In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression.
Autorzy:
Guet-McCreight A; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada. . Chameh HM; Krembil Brain Institute, University Health Network, Toronto, ON, Canada. Mazza F; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada. Prevot TD; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. ValianteTA; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.; Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Department of Surgery, University of Toronto, Toronto, ON, Canada.; Center for Advancing Neurotechnological Innovation to Application, Toronto, ON, Canada.; Max Planck-University of Toronto Center for Neural Science and Technology, Toronto, ON, Canada. Sibille E; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Hay E; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada. .; Department of Physiology, University of Toronto, Toronto, ON, Canada. .; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. .
Pokaż więcej
Źródło:
Communications biology [Commun Biol] 2024 Feb 23; Vol. 7 (1), pp. 225. Date of Electronic Publication: 2024 Feb 23.
In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression.
Autorzy:
Mazza F; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Canada.; Department of Physiology, University of Toronto, Canada. Guet-McCreight A; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Canada. ValianteTA; Krembil Brain Institute, University Healthy Network, Toronto, Canada.; Department of Electrical and Computer Engineering, University of Toronto, Toronto, Canada.; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.; Department of Surgery, University of Toronto, Toronto, Canada.; Center for Advancing Neurotechnological Innovation to Application, Toronto, Canada.; Max Planck-University of Toronto Center for Neural Science and Technology, Toronto, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Canada. Griffiths JD; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada. Hay E; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Canada.; Department of Physiology, University of Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.
Pokaż więcej
Źródło:
PLoS computational biology [PLoS Comput Biol] 2023 Apr 10; Vol. 19 (4), pp. e1010986. Date of Electronic Publication: 2023 Apr 10 (Print Publication: 2023).
An in vitro whole-cell electrophysiology dataset of human cortical neurons.
Autorzy:
Howard D; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada. Chameh HM; Krembil Brain Institute, University Health Network, Toronto, ON, M5T 1M8, Canada. Guet-McCreight A; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada. Hsiao HA; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada. Vuong M; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada. Seo YS; Krembil Brain Institute, University Health Network, Toronto, ON, M5T 1M8, Canada. Shah P; Krembil Brain Institute, University Health Network, Toronto, ON, M5T 1M8, Canada. Nigam A; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada. Chen Y; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada. Davie M; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada. Hay E; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada. ValianteTA; Krembil Brain Institute, University Health Network, Toronto, ON, M5T 1M8, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, M5S 1A4, Canada.; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, M5T 1P5, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.; Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada.; Max Planck-University of Toronto Center for Neural Science and Technology, Toronto, ON, M5S 1A4, Canada.; Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON , M5S 1A4, Canada. Tripathy SJ; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, M5T 1P5, Canada.; Department of Psychiatry, University of Toront, Toronto, ON, M5T 1R8, Canada.
An exploratory study into the influence of laterality and location of hippocampal sclerosis on seizure prognosis and global cortical thinning.
Autorzy:
Mansouri A; Department of Neurosurgery, Penn State Hershey Medical Center, Penn State University, 30 Hope Drive, Suite #1200, Hershey, PA, 17033, USA. . Germann J; University Health Network, Toronto, ON, Canada. Boutet A; University Health Network, Toronto, ON, Canada.; Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada. Elias GJB; University Health Network, Toronto, ON, Canada. Karmur B; University Health Network, Toronto, ON, Canada. Neudorfer C; University Health Network, Toronto, ON, Canada. Loh A; University Health Network, Toronto, ON, Canada. McAndrews MP; Krembil Research Institute, University Health Network, Toronto, ON, Canada. Ibrahim GM; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.; Institute of Biomaterials and Biomedical Engineering, Department of Surgery, University of Toronto, Toronto, ON, Canada.; Program in Neuroscience and Mental Health, Sickkids Research Institute, Toronto, ON, Canada. Lozano AM; Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Research Institute, Toronto, ON, Canada. ValianteTA; Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Research Institute, Toronto, ON, Canada.; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Feb 25; Vol. 11 (1), pp. 4686. Date of Electronic Publication: 2021 Feb 25.
EEG phase synchronization during semantic unification relates to individual differences in children's vocabulary skill.
Autorzy:
Panda EJ; Neurosciences and Mental Health, SickKids Research Institute, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Epilespy Research Program of the Ontario Brain Institute, Toronto, ON, Canada. Emami Z; Neurosciences and Mental Health, SickKids Research Institute, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada. ValianteTA; Epilespy Research Program of the Ontario Brain Institute, Toronto, ON, Canada.; Krembil Research Institute, University Health Network and Toronto Western Hospital, Toronto, Ontario, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Pang EW; Neurosciences and Mental Health, SickKids Research Institute, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Epilespy Research Program of the Ontario Brain Institute, Toronto, ON, Canada.; Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Pokaż więcej
Źródło:
Developmental science [Dev Sci] 2021 Jan; Vol. 24 (1), pp. e12984. Date of Electronic Publication: 2020 Jun 02.
Neurostimulation stabilizes spiking neural networks by disrupting seizure-like oscillatory transitions.
Autorzy:
Rich S; Division of Clinical and Computational Neuroscience, Krembil Research Institute, Toronto, ON, Canada. . Hutt A; Team MIMESIS, INRIA Nancy Grand Est, Strasbourg, France. Skinner FK; Division of Clinical and Computational Neuroscience, Krembil Research Institute, Toronto, ON, Canada.; Departments of Medicine (Neurology) and Physiology, University of Toronto, Toronto, ON, Canada. ValianteTA; Division of Clinical and Computational Neuroscience, Krembil Research Institute, Toronto, ON, Canada.; University of Toronto, Institute of Biomaterials and Biomedical Engineering, Toronto, ON, Canada.; University of Toronto, Institute of Medical Science, Toronto, ON, Canada.; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.; Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada. Lefebvre J; Division of Clinical and Computational Neuroscience, Krembil Research Institute, Toronto, ON, Canada.; Department of Biology, University of Ottawa, Ottawa, ON, Canada.; Department of Mathematics, University of Toronto, Toronto, ON, Canada.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 Sep 21; Vol. 10 (1), pp. 15408. Date of Electronic Publication: 2020 Sep 21.
Identification of neural networks preferentially engaged by epileptogenic mass lesions through lesion network mapping analysis.
Autorzy:
Mansouri AM; Department of Neurosurgery, Penn State Health, Hershey, PA, USA. . Germann J; University Health Network, Toronto, ON, USA. Boutet A; University Health Network, Toronto, ON, USA.; Joint Department of Medical Imaging, University of Toronto, Toronto, ON, USA. Elias GJB; University Health Network, Toronto, ON, USA. Mithani K; Faculty of Medicine, University of Toronto, Toronto, ON, USA. Chow CT; University Health Network, Toronto, ON, USA. Karmur B; Faculty of Medicine, University of Toronto, Toronto, ON, USA. Ibrahim GM; Program in Neuroscience and Mental Health, Sickkids Research Institute, Toronto, ON, USA.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, USA.; Department of Surgery, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, USA. McAndrews MP; Department of Neuropsychology, University Health Network, Toronto, ON, USA. Lozano AM; Division of Neurosurgery, University Health Network, Toronto, ON, USA. Zadeh G; Division of Neurosurgery, University Health Network, Toronto, ON, USA. ValianteTA; Division of Neurosurgery, University Health Network, Toronto, ON, USA.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 Jul 03; Vol. 10 (1), pp. 10989. Date of Electronic Publication: 2020 Jul 03.
Cluster tendency assessment in neuronal spike data.
Autorzy:
Mahallati S; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.; KITE Research Institute, University Health Network, Toronto, Canada.; Krembil Research Institute, University Health Network, Toronto, Canada.; CRANIA, University Health Network and University of Toronto, Toronto, Canada. Bezdek JC; Computer Science and Information Systems Departments, University of Melbourne, Melbourne, Australia. Popovic MR; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.; KITE Research Institute, University Health Network, Toronto, Canada.; CRANIA, University Health Network and University of Toronto, Toronto, Canada. ValianteTA; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.; Krembil Research Institute, University Health Network, Toronto, Canada.; Division of Neurosurgery, University of Toronto, Toronto, Canada.; CRANIA, University Health Network and University of Toronto, Toronto, Canada.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2019 Nov 12; Vol. 14 (11), pp. e0224547. Date of Electronic Publication: 2019 Nov 12 (Print Publication: 2019).
Bridging the Gap between Evidence and Practice for Adults with Medically Refractory Temporal Lobe Epilepsy: Is a Change in Funding Policy Needed to Stimulate a Shift in Practice?
Autorzy:
Mansouri A; Division of Neurosurgery, University of Toronto, Toronto, ON, Canada; Toronto Western Hospital, University Health Network, Toronto, ON, Canada M5T 2S8; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8P 1H1. Aldakkan A; Division of Neurosurgery, University of Toronto, Toronto, ON, Canada; Toronto Western Hospital, University Health Network, Toronto, ON, Canada M5T 2S8; Division of Neurosurgery, King Saud University, Riyadh, Saudi Arabia. Kosicka MJ; Toronto Western Hospital, University Health Network, Toronto, ON, Canada M5T 2S8. Tarride JE; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8P 1H1. ValianteTA; Division of Neurosurgery, University of Toronto, Toronto, ON, Canada; Toronto Western Hospital, University Health Network, Toronto, ON, Canada M5T 2S8; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada; Division of Fundamental Neurobiology, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada M5T 2S8; Krembil Neuroscience Center, Toronto, Canada.
Pokaż więcej
Źródło:
Epilepsy research and treatment [Epilepsy Res Treat] 2015; Vol. 2015, pp. 675071. Date of Electronic Publication: 2015 Dec 07.
Dynamic circuit motifs underlying rhythmic gain control, gating and integration.
Autorzy:
Womelsdorf T; 1] Department of Biology, York University, Toronto, Ontario, Canada. [2] Centre for Vision Research, York University, Toronto, Ontario, Canada. ValianteTA; 1] Division of Fundamental Neurobiology, Toronto Western Research Institute, Toronto, Ontario, Canada. [2] Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Sahin NT; 1] Brain Power, LLC, Boston, Massachusetts, USA. [2] Department of Psychology, Harvard University, Cambridge, Massachusetts, USA. Miller KJ; 1] Department of Physics, University of Washington, Seattle, Washington, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA. Tiesinga P; Donders Institute for Brain, Behavior, and Cognition, Radboud University Nijmegen, Nijmegen, the Netherlands.
Pokaż więcej
Źródło:
Nature neuroscience [Nat Neurosci] 2014 Aug; Vol. 17 (8), pp. 1031-9. Date of Electronic Publication: 2014 Jul 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy.
Autorzy:
Mansouri A; Division of Neurosurgery, University of Toronto, Toronto, ON, Canada M5G 1X8 ; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8. Fallah A; Division of Neurosurgery, University of Toronto, Toronto, ON, Canada M5G 1X8 ; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada L8S 4K1. McAndrews MP; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Psychology Department, University of Toronto, Toronto, ON, Canada M5T 2S8 ; Institute of Medical Sciences, University of Toronto, Toronto, Canada M5T 2S8 ; Krembil Neuroscience Center, University Health Network, Toronto, Canada M5T 2S8. Cohn M; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Psychology Department, University of Toronto, Toronto, ON, Canada M5T 2S8 ; Krembil Neuroscience Center, University Health Network, Toronto, Canada M5T 2S8. Mayor D; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Krembil Neuroscience Center, University Health Network, Toronto, Canada M5T 2S8 ; Division of Fundamental Neurobiology, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada M5T 2S8. Andrade D; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Department of Neurology, University of Toronto, Toronto, ON, Canada M5T 2S8. Carlen P; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Department of Neurology, University of Toronto, Toronto, ON, Canada M5T 2S8. Del Campo JM; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Department of Neurology, University of Toronto, Toronto, ON, Canada M5T 2S8. Tai P; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Department of Neurology, University of Toronto, Toronto, ON, Canada M5T 2S8. Wennberg RA; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Department of Neurology, University of Toronto, Toronto, ON, Canada M5T 2S8. ValianteTA; Division of Neurosurgery, University of Toronto, Toronto, ON, Canada M5G 1X8 ; Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 ; Krembil Neuroscience Center, University Health Network, Toronto, Canada M5T 2S8 ; Division of Fundamental Neurobiology, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada M5T 2S8.
Pokaż więcej
Źródło:
Epilepsy research and treatment [Epilepsy Res Treat] 2014; Vol. 2014, pp. 306382. Date of Electronic Publication: 2014 Oct 01.
Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies
