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Tytuł :
Cardiovascular outcome trials in Type 2 diabetes: food for thought.
Autorzy :
Chahade JJ; Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, T6G 2B7, Canada.
Kim R; Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, T6G 2B7, Canada.
Ussher JR; Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, T6G 2B7, Canada.
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Źródło :
Future cardiology [Future Cardiol] 2021 Feb 05. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Editorial
Opinia redakcyjna
Tytuł :
SP1-independent inhibition of FOXM1 by modified thiazolidinediones.
Autorzy :
Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Pérez DJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Unidad Radiofarmacia-Ciclotrón, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico.
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Haque M; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; Department of Oncology, University of Alberta, Edmonton, AB, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Kashfi K; Department of Molecular, Cellular, & Biomedical Sciences, City University of New York School of Medicine, New York, USA; Department of Molecular, Cellular and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, New York, USA.
Velázquez-Martínez CA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 01; Vol. 209, pp. 112902. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
The GLP-1 Receptor Agonist Liraglutide Increases Myocardial Glucose Oxidation Rates via Indirect Mechanisms and Mitigates Experimental Diabetic Cardiomyopathy.
Autorzy :
Almutairi M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Young A; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Gill R; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Aburasayn H; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Al Batran R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Chahade JJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Gandhi M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Mailloux RJ; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada. Electronic address: .
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Źródło :
The Canadian journal of cardiology [Can J Cardiol] 2021 Jan; Vol. 37 (1), pp. 140-150. Date of Electronic Publication: 2020 Mar 08.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
The Impact of Antidiabetic Therapies on Diastolic Dysfunction and Diabetic Cardiomyopathy.
Autorzy :
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Chahade JJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Kim R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
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Źródło :
Frontiers in physiology [Front Physiol] 2020 Dec 07; Vol. 11, pp. 603247. Date of Electronic Publication: 2020 Dec 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy.
Autorzy :
Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
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Źródło :
Frontiers in physiology [Front Physiol] 2020 Sep 16; Vol. 11, pp. 570421. Date of Electronic Publication: 2020 Sep 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure.
Autorzy :
Byrne NJ; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Department of Pediatrics (N.J.B., S.S., Z.H.M., J.R.B.D.), University of Alberta, Edmonton, Canada.
Soni S; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Department of Pediatrics (N.J.B., S.S., Z.H.M., J.R.B.D.), University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (S.S., R.A.B., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.
Takahara S; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (S.T.).
Ferdaoussi M; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.
Al Batran R; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (S.S., R.A.B., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Faculty of Medicine and Dentistry, and Faculty of Pharmacy and Pharmaceutical Sciences (R.A.B., A.M.D., J.M.S., J.R.U.), University of Alberta, Edmonton, Canada.
Darwesh AM; Faculty of Medicine and Dentistry, and Faculty of Pharmacy and Pharmaceutical Sciences (R.A.B., A.M.D., J.M.S., J.R.U.), University of Alberta, Edmonton, Canada.
Levasseur JL; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.
Beker D; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.
Vos DY; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.
Schmidt MA; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.
Alam AS; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.
Maayah ZH; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Department of Pediatrics (N.J.B., S.S., Z.H.M., J.R.B.D.), University of Alberta, Edmonton, Canada.
Schertzer JD; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada (J.D.S.).
Seubert JM; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Department of Pharmacology (J.M.S), University of Alberta, Edmonton, Canada.; Faculty of Medicine and Dentistry, and Faculty of Pharmacy and Pharmaceutical Sciences (R.A.B., A.M.D., J.M.S., J.R.U.), University of Alberta, Edmonton, Canada.
Ussher JR; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (S.S., R.A.B., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Faculty of Medicine and Dentistry, and Faculty of Pharmacy and Pharmaceutical Sciences (R.A.B., A.M.D., J.M.S., J.R.U.), University of Alberta, Edmonton, Canada.
Dyck JRB; Cardiovascular Research Centre (N.J.B., S.S., S.T., M.F., R.A.B., J.L.L., D.B., D.Y.V., M.A.S., A.S.A., Z.H.M., J.M.S., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.; Department of Pediatrics (N.J.B., S.S., Z.H.M., J.R.B.D.), University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (S.S., R.A.B., J.R.U., J.R.B.D.), University of Alberta, Edmonton, Canada.
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Źródło :
Circulation. Heart failure [Circ Heart Fail] 2020 Jun; Vol. 13 (6), pp. e006573. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
3-Hydroxybutyric Acid/*blood
Coenzyme A-Transferases/*deficiency
Heart Failure/*prevention & control
Myocarditis/*prevention & control
Myocardium/*enzymology
Animals ; Coenzyme A-Transferases/genetics ; Disease Models, Animal ; Fibrosis ; Heart Failure/blood ; Heart Failure/enzymology ; Heart Failure/physiopathology ; Hypertrophy, Left Ventricular/blood ; Hypertrophy, Left Ventricular/physiopathology ; Hypertrophy, Left Ventricular/prevention & control ; Inflammasomes/metabolism ; Isolated Heart Preparation ; Male ; Mice, Knockout ; Myocarditis/blood ; Myocarditis/enzymology ; Myocarditis/physiopathology ; Myocardium/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Up-Regulation ; Ventricular Dysfunction, Left/blood ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/prevention & control ; Ventricular Function, Left ; Ventricular Remodeling
Czasopismo naukowe
Tytuł :
Ketones can become the major fuel source for the heart but do not increase cardiac efficiency.
Autorzy :
Ho KL; Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Karwi QG; Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Wagg C; Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Zhang L; Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Vo K; Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Altamimi T; Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, U.S.A.
Uddin GM; Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Ussher JR; Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Lopaschuk GD; Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
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Źródło :
Cardiovascular research [Cardiovasc Res] 2020 May 13. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation.
Autorzy :
Al Batran R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Capozzi ME; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Chahade JJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Saleme B; Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Tabatabaei-Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Niu J; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Almutairi M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Byrne NJ; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Masson G; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Kim R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Mulvihill EE; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada.
Garneau L; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada; Institut du Savoir Montfort, Ottawa, ON, Canada.
Masters AR; Indiana University School of Medicine, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA.
Desta Z; Department of Medicine, Division of Clinical Pharmacology, Indianapolis, IN, USA.
Velázquez-Martínez CA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Aguer C; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada; Institut du Savoir Montfort, Ottawa, ON, Canada; School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
Crawford PA; Division of Molecular Medicine, Department of Medicine, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Sutendra G; Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Campbell JE; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Dyck JRB; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada. Electronic address: .
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Źródło :
Cell metabolism [Cell Metab] 2020 May 05; Vol. 31 (5), pp. 909-919.e8. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Cardiovascular biology of the GIP receptor.
Autorzy :
Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Chahade JJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada. Electronic address: .
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Źródło :
Peptides [Peptides] 2020 Mar; Vol. 125, pp. 170228. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cardiovascular System/*metabolism
Gastric Inhibitory Polypeptide/*pharmacology
Gastrointestinal Agents/*pharmacology
Myocytes, Cardiac/*metabolism
Receptors, Gastrointestinal Hormone/*metabolism
Animals ; Cardiovascular System/drug effects ; Humans ; Insulin Secretion ; Myocytes, Cardiac/drug effects ; Receptors, Gastrointestinal Hormone/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
l-Citrulline supplementation improves glucose and exercise tolerance in obese male mice.
Autorzy :
Eshreif A; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Al Batran R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Jamieson KL; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Darwesh AM; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Zlobine I; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Aburasayn H; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Mulvihill EE; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Heart Institute, University of Ottawa, Ottawa, ON, Canada.
Campbell JE; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Seubert JM; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
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Źródło :
Experimental physiology [Exp Physiol] 2020 Feb; Vol. 105 (2), pp. 270-281. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Dietary-Induced Obesity, Hepatic Cytochrome P450, and Lidocaine Metabolism: Comparative Effects of High-Fat Diets in Mice and Rats and Reversibility of Effects With Normalization of Diet.
Autorzy :
Al Nebaihi HM; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Al Batran R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Maayah ZH; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
El-Kadi AOS; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Brocks DR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada. Electronic address: .
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Źródło :
Journal of pharmaceutical sciences [J Pharm Sci] 2020 Feb; Vol. 109 (2), pp. 1199-1210. Date of Electronic Publication: 2019 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions.
Autorzy :
Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Pérez DJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Tabatabaei Dakhili SY; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Velázquez-Martínez CA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2019 Dec; Vol. 93, pp. 103269. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Forkhead Box Protein M1/*metabolism
Breast Neoplasms ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Electrophoretic Mobility Shift Assay ; Forkhead Box Protein M1/genetics ; Gene Expression Regulation/drug effects ; Halogens ; Humans ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.
Autorzy :
Ho KL; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.
Zhang L; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.
Wagg C; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.
Al Batran R; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Gopal K; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Levasseur J; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.
Leone T; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, USA.
Dyck JRB; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.
Ussher JR; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Muoio DM; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, 300 N Duke St, Durham, NC, USA.
Kelly DP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, USA.
Lopaschuk GD; Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.
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Źródło :
Cardiovascular research [Cardiovasc Res] 2019 Sep 01; Vol. 115 (11), pp. 1606-1616.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism*
Ventricular Function, Left*
3-Hydroxybutyric Acid/*metabolism
Heart Failure/*metabolism
Hypertrophy, Left Ventricular/*metabolism
Myocardium/*metabolism
Acetylation ; Acyl-CoA Dehydrogenase, Long-Chain/genetics ; Acyl-CoA Dehydrogenase, Long-Chain/metabolism ; Adaptation, Physiological ; Animals ; Disease Models, Animal ; Fatty Acids/metabolism ; Glucose/metabolism ; Heart Failure/pathology ; Heart Failure/physiopathology ; Hypertrophy, Left Ventricular/pathology ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Mice, Inbred C57BL ; Myocardium/pathology ; Oxidation-Reduction ; Stroke Volume
Czasopismo naukowe
Tytuł :
Role of Cytochrome p450 and Soluble Epoxide Hydrolase Enzymes and Their Associated Metabolites in the Pathogenesis of Diabetic Cardiomyopathy.
Autorzy :
Maayah ZH; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Department of Pediatrics and Medicine, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
McGinn E; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Al Batran R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Department of Pediatrics and Medicine, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Department of Pediatrics and Medicine, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Department of Pediatrics and Medicine, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
El-Kadi AOS; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Department of Pediatrics and Medicine, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
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Źródło :
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2019 Sep; Vol. 74 (3), pp. 235-245.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System/*metabolism
Diabetes Mellitus, Experimental/*enzymology
Diabetes Mellitus, Type 2/*enzymology
Diabetic Cardiomyopathies/*enzymology
Eicosanoids/*metabolism
Epoxide Hydrolases/*metabolism
Myocytes, Cardiac/*enzymology
Animals ; Atrial Natriuretic Factor/genetics ; Atrial Natriuretic Factor/metabolism ; Blood Glucose/metabolism ; Cell Line ; Cytochrome P-450 Enzyme System/genetics ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/genetics ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/genetics ; Diabetic Cardiomyopathies/pathology ; Diet, High-Fat ; Epoxide Hydrolases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Male ; Mice, Inbred C57BL ; Myocytes, Cardiac/pathology ; Natriuretic Peptide, Brain/genetics ; Natriuretic Peptide, Brain/metabolism ; Obesity/complications ; Obesity/enzymology ; Phosphorylation ; Signal Transduction ; Streptozocin ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure.
Autorzy :
Uddin GM; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.
Zhang L; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.
Shah S; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.
Fukushima A; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.
Wagg CS; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.
Gopal K; Katz Centre for Pharmacy and Health Research, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
Al Batran R; Katz Centre for Pharmacy and Health Research, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
Pherwani S; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.
Ho KL; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.; Katz Centre for Pharmacy and Health Research, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Boisvenue J; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.
Karwi QG; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.; Department of Pharmacology, College of Medicine, University of Diyala, Diyala, Iraq.
Altamimi T; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.
Wishart DS; Department of Biological Sciences, University of Alberta, Edmonton, Canada.; Metabolomics Innovation Centre, University of Alberta, Edmonton, Canada.
Dyck JRB; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.
Ussher JR; Katz Centre for Pharmacy and Health Research, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
Oudit GY; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.; Divsion of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada.
Lopaschuk GD; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, T6G 2S2, Canada. .; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. .; Alberta Diabetes Institute, University of Alberta, Edmonton, Canada. .
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Źródło :
Cardiovascular diabetology [Cardiovasc Diabetol] 2019 Jul 05; Vol. 18 (1), pp. 86. Date of Electronic Publication: 2019 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance*
Amino Acids, Branched-Chain/*metabolism
Cardiomyopathy, Dilated/*complications
Energy Metabolism/*drug effects
Heart Failure/*etiology
Myocardium/*metabolism
Adult ; Aged ; Animals ; Carboxylic Acids/pharmacology ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/physiopathology ; Case-Control Studies ; Disease Models, Animal ; Female ; Fibrosis ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Heart Failure/pathology ; Humans ; Male ; Mice, Inbred C57BL ; Middle Aged ; Myocardium/pathology ; Oxidation-Reduction ; Protein Kinase Inhibitors/pharmacology ; Protein Kinases/metabolism ; Signal Transduction/drug effects ; Young Adult
Czasopismo naukowe
Tytuł :
Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction.
Autorzy :
Wang W; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.; Department of Cardiac Surgery, University of Alberta, Edmonton, Alberta, Canada.
Zhang L; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Battiprolu PK; Amgen, San Francisco, California.
Fukushima A; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Nguyen K; Amgen, San Francisco, California.
Milner K; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Gupta A; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Altamimi T; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Byrne N; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Mori J; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Alrob OA; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Wagg C; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Fillmore N; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Wang SH; Department of Cardiac Surgery, University of Alberta, Edmonton, Alberta, Canada.
Liu DM; Amgen, San Francisco, California.
Fu A; Amgen, San Francisco, California.
Lu JY; Amgen, San Francisco, California.
Chaves M; Amgen, San Francisco, California.
Motani A; Amgen, San Francisco, California.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Reagan JD; Amgen, San Francisco, California.
Dyck JRB; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Lopaschuk GD; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
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Źródło :
JACC. Basic to translational science [JACC Basic Transl Sci] 2019 Jun 24; Vol. 4 (3), pp. 385-400. Date of Electronic Publication: 2019 Jun 24 (Print Publication: 2019).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.
Autorzy :
Saleme B; Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
Gurtu V; Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
Zhang Y; Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
Kinnaird A; Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.; Department of Surgery, University of Alberta, Edmonton, Alberta T6G 1Z1, Canada.
Boukouris AE; Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
Gopal K; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2H1, Canada.
Ussher JR; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2H1, Canada.
Sutendra G; Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada. .; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
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Źródło :
Science translational medicine [Sci Transl Med] 2019 Feb 06; Vol. 11 (478).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
Anthracyclines/*adverse effects
Cardiotoxicity/*metabolism
Carrier Proteins/*metabolism
Membrane Proteins/*metabolism
Thyroid Hormones/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cardiotoxicity/pathology ; Cardiotoxicity/physiopathology ; Cell Line, Tumor ; Doxorubicin/adverse effects ; Enzyme Stability ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice, Inbred C57BL ; Molecular Targeted Therapy ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Oxidation-Reduction ; Protein Binding ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
The antianginal ranolazine mitigates obesity-induced nonalcoholic fatty liver disease and increases hepatic pyruvate dehydrogenase activity.
Autorzy :
Al Batran R; Faculty of Pharmacy and Pharmaceutical Sciences.; Alberta Diabetes Institute.; Cardiovascular Research Centre.
Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences.; Alberta Diabetes Institute.; Cardiovascular Research Centre.
Aburasayn H; Faculty of Pharmacy and Pharmaceutical Sciences.; Alberta Diabetes Institute.; Cardiovascular Research Centre.
Eshreif A; Faculty of Pharmacy and Pharmaceutical Sciences.; Alberta Diabetes Institute.; Cardiovascular Research Centre.
Almutairi M; Faculty of Pharmacy and Pharmaceutical Sciences.; Alberta Diabetes Institute.; Cardiovascular Research Centre.
Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences.; Alberta Diabetes Institute.; Cardiovascular Research Centre.
Campbell SA; Alberta Diabetes Institute.; Department of Pharmacology, and.
Saleme B; Cardiovascular Research Centre.; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Court EA; Faculty of Pharmacy and Pharmaceutical Sciences.
Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences.; Alberta Diabetes Institute.; Cardiovascular Research Centre.
Light PE; Alberta Diabetes Institute.; Cardiovascular Research Centre.; Department of Pharmacology, and.
Sutendra G; Cardiovascular Research Centre.; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences.; Alberta Diabetes Institute.; Cardiovascular Research Centre.
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Źródło :
JCI insight [JCI Insight] 2019 Jan 10; Vol. 4 (1). Date of Electronic Publication: 2019 Jan 10.
Typ publikacji :
Journal Article
Czasopismo naukowe

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