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Tytuł:
p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Autorzy:
Sturmlechner I; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.
Zhang C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Sine CC; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
van Deursen EJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Jeganathan KB; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Hamada N; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Grasic J; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Friedman D; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Stutchman JT; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Can I; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Hamada M; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Lim DY; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Lee JH; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Ordog T; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Laberge RM; Unity Biotechnology, South San Francisco, CA 94080, USA.
Shapiro V; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
van Deursen JM; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Oct 29; Vol. 374 (6567), pp. eabb3420. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
Immunologic Surveillance*
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Animals ; Cell Cycle Checkpoints ; Cell Line ; Chemokines, CXC/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Genes, ras ; Hepatocytes/immunology ; Hepatocytes/metabolism ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Mice, Transgenic ; Proto-Oncogene Proteins p21(ras)/metabolism ; Retinoblastoma Protein/metabolism ; Stress, Physiological ; T-Lymphocytes, Cytotoxic/immunology ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Senolytic therapies for healthy longevity.
Autorzy:
van Deursen JM; Departments of Biochemistry and Molecular Biology, and Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2019 May 17; Vol. 364 (6441), pp. 636-637.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Healthy Aging*
Rejuvenation*
Atherosclerosis/*prevention & control
Cellular Senescence/*drug effects
Neoplasms/*prevention & control
Neurodegenerative Diseases/*prevention & control
Animals ; Apoptosis/drug effects ; Humans ; Longevity ; Mice ; Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice.
Autorzy:
Cho CH; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
Yoo KH; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
Oliveros A; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
Paulson S; SURF program, Neuroscience Track, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota.
Hussaini SMQ; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.; Currently at Duke University Medical Center, Durham, North Carolina.
van Deursen JM; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
Jang MH; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.; SURF program, Neuroscience Track, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
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Źródło:
Aging cell [Aging Cell] 2019 Apr; Vol. 18 (2), pp. e12899. Date of Electronic Publication: 2019 Jan 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
Cell Cycle Proteins/*metabolism
Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors
Progeria/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Animals ; Brain/metabolism ; Brain/pathology ; Cell Cycle Proteins/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Mice, Mutant Strains ; Protein Serine-Threonine Kinases/genetics ; Wnt Signaling Pathway
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Age-related decline in BubR1 impairs adult hippocampal neurogenesis.
Autorzy:
Yang Z; Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.
Jun H; Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
Choi CI; Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
Yoo KH; Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
Cho CH; Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
Hussaini SMQ; Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
Simmons AJ; Department of Anatomy and Cell Biology, Shriners Hospital for Children Pediatric Research Center, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Kim S; Department of Anatomy and Cell Biology, Shriners Hospital for Children Pediatric Research Center, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
van Deursen JM; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
Baker DJ; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
Jang MH; Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.
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Źródło:
Aging cell [Aging Cell] 2017 Jun; Vol. 16 (3), pp. 598-601. Date of Electronic Publication: 2017 Apr 06.
Typ publikacji:
Journal Article
MeSH Terms:
Aging/*genetics
Cell Cycle Proteins/*genetics
Hippocampus/*metabolism
Neural Stem Cells/*metabolism
Neurogenesis/*genetics
Neurons/*metabolism
Progeria/*genetics
Protein Serine-Threonine Kinases/*genetics
Aging/metabolism ; Aging/pathology ; Animals ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/deficiency ; Cell Differentiation ; Disease Models, Animal ; Doublecortin Domain Proteins ; Gene Expression Regulation, Developmental ; Hippocampus/pathology ; Humans ; Mice ; Mice, Transgenic ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Minichromosome Maintenance Complex Component 2/genetics ; Minichromosome Maintenance Complex Component 2/metabolism ; Neural Stem Cells/pathology ; Neuronal Plasticity/genetics ; Neurons/pathology ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Progeria/metabolism ; Progeria/pathology ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/deficiency ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Senescent intimal foam cells are deleterious at all stages of atherosclerosis.
Autorzy:
Childs BG; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Wijshake T; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA. Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, Netherlands.
Conover CA; Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN 55905, USA.
Campisi J; Buck Institute for Research on Aging, Novato, CA 94945, USA. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
van Deursen JM; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2016 Oct 28; Vol. 354 (6311), pp. 472-477. Date of Electronic Publication: 2016 Oct 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cellular Senescence*
Atherosclerosis/*pathology
Foam Cells/*pathology
Animals ; Atherosclerosis/genetics ; Chemokines/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cytokines/metabolism ; Mice ; Mice, Transgenic ; Plaque, Atherosclerotic/genetics ; Plaque, Atherosclerotic/pathology ; Receptors, LDL/genetics ; Tunica Intima/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.
Autorzy:
Kanakkanthara A; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Jeganathan KB; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Limzerwala JF; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Hamada M; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Nam HJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
van Deursen WH; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Hamada N; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Naylor RM; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Becker NA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Davies BA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
van Ree JH; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Shapiro VS; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Maher LJ 3rd; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Katzmann DJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
van Deursen JM; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2016 Sep 30; Vol. 353 (6307), pp. 1549-1552.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosomal Instability*
Gene Expression Regulation*
Cyclin A2/*metabolism
DNA Repair Enzymes/*genetics
DNA Replication/*genetics
DNA-Binding Proteins/*genetics
Protein Biosynthesis/*genetics
RNA, Messenger/*metabolism
RNA-Binding Proteins/*metabolism
Animals ; CDC2 Protein Kinase/metabolism ; Centrosome/metabolism ; Cyclin A2/genetics ; DNA Breaks, Double-Stranded ; DNA Repair ; Humans ; Kinesins/metabolism ; MRE11 Homologue Protein ; Meiosis/genetics ; Mice ; Mice, Mutant Strains ; Mitosis/genetics ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics ; S Phase/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets.
Autorzy:
Luo L; Institute of Immunotherapy, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zhu G; Department of Immunobiology and Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Xu H; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Yao S; Department of Immunobiology and Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Zhou G; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Zhu Y; Department of Immunobiology and Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Tamada K; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Huang L; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Flies AD; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Broadwater M; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Ruff W; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
van Deursen JM; Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, United States of America.
Melero I; Department of Medicine, University of Navarra, Pamplona, Spain.
Zhu Z; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Chen L; Department of Immunobiology and Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Jun 11; Vol. 10 (6), pp. e0130126. Date of Electronic Publication: 2015 Jun 11 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Arthritis, Experimental/*pathology
Asthma/*pathology
B7 Antigens/*physiology
Encephalomyelitis, Autoimmune, Experimental/*pathology
Inflammation/*pathology
Th1 Cells/*immunology
Th17 Cells/*immunology
Th2 Cells/*immunology
Animals ; Apoptosis ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/immunology ; Asthma/chemically induced ; Asthma/immunology ; Blotting, Western ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Female ; Humans ; Immunoenzyme Techniques ; Inflammation/chemically induced ; Inflammation/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cyclin B2 and p53 control proper timing of centrosome separation.
Autorzy:
Nam HJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
van Deursen JM; 1] Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA [2] Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
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Źródło:
Nature cell biology [Nat Cell Biol] 2014 Jun; Vol. 16 (6), pp. 538-49. Date of Electronic Publication: 2014 Apr 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Chromosome Segregation*
Centrosome/*metabolism
Cyclin B2/*metabolism
Tumor Suppressor Protein p53/*metabolism
Aneuploidy ; Animals ; Aurora Kinase A/metabolism ; Cell Cycle Proteins/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Chromosome Aberrations ; Cyclin B1/deficiency ; Cyclin B1/genetics ; Cyclin B2/deficiency ; Cyclin B2/genetics ; Female ; Genes, APC ; Intestinal Neoplasms/genetics ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; RNA Interference ; Separase/metabolism ; Signal Transduction ; Time Factors ; Transfection ; Polo-Like Kinase 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The role of senescent cells in ageing.
Autorzy:
van Deursen JM; Department of Pediatric and Adolescent Medicine and Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
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Źródło:
Nature [Nature] 2014 May 22; Vol. 509 (7501), pp. 439-46.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Aging/*pathology
Cellular Senescence/*physiology
Animals ; Disease ; Humans ; Longevity ; Mitosis ; Models, Biological
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Impact of genomic damage and ageing on stem cell function.
Autorzy:
Behrens A; Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK, and the School of Medicine, King's College London, Guy's Campus, London, SE1 1UL, UK.
van Deursen JM; Department of Pediatric and Adolescent Medicine and the Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Rudolph KL; Leibniz Institute of Age Research, Fritz Lipmann Institute e.V., Jena, 07745, Germany, and the Research Group on Molecular Aging, Faculty of Medicine, Friedrich-Schiller-University, Jena, Germany.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, and the Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, and Systems Biology of Cologne, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany.
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Źródło:
Nature cell biology [Nat Cell Biol] 2014 Mar; Vol. 16 (3), pp. 201-7.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
DNA Damage*
Adult Stem Cells/*physiology
Aneuploidy ; Animals ; Cells, Cultured ; Cellular Senescence ; DNA Repair ; Genome, Human ; Humans ; Neoplasms/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
Autorzy:
Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905, USA.
Dawlaty MM
Wijshake T
Jeganathan KB
Malureanu L
van Ree JH
Crespo-Diaz R
Reyes S
Seaburg L
Shapiro V
Behfar A
Terzic A
van de Sluis B
van Deursen JM
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Źródło:
Nature cell biology [Nat Cell Biol] 2013 Jan; Vol. 15 (1), pp. 96-102. Date of Electronic Publication: 2012 Dec 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression*
Aging/*metabolism
Lung Neoplasms/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Skin Neoplasms/*metabolism
9,10-Dimethyl-1,2-benzanthracene ; Aging/pathology ; Aneuploidy ; Animals ; Cell Count ; Cell Cycle Proteins ; Cells, Cultured ; Chromosomal Instability ; Female ; Life Expectancy ; Lung Neoplasms/chemically induced ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Phenotype ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/physiology ; Skin Neoplasms/chemically induced ; Stem Cells/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reprogramming to pluripotency can conceal somatic cell chromosomal instability.
Autorzy:
Hamada M; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.
Malureanu LA
Wijshake T
Zhou W
van Deursen JM
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Źródło:
PLoS genetics [PLoS Genet] 2012; Vol. 8 (8), pp. e1002913. Date of Electronic Publication: 2012 Aug 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Aneuploidy*
Induced Pluripotent Stem Cells*/cytology
Induced Pluripotent Stem Cells*/metabolism
Cell Differentiation/*genetics
Chromosomal Instability/*genetics
Animals ; Cell Cycle Proteins ; Cell Line ; Fibroblasts ; Humans ; Mice ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.
Autorzy:
Wijshake T; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
Malureanu LA
Baker DJ
Jeganathan KB
van de Sluis B
van Deursen JM
Pokaż więcej
Źródło:
PLoS genetics [PLoS Genet] 2012; Vol. 8 (12), pp. e1003138. Date of Electronic Publication: 2012 Dec 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aging/*genetics
Chromosome Disorders/*genetics
Longevity/*genetics
Protein Serine-Threonine Kinases/*genetics
Alleles ; Animals ; Cell Cycle Proteins ; Chromosome Disorders/physiopathology ; Humans ; Mice ; Mice, Transgenic ; Mosaicism ; Mutation ; Phenotype ; Protein Serine-Threonine Kinases/physiology
SCR Disease Name:
Mosaic variegated aneuploidy syndrome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Autorzy:
Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Wijshake T
Tchkonia T
LeBrasseur NK
Childs BG
van de Sluis B
Kirkland JL
van Deursen JM
Pokaż więcej
Źródło:
Nature [Nature] 2011 Nov 02; Vol. 479 (7372), pp. 232-6. Date of Electronic Publication: 2011 Nov 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aging/*physiology
Cellular Senescence/*physiology
Cyclin-Dependent Kinase Inhibitor p16/*metabolism
Adipose Tissue/cytology ; Adipose Tissue/drug effects ; Adipose Tissue/pathology ; Aging/drug effects ; Animals ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Cell Count ; Cell Cycle Proteins ; Cells, Cultured ; Cellular Senescence/drug effects ; Eye/cytology ; Eye/drug effects ; Eye/pathology ; Female ; Gene Expression ; Genotype ; Longevity/drug effects ; Longevity/physiology ; Male ; Mice ; Mice, Transgenic ; Muscle, Skeletal/cytology ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology ; Phenotype ; Progeria/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Tacrolimus/analogs & derivatives ; Tacrolimus/pharmacology ; Time Factors ; Weaning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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