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Wyszukujesz frazę ""V\(D\)J Recombination"" wg kryterium: Temat


Tytuł :
Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning.
Autorzy :
Nesterenko PA; Molecular Biology Institute, University of California, Los Angeles, CA 90095.
McLaughlin J; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Cheng D; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Bangayan NJ; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
Burton Sojo G; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Seet CS; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Qin Y; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Mao Z; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
Obusan MB; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Phillips JW; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Witte ON; Molecular Biology Institute, University of California, Los Angeles, CA 90095; .; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 19; Vol. 118 (3).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Forkhead Transcription Factors/*genetics
Interferon-gamma/*genetics
Tumor Necrosis Factor-alpha/*genetics
V(D)J Recombination/*genetics
CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/virology ; Cloning, Molecular ; Cytomegalovirus/immunology ; Cytomegalovirus/pathogenicity ; Epitopes/immunology ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/virology ; Herpesvirus 4, Human/immunology ; Herpesvirus 4, Human/pathogenicity ; Humans ; RNA, Messenger/genetics ; RNA-Seq ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Single-Cell Analysis ; T-Lymphocytes, Regulatory/immunology ; V(D)J Recombination/immunology
Czasopismo naukowe
Tytuł :
Genetic interaction between the non-homologous end-joining factors during B and T lymphocyte development: In vivo mouse models.
Autorzy :
Castañeda-Zegarra S; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.
Fernandez-Berrocal M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.; Behavioural Neurobiology MS Program, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany.
Tkachov M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.
Yao R; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.
Upfold NLE; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.
Oksenych V; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.; Department of Biosciences and Nutrition (BioNut), Karolinska Institutet, Huddinge, Sweden.; Department of Clinical Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2020 Oct; Vol. 92 (4), pp. e12936.
Typ publikacji :
Journal Article; Review
MeSH Terms :
B-Lymphocytes/*immunology
DNA End-Joining Repair/*immunology
Immunoglobulin Class Switching/*immunology
T-Lymphocytes/*immunology
V(D)J Recombination/*immunology
Animals ; DNA End-Joining Repair/genetics ; Immunoglobulin Class Switching/genetics ; Mice ; Models, Animal ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
Templated insertions at VD and DJ junctions create unique B-cell receptors in the healthy B-cell repertoire.
Autorzy :
Koning MT; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Vletter EM; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Rademaker R; Genmab, Utrecht, The Netherlands.
Vergroesen RD; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Trollmann IJM; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Parren P; Genmab, Utrecht, The Netherlands.
van Bergen CAM; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Scherer HU; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Kiełbasa SM; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.
Toes REM; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Veelken H; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
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Źródło :
European journal of immunology [Eur J Immunol] 2020 Dec; Vol. 50 (12), pp. 2099-2101. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*immunology
Receptors, Antigen, B-Cell/*genetics
V(D)J Recombination/*genetics
VDJ Recombinases/*genetics
Adaptive Immunity/genetics ; Adaptive Immunity/immunology ; Humans ; Receptors, Antigen, B-Cell/immunology ; V(D)J Recombination/immunology ; VDJ Recombinases/immunology
Raport
Tytuł :
CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning.
Autorzy :
Ba Z; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
Lou J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Ye AY; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Dai HQ; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Dring EW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Lin SG; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Jain S; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Kyritsis N; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Kieffer-Kwon KR; Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA.; Center of Cancer Research, NCI, NIH, Bethesda, MD, USA.
Casellas R; Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA. .; Center of Cancer Research, NCI, NIH, Bethesda, MD, USA. .
Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature [Nature] 2020 Oct; Vol. 586 (7828), pp. 305-310. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
V(D)J Recombination*/genetics
CCCTC-Binding Factor/*metabolism
Cell Cycle Proteins/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
Animals ; Cell Line ; Chromatin/genetics ; Chromatin/metabolism ; DNA-Binding Proteins/metabolism ; Female ; G1 Phase ; Genes, Immunoglobulin Heavy Chain/genetics ; Humans ; Indoleacetic Acids/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Precursor Cells, B-Lymphoid/immunology ; Precursor Cells, B-Lymphoid/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Inefficient V(D)J recombination underlies monogenic T cell receptor β expression.
Autorzy :
Wu GS; Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Bassing CH; Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; .; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18172-18174. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
V(D)J Recombination*
Genes, T-Cell Receptor beta/*physiology
Animals ; Female ; Gene Expression Regulation/physiology ; Heterozygote ; Male ; Mice ; T-Lymphocytes
Czasopismo naukowe
Tytuł :
Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet.
Autorzy :
Liu S; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Yuan S; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China. .; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, 266237, Qingdao, People's Republic of China. .
Gao X; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Tao X; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Yu W; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Li X; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Chen S; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Xu A; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China. .; School of Life Sciences, Beijing University of Chinese Medicine, 100029, Beijing, People's Republic of China. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 09; Vol. 11 (1), pp. 4515. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
V(D)J Recombination*
DNA Transposable Elements/*genetics
DNA-Binding Proteins/*metabolism
Lancelets/*genetics
YY1 Transcription Factor/*metabolism
Animals ; Gene Knockdown Techniques ; Genes, RAG-1 ; Genomic Instability ; HEK293 Cells ; HeLa Cells ; Humans ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/isolation & purification
Czasopismo naukowe
Tytuł :
DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination.
Autorzy :
Anne Esguerra Z; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States.
Watanabe G; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States.
Okitsu CY; Department of Urology, USC Norris Comprehensive Cancer Ctr, Los Angeles, CA, 90089 United States.
Hsieh CL; Department of Urology, USC Norris Comprehensive Cancer Ctr, Los Angeles, CA, 90089 United States.
Lieber MR; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2020 Apr; Vol. 120, pp. 93-100. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
V(D)J Recombination*/drug effects
DNA-Activated Protein Kinase/*antagonists & inhibitors
DNA-Activated Protein Kinase/*genetics
DNA-Binding Proteins/*antagonists & inhibitors
DNA-Binding Proteins/*genetics
Animals ; DNA Repair ; DNA-Activated Protein Kinase/deficiency ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/metabolism ; Endonucleases/deficiency ; Endonucleases/genetics ; Endonucleases/metabolism ; Humans ; In Vitro Techniques ; Mice ; Mice, Knockout ; Mice, SCID ; Mutation ; Nuclear Proteins/deficiency ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.
Autorzy :
Oudinet C; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France.
Braikia FZ; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France.
Dauba A; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France.
Khamlichi AA; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Apr 17; Vol. 48 (7), pp. 3553-3566.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
V(D)J Recombination*
Immunoglobulin Heavy Chains/*genetics
Alleles ; Animals ; DNA Helicases/metabolism ; DNA Methylation ; Enhancer Elements, Genetic ; Homeodomain Proteins/metabolism ; Mice ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis.
Autorzy :
Lion M; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Muhire B; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Namiki Y; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Tolstorukov MY; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; .
Oettinger MA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; .; Department of Genetics, Harvard Medical School, Boston, MA 02115.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 10; Vol. 117 (10), pp. 5453-5462. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement, B-Lymphocyte*
V(D)J Recombination*
B-Lymphocytes/*physiology
Chromatin/*metabolism
Lymphopoiesis/*genetics
Receptors, Antigen/*genetics
Animals ; Chromatin/chemistry ; Genetic Loci ; Genetic Testing ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin kappa-Chains/genetics ; Lymphoma/genetics ; Mice ; Mice, Inbred C57BL ; Micrococcal Nuclease ; Nucleosomes ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Czasopismo naukowe
Tytuł :
Nucleolar localization of RAG1 modulates V(D)J recombination activity.
Autorzy :
Brecht RM; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06529.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
Liu CC; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
Beilinson HA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
Khitun A; Department of Chemistry, Yale University, New Haven, CT 06520.; Chemical Biology Institute, Yale University, West Haven, CT 06516.
Slavoff SA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06529.; Department of Chemistry, Yale University, New Haven, CT 06520.; Chemical Biology Institute, Yale University, West Haven, CT 06516.
Schatz DG; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06529; .; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 25; Vol. 117 (8), pp. 4300-4309. Date of Electronic Publication: 2020 Feb 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
V(D)J Recombination*
Cell Nucleolus/*metabolism
Homeodomain Proteins/*metabolism
Amino Acid Motifs ; Animals ; Cell Nucleolus/genetics ; Cells, Cultured ; Homeodomain Proteins/chemistry ; Homeodomain Proteins/genetics ; Mice ; Precursor Cells, B-Lymphoid/metabolism ; Protein Transport
Czasopismo naukowe
Tytuł :
NBIGV-DB: A dedicated database of non-B cell derived immunoglobulin variable region.
Autorzy :
Zhang C; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China; Key Laboratory of Immunology, National Health Commission, Beijing 100191, China.
Xiao L; Department of Clinical Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Huang Y; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Institute of Computational Medicine, School of Computer Science & Engineering, Hebei University of Technology, Tianjin 300401, China.
Zhang L; Division of HIV/AIDS and Sexually-transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, China.
Jiang D; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Shao W; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zheng J; Key Laboratory of Immunology, National Health Commission, Beijing 100191, China.
Hu F; Key Laboratory of Immunology, National Health Commission, Beijing 100191, China.
Chu M; Key Laboratory of Immunology, National Health Commission, Beijing 100191, China.
Huang J; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Gong X; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zhou Y; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Qiu X; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Mar 10; Vol. 772, pp. 145378. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Nucleotide Sequencing/*methods
Immunoglobulin Variable Region/*genetics
Immunoglobulin Variable Region/*metabolism
Algorithms ; Animals ; Cell Adhesion ; Cell Movement ; Cell Survival ; Databases, Genetic ; Humans ; Mice ; Sequence Analysis, DNA ; V(D)J Recombination
Czasopismo naukowe
Tytuł :
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium.
Autorzy :
Bagaev DV; Pirogov Russian Medical State University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Vroomans RMA; Origins Center, Groningen, The Netherlands.; Institute for Advanced Study, University of Amsterdam, Amsterdam, The Netherlands.
Samir J; Kirby Institute for Infection and Immunity, UNSW Sydney, Sydney, Australia.; School of Medical Sciences, UNSW Sydney, Sydney, Australia.
Stervbo U; Center for Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
Rius C; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Dolton G; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Greenshields-Watson A; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Attaf M; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Egorov ES; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Zvyagin IV; Pirogov Russian Medical State University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Babel N; Center for Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
Cole DK; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.; Immunocore Ltd., Abingdon, OX14 4RY, UK.
Godkin AJ; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Sewell AK; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Kesmir C; Theoretical Biology and Bioinformatics Department, Science Faculty, Utrecht University, Utrecht, Netherlands.
Chudakov DM; Pirogov Russian Medical State University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
Luciani F; Kirby Institute for Infection and Immunity, UNSW Sydney, Sydney, Australia.; School of Medical Sciences, UNSW Sydney, Sydney, Australia.
Shugay M; Pirogov Russian Medical State University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jan 08; Vol. 48 (D1), pp. D1057-D1062.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Databases, Genetic*
Nucleotide Motifs*
V(D)J Recombination*
Computational Biology/*methods
Receptors, Antigen, T-Cell/*genetics
Amino Acid Sequence ; High-Throughput Nucleotide Sequencing ; Humans ; Position-Specific Scoring Matrices ; Receptors, Antigen, T-Cell/chemistry ; Sequence Analysis, DNA ; Software ; Web Browser
Czasopismo naukowe
Tytuł :
VDJbase: an adaptive immune receptor genotype and haplotype database.
Autorzy :
Omer A; Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
Shemesh O; Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
Peres A; Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
Polak P; Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
Shepherd AJ; Institute of Structural and Molecular Biology, Birkbeck, University of London, London, UK.
Watson CT; University of Louisville School of Medicine, Biochemistry and Molecular Genetics, Louisville, KY 40292, USA.
Boyd SD; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Collins AM; School of Biotechnology and Biomolecular Sciences, University of NSW, Kensington, Sydney, NSW 2052, Australia.
Lees W; Institute of Structural and Molecular Biology, Birkbeck, University of London, London, UK.
Yaari G; Bioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jan 08; Vol. 48 (D1), pp. D1051-D1056.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Databases, Genetic*
Genotype*
Haplotypes*
V(D)J Recombination*
Computational Biology/*methods
Receptors, Immunologic/*genetics
Humans ; Molecular Sequence Annotation ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, T-Cell/genetics ; Software ; Software Design ; Web Browser ; Workflow
Czasopismo naukowe
Tytuł :
Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF.
Autorzy :
Beck C; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.
Castañeda-Zegarra S; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.
Huse C; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.
Xing M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.
Oksenych V; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.; Department of Biosciences and Nutrition (BioNuT), Karolinska Institutet, 14183 Huddinge, Sweden.
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Źródło :
Biomolecules [Biomolecules] 2019 Dec 30; Vol. 10 (1). Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
V(D)J Recombination*
Adaptor Proteins, Signal Transducing/*metabolism
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*deficiency
Animals ; Cell Line ; Cell Proliferation ; DNA Damage ; DNA Repair ; DNA-Binding Proteins/genetics ; Mice ; Mice, Knockout ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Germline DNA Retention in Murine and Human Rearranged T Cell Receptor Gene Coding Joints: Alternative Recombination Signal Sequences and V(D)J Recombinase Errors.
Autorzy :
Mika J; Data Mining Division, Silesian University of Technology, Gliwice, Poland.
Kabacik S; Cancer Mechanisms and Biomarkers Group, Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards Public Health England Chilton, Didcot, United Kingdom.
Badie C; Cancer Mechanisms and Biomarkers Group, Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards Public Health England Chilton, Didcot, United Kingdom.
Polanska J; Data Mining Division, Silesian University of Technology, Gliwice, Poland.
Candéias SM; Université Grenoble Alpes, CEA, CNRS, IRIG-LCBM, Grenoble, France.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Nov 08; Vol. 10, pp. 2637. Date of Electronic Publication: 2019 Nov 08 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor*
V(D)J Recombination*
Animals ; DNA ; Humans ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred CBA ; VDJ Recombinases
Czasopismo naukowe
Tytuł :
Loop extrusion mediates physiological Igh locus contraction for RAG scanning.
Autorzy :
Dai HQ; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
Hu H; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Lou J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Ye AY; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Ba Z; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Zhang X; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Zhang Y; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Zhao L; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Yoon HS; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Chapdelaine-Williams AM; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Kyritsis N; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Chen H; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Johnson K; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Lin S; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Conte A; Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA.; Center of Cancer Research, NCI, NIH, Bethesda, MD, USA.
Casellas R; Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA.; Center of Cancer Research, NCI, NIH, Bethesda, MD, USA.
Lee CS; Department of Life Science, National Tsing Hua University, Institute of Molecular and Cellular Biology, Hsinchu, Taiwan, R.O.C.. .
Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature [Nature] 2021 Feb; Vol. 590 (7845), pp. 338-343. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleic Acid Conformation*
B-Lymphocytes/*metabolism
DNA-Binding Proteins/*metabolism
Endonucleases/*metabolism
Homeodomain Proteins/*metabolism
Immunoglobulin Heavy Chains/*genetics
Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/enzymology ; Cell Line ; Cells, Cultured ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/genetics ; Down-Regulation ; Endonucleases/deficiency ; Endonucleases/genetics ; G1 Phase Cell Cycle Checkpoints ; High-Throughput Nucleotide Sequencing ; Homeodomain Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Proteins/genetics ; Proteins/metabolism ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides.
Autorzy :
Ashley J; Technical University of Denmark, Department of Health Technology, Kgs. Lyngby 2800, Denmark.; International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga Braga 4715-330, Portugal.
Schaap-Johansen AL; Technical University of Denmark, Department of Health Technology, Kgs. Lyngby 2800, Denmark.
Mohammadniaei M; Technical University of Denmark, Department of Health Technology, Kgs. Lyngby 2800, Denmark.
Naseri M; Technical University of Denmark, Department of Health Technology, Kgs. Lyngby 2800, Denmark.
Marcatili P; Technical University of Denmark, Department of Health Technology, Kgs. Lyngby 2800, Denmark.
Prado M; International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga Braga 4715-330, Portugal.
Sun Y; Technical University of Denmark, Department of Health Technology, Kgs. Lyngby 2800, Denmark.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 25; Vol. 49 (2), pp. 1065-1074.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aptamers, Nucleotide/*metabolism
DNA Nucleotidylexotransferase/*physiology
Drug Evaluation, Preclinical/*methods
Aptamers, Nucleotide/biosynthesis ; Aptamers, Nucleotide/isolation & purification ; Binding Sites ; DNA/metabolism ; DNA, Single-Stranded/metabolism ; Electrophoretic Mobility Shift Assay ; Gene Library ; High-Throughput Nucleotide Sequencing ; Lactoferrin/metabolism ; Nucleic Acid Amplification Techniques ; Protein Binding ; Substrate Specificity ; Thrombin/metabolism ; V(D)J Recombination
Czasopismo naukowe
Tytuł :
Reading the B-cell receptor immunome in chronic lymphocytic leukemia: revelations and applications.
Autorzy :
Hengeveld PJ; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
Levin MD; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
Kolijn PM; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
Langerak AW; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands. Electronic address: .
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Źródło :
Experimental hematology [Exp Hematol] 2021 Jan; Vol. 93, pp. 14-24. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunogenetic Phenomena*
Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
Receptors, Antigen, B-Cell/*genetics
Animals ; High-Throughput Nucleotide Sequencing ; Humans ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Mutation ; Receptors, Antigen, B-Cell/chemistry ; Receptors, Antigen, B-Cell/immunology ; V(D)J Recombination
Czasopismo naukowe
Tytuł :
Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.
Autorzy :
Rodríguez-Caparrós A; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Álvarez-Santiago J; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Del Valle-Pastor MJ; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Suñé C; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
López-Ros J; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Hernández-Munain C; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 11; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enhancer Elements, Genetic/*genetics
Gene Expression Regulation/*genetics
Genes, T-Cell Receptor/*genetics
T-Lymphocytes/*immunology
Animals ; Chromatin/genetics ; Chromatin/immunology ; Enhancer Elements, Genetic/immunology ; Gene Expression Regulation/immunology ; Genes, T-Cell Receptor/immunology ; Humans ; Signal Transduction/genetics ; Signal Transduction/immunology ; Transcription, Genetic/genetics ; Transcription, Genetic/immunology ; V(D)J Recombination/genetics ; V(D)J Recombination/immunology
Czasopismo naukowe
Tytuł :
The Yin and Yang of RNA surveillance in B lymphocytes and antibody-secreting plasma cells.
Autorzy :
Lambert JM; UMR CNRS 7276 - INSERM 1268 - Université de Limoges, Centre de Biologie et de Recherche en Santé, 2 rue du Dr Marcland, Limoges F-87025, France.
Srour N; UMR CNRS 7276 - INSERM 1268 - Université de Limoges, Centre de Biologie et de Recherche en Santé, 2 rue du Dr Marcland, Limoges F-87025, France.
Delpy L; UMR CNRS 7276 - INSERM 1268 - Université de Limoges, Centre de Biologie et de Recherche en Santé, 2 rue du Dr Marcland, Limoges F-87025, France.
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Źródło :
BMB reports [BMB Rep] 2019 Dec; Vol. 52 (12), pp. 671-678.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genes, Immunoglobulin*
Nonsense Mediated mRNA Decay*
B-Lymphocytes/*immunology
Immunoglobulins/*genetics
Plasma Cells/*immunology
V(D)J Recombination/*genetics
Alleles ; Animals ; Antibody Formation/genetics ; B-Lymphocytes/metabolism ; Codon, Nonsense/metabolism ; Humans ; Immunoglobulins/immunology ; Plasma Cells/metabolism ; RNA Splicing ; RNA, Messenger/metabolism ; V(D)J Recombination/immunology
Czasopismo naukowe

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