang District, Guiyang, 550004, Guizhou, China. .
Zhu X; Department of Thoracic Surgery, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yungang District, Guiyang, 550004, Guizhou, China.
Wang K; Department of Thoracic Surgery, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yungang District, Guiyang, 550004, Guizhou, China.
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Źródło :
Lung [Lung] 2022 Feb; Vol. 200 (1), pp. 107-117. Date of Electronic Publication: 2022 Jan 11.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/pathology
Gene Expression Regulation, Neoplastic*/genetics
Lung Neoplasms*/pathology
MicroRNAs*/metabolism
Neoplasm Proteins*/genetics
RNA, Circular*/genetics
Up-Regulation*
Animals ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Disease Models, Animal ; Gene Knockdown Techniques ; Heterografts ; Humans
Czasopismo naukowe
Tytuł :
Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis.
Autorzy :
Fang J; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Jiang G; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Mao W; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Huang L; Department of Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Huang C; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Wang S; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Xue H; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Ke J; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Ni Q; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
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Źródło :
Bioengineered [Bioengineered] 2022 Feb; Vol. 13 (2), pp. 3707-3723.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Signal Transduction*
Up-Regulation*
Basic-Leucine Zipper Transcription Factors/*metabolism
Breast Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
RNA, Long Noncoding/*biosynthesis
Aged ; Basic-Leucine Zipper Transcription Factors/genetics ; Breast Neoplasms/genetics ; Female ; Humans ; MCF-7 Cells ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Proteins/genetics ; RNA, Long Noncoding/genetics
Czasopismo naukowe

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