Temat: "VOLTAGE" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats.
Autorzy:: Martinez-Arguelles DB; Department of Medicine, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.
Nedow JW; Department of Medicine, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.
Gukasyan HJ; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United States.
Papadopoulos V; Department of Medicine, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United States.; Pokaż więcej
Źródło:: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jan 04; Vol. 13, pp. 1003017. Date of Electronic Publication: 2023 Jan 04 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Voltage-Dependent Anion Channel 1*/chemistry
Voltage-Dependent Anion Channel 1*/metabolism
Rats ; Male ; Animals ; Peptides/metabolism ; Voltage-Dependent Anion Channels ; Testosterone ; Administration, Oral

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Skocz do pozycji: 2.

Tytuł:: Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.
Autorzy:: Alghamdi MA; Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia.; Genomics and Personalized Medicine Unit, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Al-Eitan LN; Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid, Jordan.; Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, Jordan.
Asiri A; Department of Child Health, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Rababa'h DM; Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Alqahtani SA; Neurology Department, Neuroscience Centre, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Aldarami MS; Neurology Department, Neuroscience Centre, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Alsaeedi MA; Neurology Department, Neuroscience Centre, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Almuidh RS; Neurology Department, Neuroscience Centre, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Alzahrani AA; Neurology Department, Neuroscience Centre, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Sakah AH; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
El Nashar EM; Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia.; Department of Histology and Cell Biology, Faculty of Medicine, Benha University, Benha, Egypt.
Otaif MY; Department of Pediatric, Neurology section, Abha Maternity and Childern Hospital, Abha, Saudi Arabia.
Abdel Ghaffar NF; Neurology Department, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Giza, Egypt.; Neurology Department, Aseer Central Hospital, Abha, Saudi Arabia.; Pokaż więcej
Źródło:: Annals of medicine [Ann Med] 2022 Dec; Vol. 54 (1), pp. 1938-1951.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Epilepsy*/drug therapy
Epilepsy*/genetics
NAV1.1 Voltage-Gated Sodium Channel*/genetics
Humans ; NAV1.2 Voltage-Gated Sodium Channel/genetics ; NAV1.3 Voltage-Gated Sodium Channel/genetics ; Polymorphism, Genetic ; Prognosis ; Saudi Arabia ; Sodium Channels/genetics ; Voltage-Gated Sodium Channel beta-1 Subunit/genetics

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Szczegóły

Skocz do pozycji: 3.

Tytuł:: Exploring the Pivotal Components Influencing the Side Effects Induced by an Analgesic-Antitumor Peptide from Scorpion Venom on Human Voltage-Gated Sodium Channels 1.4 and 1.5 through Computational Simulation.
Autorzy:: Zhao F; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Fang L; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Wang Q; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Ye Q; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
He Y; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Xu W; Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Song Y; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.; Pokaż więcej
Źródło:: Toxins [Toxins (Basel)] 2022 Dec 31; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 31.
Typ publikacji:: Journal Article
MeSH Terms:: Scorpion Venoms*/chemistry
Voltage-Gated Sodium Channels*
Spider Venoms*/chemistry
Humans ; Analgesics/adverse effects ; Peptides/pharmacology ; Computer Simulation ; NAV1.7 Voltage-Gated Sodium Channel

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Skocz do pozycji: 4.

Tytuł:: Upregulation of Na v 1.6 Mediated by the p38 MAPK Pathway in the Dorsal Root Ganglia Contributes to Cancer-Induced Bone Pain in Rats.
Autorzy:: Lin M; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.
Chen X; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.
Wu S; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.
Chen P; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.
Wan H; Department of Anesthesiology, First Affiliated Hospital of Yangtze University, First People's Hospital of Jingzhou, Jingzhou 434000, China.
Ma S; Fujian Provincial Maternity and Children's Hospital, Fuzhou 350000, China.
Lin N; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.
Liao Y; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.
Zheng T; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.
Jiang J; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.
Zheng X; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350000, China.; Fujian Emergency Medical Center, Fujian Provincial Key Laboratory of Critical Care Medicine, Fuzhou 350000, China.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Oct 26; Vol. 11 (21). Date of Electronic Publication: 2022 Oct 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: p38 Mitogen-Activated Protein Kinases*/metabolism
NAV1.6 Voltage-Gated Sodium Channel*/genetics
NAV1.6 Voltage-Gated Sodium Channel*/metabolism
Cancer Pain*/genetics
Cancer Pain*/metabolism
Animals ; Rats ; Bone Neoplasms/complications ; Bone Neoplasms/metabolism ; Ganglia, Spinal/metabolism ; Pain/genetics ; Pain/metabolism ; Rats, Sprague-Dawley ; Up-Regulation ; Voltage-Gated Sodium Channels/metabolism

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Skocz do pozycji: 5.

Tytuł:: "Virtual patch clamp analysis" for predicting the functional significance of pathogenic variants in sodium channels.
Autorzy:: Bielopolski N; QR Genetics, Tel Aviv, Israel. Electronic address: .
Heyman E; Pediatric Epilepsy Department, Shamir Medical Center, Asaf Ha Rofeh, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: .
Bassan H; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Pediatric Neurology Unit, Shamir Medical Center, Asaf HaRofeh, Israel. Electronic address: .
BenZeev B; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Pediatric Neurology Unit, Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel. Electronic address: .
Tzadok M; Pediatric Neurology Unit, Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel. Electronic address: .
Ginsberg M; Rare Diseases Institute-Magen, Edith Wolfson Medical Center, Holon, Israel; Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .
Blumkin L; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Rare Diseases Institute-Magen, Edith Wolfson Medical Center, Holon, Israel; Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .
Michaeli Y; Rare Diseases Institute-Magen, Edith Wolfson Medical Center, Holon, Israel; Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .
Sokol R; Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .
Yosha-Orpaz N; Rare Diseases Institute-Magen, Edith Wolfson Medical Center, Holon, Israel; Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .
Hady-Cohen R; Rare Diseases Institute-Magen, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .
Banne E; Pediatric Epilepsy Department, Shamir Medical Center, Asaf Ha Rofeh, Israel; Genetics Institute, Edith Wolfson Medical Center, Holon, Israel.
Lev D; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Rare Diseases Institute-Magen, Edith Wolfson Medical Center, Holon, Israel; Genetics Institute, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .
Lerman-Sagie T; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Rare Diseases Institute-Magen, Edith Wolfson Medical Center, Holon, Israel; Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .
Wald-Altman S; QR Genetics, Tel Aviv, Israel. Electronic address: .
Nissenkorn A; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Rare Diseases Institute-Magen, Edith Wolfson Medical Center, Holon, Israel; Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel. Electronic address: .; Pokaż więcej
Źródło:: Epilepsy research [Epilepsy Res] 2022 Oct; Vol. 186, pp. 107002. Date of Electronic Publication: 2022 Aug 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Epilepsies, Myoclonic*/genetics
NAV1.1 Voltage-Gated Sodium Channel*/genetics
NAV1.1 Voltage-Gated Sodium Channel*/metabolism
Humans ; Mutation/genetics ; NAV1.2 Voltage-Gated Sodium Channel/genetics ; Phenotype ; Sodium/metabolism

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Szczegóły

Skocz do pozycji: 6.

Tytuł:: E as in Enigma: The Mysterious Role of the Voltage-Dependent Anion Channel Glutamate E73.
Autorzy:: Rister AB; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, 80336 Munich, Germany.
Gudermann T; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, 80336 Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung, Partner Site Munich Heart Alliance, Munich, Germany.
Schredelseker J; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, 80336 Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung, Partner Site Munich Heart Alliance, Munich, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 23; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 23.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Glutamic Acid*/metabolism
Voltage-Dependent Anion Channel 1*/metabolism
Voltage-Dependent Anion Channels/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondria/metabolism

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Skocz do pozycji: 7.

Tytuł:: Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Narirutin via Block of Na v 1.7 Voltage-Gated Sodium Channel.
Autorzy:: Yang H; Department of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Shan Z; Laboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.; Department of Anesthesiology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen 518020, China.; Shenzhen Engineering Research Center of Anesthesiology, Shenzhen 518020, China.
Guo W; Department of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Wang Y; Department of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Cai S; Department of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Li F; Department of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Huang Q; Department of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Liu JA; Department of Neuroscience, City University of Hong Kong, Hong Kong 999077, China.
Cheung CW; Laboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.
Cai S; Department of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 27; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 27.
Typ publikacji:: Journal Article
MeSH Terms:: Biological Products*/pharmacology
Biological Products*/therapeutic use
Biological Products*/metabolism
Neuralgia*/drug therapy
Neuralgia*/metabolism
Voltage-Gated Sodium Channels*/metabolism
Rats ; Humans ; Animals ; HEK293 Cells ; Rats, Sprague-Dawley ; Ganglia, Spinal/metabolism ; Tetrodotoxin/pharmacology ; Sensory Receptor Cells/metabolism ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Analgesics/metabolism ; NAV1.7 Voltage-Gated Sodium Channel/metabolism

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Skocz do pozycji: 8.

Tytuł:: Discovery of pyridyl urea sulfonamide inhibitors of Na V 1.7.
Autorzy:: Butler JR; Department of Medicinal Chemistry, Cambridge, MA 02142, USA. Electronic address: .
Rescourio G; Department of Medicinal Chemistry, Cambridge, MA 02142, USA.
Milgram BC; Department of Medicinal Chemistry, Cambridge, MA 02142, USA.
Foti RS; Department of Pharmacokinetics and Drug Metabolism, Cambridge, MA 02142, USA.
Kornecook T; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Ligutti J; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Moyer BD; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Taborn K; Department of Neuroscience, Cambridge, MA 02142, USA.
Youngblood BD; Department of Neuroscience, Cambridge, MA 02142, USA.
Yu V; Department of Neuroscience, Cambridge, MA 02142, USA.
Shimanovich R; Drug Product Technologies, Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, USA.
Boezio A; Department of Medicinal Chemistry, Cambridge, MA 02142, USA.
Weiss M; Department of Medicinal Chemistry, Cambridge, MA 02142, USA.; Pokaż więcej
Źródło:: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Oct 01; Vol. 73, pp. 128892. Date of Electronic Publication: 2022 Jul 16.
Typ publikacji:: Journal Article
MeSH Terms:: NAV1.7 Voltage-Gated Sodium Channel*/metabolism
Quinolones*
Humans ; Pain/drug therapy ; Structure-Activity Relationship ; Sulfanilamide ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; Urea/pharmacology ; Voltage-Gated Sodium Channel Blockers/chemistry

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Szczegóły

Skocz do pozycji: 9.

Tytuł:: µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype Na V 1.7.
Autorzy:: McMahon KL; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Tran HNT; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Deuis JR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Craik DJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Vetter I; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.; The School of Pharmacy, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Schroeder CI; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.; Pokaż więcej
Źródło:: Toxins [Toxins (Basel)] 2022 Aug 30; Vol. 14 (9). Date of Electronic Publication: 2022 Aug 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
MeSH Terms:: Conotoxins*/chemistry
Conotoxins*/pharmacology
Voltage-Gated Sodium Channel Blockers*/chemistry
Voltage-Gated Sodium Channel Blockers*/pharmacology
Analgesics/chemistry ; Analgesics/pharmacology ; Animals ; Cysteine ; Humans ; NAV1.4 Voltage-Gated Sodium Channel ; NAV1.7 Voltage-Gated Sodium Channel ; Peptides

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Skocz do pozycji: 10.

Tytuł:: The effect of the voltage-gated sodium channel Na V 1.7 blocker PF-05089771 on cough in the guinea pig.
Autorzy:: Brozmanova M; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. Electronic address: .
Buday T; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Konarska M; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Plevkova J; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. Electronic address: .; Pokaż więcej
Źródło:: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2022 May; Vol. 299, pp. 103856. Date of Electronic Publication: 2022 Jan 31.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antitussive Agents*/pharmacology
Antitussive Agents*/therapeutic use
Voltage-Gated Sodium Channels*/physiology
Animals ; Cough/drug therapy ; Guinea Pigs ; Phenyl Ethers ; Sulfonamides ; Voltage-Gated Sodium Channel Blockers/pharmacology ; Voltage-Gated Sodium Channel Blockers/therapeutic use

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Skocz do pozycji: 11.

Tytuł:: Non-canonical endogenous expression of voltage-gated sodium channel Na V 1.7 subtype by the TE671 rhabdomyosarcoma cell line.
Autorzy:: Ngum NM; School of Life Sciences, University of Nottingham, Nottingham, UK.
Aziz MYA; School of Life Sciences, University of Nottingham, Nottingham, UK.
Mohammed Latif L; School of Life Sciences, University of Nottingham, Nottingham, UK.
Wall RJ; School of Life Sciences, University of Nottingham, Nottingham, UK.
Duce IR; School of Life Sciences, University of Nottingham, Nottingham, UK.
Mellor IR; School of Life Sciences, University of Nottingham, Nottingham, UK.; Pokaż więcej
Źródło:: The Journal of physiology [J Physiol] 2022 May; Vol. 600 (10), pp. 2499-2513. Date of Electronic Publication: 2022 Apr 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: NAV1.7 Voltage-Gated Sodium Channel*/genetics
NAV1.7 Voltage-Gated Sodium Channel*/metabolism
Rhabdomyosarcoma*/genetics
Cell Line ; Humans ; NAV1.4 Voltage-Gated Sodium Channel ; Pain ; Sodium Channel Blockers/pharmacology ; Tetrodotoxin/pharmacology

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Szczegóły

Skocz do pozycji: 12.

Tytuł:: Design, synthesis, and mechanism of action of novel μ-conotoxin KIIIA analogues for inhibition of the voltage-gated sodium channel Na v 1.7.
Autorzy:: Zhao Z; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Pan T; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Chen S; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Harvey PJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
Zhang J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Li X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Yang M; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Huang L; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Wang S; Qingdao Central Hospital, Central Hospital Affiliated to Qingdao University, Qingdao, China.
Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
Jiang T; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Yu R; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address: .; Pokaż więcej
Źródło:: The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 103068. Date of Electronic Publication: 2023 Feb 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Analgesics*/pharmacology
Analgesics*/chemistry
Conotoxins*/chemistry
Conotoxins*/pharmacology
NAV1.7 Voltage-Gated Sodium Channel*
Voltage-Gated Sodium Channel Blockers*/chemistry
Voltage-Gated Sodium Channel Blockers*/pharmacology
Humans ; Disulfides/metabolism ; HEK293 Cells ; Molecular Dynamics Simulation ; Pain/chemically induced ; Pain/drug therapy ; Peptides/pharmacology ; Peptides/metabolism

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Szczegóły

Skocz do pozycji: 13.

Tytuł:: Neonatal Na V 1.5 channels: pharmacological distinctiveness of a cancer-related voltage-gated sodium channel splice variant.
Autorzy:: Fraser SP; Department of Life Sciences, Neuroscience Solutions to Cancer Research Group, Imperial College London, London, UK.
Onkal R; Department of Life Sciences, Neuroscience Solutions to Cancer Research Group, Imperial College London, London, UK.; Biotechnology Research Centre, Cyprus International University, Mersin 10, Turkey.
Theys M; Department of Basic and Applied Medical Sciences, University of Ghent, Ghent, Belgium.
Bosmans F; Department of Basic and Applied Medical Sciences, University of Ghent, Ghent, Belgium.
Djamgoz MBA; Department of Life Sciences, Neuroscience Solutions to Cancer Research Group, Imperial College London, London, UK.; Biotechnology Research Centre, Cyprus International University, Mersin 10, Turkey.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2022 Feb; Vol. 179 (3), pp. 473-486. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinoma*
Spider Venoms*/chemistry
Voltage-Gated Sodium Channels*/metabolism
Humans ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Voltage-Gated Sodium Channel Blockers/chemistry ; Voltage-Gated Sodium Channel Blockers/pharmacology

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Skocz do pozycji: 14.

Tytuł:: Design, Synthesis, and Evaluation of Novel Benzo[ d ]isoxazole Derivatives as Anticonvulsants by Selectively Blocking the Voltage-Gated Sodium Channel Na V 1.1.
Autorzy:: Huang X; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Dong S; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Liu H; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Wan P; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Wang T; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang 330006, China.
Quan H; School of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Wang Z; School of Information and Control, Shenyang Institute of Technology, Shenyang 113122, China.
Wang Z; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.; Nanchang Yichou Technology Co., Ltd, Nanchang 330036, China.; Pokaż więcej
Źródło:: ACS chemical neuroscience [ACS Chem Neurosci] 2022 Mar 16; Vol. 13 (6), pp. 834-845. Date of Electronic Publication: 2022 Feb 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anticonvulsants*/pharmacology
Voltage-Gated Sodium Channels*
Humans ; Isoxazoles ; NAV1.7 Voltage-Gated Sodium Channel ; Seizures/chemically induced ; Seizures/drug therapy ; Sodium Channel Blockers/pharmacology ; Voltage-Gated Sodium Channel Blockers/pharmacology

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Szczegóły

Skocz do pozycji: 15.

Tytuł:: Inhibition of voltage-gated sodium ion channel by corannulene and computational inversion blockage underlying mechanisms.
Autorzy:: Zuo X; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.
Yin H; College of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, 300071, China.
Li X; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.
Jia Z; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.
Wang Y; Beijing Key Laboratory of Ionic Liquids Clean Process, CAS Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. Electronic address: .
Yang Z; College of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, 300071, China. Electronic address: .
Feng X; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China. Electronic address: .; Pokaż więcej
Źródło:: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 May 14; Vol. 656, pp. 70-77. Date of Electronic Publication: 2023 Mar 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Voltage-Gated Sodium Channels*
Potassium Channels, Voltage-Gated*
Polycyclic Aromatic Hydrocarbons*
Protein Binding

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 16.

Tytuł:: The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
Autorzy:: Duran P; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York, USA.
Loya-López S; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York, USA.
Ran D; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Tang C; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York, USA.; NYU Pain Research Center, New York, New York, USA.; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hunan Normal University, Changsha, China.
Calderon-Rivera A; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York, USA.
Gomez K; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York, USA.
Stratton HJ; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Huang S; Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.
Xu YM; Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona, USA.
Wijeratne EMK; Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona, USA.
Perez-Miller S; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York, USA.
Shan Z; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Cai S; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Gabrielsen AT; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Dorame A; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Masterson KA; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Alsbiei O; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Madura CL; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Luo G; Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona, USA.
Moutal A; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Streicher J; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Zamponi GW; Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.
Gunatilaka AAL; Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona, USA.
Khanna R; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York, USA.; NYU Pain Research Center, New York, New York, USA.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2023 May; Vol. 180 (9), pp. 1267-1285. Date of Electronic Publication: 2023 Jan 15.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium Channels, T-Type*/metabolism
Voltage-Gated Sodium Channels*/metabolism
Mice ; Rats ; Animals ; Rats, Sprague-Dawley ; Sodium/metabolism ; Calcium/metabolism ; Ganglia, Spinal/metabolism ; Pain, Postoperative/drug therapy

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 17.

Tytuł:: ANP32B promotes lung cancer progression by regulating VDAC1.
Autorzy:: Li T; Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address: .
Wang N; Department of Pediatrics, The First Hospital of Hebei Medical University. Shijiazhuang, China.
Li S; Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Yan H; Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Gao S; Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Gao W; Department of Cardiac Surgery, The Second Hospital of Hebei Medical University. Shijiazhuang, China.
Xu R; Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.; Pokaż więcej
Źródło:: Gene [Gene] 2023 Apr 05; Vol. 859, pp. 147200. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:: Journal Article
MeSH Terms:: Lung Neoplasms*/pathology
Nuclear Proteins*/metabolism
Voltage-Dependent Anion Channel 1*/genetics
Voltage-Dependent Anion Channel 1*/metabolism
Humans ; Apoptosis/genetics ; Cell Proliferation/genetics

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 18.

Tytuł:: DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1.
Autorzy:: Huang L; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.; Cancer Institute, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
Wei B; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.; Cancer Institute, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
Zhao Y; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.; Cancer Institute, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
Gong X; Nanjing Maternal and Child Health Institute, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China. .
Chen L; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. .; Cancer Institute, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. .; Pokaż więcej
Źródło:: Molecular medicine (Cambridge, Mass.) [Mol Med] 2023 Jun 06; Vol. 29 (1), pp. 72. Date of Electronic Publication: 2023 Jun 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Voltage-Dependent Anion Channel 1*/genetics
Voltage-Dependent Anion Channel 1*/metabolism
Triple Negative Breast Neoplasms*
Humans ; Mice ; Animals ; Mitochondria/metabolism ; Ubiquitination ; Ubiquitin-Protein Ligases ; Apoptosis ; Dyneins/metabolism

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 19.

Tytuł:: Influence of combined voltage-gated sodium channel Na V 1.7 and Na V 1.8 inhibitors on cough in a guinea pig model.
Autorzy:: Brozmanova M; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. Electronic address: .
Buday T; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Jakusova J; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Melegova J; Central Animal Facility, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Plevkova J; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.; Pokaż więcej
Źródło:: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2023 Jun; Vol. 312, pp. 104043. Date of Electronic Publication: 2023 Mar 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antitussive Agents*/therapeutic use
Voltage-Gated Sodium Channels*/metabolism
Guinea Pigs ; Animals ; Cough/chemically induced ; Cough/drug therapy ; Cough/metabolism ; Vagus Nerve/physiology ; Sodium Channel Blockers/adverse effects

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 20.

Tytuł:: Molecular Dynamics Simulations of Ion Permeation in Human Voltage-Gated Sodium Channels.
Autorzy:: Alberini G; Center for Synaptic Neuroscience and Technology (), Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Alexis Paz S; Departamento de Química Teórica y Computacional, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Fisicoquímica de Córdoba (INFIQC), X5000HUA Córdoba, Argentina.
Corradi B; Center for Synaptic Neuroscience and Technology (), Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.; Department of Experimental Medicine, Università degli Studi di Genova, Viale Benedetto XV 3, 16132 Genova, Italy.
Abrams CF; Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States.
Benfenati F; Center for Synaptic Neuroscience and Technology (), Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Maragliano L; Center for Synaptic Neuroscience and Technology (), Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.; Department of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy.; Pokaż więcej
Źródło:: Journal of chemical theory and computation [J Chem Theory Comput] 2023 May 23; Vol. 19 (10), pp. 2953-2972. Date of Electronic Publication: 2023 Apr 28.
Typ publikacji:: Journal Article
MeSH Terms:: Molecular Dynamics Simulation*
Voltage-Gated Sodium Channels*/chemistry
Voltage-Gated Sodium Channels*/metabolism
Humans ; Bacteria/metabolism ; Ions/metabolism ; Lysine

Czasopismo naukowe

na półce

Szczegóły

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