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Tytuł :
Non-canonical endogenous expression of voltage-gated sodium channel Na V 1.7 subtype by the TE671 rhabdomyosarcoma cell line.
Autorzy :
Ngum NM; School of Life Sciences, University of Nottingham, Nottingham, UK.
Aziz MYA; School of Life Sciences, University of Nottingham, Nottingham, UK.
Mohammed Latif L; School of Life Sciences, University of Nottingham, Nottingham, UK.
Wall RJ; School of Life Sciences, University of Nottingham, Nottingham, UK.
Duce IR; School of Life Sciences, University of Nottingham, Nottingham, UK.
Mellor IR; School of Life Sciences, University of Nottingham, Nottingham, UK.
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Źródło :
The Journal of physiology [J Physiol] 2022 May; Vol. 600 (10), pp. 2499-2513. Date of Electronic Publication: 2022 Apr 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebellar Neoplasms*
Rhabdomyosarcoma*/genetics
Voltage-Gated Sodium Channels*/genetics
Cell Line ; Humans ; NAV1.4 Voltage-Gated Sodium Channel ; NAV1.6 Voltage-Gated Sodium Channel/metabolism ; NAV1.7 Voltage-Gated Sodium Channel/genetics ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Pain ; Sodium/metabolism ; Sodium Channel Blockers/pharmacology ; Tetrodotoxin/pharmacology
Czasopismo naukowe
Tytuł :
The effect of the voltage-gated sodium channel Na V 1.7 blocker PF-05089771 on cough in the guinea pig.
Autorzy :
Brozmanova M; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. Electronic address: .
Buday T; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Konarska M; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Plevkova J; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. Electronic address: .
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Źródło :
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2022 May; Vol. 299, pp. 103856. Date of Electronic Publication: 2022 Jan 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antitussive Agents*/pharmacology
Antitussive Agents*/therapeutic use
Voltage-Gated Sodium Channels*/physiology
Animals ; Cough/drug therapy ; Guinea Pigs ; Phenyl Ethers ; Sulfonamides ; Voltage-Gated Sodium Channel Blockers/pharmacology ; Voltage-Gated Sodium Channel Blockers/therapeutic use
Czasopismo naukowe
Tytuł :
Design, Synthesis, and Evaluation of Novel Benzo[ d ]isoxazole Derivatives as Anticonvulsants by Selectively Blocking the Voltage-Gated Sodium Channel Na V 1.1.
Autorzy :
Huang X; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Dong S; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Liu H; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Wan P; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Wang T; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang 330006, China.
Quan H; School of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Wang Z; School of Information and Control, Shenyang Institute of Technology, Shenyang 113122, China.
Wang Z; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.; Nanchang Yichou Technology Co., Ltd, Nanchang 330036, China.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2022 Mar 16; Vol. 13 (6), pp. 834-845. Date of Electronic Publication: 2022 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anticonvulsants*/pharmacology
Voltage-Gated Sodium Channels*
Humans ; Isoxazoles ; NAV1.7 Voltage-Gated Sodium Channel ; Seizures/chemically induced ; Seizures/drug therapy ; Sodium Channel Blockers/pharmacology ; Voltage-Gated Sodium Channel Blockers/pharmacology
Czasopismo naukowe
Tytuł :
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms.
Autorzy :
Mancino AS; Integrated Program in Neuroscience, McGill University, Montréal, Quebec, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.
Glass WG; Department of Biochemistry, University of Oxford, Oxford, UK.
Yan Y; Integrated Program in Neuroscience, McGill University, Montréal, Quebec, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.
Biggin PC; Department of Biochemistry, University of Oxford, Oxford, UK.
Bowie D; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.
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Źródło :
The Journal of general physiology [J Gen Physiol] 2022 May 02; Vol. 154 (5). Date of Electronic Publication: 2022 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Voltage-Gated Sodium Channels*/metabolism
Adult ; Electrophysiological Phenomena ; Humans ; Infant, Newborn ; Molecular Dynamics Simulation ; Mutation ; NAV1.5 Voltage-Gated Sodium Channel ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł :
The diffuse distribution of Nav1.2 on mid-axonal regions is a marker for unmyelinated fibers in the central nervous system.
Autorzy :
Yamano R; Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science, 1-3 Miyakodanitatara, Kyotanabe-shi, Kyoto, 610-0394, Japan.
Miyazaki H; Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science, 1-3 Miyakodanitatara, Kyotanabe-shi, Kyoto, 610-0394, Japan. Electronic address: .
Nukina N; Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science, 1-3 Miyakodanitatara, Kyotanabe-shi, Kyoto, 610-0394, Japan. Electronic address: .
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Źródło :
Neuroscience research [Neurosci Res] 2022 Apr; Vol. 177, pp. 145-150. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Axons*/physiology
Voltage-Gated Sodium Channels*
Central Nervous System ; Immunohistochemistry ; NAV1.2 Voltage-Gated Sodium Channel
Czasopismo naukowe
Tytuł :
The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na V 1.7 via the Ubiquitin-Ligase NEDD4-2.
Autorzy :
Deftu AF; Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Chu Sin Chung P; Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Laedermann CJ; Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Gillet L; Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Pertin M; Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Kirschmann G; Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Decosterd I; Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland .; Department of Fundamental Neurosciences, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland.
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Źródło :
ENeuro [eNeuro] 2022 Mar 04; Vol. 9 (2). Date of Electronic Publication: 2022 Mar 04 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metformin*/metabolism
Metformin*/pharmacology
Voltage-Gated Sodium Channels*/metabolism
Animals ; Ganglia, Spinal/metabolism ; Hypoglycemic Agents/pharmacology ; Mice ; NAV1.8 Voltage-Gated Sodium Channel/metabolism ; Nedd4 Ubiquitin Protein Ligases/metabolism ; Ubiquitin/metabolism ; Ubiquitin/pharmacology ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Histamine Sensitization of the Voltage-Gated Sodium Channel Nav1.7 Contributes to Histaminergic Itch in Mice.
Autorzy :
Li S; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Ding M; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Wu Y; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Xue S; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Ji Y; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Zhang P; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Zhang Z; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Cao Z; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Zhang F; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2022 Mar 02; Vol. 13 (5), pp. 700-710. Date of Electronic Publication: 2022 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Histamine*/metabolism
Voltage-Gated Sodium Channels*/metabolism
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Ganglia, Spinal/metabolism ; Humans ; Mice ; NAV1.7 Voltage-Gated Sodium Channel/genetics ; Tetrodotoxin/pharmacology
Czasopismo naukowe
Tytuł :
Scn1b expression in the adult mouse heart modulates Na entry and diastolic function.
Autorzy :
Cervantes DO; Department of Physiology, New York Medical College, Valhalla, New York.
Pizzo E; Department of Physiology, New York Medical College, Valhalla, New York.
Ketkar H; Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York.
Parambath SP; Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York.
Tang S; Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York.
Cianflone E; Department of Physiology, New York Medical College, Valhalla, New York.; Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Cannata A; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, London, United Kingdom.
Vinukonda G; Department of Pediatrics, New York Medical College, Valhalla, New York.
Jain S; Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York.
Jacobson JT; Department of Physiology, New York Medical College, Valhalla, New York.; Department of Cardiology, Westchester Medical Center, Valhalla, New York.
Rota M; Department of Physiology, New York Medical College, Valhalla, New York.
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2022 Jun 01; Vol. 322 (6), pp. H975-H993. Date of Electronic Publication: 2022 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Sodium*/metabolism
Voltage-Gated Sodium Channels*/metabolism
Action Potentials ; Animals ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Diastole ; Mice ; Myocytes, Cardiac/metabolism ; Voltage-Gated Sodium Channel beta-1 Subunit/genetics ; Voltage-Gated Sodium Channel beta-1 Subunit/metabolism
Czasopismo naukowe
Tytuł :
Neonatal Na V 1.5 channels: pharmacological distinctiveness of a cancer-related voltage-gated sodium channel splice variant.
Autorzy :
Fraser SP; Department of Life Sciences, Neuroscience Solutions to Cancer Research Group, Imperial College London, London, UK.
Onkal R; Department of Life Sciences, Neuroscience Solutions to Cancer Research Group, Imperial College London, London, UK.; Biotechnology Research Centre, Cyprus International University, Mersin 10, Turkey.
Theys M; Department of Basic and Applied Medical Sciences, University of Ghent, Ghent, Belgium.
Bosmans F; Department of Basic and Applied Medical Sciences, University of Ghent, Ghent, Belgium.
Djamgoz MBA; Department of Life Sciences, Neuroscience Solutions to Cancer Research Group, Imperial College London, London, UK.; Biotechnology Research Centre, Cyprus International University, Mersin 10, Turkey.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2022 Feb; Vol. 179 (3), pp. 473-486. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma*
Spider Venoms*/chemistry
Voltage-Gated Sodium Channels*/metabolism
Humans ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Voltage-Gated Sodium Channel Blockers/chemistry ; Voltage-Gated Sodium Channel Blockers/pharmacology
Czasopismo naukowe
Tytuł :
The small molecule compound C65780 alleviates pain by stabilizing voltage-gated sodium channels in the inactivated and slowly-recovering state.
Autorzy :
Kong X; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
Li Y; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
Perez-Miller S; Department of Molecular Pathobiology, College of Dentistry, New York University, 433 1(St) Avenue, New York, NY, 10010, USA.
Luo G; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
Liao Q; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
Wu X; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
Liang S; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
Tang C; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China. Electronic address: .
Khanna R; Department of Molecular Pathobiology, College of Dentistry, New York University, 433 1(St) Avenue, New York, NY, 10010, USA; College of Dentistry, New York University and NYU Pain Research Center, New York University, 433 1(St) Avenue, New York, NY, 10010, USA. Electronic address: .
Liu Z; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2022 Jul 01; Vol. 212, pp. 109057. Date of Electronic Publication: 2022 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Neuralgia*
Voltage-Gated Sodium Channels*
Action Potentials ; Amitriptyline ; Analgesics/pharmacology ; Animals ; Ganglia, Spinal/metabolism ; Mice ; NAV1.7 Voltage-Gated Sodium Channel/metabolism
Czasopismo naukowe
Tytuł :
Knockdown of rno_circRNA_009194 Improves Outcomes in Traumatic Brain Injury Rats through Inhibiting Voltage-Gated Sodium Channel Nav1.3.
Autorzy :
Huang XJ; Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Su GJ; Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Wu CW; Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Sha XS; Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Zou JF; Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Liu XS; Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Li M; Department of Radiology, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
He Y; Department of Intensive Care Unit, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
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Źródło :
Journal of neurotrauma [J Neurotrauma] 2022 Jan; Vol. 39 (1-2), pp. 196-210. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Injuries, Traumatic*/genetics
Brain Injuries, Traumatic*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Voltage-Gated Sodium Channels*/genetics
Voltage-Gated Sodium Channels*/metabolism
Animals ; Down-Regulation ; Hippocampus/metabolism ; NAV1.3 Voltage-Gated Sodium Channel ; RNA, Circular/genetics ; Rats
Czasopismo naukowe
Tytuł :
Differences in local anaesthetic and antiepileptic binding in the inactivated state of human sodium channel Nav1.4.
Autorzy :
Buyan A; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
Whitfield AA; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
Corry B; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 Dec 21; Vol. 120 (24), pp. 5553-5563. Date of Electronic Publication: 2021 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anesthetics, Local*/chemistry
Anesthetics, Local*/metabolism
Anesthetics, Local*/pharmacology
Voltage-Gated Sodium Channels*/metabolism
Anti-Arrhythmia Agents/pharmacology ; Anticonvulsants ; Binding Sites ; Humans ; Lidocaine/chemistry ; Lidocaine/metabolism ; Lidocaine/pharmacology ; NAV1.4 Voltage-Gated Sodium Channel ; Sodium Channel Blockers/chemistry ; Sodium Channel Blockers/metabolism ; Sodium Channel Blockers/pharmacology
Czasopismo naukowe
Tytuł :
Investigation of binding modes of spider toxin-human voltage-gated sodium channel subtybe 1.7.
Autorzy :
Gao S; Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, Jilin University, Changchun, China.
Na R; College of plant protection, Henan Agricultural University, Zhengzhou, P.R China.
Yang L; Department of Mycology, Shanghai Dermatology Hospital, Shanghai, China.
Yu H; College of Science, Beihua Univesrity, Jilin, China.
Zhao X; Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, Jilin University, Changchun, China.
Huang X; College of plant protection, Henan Agricultural University, Zhengzhou, P.R China.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Sep; Vol. 39 (14), pp. 4981-4989. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Spider Venoms*
Voltage-Gated Sodium Channels*/genetics
Biophysical Phenomena ; Humans ; Molecular Docking Simulation ; NAV1.7 Voltage-Gated Sodium Channel ; Peptides
Czasopismo naukowe
Tytuł :
MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord.
Autorzy :
Sun L; The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Xia R; The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Jiang J; The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Wen T; The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Huang Z; The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Qian R; The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Zhang MD; Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, Stockholm, 17177, Sweden.
Zhou M; The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Peng C; The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China. Electronic address: .
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Źródło :
Progress in neurobiology [Prog Neurobiol] 2021 Jul; Vol. 202, pp. 102024. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MicroRNAs*/genetics
Neuralgia*
Voltage-Gated Sodium Channels*
Animals ; Calcium Channels ; Ganglia, Spinal ; Hyperalgesia/drug therapy ; Mice ; NAV1.8 Voltage-Gated Sodium Channel/genetics ; NAV1.9 Voltage-Gated Sodium Channel ; Rats ; Rats, Sprague-Dawley ; Spinal Cord
Czasopismo naukowe
Tytuł :
Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.
Autorzy :
Nguyen HX; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Wu T; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Needs D; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Zhang H; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Perelli RM; Department of Pediatrics, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
DeLuca S; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Yang R; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Tian M; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Landstrom AP; Department of Pediatrics, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Henriquez C; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Bursac N; Department of Biomedical Engineering, Duke University, Durham, NC, USA. .
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Źródło :
Nature communications [Nat Commun] 2022 Feb 02; Vol. 13 (1), pp. 620. Date of Electronic Publication: 2022 Feb 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arrhythmias, Cardiac/*physiopathology
Arrhythmias, Cardiac/*therapy
Muscle Proteins/*genetics
Myocytes, Cardiac/*physiology
Voltage-Gated Sodium Channels/*metabolism
Action Potentials/physiology ; Animals ; Cardiac Electrophysiology ; Female ; Genetic Therapy ; HEK293 Cells ; Humans ; Male ; Mice ; Muscle Proteins/metabolism ; NAV1.5 Voltage-Gated Sodium Channel/genetics ; NAV1.5 Voltage-Gated Sodium Channel/metabolism ; Rats ; Rats, Sprague-Dawley ; Voltage-Gated Sodium Channels/genetics
Czasopismo naukowe
Tytuł :
Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel.
Autorzy :
Yang X; Department of Basic Medicine, Chuxiong Medical College, Chuxiong, 675005, China. Electronic address: .
Dai Y; Department of Basic Medicine, Chuxiong Medical College, Chuxiong, 675005, China.
Ji Z; Department of Basic Medicine, Chuxiong Medical College, Chuxiong, 675005, China.
Zhang X; Department of Basic Medicine, Chuxiong Medical College, Chuxiong, 675005, China.
Fu W; Department of Basic Medicine, Chuxiong Medical College, Chuxiong, 675005, China.
Han C; Department of Basic Medicine, Chuxiong Medical College, Chuxiong, 675005, China.
Xu Y; Department of Basic Medicine, Chuxiong Medical College, Chuxiong, 675005, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Dec 05; Vol. 281, pp. 114495. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Chive*
Analgesics/*therapeutic use
Pain/*drug therapy
Plant Extracts/*therapeutic use
Voltage-Gated Sodium Channel Blockers/*therapeutic use
Acetic Acid ; Analgesics/pharmacology ; Animals ; Cell Survival/drug effects ; Formaldehyde ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/physiology ; HEK293 Cells ; Hot Temperature ; Humans ; Locomotion/drug effects ; Male ; Mice, Inbred C57BL ; NAV1.7 Voltage-Gated Sodium Channel/physiology ; Nociceptors/physiology ; Pain/etiology ; Plant Extracts/pharmacology ; Plant Roots ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/physiology ; Voltage-Gated Sodium Channel Blockers/pharmacology
SCR Organism :
Allium macrostemon
Czasopismo naukowe
Tytuł :
Contributions of Na V 1.8 and Na V 1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons.
Autorzy :
Alsaloum M; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Center for Neuroscience and Regeneration Research, Yale University, West Haven, CT, USA.; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA.; Yale Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA.; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
Labau JIR; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Center for Neuroscience and Regeneration Research, Yale University, West Haven, CT, USA.; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Centre, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Liu S; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Center for Neuroscience and Regeneration Research, Yale University, West Haven, CT, USA.; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA.
Estacion M; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Center for Neuroscience and Regeneration Research, Yale University, West Haven, CT, USA.; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA.
Zhao P; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Center for Neuroscience and Regeneration Research, Yale University, West Haven, CT, USA.; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA.
Dib-Hajj F; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Center for Neuroscience and Regeneration Research, Yale University, West Haven, CT, USA.; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA.
Waxman SG; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. .; Center for Neuroscience and Regeneration Research, Yale University, West Haven, CT, USA. .; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Dec 20; Vol. 11 (1), pp. 24283. Date of Electronic Publication: 2021 Dec 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Induced Pluripotent Stem Cells/*metabolism
NAV1.8 Voltage-Gated Sodium Channel/*physiology
Neurons/*metabolism
Somatosensory Cortex/*physiology
Action Potentials/drug effects ; Autopsy ; Cell Differentiation ; Electrophysiology ; Humans ; Immunohistochemistry ; Membrane Potentials ; Mutation ; NAV1.9 Voltage-Gated Sodium Channel/physiology ; Neurosciences ; Pain ; Patch-Clamp Techniques ; Protein Isoforms ; Sensory Receptor Cells/metabolism
Czasopismo naukowe
Tytuł :
Voltage-gated sodium channel-dependent retroaxonal modulation of photoreceptor function during post-natal development in mice.
Autorzy :
Smith BJ; Department of Biology, Dalhousie University, Halifax, NS, Canada.
Côté PD; Department of Biology, Dalhousie University, Halifax, NS, Canada.; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada.
Tremblay F; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada.; Department of Physiology and Biophysics, Dalhousie University, Halifax, NS, Canada.; Izaak Walton Killam Health Centre, Halifax, NS, Canada.
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Źródło :
Developmental neurobiology [Dev Neurobiol] 2021 May; Vol. 81 (4), pp. 353-365. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electroretinography*/methods
Voltage-Gated Sodium Channels*/metabolism
Animals ; Mice ; Mice, Knockout ; NAV1.6 Voltage-Gated Sodium Channel ; Retina/metabolism ; Retinal Ganglion Cells/metabolism
Czasopismo naukowe
Tytuł :
Ca2+-dependent modulation of voltage-gated myocyte sodium channels.
Autorzy :
Salvage SC; Department of Biochemistry, University of Cambridge, Cambridge, U.K.
Habib ZF; Department of Biochemistry, University of Cambridge, Cambridge, U.K.; Physiological Laboratory, University of Cambridge, Cambridge, U.K.
Matthews HR; Physiological Laboratory, University of Cambridge, Cambridge, U.K.
Jackson AP; Department of Biochemistry, University of Cambridge, Cambridge, U.K.
Huang CL; Department of Biochemistry, University of Cambridge, Cambridge, U.K.; Physiological Laboratory, University of Cambridge, Cambridge, U.K.
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Źródło :
Biochemical Society transactions [Biochem Soc Trans] 2021 Nov 01; Vol. 49 (5), pp. 1941-1961.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Calcium Signaling*
Ion Channel Gating*
Calcium/*metabolism
Myocytes, Cardiac/*metabolism
NAV1.4 Voltage-Gated Sodium Channel/*metabolism
NAV1.5 Voltage-Gated Sodium Channel/*metabolism
Sodium/*metabolism
Action Potentials ; Animals ; Binding Sites ; Disease Models, Animal ; Flecainide/therapeutic use ; Humans ; Mice ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Tachycardia, Ventricular/drug therapy ; Tachycardia, Ventricular/genetics ; Tachycardia, Ventricular/metabolism ; Treatment Outcome ; Voltage-Gated Sodium Channel Blockers/therapeutic use
SCR Disease Name :
Polymorphic catecholergic ventricular tachycardia
Czasopismo naukowe
Tytuł :
The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1.9, Nav1.8 and Nav1.7.
Autorzy :
Bothe SN; Institute of Physiology, Uniklinik RWTH Aachen, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany; Research Training Group 2416 MultiSenses-MultiScales, RWTH Aachen University, Aachen, Germany.
Lampert A; Institute of Physiology, Uniklinik RWTH Aachen, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany; Research Training Group 2416 MultiSenses-MultiScales, RWTH Aachen University, Aachen, Germany; Research Training Group 2415 ME3T, RWTH Aachen University, Aachen, Germany. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Oct 01; Vol. 428, pp. 115676. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insecticides/*pharmacology
NAV1.7 Voltage-Gated Sodium Channel/*physiology
NAV1.8 Voltage-Gated Sodium Channel/*physiology
Nitriles/*pharmacology
Pyrethrins/*pharmacology
Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; NAV1.9 Voltage-Gated Sodium Channel/physiology
Czasopismo naukowe

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