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Wyszukujesz frazę ""Vafai SB"" wg kryterium: Autor


Wyświetlanie 1-5 z 5
Tytuł:
Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.
Autorzy:
Vafai SB; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States of America.; Broad Institute of MIT and Harvard, Cambridge, MA, United States of America.
Mevers E; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States of America.
Higgins KW; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States of America.; Broad Institute of MIT and Harvard, Cambridge, MA, United States of America.
Fomina Y; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States of America.; Broad Institute of MIT and Harvard, Cambridge, MA, United States of America.
Zhang J; Department of Dermatology, Massachusetts General Hospital, Boston, MA, United States of America.
Mandinova A; Department of Dermatology, Massachusetts General Hospital, Boston, MA, United States of America.
Newman D; Natural Products Branch, National Cancer Institute, Frederick, MD, United States of America.
Shaw SY; Center for Systems Biology, Massachusetts General Hospital, Boston, MA, United States of America.
Clardy J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States of America.
Mootha VK; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States of America.; Broad Institute of MIT and Harvard, Cambridge, MA, United States of America.; Department of Systems Biology, Harvard Medical School, Boston, MA, United States of America.
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Źródło:
PloS one [PLoS One] 2016 Sep 13; Vol. 11 (9), pp. e0162686. Date of Electronic Publication: 2016 Sep 13 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Biological Products/*pharmacology
Electron Transport Complex I/*deficiency
Electron Transport Complex I/*metabolism
Naphthoquinones/*pharmacology
Animals ; Bignoniaceae/chemistry ; Biological Products/chemistry ; CRISPR-Cas Systems ; Cell Line ; Drug Evaluation, Preclinical ; Electron Transport Complex I/genetics ; Ericaceae/chemistry ; Gene Editing ; Gene Knockout Techniques ; High-Throughput Screening Assays ; Mice ; Myoblasts/drug effects ; Myoblasts/metabolism ; Naphthoquinones/chemistry ; Oxidative Phosphorylation ; Smegmamorpha/metabolism
Czasopismo naukowe
Tytuł:
Medicine. A common pathway for a rare disease?
Autorzy:
Vafai SB; Howard Hughes Medical Institute, Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Mootha VK
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Źródło:
Science (New York, N.Y.) [Science] 2013 Dec 20; Vol. 342 (6165), pp. 1453-4.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms:
Molecular Targeted Therapy*
Leigh Disease/*drug therapy
Mitochondrial Diseases/*drug therapy
Multiprotein Complexes/*antagonists & inhibitors
Neuroprotective Agents/*therapeutic use
Sirolimus/*therapeutic use
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Animals ; Mechanistic Target of Rapamycin Complex 1
Czasopismo naukowe
Tytuł:
Mitochondrial disorders as windows into an ancient organelle.
Autorzy:
Vafai SB; Department of Molecular Biology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Mootha VK
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Źródło:
Nature [Nature] 2012 Nov 15; Vol. 491 (7424), pp. 374-83.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Mitochondria/*genetics
Mitochondria/*metabolism
Mitochondrial Diseases/*genetics
Mitochondrial Diseases/*pathology
Biological Evolution ; Electron Transport/physiology ; Humans ; Mitochondria/pathology
Czasopismo naukowe
Tytuł:
Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease.
Autorzy:
Lieber DS; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Vafai SB
Horton LC
Slate NG
Liu S
Borowsky ML
Calvo SE
Schmahmann JD
Mootha VK
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Źródło:
BMC medical genetics [BMC Med Genet] 2012 Jan 06; Vol. 13, pp. 3. Date of Electronic Publication: 2012 Jan 06.
Typ publikacji:
Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
DNA Mutational Analysis*
Exome*
High-Throughput Nucleotide Sequencing*
Mitochondrial Diseases/*diagnosis
Wolfram Syndrome/*diagnosis
Atrophy ; Brain/pathology ; DNA, Mitochondrial/chemistry ; Diagnosis, Differential ; Exons ; Homozygote ; Humans ; Magnetic Resonance Imaging ; Male ; Membrane Proteins/genetics ; Middle Aged ; Mitochondrial Diseases/genetics ; Mutation, Missense ; Wolfram Syndrome/genetics
Czasopismo naukowe
    Wyświetlanie 1-5 z 5

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