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Wyszukujesz frazę ""Vagstad AL"" wg kryterium: Autor


Tytuł:
Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments.
Autorzy:
Schmalhofer M; TUM School of Natural Sciences, Department of Bioscience, Centre for Protein Assemblies, Chair of Biochemistry, Technical University of Munich, 85748, Garching, Germany.
Vagstad AL; Eidgenössische Technische Hochschule (ETH) Zürich, Institute of Microbiology, Zürich, 8093, Switzerland.
Zhou Q; Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, 35043, Marburg, Germany.
Bode HB; Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, 35043, Marburg, Germany.; Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, 60438, Frankfurt, Germany.; Department of Chemistry, Phillips Universität Marburg, 35043, Marburg, Germany.; Center for Synthetic Microbiology (SYNMIKRO), Phillips Universität Marburg, 35043, Marburg, Germany.; Senckenberg Gesellschaft für Naturforschung, 60325, Frankfurt, Germany.
Groll M; TUM School of Natural Sciences, Department of Bioscience, Centre for Protein Assemblies, Chair of Biochemistry, Technical University of Munich, 85748, Garching, Germany.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Mar 16, pp. e2400184. Date of Electronic Publication: 2024 Mar 16.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S -Adenosyl-l-methionine Peptide Epimerization.
Autorzy:
Walls WG; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, Zürich 8093, Switzerland.
Delridge T; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, Zürich 8093, Switzerland.
Broderick WE; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Broderick JB; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2024 Feb 28; Vol. 146 (8), pp. 5550-5559. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
S-Adenosylmethionine*/chemistry
Methionine*
Carbon ; Peptides/chemistry ; Amino Acids ; Racemethionine ; Valine
Czasopismo naukowe
Tytuł:
Engineering ribosomally synthesized and posttranslationally modified peptides as new antibiotics.
Autorzy:
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland. Electronic address: .
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Źródło:
Current opinion in biotechnology [Curr Opin Biotechnol] 2023 Apr; Vol. 80, pp. 102891. Date of Electronic Publication: 2023 Jan 24.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Bacterial Agents*/pharmacology
Biological Products*/metabolism
Peptides/chemistry ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł:
Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase.
Autorzy:
Mordhorst S; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Badmann T; Chair of Biochemistry, Center for Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Str. 8, 85748 Garching, Germany.
Bösch NM; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Morinaka BI; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Rauch H; Chair of Biochemistry, Center for Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Str. 8, 85748 Garching, Germany.
Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Groll M; Chair of Biochemistry, Center for Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Str. 8, 85748 Garching, Germany.
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
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Źródło:
ACS chemical biology [ACS Chem Biol] 2023 Mar 17; Vol. 18 (3), pp. 528-536. Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arginase*/metabolism
Arginine*/metabolism
Ornithine/metabolism ; Peptides/metabolism ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł:
Emulating nonribosomal peptides with ribosomal biosynthetic strategies.
Autorzy:
Mordhorst S; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4 8093 Zürich Switzerland .
Ruijne F; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen Nijenborgh 7, 9747 AG Groningen The Netherlands .
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4 8093 Zürich Switzerland .
Kuipers OP; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen Nijenborgh 7, 9747 AG Groningen The Netherlands .
Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4 8093 Zürich Switzerland .
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Źródło:
RSC chemical biology [RSC Chem Biol] 2022 Dec 06; Vol. 4 (1), pp. 7-36. Date of Electronic Publication: 2022 Dec 06 (Print Publication: 2023).
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Posttranslationally Acting Arginases Provide a Ribosomal Route to Non-proteinogenic Ornithine Residues in Diverse Peptide Sequences.
Autorzy:
Mordhorst S; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Morinaka BI; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Nov 23; Vol. 59 (48), pp. 21442-21447. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arginase/*metabolism
Cyanobacteria/*enzymology
Ornithine/*metabolism
Peptides/*metabolism
Ribosomes/*metabolism
Amino Acid Sequence ; Arginase/chemistry ; Molecular Conformation ; Ornithine/chemistry ; Peptides/chemistry ; Protein Processing, Post-Translational ; Ribosomes/chemistry
Czasopismo naukowe
Tytuł:
Landornamides: Antiviral Ornithine-Containing Ribosomal Peptides Discovered through Genome Mining.
Autorzy:
Bösch NM; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Borsa M; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Greczmiel U; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Morinaka BI; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.
Gugger M; Institut Pasteur, Collection des Cyanobactéries, Département de Microbiologie, 75015, Paris, France.
Oxenius A; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Jul 13; Vol. 59 (29), pp. 11763-11768. Date of Electronic Publication: 2020 May 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Data Mining*
Databases, Genetic*
Antiviral Agents/*chemical synthesis
Bacterial Proteins/*chemical synthesis
Ornithine/*chemistry
Peptides/*chemistry
Ribosomal Proteins/*chemical synthesis
Ribosomes/*chemistry
Animals ; Antiviral Agents/pharmacology ; Bacterial Proteins/pharmacology ; Cell Line ; Computational Biology ; Cyanobacteria/chemistry ; Escherichia coli/genetics ; Lymphocytic Choriomeningitis/drug therapy ; Lymphocytic choriomeningitis virus ; Mice ; Multigene Family ; Peptides/chemical synthesis ; Peptides/pharmacology ; Protein Processing, Post-Translational ; Ribosomal Proteins/pharmacology
Czasopismo naukowe
Tytuł:
Introduction of d-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-l-Methionine Radical Epimerase.
Autorzy:
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Kuranaga T; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.
Püntener S; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Pattabiraman VR; Laboratory of Organic Chemistry, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.
Bode JW; Laboratory of Organic Chemistry, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.
Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Feb 18; Vol. 58 (8), pp. 2246-2250. Date of Electronic Publication: 2019 Jan 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acids/*metabolism
Peptides/*metabolism
Racemases and Epimerases/*metabolism
S-Adenosylmethionine/*metabolism
Amino Acids/chemistry ; Free Radicals/chemistry ; Free Radicals/metabolism ; Molecular Conformation ; Peptides/chemistry ; Protein Processing, Post-Translational ; Racemases and Epimerases/chemistry ; S-Adenosylmethionine/chemistry
Czasopismo naukowe
Tytuł:
Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis.
Autorzy:
Byer AS; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Yang H; Department of Chemistry , Northwestern University , Evanston , Illinois 60208 , United States.
McDaniel EC; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Kathiresan V; Department of Chemistry , Northwestern University , Evanston , Illinois 60208 , United States.
Impano S; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Pagnier A; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Watts H; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Denler C; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Vagstad AL; Institute of Microbiology , Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 4 , Zürich 8093 , Switzerland.
Piel J; Institute of Microbiology , Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 4 , Zürich 8093 , Switzerland.
Duschene KS; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Shepard EM; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Shields TP; Cassia, LLC , 3030 Bunker Hill Street, Ste. 214 , San Diego , California 92109 , United States.
Scott LG; Cassia, LLC , 3030 Bunker Hill Street, Ste. 214 , San Diego , California 92109 , United States.
Lilla EA; Department of Biochemistry , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Yokoyama K; Department of Biochemistry , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Broderick WE; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
Hoffman BM; Department of Chemistry , Northwestern University , Evanston , Illinois 60208 , United States.
Broderick JB; Department of Chemistry & Biochemistry , Montana State University , Bozeman , Montana 59717 , United States.
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2018 Jul 18; Vol. 140 (28), pp. 8634-8638. Date of Electronic Publication: 2018 Jul 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Bacteria/*enzymology
Cobamides/*metabolism
Deoxyadenosines/*metabolism
Enzymes/*metabolism
S-Adenosylmethionine/*metabolism
Acetyltransferases ; Bacteria/chemistry ; Bacteria/metabolism ; Biocatalysis ; Cobamides/chemistry ; Deoxyadenosines/chemistry ; Electron Spin Resonance Spectroscopy ; Enzymes/chemistry ; Escherichia coli/chemistry ; Escherichia coli/enzymology ; Escherichia coli/metabolism ; Models, Molecular ; Protein Conformation ; S-Adenosylmethionine/chemistry
Czasopismo naukowe
Tytuł:
Natural noncanonical protein splicing yields products with diverse β-amino acid residues.
Autorzy:
Morinaka BI; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Lakis E; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Verest M; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Helf MJ; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Scalvenzi T; Collection des Cyanobactéries, Département de Microbiologie, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Cedex 15, 75015 Paris, France.
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Sims J; Institute of Agricultural Sciences, ETH Zurich, Schmelzbergstraße 9, 8092 Zurich, Switzerland.
Sunagawa S; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Gugger M; Collection des Cyanobactéries, Département de Microbiologie, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Cedex 15, 75015 Paris, France.
Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland. .
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Źródło:
Science (New York, N.Y.) [Science] 2018 Feb 16; Vol. 359 (6377), pp. 779-782.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Processing, Post-Translational*
Protein Splicing*
Amino Acids/*metabolism
Bacterial Proteins/*metabolism
Cyanobacteria/*metabolism
Amides/chemistry ; Amino Acid Sequence ; Amino Acids/chemistry ; Bacterial Proteins/genetics ; Cyanobacteria/genetics ; Escherichia coli/genetics ; Genetic Loci ; Mutation ; Tyramine/chemistry
Czasopismo naukowe
Tytuł:
Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain.
Autorzy:
Barajas JF; Department of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Finzel K; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
Valentic TR; Department of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Shakya G; Department of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Gamarra N; Department of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Martinez D; Department of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Meier JL; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
Vagstad AL; Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA.
Newman AG; Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA.
Townsend CA; Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA.
Burkart MD; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA. .
Tsai SC; Department of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, 92697, USA. .
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Oct 10; Vol. 55 (42), pp. 13005-13009.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Acyl Carrier Protein/*chemistry
Polyketides/*chemistry
Acyl Carrier Protein/metabolism ; Molecular Conformation ; Molecular Docking Simulation ; Polyketides/metabolism ; Protein Binding ; Protein Conformation
Czasopismo naukowe
Tytuł:
Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria.
Autorzy:
Freeman MF; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Vagstad AL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland. Electronic address: .
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Źródło:
Current opinion in chemical biology [Curr Opin Chem Biol] 2016 Apr; Vol. 31, pp. 8-14. Date of Electronic Publication: 2015 Nov 25.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Biosynthesis*
Bacteria/*metabolism
Theonella/*metabolism
Animals ; Theonella/microbiology
Czasopismo naukowe
Tytuł:
Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA.
Autorzy:
Huitt-Roehl CR; Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States.
Hill EA; Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States.
Adams MM; Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States.
Vagstad AL; Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States.
Li JW; Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States.
Townsend CA; Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States.
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Źródło:
ACS chemical biology [ACS Chem Biol] 2015 Jun 19; Vol. 10 (6), pp. 1443-9. Date of Electronic Publication: 2015 Mar 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Metabolic Engineering*
Aspergillus/*enzymology
Fungal Proteins/*chemistry
Polyketide Synthases/*chemistry
Polyketides/*chemistry
Acetyl Coenzyme A/chemistry ; Acetyl Coenzyme A/metabolism ; Aflatoxin B1/biosynthesis ; Aflatoxin B1/chemistry ; Aspergillus/chemistry ; Aspergillus/genetics ; Catalytic Domain ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression ; Kinetics ; Naphthalenes/chemistry ; Naphthalenes/metabolism ; Polyketide Synthases/genetics ; Polyketide Synthases/metabolism ; Polyketides/metabolism ; Pyrones/chemistry ; Pyrones/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł:
Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products.
Autorzy:
Morinaka BI; Institute of Microbiology, Eigenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zurich (Switzerland).
Vagstad AL
Helf MJ
Gugger M
Kegler C
Freeman MF
Bode HB
Piel J
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Aug 04; Vol. 53 (32), pp. 8503-7. Date of Electronic Publication: 2014 Jun 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acids/*chemistry
Racemases and Epimerases/*chemistry
S-Adenosylmethionine/*chemistry
Biological Products/metabolism ; Stereoisomerism
Czasopismo naukowe
Tytuł:
Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.
Autorzy:
Newman AG; Department of Chemistry, The Johns Hopkins University , 3400 N. Charles Street, Baltimore, Maryland 21218, United States.
Vagstad AL
Storm PA
Townsend CA
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2014 May 21; Vol. 136 (20), pp. 7348-62. Date of Electronic Publication: 2014 May 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Polyketide Synthases/*metabolism
Polyketides/*metabolism
Biocatalysis ; Molecular Structure ; Polyketide Synthases/chemistry ; Polyketides/chemistry
Czasopismo naukowe
Tytuł:
Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products.
Autorzy:
Vagstad AL; Department of Chemistry, The Johns Hopkins University, 3400 N. Charles St, Baltimore, MD 21218, USA.
Newman AG
Storm PA
Belecki K
Crawford JM
Townsend CA
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2013 Feb 04; Vol. 52 (6), pp. 1718-21. Date of Electronic Publication: 2013 Jan 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Fungi/*enzymology
Polyketide Synthases/*metabolism
Catalytic Domain ; Cyclization ; Metabolic Engineering ; Polyketide Synthases/chemistry ; Transaldolase/chemistry ; Transaldolase/metabolism
Czasopismo naukowe
Tytuł:
Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.
Autorzy:
Newman AG; Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.
Vagstad AL
Belecki K
Scheerer JR
Townsend CA
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Źródło:
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2012 Dec 14; Vol. 48 (96), pp. 11772-4. Date of Electronic Publication: 2012 Oct 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Ascomycota/*enzymology
Perylene/*analogs & derivatives
Polyketide Synthases/*metabolism
Pyrones/*metabolism
Ascomycota/chemistry ; Ascomycota/metabolism ; Perylene/chemistry ; Perylene/metabolism ; Polyketide Synthases/chemistry ; Protein Structure, Tertiary ; Pyrones/chemistry ; Thiolester Hydrolases/chemistry ; Thiolester Hydrolases/metabolism
Czasopismo naukowe
Tytuł:
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.
Autorzy:
Vagstad AL; Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland, USA.
Bumpus SB
Belecki K
Kelleher NL
Townsend CA
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2012 Apr 18; Vol. 134 (15), pp. 6865-77. Date of Electronic Publication: 2012 Apr 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Biocatalysis*
Polyketide Synthases/*metabolism
Catalytic Domain ; Fungal Proteins ; Kinetics ; Polyketide Synthases/chemistry
Czasopismo naukowe
Tytuł:
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.
Autorzy:
Crawford JM; Department of Chemistry, Johns Hopkins University, Maryland 21218, USA.
Korman TP
Labonte JW
Vagstad AL
Hill EA
Kamari-Bidkorpeh O
Tsai SC
Townsend CA
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Źródło:
Nature [Nature] 2009 Oct 22; Vol. 461 (7267), pp. 1139-43.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Aspergillus/*enzymology
Polyketide Synthases/*chemistry
Polyketide Synthases/*metabolism
Aflatoxin B1/biosynthesis ; Anthracenes/metabolism ; Anthraquinones/metabolism ; Catalytic Domain ; Crystallography, X-Ray ; Cyclization ; Models, Molecular ; Oxidation-Reduction ; Palmitic Acid/metabolism ; Protein Structure, Tertiary ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases.
Autorzy:
Crawford JM; Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.
Vagstad AL
Ehrlich KC
Udwary DW
Townsend CA
Pokaż więcej
Źródło:
Chembiochem : a European journal of chemical biology [Chembiochem] 2008 Jul 02; Vol. 9 (10), pp. 1559-63.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Bacterial Proteins/*metabolism
Fatty Acid Synthase, Type II/*metabolism
Fungal Proteins/*metabolism
Pantetheine/*analogs & derivatives
Transferases (Other Substituted Phosphate Groups)/*metabolism
Acyl Carrier Protein/metabolism ; Anthraquinones/chemistry ; Anthraquinones/metabolism ; Bacterial Proteins/genetics ; Base Sequence ; Carrier Proteins/metabolism ; Conserved Sequence ; Models, Molecular ; Molecular Sequence Data ; Pantetheine/metabolism ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Substrate Specificity ; Transferases (Other Substituted Phosphate Groups)/chemistry ; Transferases (Other Substituted Phosphate Groups)/genetics
Czasopismo naukowe

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