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Wyszukujesz frazę ""VIRAL nonstructural proteins"" wg kryterium: Temat


Tytuł :
Identification and characterization of new potent inhibitors of dengue virus NS5 proteinase from Andrographis paniculata supercritical extracts on in animal cell culture and in silico approaches.
Autorzy :
Kaushik S; Department of Genetics, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Dar L; All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Kaushik S; Centre for Biotechnology, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Yadav JP; Department of Genetics, Maharshi Dayanand University, Rohtak, 124001, Haryana, India. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113541. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Andrographis*/chemistry
Molecular Docking Simulation*
Antiviral Agents/*pharmacology
Dengue/*prevention & control
Dengue Virus/*drug effects
Diterpenes/*pharmacology
Enzyme Inhibitors/*pharmacology
Plant Extracts/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Aedes ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; Cell Line ; Dengue/virology ; Dengue Virus/enzymology ; Dengue Virus/growth & development ; Diterpenes/chemistry ; Diterpenes/isolation & purification ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Plant Extracts/isolation & purification ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Autorzy :
Kim Y; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.
Wower J; Department of Animal Sciences, Auburn University, Auburn, AL, 36849, USA.
Maltseva N; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.
Chang C; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.
Jedrzejczak R; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.
Wilamowski M; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60367, USA.
Kang S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, 60367, USA.
Nicolaescu V; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, 60367, USA.
Randall G; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, 60367, USA.
Michalska K; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.
Joachimiak A; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667, USA. .; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA. .; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60367, USA. .
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Źródło :
Communications biology [Commun Biol] 2021 Feb 09; Vol. 4 (1), pp. 193. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
COVID-19/*virology
Endoribonucleases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Pyrrolidines/*pharmacology
SARS-CoV-2/*drug effects
SARS-CoV-2/*enzymology
Thymine/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
A549 Cells ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Catalytic Domain ; Crystallography, X-Ray ; Endoribonucleases/chemistry ; Endoribonucleases/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Ligands ; Models, Molecular ; Protein Conformation ; Pyrrolidines/chemistry ; Pyrrolidines/pharmacokinetics ; Thymine/chemistry ; Thymine/pharmacokinetics ; Uridine/metabolism ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs.
Autorzy :
Narayanan N; Laboratory of Genomic Integrity and Evolution, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad 121001, Haryana, India; Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Nair DT; Laboratory of Genomic Integrity and Evolution, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad 121001, Haryana, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jan 31; Vol. 168, pp. 272-278. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Exoribonucleases/*antagonists & inhibitors
Ritonavir/*pharmacology
SARS-CoV-2/*drug effects
Viral Nonstructural Proteins/*antagonists & inhibitors
Amino Acid Sequence ; Antiviral Agents/administration & dosage ; Antiviral Agents/chemistry ; COVID-19/virology ; Catalytic Domain ; Computer Simulation ; Drug Evaluation, Preclinical ; Drug Synergism ; Drug Therapy, Combination ; Exoribonucleases/chemistry ; Exoribonucleases/genetics ; Genome, Viral/drug effects ; Humans ; Molecular Dynamics Simulation ; Pandemics ; Ritonavir/administration & dosage ; Ritonavir/chemistry ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.
Autorzy :
Pillon MC; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA. .; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA. .
Frazier MN; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Dillard LB; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Williams JG; Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Kocaman S; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Krahn JM; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Perera L; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Hayne CK; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Gordon J; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.; Cambridge Institute for Medical Research, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
Stewart ZD; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Sobhany M; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Deterding LJ; Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Hsu AL; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Dandey VP; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Borgnia MJ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
Stanley RE; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 27; Vol. 12 (1), pp. 636. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoribonucleases/*chemistry
Endoribonucleases/*ultrastructure
SARS-CoV-2/*enzymology
Viral Nonstructural Proteins/*chemistry
Viral Nonstructural Proteins/*ultrastructure
Amino Acid Sequence ; Catalytic Domain ; Cryoelectron Microscopy ; Endoribonucleases/metabolism ; Models, Chemical ; Models, Molecular ; SARS-CoV-2/chemistry ; Uridine Triphosphate/metabolism ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Role of Chikungunya nsP3 in Regulating G3BP1 Activity, Stress Granule Formation and Drug Efficacy.
Autorzy :
Lu X; Griffith Institute for Drug Discovery, Nathan, Australia; School of Environment and Sciences, Griffith University, Brisbane, Australia.
Alam U; Griffith Institute for Drug Discovery, Nathan, Australia; School of Environment and Sciences, Griffith University, Brisbane, Australia.
Willis C; School of Environment and Sciences, Griffith University, Brisbane, Australia.
Kennedy D; Griffith Institute for Drug Discovery, Nathan, Australia; School of Environment and Sciences, Griffith University, Brisbane, Australia. Electronic address: .
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Źródło :
Archives of medical research [Arch Med Res] 2021 Jan; Vol. 52 (1), pp. 48-57. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Bortezomib/*pharmacology
Chikungunya Fever/*drug therapy
Chikungunya virus/*genetics
Cytoplasmic Granules/*metabolism
DNA Helicases/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
RNA Helicases/*metabolism
RNA Recognition Motif Proteins/*metabolism
Viral Nonstructural Proteins/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Chikungunya Fever/metabolism ; Chikungunya Fever/pathology ; Chikungunya virus/metabolism ; Chlorocebus aethiops ; Cytoplasmic Granules/drug effects ; Cytoplasmic Granules/pathology ; DNA Helicases/genetics ; Down-Regulation ; Drug Resistance, Neoplasm ; Female ; HEK293 Cells ; HeLa Cells ; Humans ; MCF-7 Cells ; Poly-ADP-Ribose Binding Proteins/genetics ; RNA Helicases/genetics ; RNA Recognition Motif Proteins/genetics ; Transfection ; Vero Cells ; Viral Nonstructural Proteins/administration & dosage ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Structural and functional insights into non-structural proteins of coronaviruses.
Autorzy :
Rohaim MA; Department of Virology, Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, UK. Electronic address: .
El Naggar RF; Department of Virology, Faculty of Veterinary Medicine, University of Sadat City, 32897, Sadat, Egypt. Electronic address: .
Clayton E; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, UK. Electronic address: .
Munir M; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, UK. Electronic address: .
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Źródło :
Microbial pathogenesis [Microb Pathog] 2021 Jan; Vol. 150, pp. 104641. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Coronavirus/*physiology
Viral Nonstructural Proteins/*chemistry
Viral Nonstructural Proteins/*metabolism
Animals ; COVID-19/virology ; Coronavirus/chemistry ; Coronavirus/genetics ; Coronavirus/metabolism ; Genome, Viral ; Humans ; Structure-Activity Relationship ; Viral Nonstructural Proteins/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Pharmacoinformatics approach based identification of potential Nsp15 endoribonuclease modulators for SARS-CoV-2 inhibition.
Autorzy :
Savale RU; Department of Bioinformatics, Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth Deemed University, Pune-Satara Road, Pune, India.
Bhowmick S; Department of Chemical Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India.
Osman SM; Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia. Electronic address: .
Alasmary FA; Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Almutairi TM; Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Abdullah DS; Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Patil PC; Department of Bioinformatics, Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth Deemed University, Pune-Satara Road, Pune, India.
Islam MA; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom; School of Health Sciences, University of Kwazulu-Natal, Westville Campus, Durban, South Africa; Department of Chemical Pathology, Faculty of Health Sciences, University of Pretoria and National Health Laboratory Service Tshwane Academic Division, Pretoria, South Africa. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Mar 30; Vol. 700, pp. 108771. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
COVID-19/*virology
Endoribonucleases/*antagonists & inhibitors
SARS-CoV-2/*drug effects
SARS-CoV-2/*enzymology
Viral Nonstructural Proteins/*antagonists & inhibitors
Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; COVID-19/metabolism ; Databases, Chemical ; Drug Evaluation, Preclinical ; Endoribonucleases/chemistry ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Enzyme Inhibitors/pharmacology ; Humans ; In Vitro Techniques ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; User-Computer Interface ; Viral Nonstructural Proteins/chemistry
Czasopismo naukowe
Tytuł :
Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation.
Autorzy :
Lapointe CP; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Grosely R; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Johnson AG; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305.
Wang J; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Fernández IS; Department of Biochemistry and Molecular Biophysics, Columbia University, New York City, NY 10032.
Puglisi JD; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Feb 09; Vol. 118 (6).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
COVID-19/*genetics
COVID-19/*metabolism
COVID-19/*virology
RNA, Messenger/*metabolism
Ribosomes/*metabolism
SARS-CoV-2/*metabolism
Viral Nonstructural Proteins/*metabolism
Eukaryotic Initiation Factors/metabolism ; Humans ; Pandemics ; Peptide Chain Initiation, Translational/genetics ; Protein Biosynthesis ; Protein Processing, Post-Translational ; RNA, Messenger/genetics ; RNA, Viral/genetics ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosome Subunits, Small, Eukaryotic/metabolism ; Ribosomes/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit.
Autorzy :
Slanina H; Institute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.
Madhugiri R; Institute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.
Bylapudi G; Institute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.
Schultheiß K; Institute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.
Karl N; Institute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany.
Gulyaeva A; Department of Medical Microbiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Gorbalenya AE; Department of Medical Microbiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.
Linne U; Mass Spectrometry Facility, Department of Chemistry, Philipps University Marburg, 35043 Marburg, Germany.
Ziebuhr J; Institute of Medical Virology, Justus Liebig University Giessen, 35392 Giessen, Germany; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Feb 09; Vol. 118 (6).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Coronavirus 229E, Human/*genetics
RNA-Binding Proteins/*metabolism
SARS-CoV-2/*genetics
Viral Nonstructural Proteins/*metabolism
Amino Acid Sequence ; Amino Acid Substitution ; Asparagine/genetics ; Cell Line ; Conserved Sequence ; Coronavirus 229E, Human/physiology ; Coronavirus RNA-Dependent RNA Polymerase/genetics ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Humans ; Manganese/metabolism ; Protein Domains ; RNA-Binding Proteins/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Transcription, Genetic ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Drug designing against NSP15 of SARS-COV2 via high throughput computational screening and structural dynamics approach.
Autorzy :
Batool A; Department of Bioinformatics Shaheed Benazir Bhutto Women University, Peshawar, Pakistan.
Bibi N; Department of Bioinformatics Shaheed Benazir Bhutto Women University, Peshawar, Pakistan. Electronic address: .
Amin F; Department of Bioinformatics Shaheed Benazir Bhutto Women University, Peshawar, Pakistan.
Kamal MA; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia; Novel Global Community Educational Foundation, Australia.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Feb 05; Vol. 892, pp. 173779. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
SARS-CoV-2*
Antiviral Agents/*pharmacology
Benzamides/*pharmacology
COVID-19/*metabolism
Endoribonucleases/*metabolism
Piperidines/*pharmacology
Viral Nonstructural Proteins/*metabolism
Antiviral Agents/pharmacokinetics ; Antiviral Agents/toxicity ; Benzamides/pharmacokinetics ; Drug Design ; Endoribonucleases/chemistry ; High-Throughput Screening Assays ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Piperidines/pharmacokinetics ; Viral Nonstructural Proteins/chemistry
Czasopismo naukowe
Tytuł :
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression.
Autorzy :
Zhang K; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Makio T; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Dehghan I; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Gao S; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Xie Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37235, USA.
Zhong H; Department of Biological Sciences, Hunter College, New York, NY 10065, USA.
Esparza M; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kehrer T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kumar A; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Hobman TC; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Ptak C; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Gao B; Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Minna JD; Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chen Z; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ren Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37235, USA.
Wozniak RW; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Fontoura BMA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. .
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Źródło :
Science advances [Sci Adv] 2021 Feb 05; Vol. 7 (6). Date of Electronic Publication: 2021 Feb 05 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression*
COVID-19/*metabolism
Host Microbial Interactions/*genetics
RNA, Messenger/*metabolism
SARS-CoV-2/*metabolism
Viral Nonstructural Proteins/*metabolism
Virulence Factors/*metabolism
Active Transport, Cell Nucleus/genetics ; Animals ; COVID-19/virology ; Chlorocebus aethiops ; HEK293 Cells ; Humans ; Nuclear Pore/metabolism ; Nucleocytoplasmic Transport Proteins/genetics ; Nucleocytoplasmic Transport Proteins/metabolism ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; SARS-CoV-2/chemistry ; Transfection ; Vero Cells ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Dengue diagnostics: serious inaccuracies are likely to occur if pre-analytical conditions are not strictly followed.
Autorzy :
Iani FCM; Fundação Ezequiel Dias, Diretoria do Instituto Octávio Magalhães, Serviço de Virologia e Riquetsioses, Belo Horizonte, MG, Brasil.
Caetano ACB; Centro Universitário de Belo Horizonte, Belo Horizonte, MG, Brasil.
Cocovich JCW; Centro Universitário de Belo Horizonte, Belo Horizonte, MG, Brasil.
Amâncio FF; Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Belo Horizonte, MG, Brasil.
Pereira MA; Fundação Ezequiel Dias, Diretoria do Instituto Octávio Magalhães, Serviço de Virologia e Riquetsioses, Belo Horizonte, MG, Brasil.
Adelino TÉR; Fundação Ezequiel Dias, Diretoria do Instituto Octávio Magalhães, Serviço de Virologia e Riquetsioses, Belo Horizonte, MG, Brasil.
Caldas S; Fundação Ezequiel Dias, Diretoria de Pesquisa e Desenvolvimento, Serviço de Biotecnologia e Saúde, Belo Horizonte, MG, Brasil.
Silva MVF; Fundação Ezequiel Dias, Diretoria do Instituto Octávio Magalhães, Serviço de Virologia e Riquetsioses, Belo Horizonte, MG, Brasil.
Pereira GC; Fundação Ezequiel Dias, Diretoria do Instituto Octávio Magalhães, Serviço de Virologia e Riquetsioses, Belo Horizonte, MG, Brasil.
Duarte MM; Fundação Ezequiel Dias, Diretoria do Instituto Octávio Magalhães, Serviço de Virologia e Riquetsioses, Belo Horizonte, MG, Brasil.
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Źródło :
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2021 Jan 29; Vol. 115, pp. e200287. Date of Electronic Publication: 2021 Jan 29 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Viral/*blood
Dengue/*diagnosis
Dengue Virus/*isolation & purification
Enzyme-Linked Immunosorbent Assay/*methods
Immunologic Tests/*methods
Reverse Transcriptase Polymerase Chain Reaction/*methods
Viral Nonstructural Proteins/*immunology
Antibodies, Viral/blood ; Antigens, Viral/immunology ; Dengue/blood ; Dengue/virology ; Dengue Virus/genetics ; Dengue Virus/immunology ; Humans ; Predictive Value of Tests ; Sensitivity and Specificity ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Structure of Nonstructural Protein 1 from SARS-CoV-2.
Autorzy :
Clark LK; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Green TJ; Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA .
Petit CM; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA .
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Źródło :
Journal of virology [J Virol] 2021 Jan 28; Vol. 95 (4). Date of Electronic Publication: 2021 Jan 28 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19/*virology
SARS-CoV-2/*chemistry
Viral Nonstructural Proteins/*chemistry
Amino Acid Sequence ; Cell Line ; Crystallography, X-Ray ; Humans ; Protein Conformation ; SARS-CoV-2/genetics ; Sequence Alignment ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice.
Autorzy :
Gutierrez-Alvarez J; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain.
Wang L; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain.
Fernandez-Delgado R; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain.
Li K; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
McCray PB Jr; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Perlman S; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Sola I; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain.
Zuñiga S; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain .
Enjuanes L; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain .
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Źródło :
Journal of virology [J Virol] 2021 Jan 13; Vol. 95 (3). Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Coronavirus Infections/*virology
Middle East Respiratory Syndrome Coronavirus/*pathogenicity
Viral Nonstructural Proteins/*metabolism
Animals ; Cell Line ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Cytokines/metabolism ; DNA, Complementary/genetics ; Dipeptidyl Peptidase 4/genetics ; Genome, Viral/genetics ; Humans ; Immunity, Innate ; Lung/immunology ; Lung/pathology ; Lung/virology ; Mice ; Mice, Transgenic ; Middle East Respiratory Syndrome Coronavirus/genetics ; Mutation ; Viral Load ; Viral Nonstructural Proteins/genetics ; Virulence/genetics
Czasopismo naukowe
Tytuł :
The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase.
Autorzy :
Alhammad YMO; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Kashipathy MM; Protein Structure Laboratory, University of Kansas, Lawrence, Kansas, USA.
Roy A; High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, USA.
Gagné JP; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Québec City, Quebec, Canada.; Oncology Division, CHU de Québec Research Center, Québec City, Quebec, Canada.
McDonald P; High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, USA.
Gao P; Protein Production Group, University of Kansas, Lawrence, Kansas, USA.
Nonfoux L; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Québec City, Quebec, Canada.; Oncology Division, CHU de Québec Research Center, Québec City, Quebec, Canada.
Battaile KP; NYX, New York Structural Biology Center, Upton, New York, USA.
Johnson DK; Molecular Graphics and Modeling Laboratory and the Computational Chemical Biology Core, University of Kansas, Lawrence, Kansas, USA.
Holmstrom ED; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Poirier GG; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Québec City, Quebec, Canada.; Oncology Division, CHU de Québec Research Center, Québec City, Quebec, Canada.
Lovell S; Protein Structure Laboratory, University of Kansas, Lawrence, Kansas, USA.
Fehr AR; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA .
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Źródło :
Journal of virology [J Virol] 2021 Jan 13; Vol. 95 (3). Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
N-Glycosyl Hydrolases/*metabolism
SARS-CoV-2/*enzymology
Viral Nonstructural Proteins/*metabolism
Adenosine Diphosphate Ribose/chemistry ; Adenosine Diphosphate Ribose/metabolism ; Amino Acid Sequence ; Coronavirus/chemistry ; Coronavirus/enzymology ; Coronavirus/metabolism ; Crystallography, X-Ray ; Humans ; Hydrolysis ; Kinetics ; N-Glycosyl Hydrolases/chemistry ; Protein Binding ; Protein Domains ; SARS-CoV-2/chemistry ; SARS-CoV-2/metabolism ; Viral Nonstructural Proteins/chemistry
Czasopismo naukowe
Tytuł :
ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4.
Autorzy :
Hammond RG; Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294.
Schormann N; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
McPherson RL; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
Leung AKL; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.; Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287.
Deivanayagam CCS; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
Johnson MA; Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 12; Vol. 118 (2).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adenosine Diphosphate Ribose/*chemistry
Coronavirus/*enzymology
Pyrophosphatases/*chemistry
Viral Nonstructural Proteins/*chemistry
Animals ; Binding Sites ; Chiroptera ; Coronavirus/genetics ; Crystallography, X-Ray ; Hydrolysis ; Pyrophosphatases/genetics ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
A broadly protective antibody that targets the flavivirus NS1 protein.
Autorzy :
Modhiran N; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Song H; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
Liu L; Division of Laboratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Bletchly C; Microbiology, Pathology Queensland, Queensland Health, Herston, Queensland, Australia.
Brillault L; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.; Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Australia.
Amarilla AA; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Xu X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Qi J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Chai Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Cheung STM; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Traves R; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Setoh YX; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Bibby S; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Scott CAP; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Freney ME; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Newton ND; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Khromykh AA; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Chappell KJ; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Muller DA; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Stacey KJ; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Landsberg MJ; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Shi Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .
Gao GF; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
Young PR; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia. .
Watterson D; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 08; Vol. 371 (6525), pp. 190-194.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*chemistry
Antibodies, Viral/*chemistry
Dengue Virus/*immunology
Viral Nonstructural Proteins/*immunology
West Nile virus/*immunology
Zika Virus/*immunology
Animals ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; CHO Cells ; Cell Line ; Cricetulus ; Cross Reactions ; Dengue/prevention & control ; Dengue/therapy ; Disease Models, Animal ; Humans ; Mice ; Protein Domains ; Viral Nonstructural Proteins/chemistry ; Viremia/therapy ; West Nile Fever/prevention & control ; West Nile Fever/therapy ; Zika Virus Infection/prevention & control ; Zika Virus Infection/therapy
Czasopismo naukowe
Tytuł :
Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
Autorzy :
Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Akey DL; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Wong MP; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.; Infectious Diseases and Immunity Graduate Group, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Brown WC; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Lo NTN; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.; Infectious Diseases and Immunity Graduate Group, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Puerta-Guardo H; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Tramontini Gomes de Sousa F; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Wang C; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Konwerski JR; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Espinosa DA; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Bockhaus NJ; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Glasner DR; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Li J; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Blanc SF; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Juan EY; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Elledge SJ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, and Program in Virology, Harvard Medical School, Boston, MA 02115, USA.
Mina MJ; Center for Communicable Disease Dynamics, Department of Epidemiology, and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Beatty PR; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Smith JL; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. .; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 08; Vol. 371 (6525), pp. 194-200.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*chemistry
Antibodies, Viral/*chemistry
Dengue Virus/*immunology
Viral Nonstructural Proteins/*immunology
West Nile virus/*immunology
Zika Virus/*immunology
Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Cross Reactions ; Crystallography, X-Ray ; Dengue/prevention & control ; Dengue/therapy ; Endothelium/immunology ; Glycocalyx/immunology ; Humans ; Mice ; Protein Conformation, beta-Strand ; Protein Domains ; Viral Nonstructural Proteins/chemistry ; West Nile Fever/prevention & control ; West Nile Fever/therapy ; Zika Virus Infection/prevention & control ; Zika Virus Infection/therapy
Czasopismo naukowe
Tytuł :
Lysine 164 is critical for SARS-CoV-2 Nsp1 inhibition of host gene expression.
Autorzy :
Shen Z; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, PR China.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China.
Zhang G; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China.
Yang Y; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, PR China.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China.
Li M; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, PR China.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China.
Yang S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China.
Peng G; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, PR China.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China.
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Źródło :
The Journal of general virology [J Gen Virol] 2021 Jan; Vol. 102 (1). Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Host-Pathogen Interactions/*genetics
Lysine/*genetics
Ribosomal Proteins/*genetics
Ribosome Subunits, Small, Eukaryotic/*genetics
SARS-CoV-2/*genetics
Viral Nonstructural Proteins/*genetics
Amino Acid Sequence ; Amino Acid Substitution ; Computational Biology/methods ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Regulation ; Genes, Reporter ; HEK293 Cells ; Humans ; Luciferases/genetics ; Luciferases/metabolism ; Lysine/metabolism ; Mutation ; Ribosomal Proteins/antagonists & inhibitors ; Ribosomal Proteins/metabolism ; Ribosome Subunits, Small, Eukaryotic/metabolism ; Ribosome Subunits, Small, Eukaryotic/virology ; SARS Virus/genetics ; SARS Virus/metabolism ; SARS-CoV-2/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Signal Transduction ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 nucleocapsid and Nsp3 binding: an in silico study.
Autorzy :
Khan MT; Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan.
Zeb MT; Senior Research Officer, In-Charge Genomic Laboratory, Veterinary Research Institute, Peshawar, 25000, Pakistan.
Ahsan H; Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Ahmed A; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Ali A; 1-State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, and Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District China, Shanghai, 200240, China.; 2-Peng Cheng Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nanshan District, Shenzhen, 518055, Guangdong, China.
Akhtar K; National University of Science and Technology, Islamabad, Pakistan.
Malik SI; Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan.
Cui Z; Department of Respiratory Medicine, XinHua Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, CN 200025, China.
Ali S; Quaid-I-Azam University Islamabad, Islamabad, Pakistan.
Khan AS; Department of Microbiology, Kohat University of Science and Technology, Kohat, Pakistan.
Ahmad M; School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Wei DQ; 1-State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, and Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District China, Shanghai, 200240, China. .; 2-Peng Cheng Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nanshan District, Shenzhen, 518055, Guangdong, China. .
Irfan M; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.
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Źródło :
Archives of microbiology [Arch Microbiol] 2021 Jan; Vol. 203 (1), pp. 59-66. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Coronavirus Nucleocapsid Proteins/*metabolism
Coronavirus Papain-Like Proteases/*metabolism
SARS-CoV-2/*metabolism
Viral Nonstructural Proteins/*metabolism
COVID-19/drug therapy ; Computer Simulation ; Coronavirus Nucleocapsid Proteins/genetics ; Coronavirus Papain-Like Proteases/genetics ; Crystallography, X-Ray ; Drug Design ; Genome, Viral ; Humans ; Molecular Docking Simulation ; Nucleocapsid/metabolism ; Protein Binding/physiology ; RNA-Binding Proteins/metabolism ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe

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