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Wyszukujesz frazę ""V\(D\)J recombination"" wg kryterium: Temat


Tytuł :
Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning.
Autorzy :
Nesterenko PA; Molecular Biology Institute, University of California, Los Angeles, CA 90095.
McLaughlin J; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Cheng D; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Bangayan NJ; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
Burton Sojo G; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Seet CS; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Qin Y; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Mao Z; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
Obusan MB; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Phillips JW; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Witte ON; Molecular Biology Institute, University of California, Los Angeles, CA 90095; .; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 19; Vol. 118 (3).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Forkhead Transcription Factors/*genetics
Interferon-gamma/*genetics
Tumor Necrosis Factor-alpha/*genetics
V(D)J Recombination/*genetics
CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/virology ; Cloning, Molecular ; Cytomegalovirus/immunology ; Cytomegalovirus/pathogenicity ; Epitopes/immunology ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/virology ; Herpesvirus 4, Human/immunology ; Herpesvirus 4, Human/pathogenicity ; Humans ; RNA, Messenger/genetics ; RNA-Seq ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Single-Cell Analysis ; T-Lymphocytes, Regulatory/immunology ; V(D)J Recombination/immunology
Czasopismo naukowe
Tytuł :
Templated insertions at VD and DJ junctions create unique B-cell receptors in the healthy B-cell repertoire.
Autorzy :
Koning MT; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Vletter EM; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Rademaker R; Genmab, Utrecht, The Netherlands.
Vergroesen RD; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Trollmann IJM; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Parren P; Genmab, Utrecht, The Netherlands.
van Bergen CAM; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Scherer HU; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Kiełbasa SM; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.
Toes REM; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Veelken H; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
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Źródło :
European journal of immunology [Eur J Immunol] 2020 Dec; Vol. 50 (12), pp. 2099-2101. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*immunology
Receptors, Antigen, B-Cell/*genetics
V(D)J Recombination/*genetics
VDJ Recombinases/*genetics
Adaptive Immunity/genetics ; Adaptive Immunity/immunology ; Humans ; Receptors, Antigen, B-Cell/immunology ; V(D)J Recombination/immunology ; VDJ Recombinases/immunology
Raport
Tytuł :
TRBV and TRBJ usage, when paired with specific HLA alleles, associates with distinct head and neck cancer survival rates.
Autorzy :
Arndt MF; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Koohestani DM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Chobrutskiy BI; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Mihyu MM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Diaz M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Gozlan EC; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Yeagley M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Zaman S; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Roca AM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States. Electronic address: .
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Źródło :
Human immunology [Hum Immunol] 2020 Dec; Vol. 81 (12), pp. 692-696. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Alleles*
Genes, T-Cell Receptor beta*
V(D)J Recombination*
HLA Antigens/*genetics
Head and Neck Neoplasms/*genetics
Head and Neck Neoplasms/*mortality
Histocompatibility Antigens Class I/*genetics
Histocompatibility Antigens Class II/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Disease-Free Survival ; Exome ; Head and Neck Neoplasms/blood ; Head and Neck Neoplasms/pathology ; Humans ; Kaplan-Meier Estimate ; Prognosis ; Survival Rate
Czasopismo naukowe
Tytuł :
The recent advances in non-homologous end-joining through the lens of lymphocyte development.
Autorzy :
Wang XS; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY 10032, United States; Graduate Program of Pathobiology and Molecular Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY 10032, United States.
Lee BJ; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY 10032, United States.
Zha S; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY 10032, United States; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY 10032, United States; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY 10032, United States; Department of Immunology and Microbiology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY 10032, United States. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2020 Oct; Vol. 94, pp. 102874. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
DNA End-Joining Repair*
Immunoglobulin Class Switching*
V(D)J Recombination*
B-Lymphocytes/*metabolism
Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; B-Lymphocytes/immunology ; DNA-Activated Protein Kinase/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Genetic interaction between the non-homologous end-joining factors during B and T lymphocyte development: In vivo mouse models.
Autorzy :
Castañeda-Zegarra S; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.
Fernandez-Berrocal M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.; Behavioural Neurobiology MS Program, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany.
Tkachov M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.
Yao R; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.
Upfold NLE; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.
Oksenych V; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Clinic of Medicine, Trondheim University Hospital, Trondheim, Norway.; Department of Biosciences and Nutrition (BioNut), Karolinska Institutet, Huddinge, Sweden.; Department of Clinical Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2020 Oct; Vol. 92 (4), pp. e12936.
Typ publikacji :
Journal Article; Review
MeSH Terms :
B-Lymphocytes/*immunology
DNA End-Joining Repair/*immunology
Immunoglobulin Class Switching/*immunology
T-Lymphocytes/*immunology
V(D)J Recombination/*immunology
Animals ; DNA End-Joining Repair/genetics ; Immunoglobulin Class Switching/genetics ; Mice ; Models, Animal ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
Inefficient V(D)J recombination underlies monogenic T cell receptor β expression.
Autorzy :
Wu GS; Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Bassing CH; Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; .; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18172-18174. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
V(D)J Recombination*
Genes, T-Cell Receptor beta/*physiology
Animals ; Female ; Gene Expression Regulation/physiology ; Heterozygote ; Male ; Mice ; T-Lymphocytes
Czasopismo naukowe
Tytuł :
CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning.
Autorzy :
Ba Z; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
Lou J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Ye AY; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Dai HQ; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Dring EW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Lin SG; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Jain S; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Kyritsis N; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Kieffer-Kwon KR; Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA.; Center of Cancer Research, NCI, NIH, Bethesda, MD, USA.
Casellas R; Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA. .; Center of Cancer Research, NCI, NIH, Bethesda, MD, USA. .
Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature [Nature] 2020 Oct; Vol. 586 (7828), pp. 305-310. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
V(D)J Recombination*/genetics
CCCTC-Binding Factor/*metabolism
Cell Cycle Proteins/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
Animals ; Cell Line ; Chromatin/genetics ; Chromatin/metabolism ; DNA-Binding Proteins/metabolism ; Female ; G1 Phase ; Genes, Immunoglobulin Heavy Chain/genetics ; Humans ; Indoleacetic Acids/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Precursor Cells, B-Lymphoid/immunology ; Precursor Cells, B-Lymphoid/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet.
Autorzy :
Liu S; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Yuan S; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China. .; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, 266237, Qingdao, People's Republic of China. .
Gao X; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Tao X; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Yu W; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Li X; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Chen S; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China.
Xu A; State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, People's Republic of China. .; School of Life Sciences, Beijing University of Chinese Medicine, 100029, Beijing, People's Republic of China. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 09; Vol. 11 (1), pp. 4515. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
V(D)J Recombination*
DNA Transposable Elements/*genetics
DNA-Binding Proteins/*metabolism
Lancelets/*genetics
YY1 Transcription Factor/*metabolism
Animals ; Gene Knockdown Techniques ; Genes, RAG-1 ; Genomic Instability ; HEK293 Cells ; HeLa Cells ; Humans ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/isolation & purification
Czasopismo naukowe
Tytuł :
DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination.
Autorzy :
Anne Esguerra Z; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States.
Watanabe G; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States.
Okitsu CY; Department of Urology, USC Norris Comprehensive Cancer Ctr, Los Angeles, CA, 90089 United States.
Hsieh CL; Department of Urology, USC Norris Comprehensive Cancer Ctr, Los Angeles, CA, 90089 United States.
Lieber MR; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2020 Apr; Vol. 120, pp. 93-100. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
V(D)J Recombination*/drug effects
DNA-Activated Protein Kinase/*antagonists & inhibitors
DNA-Activated Protein Kinase/*genetics
DNA-Binding Proteins/*antagonists & inhibitors
DNA-Binding Proteins/*genetics
Animals ; DNA Repair ; DNA-Activated Protein Kinase/deficiency ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/metabolism ; Endonucleases/deficiency ; Endonucleases/genetics ; Endonucleases/metabolism ; Humans ; In Vitro Techniques ; Mice ; Mice, Knockout ; Mice, SCID ; Mutation ; Nuclear Proteins/deficiency ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis.
Autorzy :
Lion M; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Muhire B; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Namiki Y; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Tolstorukov MY; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; .
Oettinger MA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; .; Department of Genetics, Harvard Medical School, Boston, MA 02115.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 10; Vol. 117 (10), pp. 5453-5462. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement, B-Lymphocyte*
V(D)J Recombination*
B-Lymphocytes/*physiology
Chromatin/*metabolism
Lymphopoiesis/*genetics
Receptors, Antigen/*genetics
Animals ; Chromatin/chemistry ; Genetic Loci ; Genetic Testing ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin kappa-Chains/genetics ; Lymphoma/genetics ; Mice ; Mice, Inbred C57BL ; Micrococcal Nuclease ; Nucleosomes ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Czasopismo naukowe
Tytuł :
Nucleolar localization of RAG1 modulates V(D)J recombination activity.
Autorzy :
Brecht RM; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06529.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
Liu CC; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
Beilinson HA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
Khitun A; Department of Chemistry, Yale University, New Haven, CT 06520.; Chemical Biology Institute, Yale University, West Haven, CT 06516.
Slavoff SA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06529.; Department of Chemistry, Yale University, New Haven, CT 06520.; Chemical Biology Institute, Yale University, West Haven, CT 06516.
Schatz DG; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06529; .; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 25; Vol. 117 (8), pp. 4300-4309. Date of Electronic Publication: 2020 Feb 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
V(D)J Recombination*
Cell Nucleolus/*metabolism
Homeodomain Proteins/*metabolism
Amino Acid Motifs ; Animals ; Cell Nucleolus/genetics ; Cells, Cultured ; Homeodomain Proteins/chemistry ; Homeodomain Proteins/genetics ; Mice ; Precursor Cells, B-Lymphoid/metabolism ; Protein Transport
Czasopismo naukowe
Tytuł :
Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.
Autorzy :
Hübschmann D; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.; Heidelberg Institute of Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.; Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Kleinheinz K; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.
Wagener R; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Düsseldorf, Germany.
Bernhart SH; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
López C; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.
Toprak UH; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sungalee S; EMBL Heidelberg, Genome Biology, Heidelberg, Germany.
Ishaque N; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ-HIPO, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kretzmer H; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Kreuz M; Institute for Medical Informatics Statistics and Epidemiology, Leipzig, Germany.
Waszak SM; EMBL Heidelberg, Genome Biology, Heidelberg, Germany.
Paramasivam N; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
Ammerpohl O; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.
Aukema SM; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany.
Beekman R; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Bergmann AK; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Bieg M; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ-HIPO, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Binder H; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.
Borkhardt A; University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Düsseldorf, Germany.
Borst C; Department of Internal Medicine/Hematology, Friedrich-Ebert-Hospital, Neumünster, Neumünster, Germany.
Brors B; Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bruns P; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carrillo de Santa Pau E; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, Madrid, Spain.
Claviez A; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Doose G; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Haake A; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.
Karsch D; Department for Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Haas S; Department of Internal Medicine/Hematology, Friedrich-Ebert-Hospital, Neumünster, Neumünster, Germany.
Hansmann ML; Senckenberg Institute of Pathology, University of Frankfurt Medical School, Frankfurt am Main, Germany.
Hoell JI; University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Düsseldorf, Germany.
Hovestadt V; Division of Molecular Genetics, German Cancer Consortium (DKFK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Huang B; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China.
Hummel M; Institute of Pathology, Charité - University Medicine Berlin, Berlin, Germany.
Jäger-Schmidt C; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kerssemakers JNA; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Korbel JO; EMBL Heidelberg, Genome Biology, Heidelberg, Germany.
Kube D; Department of Hematology and Oncology, Georg-Augusts-University of Göttingen, Göttingen, Germany.
Lawerenz C; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lenze D; Institute of Pathology, Charité - University Medicine Berlin, Berlin, Germany.
Martens JHA; Department of Molecular Biology, Radboud University, Faculty of Science, Nijmegen, The Netherlands.
Ott G; Department of Clinical Pathology, Robert-Bosch-Hospital and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, Germany.
Radlwimmer B; Division of Molecular Genetics, German Cancer Consortium (DKFK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Reisinger E; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Richter J; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany.
Rico D; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Rosenstiel P; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Rosenwald A; Institute of Pathology, University of Wuerzburg and Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany.
Schillhabel M; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Stilgenbauer S; Department for Internal Medicine III, Ulm University, Ulm, Germany.
Stadler PF; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.
Martín-Subero JI; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Szczepanowski M; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany.
Warsow G; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Weniger MA; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School, Essen, Germany.; German Cancer Consortium (DKTK), Essen, Germany.
Zapatka M; Division of Molecular Genetics, German Cancer Consortium (DKFK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Valencia A; Barcelona Supercomputing Centre (BSC), Barcelona, Spain.; ICREA, Barcelona, Spain.
Stunnenberg HG; Department of Molecular Biology, Radboud University, Faculty of Science, Nijmegen, The Netherlands.
Lichter P; Division of Molecular Genetics, German Cancer Consortium (DKFK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Möller P; Institute of Pathology, Medical Faculty of the Ulm University, Ulm, Germany.
Loeffler M; Institute for Medical Informatics Statistics and Epidemiology, Leipzig, Germany.
Eils R; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.
Klapper W; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany.
Hoffmann S; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Trümper L; Department of Hematology and Oncology, Georg-Augusts-University of Göttingen, Göttingen, Germany.
Küppers R; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School, Essen, Germany. .; German Cancer Consortium (DKTK), Essen, Germany. .
Schlesner M; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Institute for Informatics, Faculty of Computer Science and Medical Faculty, University of Augsburg, Augsburg, Germany. .
Siebert R; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany. .; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany. .
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Corporate Authors :
ICGC MMML-Seq consortium
ICGC DE-Mining consortium
BLUEPRINT consortium
Źródło :
Leukemia [Leukemia] 2021 Jul; Vol. 35 (7), pp. 2002-2016. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome/*genetics
Germinal Center/*metabolism
Lymphoma, B-Cell/*genetics
Mutation/*genetics
Adult ; B-Lymphocytes/metabolism ; Cell Line ; Cell Line, Tumor ; Genes, Immunoglobulin/genetics ; HeLa Cells ; Hep G2 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunoglobulin Class Switching/genetics ; K562 Cells ; MCF-7 Cells ; Somatic Hypermutation, Immunoglobulin/genetics ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
TRUST4: immune repertoire reconstruction from bulk and single-cell RNA-seq data.
Autorzy :
Song L; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Cohen D; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Ouyang Z; Department of Biotechnology, Beijing Institue of Radiation Medicine, Beijing, China.
Cao Y; College of Life Sciences, Sichuan University, Chengdu, China.
Hu X; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Liu XS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. .; Harvard T.H. Chan School of Public Health, Boston, MA, USA. .; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. .
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Źródło :
Nature methods [Nat Methods] 2021 Jun; Vol. 18 (6), pp. 627-630. Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Receptors, Immunologic/*genetics
Sequence Analysis, RNA/*methods
Single-Cell Analysis/*methods
Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, T-Cell/genetics ; V(D)J Recombination
Czasopismo naukowe
Tytuł :
The Evolution of Rag Gene Enhancers and Transcription Factor E and Id Proteins in the Adaptive Immune System.
Autorzy :
Yoshikawa G; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji 611-0011, Japan.
Miyazaki K; Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Ogata H; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji 611-0011, Japan.
Miyazaki M; Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 31; Vol. 22 (11). Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enhancer Elements, Genetic*
Evolution, Molecular*
Adaptive Immunity/*genetics
Homeodomain Proteins/*genetics
Transcription Factors/*genetics
Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Gene Expression Regulation ; Humans ; Regulatory Sequences, Nucleic Acid ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Transcription Factors/metabolism ; V(D)J Recombination
Czasopismo naukowe
Tytuł :
RAG deficiencies: Recent advances in disease pathogenesis and novel therapeutic approaches.
Autorzy :
Bosticardo M; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Pala F; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 May; Vol. 51 (5), pp. 1028-1038. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genetic Predisposition to Disease*
DNA-Binding Proteins/*genetics
Homeodomain Proteins/*genetics
Nuclear Proteins/*genetics
Severe Combined Immunodeficiency/*etiology
Severe Combined Immunodeficiency/*therapy
V(D)J Recombination/*genetics
Animals ; Diagnosis, Differential ; Disease Management ; Disease Models, Animal ; Genetic Association Studies ; Genetic Therapy ; Genotype ; Humans ; Mutation ; Phenotype ; Severe Combined Immunodeficiency/diagnosis
Czasopismo naukowe
Tytuł :
Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.
Autorzy :
Oudinet C; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France.
Braikia FZ; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France.
Dauba A; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France.
Khamlichi AA; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Apr 17; Vol. 48 (7), pp. 3553-3566.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
V(D)J Recombination*
Immunoglobulin Heavy Chains/*genetics
Alleles ; Animals ; DNA Helicases/metabolism ; DNA Methylation ; Enhancer Elements, Genetic ; Homeodomain Proteins/metabolism ; Mice ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF.
Autorzy :
Beck C; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.
Castañeda-Zegarra S; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.
Huse C; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.
Xing M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.
Oksenych V; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway.; Department of Biosciences and Nutrition (BioNuT), Karolinska Institutet, 14183 Huddinge, Sweden.
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Źródło :
Biomolecules [Biomolecules] 2019 Dec 30; Vol. 10 (1). Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
V(D)J Recombination*
Adaptor Proteins, Signal Transducing/*metabolism
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*deficiency
Animals ; Cell Line ; Cell Proliferation ; DNA Damage ; DNA Repair ; DNA-Binding Proteins/genetics ; Mice ; Mice, Knockout ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Germline DNA Retention in Murine and Human Rearranged T Cell Receptor Gene Coding Joints: Alternative Recombination Signal Sequences and V(D)J Recombinase Errors.
Autorzy :
Mika J; Data Mining Division, Silesian University of Technology, Gliwice, Poland.
Kabacik S; Cancer Mechanisms and Biomarkers Group, Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards Public Health England Chilton, Didcot, United Kingdom.
Badie C; Cancer Mechanisms and Biomarkers Group, Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards Public Health England Chilton, Didcot, United Kingdom.
Polanska J; Data Mining Division, Silesian University of Technology, Gliwice, Poland.
Candéias SM; Université Grenoble Alpes, CEA, CNRS, IRIG-LCBM, Grenoble, France.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Nov 08; Vol. 10, pp. 2637. Date of Electronic Publication: 2019 Nov 08 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor*
V(D)J Recombination*
Animals ; DNA ; Humans ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred CBA ; VDJ Recombinases
Czasopismo naukowe
Tytuł :
FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.
Autorzy :
Milanovic M; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Shao Z; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Estes VM; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Wang XS; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Menolfi D; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Lin X; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Lee BJ; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Xu J; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093.
Cupo OM; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Wang D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093.
Zha S; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032; .; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.; Division of Pediatric Oncology, Hematology and Stem Cell Transplantation, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032; and.; Department of Immunology and Microbiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Mar 15; Vol. 206 (6), pp. 1228-1239. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocytes/*immunology
Lymphoma/*genetics
Protein Domains/*genetics
Animals ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/immunology ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Codon, Nonsense ; Disease Models, Animal ; Gene Knock-In Techniques ; Humans ; Lymphocytes/pathology ; Lymphoma/immunology ; Lymphoma/pathology ; Male ; Mice ; Mice, Knockout ; Protein Stability ; V(D)J Recombination/genetics ; V(D)J Recombination/immunology
Czasopismo naukowe
Tytuł :
NBIGV-DB: A dedicated database of non-B cell derived immunoglobulin variable region.
Autorzy :
Zhang C; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China; Key Laboratory of Immunology, National Health Commission, Beijing 100191, China.
Xiao L; Department of Clinical Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Huang Y; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Institute of Computational Medicine, School of Computer Science & Engineering, Hebei University of Technology, Tianjin 300401, China.
Zhang L; Division of HIV/AIDS and Sexually-transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, China.
Jiang D; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Shao W; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zheng J; Key Laboratory of Immunology, National Health Commission, Beijing 100191, China.
Hu F; Key Laboratory of Immunology, National Health Commission, Beijing 100191, China.
Chu M; Key Laboratory of Immunology, National Health Commission, Beijing 100191, China.
Huang J; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Gong X; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zhou Y; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Qiu X; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Mar 10; Vol. 772, pp. 145378. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Nucleotide Sequencing/*methods
Immunoglobulin Variable Region/*genetics
Immunoglobulin Variable Region/*metabolism
Algorithms ; Animals ; Cell Adhesion ; Cell Movement ; Cell Survival ; Databases, Genetic ; Humans ; Mice ; Sequence Analysis, DNA ; V(D)J Recombination
Czasopismo naukowe

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