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Wyświetlanie 1-20 z 33
Tytuł:
Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma.
Autorzy:
Parmigiani E; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
Taylor V; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
Giachino C; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
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Źródło:
Cells [Cells] 2020 Oct 15; Vol. 9 (10). Date of Electronic Publication: 2020 Oct 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Signal Transduction*
Brain Neoplasms/*genetics
Genes, Tumor Suppressor/*physiology
Glioma/*genetics
Oncogenes/*physiology
Receptors, Notch/*physiology
Brain Neoplasms/pathology ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Gene Expression Regulation, Neoplastic ; Glioma/pathology ; Homeostasis ; Humans ; Neoplastic Stem Cells/pathology ; Neural Stem Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tead transcription factors differentially regulate cortical development.
Autorzy:
Mukhtar T; Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058, Basel, Switzerland.
Breda J; Biozentrum, University of Basel, Klingelbergstrasse 50-70, CH-4056, Basel, Switzerland.
Grison A; Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058, Basel, Switzerland.
Karimaddini Z; Swiss Institute of Bioinformatics (SIB), Mattenstrasse 26, CH-4058, Basel, Switzerland.; Computational Biology Group, Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, CH-4058, Basel, Switzerland.
Grobecker P; Biozentrum, University of Basel, Klingelbergstrasse 50-70, CH-4056, Basel, Switzerland.
Iber D; Swiss Institute of Bioinformatics (SIB), Mattenstrasse 26, CH-4058, Basel, Switzerland.; Computational Biology Group, Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, CH-4058, Basel, Switzerland.
Beisel C; Department of Biosystems Science and Engineering, Mattenstrasse 26, ETH Zürich, CH-4058, Basel, Switzerland.
van Nimwegen E; Biozentrum, University of Basel, Klingelbergstrasse 50-70, CH-4056, Basel, Switzerland.
Taylor V; Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058, Basel, Switzerland. verdon..
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Źródło:
Scientific reports [Sci Rep] 2020 Mar 13; Vol. 10 (1), pp. 4625. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
Cerebral Cortex/*growth & development
DNA-Binding Proteins/*genetics
Transcription Factors/*metabolism
Animals ; Cell Adhesion Molecules, Neuronal/genetics ; Cell Line ; Cerebral Cortex/metabolism ; Chromatin Immunoprecipitation ; DNA-Binding Proteins/metabolism ; Extracellular Matrix Proteins/genetics ; Female ; Hippo Signaling Pathway ; Humans ; Mice ; Nerve Tissue Proteins/genetics ; Neural Stem Cells ; Organ Specificity ; Protein Serine-Threonine Kinases/genetics ; Reelin Protein ; Serine Endopeptidases/genetics ; TEA Domain Transcription Factors ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.
Autorzy:
Huang S; Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Park J; Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Qiu C; Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Chung KW; Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Li SY; Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Sirin Y; Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Han SH; Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Taylor V; Department of Biomedicine, University of Basel, Basel, Switzerland.
Zimber-Strobl U; Research Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environment and Health, Munich, Germany.
Susztak K; Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2018 Sep 18; Vol. 16 (9), pp. e2005233. Date of Electronic Publication: 2018 Sep 18 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins/*metabolism
High Mobility Group Proteins/*metabolism
Jagged-1 Protein/*metabolism
Kidney/*metabolism
Kidney/*pathology
Mitochondrial Proteins/*metabolism
Receptor, Notch2/*metabolism
Transcription Factors/*metabolism
Animals ; Cell Dedifferentiation ; Cell Proliferation ; Epithelial Cells/metabolism ; Fibrosis ; Gene Ontology ; Genotype ; Humans ; Kidney Tubules/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Biological ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Untangling Cortical Complexity During Development.
Autorzy:
Mukhtar T; Department of Biomedicine, University of Basel, Basel, Switzerland.
Taylor V; Department of Biomedicine, University of Basel, Basel, Switzerland.
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Źródło:
Journal of experimental neuroscience [J Exp Neurosci] 2018 Mar 01; Vol. 12, pp. 1179069518759332. Date of Electronic Publication: 2018 Mar 01 (Print Publication: 2018).
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.
Autorzy:
Wang Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.
Wu B
Chamberlain AA
Lui W
Koirala P
Susztak K
Klein D
Taylor V
Zhou B
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Źródło:
PloS one [PLoS One] 2013; Vol. 8 (4), pp. e60244. Date of Electronic Publication: 2013 Apr 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Expression Regulation, Developmental*
Bone Morphogenetic Protein 2/*metabolism
Endocardium/*metabolism
Heart Valves/*metabolism
Myocardium/*metabolism
Receptor, Notch1/*metabolism
Wnt4 Protein/*metabolism
Adaptor Proteins, Signal Transducing ; Animals ; Bone Morphogenetic Protein 2/genetics ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Embryo, Mammalian ; Endocardium/embryology ; Epithelial-Mesenchymal Transition/genetics ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Heart Valves/embryology ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Jagged-1 Protein ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Transgenic ; Organogenesis/genetics ; Receptor, Notch1/genetics ; Serrate-Jagged Proteins ; Signal Transduction ; Wnt4 Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters.
Autorzy:
Tchorz JS; Novartis Institute for Biomedical Research, Developmental and Molecular Pathways, Novartis Pharma AG, Basel, Switzerland.
Suply T
Ksiazek I
Giachino C
Cloëtta D
Danzer CP
Doll T
Isken A
Lemaistre M
Taylor V
Bettler B
Kinzel B
Mueller M
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (1), pp. e30011. Date of Electronic Publication: 2012 Jan 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Loci/*genetics
Integrases/*metabolism
Mutagenesis, Insertional/*methods
Promoter Regions, Genetic/*genetics
Proteins/*genetics
Transgenes/*genetics
Animals ; Attachment Sites, Microbiological/genetics ; Embryonic Stem Cells/metabolism ; Genes, Reporter/genetics ; Green Fluorescent Proteins/metabolism ; Luciferases/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Organ Specificity/genetics ; RNA, Untranslated
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh.
Autorzy:
Favaro R; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy.
Valotta M
Ferri AL
Latorre E
Mariani J
Giachino C
Lancini C
Tosetti V
Ottolenghi S
Taylor V
Nicolis SK
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Źródło:
Nature neuroscience [Nat Neurosci] 2009 Oct; Vol. 12 (10), pp. 1248-56. Date of Electronic Publication: 2009 Sep 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hippocampus*/cytology
Hippocampus*/embryology
Hippocampus*/growth & development
Embryonic Stem Cells/*physiology
Gene Expression Regulation, Developmental/*physiology
Hedgehog Proteins/*physiology
Neurons/*physiology
SOXB1 Transcription Factors/*physiology
Age Factors ; Animals ; Animals, Newborn ; Bromodeoxyuridine/metabolism ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Survival ; Cells, Cultured ; Chromatin Immunoprecipitation/methods ; Culture Media, Conditioned/pharmacology ; DNA Nucleotidyltransferases/genetics ; Electrophoretic Mobility Shift Assay/methods ; Embryo, Mammalian ; Enzyme Inhibitors/pharmacology ; Female ; Gene Expression Regulation, Developmental/genetics ; Glial Fibrillary Acidic Protein ; Green Fluorescent Proteins/genetics ; Hedgehog Proteins/antagonists & inhibitors ; In Situ Nick-End Labeling/methods ; Intercellular Signaling Peptides and Proteins/pharmacology ; Intermediate Filament Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation/genetics ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Nestin ; Neurogenesis/genetics ; RNA, Messenger/metabolism ; SOXB1 Transcription Factors/deficiency ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Wnt3 Protein ; Wnt3A Protein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 33

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