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Tytuł:
Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes.
Autorzy:
Rombaut D; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Chiu HS; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Decaesteker B; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Everaert C; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Yigit N; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Peltier A; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée contre le Cancer, F-75005, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, F-75005, Paris, France.
Janoueix-Lerosey I; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée contre le Cancer, F-75005, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, F-75005, Paris, France.
Bartenhagen C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937, Cologne, Germany.
Fischer M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937, Cologne, Germany.
Roberts S; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
D'Haene N; Hôpital Erasme, Cliniques Universitaires de Bruxelles, Bruxelles, 1070, Belgium.
De Preter K; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Speleman F; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Denecker G; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Sumazin P; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Vandesompele J; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Lefever S; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
Mestdagh P; Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium. .; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium. .
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Źródło:
Scientific reports [Sci Rep] 2019 Apr 05; Vol. 9 (1), pp. 5685. Date of Electronic Publication: 2019 Apr 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroblastoma/*genetics
RNA, Long Noncoding/*genetics
Cell Line, Tumor ; Gene Drive Technology/methods ; Gene Expression Profiling/methods ; Humans ; Neural Stem Cells/physiology ; Sequence Analysis, RNA/methods ; Signal Transduction/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A mechanistic classification of clinical phenotypes in neuroblastoma.
Autorzy:
Ackermann S; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Cartolano M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
Hero B; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.
Welte A; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Kahlert Y; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Roderwieser A; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Bartenhagen C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Walter E; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Gecht J; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.
Kerschke L; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
Volland R; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.
Menon R; NEO New Oncology GmbH, Cologne, Germany.
Heuckmann JM; NEO New Oncology GmbH, Cologne, Germany.
Gartlgruber M; Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Hartlieb S; Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Henrich KO; Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Okonechnikov K; Division of Pediatric Neurooncology, German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Altmüller J; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Center for Genomics, University of Cologne, Cologne, Germany.
Nürnberg P; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Center for Genomics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Lefever S; Center for Medical Genetics, Ghent University, Ghent, Belgium.
de Wilde B; Center for Medical Genetics, Ghent University, Ghent, Belgium.
Sand F; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Ikram F; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan.
Rosswog C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Fischer J; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Theissen J; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.
Hertwig F; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Berlin Institute of Health, Berlin, Germany.
Singhi AD; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Simon T; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.
Vogel W; Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.; Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany.
Perner S; Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.; Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany.
Krug B; Department of Diagnostic and Interventional Radiology, University Hospital of Cologne, Cologne, Germany.
Schmidt M; Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
Rahmann S; Genome Informatics, Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Computer Science, TU Dortmund, Dortmund, Germany.
Achter V; Computing Center, University of Cologne, Cologne, Germany.
Lang U; Computing Center, University of Cologne, Cologne, Germany.; Department of Informatics, University of Cologne, Cologne, Germany.
Vokuhl C; Kiel Pediatric Tumor Registry, Department of Pediatric Pathology, University of Kiel, Kiel, Germany.
Ortmann M; Department of Pathology, University of Cologne, Cologne, Germany.
Büttner R; Department of Pathology, University of Cologne, Cologne, Germany.
Eggert A; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Berlin Institute of Health, Berlin, Germany.
Speleman F; Center for Medical Genetics, Ghent University, Ghent, Belgium.
O'Sullivan RJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center, Pittsburgh, PA, USA.
Thomas RK; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pathology, University of Cologne, Cologne, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Berthold F; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.
Vandesompele J; Center for Medical Genetics, Ghent University, Ghent, Belgium.
Schramm A; Department of Medical Oncology, West German Cancer Center Essen, University of Duisburg-Essen, Essen, Germany.
Westermann F; Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Schulte JH; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Berlin Institute of Health, Berlin, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Peifer M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
Fischer M; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany. .; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2018 Dec 07; Vol. 362 (6419), pp. 1165-1170.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroblastoma/*classification
Neuroblastoma/*mortality
Telomere Homeostasis/*genetics
Child ; Child, Preschool ; Disease-Free Survival ; Exome/genetics ; Genome, Human ; Humans ; Metabolic Networks and Pathways/genetics ; Mutation ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Prognosis ; Sequence Analysis, DNA ; Tumor Suppressor Protein p53/genetics ; ras Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors.
Autorzy:
Vanhauwaert S; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Decaesteker B; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
De Brouwer S; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Leonelli C; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Durinck K; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Mestdagh P; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Vandesompele J; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Sermon K; Research Group Reproduction and Genetics, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.
Denecker G; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Van Neste C; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Speleman F; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
De Preter K; Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium. .; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium. .
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Źródło:
Scientific reports [Sci Rep] 2018 Nov 30; Vol. 8 (1), pp. 17468. Date of Electronic Publication: 2018 Nov 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
Forkhead Box Protein M1/*metabolism
Neuroblastoma/*drug therapy
Neuroblastoma/*metabolism
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Cell Cycle/genetics ; Computer Simulation ; DNA Damage/genetics ; Drug Design ; Embryonic Stem Cells/metabolism ; Embryonic Stem Cells/pathology ; Genes, myc ; Humans ; Mice ; Mice, Transgenic ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Prognosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A unified censored normal regression model for qPCR differential gene expression analysis.
Autorzy:
Pipelers P; Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium.
Clement L; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.; Bioinformatics Institute Ghent from Nucleotides to Networks (BIG N2N), Ghent University, Ghent, Belgium.
Vynck M; Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium.
Hellemans J; Center for Medical Genetics, Ghent University, Ghent, Belgium.; Biogazelle, Zwijnaarde, Belgium.
Vandesompele J; Bioinformatics Institute Ghent from Nucleotides to Networks (BIG N2N), Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University, Ghent, Belgium.; Biogazelle, Zwijnaarde, Belgium.
Thas O; Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium.; Bioinformatics Institute Ghent from Nucleotides to Networks (BIG N2N), Ghent University, Ghent, Belgium.; National Institute for Applied Statistics Research Australia (NIASRA), School of Mathematics and Applied Statistics, University of Wollongong, Wollongong, NSW 2522, Australia.
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Źródło:
PloS one [PLoS One] 2017 Aug 17; Vol. 12 (8), pp. e0182832. Date of Electronic Publication: 2017 Aug 17 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Profiling/*methods
Molecular Diagnostic Techniques/*methods
Neuroblastoma/*genetics
Polymerase Chain Reaction/*methods
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Child ; Child, Preschool ; Gene Expression Profiling/standards ; Humans ; MicroRNAs/genetics ; Molecular Diagnostic Techniques/standards ; N-Myc Proto-Oncogene Protein/genetics ; N-Myc Proto-Oncogene Protein/metabolism ; Neuroblastoma/diagnosis ; Neuroblastoma/metabolism ; Polymerase Chain Reaction/standards ; Reference Standards ; Sensitivity and Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma.
Autorzy:
Rihani A; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
Van Goethem A; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
Ongenaert M; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
De Brouwer S; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
Volders PJ; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
Agarwal S; Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
De Preter K; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
Mestdagh P; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
Shohet J; Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Speleman F; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
Vandesompele J; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
Van Maerken T; Center for Medical Genetics, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium.
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Źródło:
Scientific reports [Sci Rep] 2015 Mar 12; Vol. 5, pp. 9027. Date of Electronic Publication: 2015 Mar 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling*
Gene Expression Regulation, Neoplastic*/drug effects
Genome-Wide Association Study*
MicroRNAs/*genetics
Neuroblastoma/*genetics
Neuroblastoma/*metabolism
Tumor Suppressor Protein p53/*metabolism
Cell Line, Tumor ; Cell Proliferation ; Humans ; Imidazoles/pharmacology ; Piperazines/pharmacology ; Promoter Regions, Genetic ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients.
Autorzy:
Rihani A; Center for Medical Genetics, Ghent University, Ghent, Belgium.
De Wilde B; Center for Medical Genetics, Ghent University, Ghent, Belgium.
Zeka F; Center for Medical Genetics, Ghent University, Ghent, Belgium.
Laureys G; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.
Francotte N; Département de pédiatrie, hémato-oncologie, SUHOPL- CHC (Service Universitaire d'HématoOncologie Pédiatrique Centre Hospitalier Chrétien) Espérance, St Nicolas Belgium.
Tonini GP; Neuroblastoma Laboratory, Onco/Hematology Laboratory, Department of Women's and Children's Health, University of Padua, Pediatric Research Institute, Fondazione Città della Speranza, Padua, Italy.
Coco S; Lung Cancer Unit, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Azienda Ospedaliera Universitaria San Martino - IST (Istituto Nazionale per la Ricerca sul Cancro), Genoa, Italy.
Versteeg R; Departement of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Noguera R; Department of Pathology, Medical School, University of Valencia, Valencia, Spain.
Schulte JH; German Cancer Consortium (DKTK), Germany; Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Essen, Germany; Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.
Eggert A; Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Essen, Germany.
Stallings RL; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, and National Children's Research Centre, Dublin, Ireland.
Speleman F; Center for Medical Genetics, Ghent University, Ghent, Belgium.
Vandesompele J; Center for Medical Genetics, Ghent University, Ghent, Belgium.
Van Maerken T; Center for Medical Genetics, Ghent University, Ghent, Belgium.
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Źródło:
PloS one [PLoS One] 2014 Dec 11; Vol. 9 (12), pp. e114696. Date of Electronic Publication: 2014 Dec 11 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Amplification*
Polymorphism, Single Nucleotide*
Caspase 8/*genetics
Neuroblastoma/*diagnosis
Neuroblastoma/*genetics
Nuclear Proteins/*genetics
Oncogene Proteins/*genetics
Disease-Free Survival ; Gene Expression Regulation, Neoplastic ; Genotyping Techniques ; Humans ; Infant ; N-Myc Proto-Oncogene Protein ; Neoplasm Staging ; Neuroblastoma/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastoma.
Autorzy:
Kumps C; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
Van Roy N
Heyrman L
Goossens D
Del-Favero J
Noguera R
Vandesompele J
Speleman F
De Preter K
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Źródło:
BMC genomics [BMC Genomics] 2010 May 12; Vol. 11, pp. 298. Date of Electronic Publication: 2010 May 12.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroblastoma/*genetics
Nucleic Acid Amplification Techniques/*methods
DNA Copy Number Variations ; Humans ; Nucleic Acid Amplification Techniques/economics ; Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival.
Autorzy:
Bray I; Department of Cancer Genetics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Bryan K
Prenter S
Buckley PG
Foley NH
Murphy DM
Alcock L
Mestdagh P
Vandesompele J
Speleman F
London WB
McGrady PW
Higgins DG
O'Meara A
O'Sullivan M
Stallings RL
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Źródło:
PloS one [PLoS One] 2009 Nov 16; Vol. 4 (11), pp. e7850. Date of Electronic Publication: 2009 Nov 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosome Aberrations*
Gene Expression Regulation, Neoplastic*
MicroRNAs*/metabolism
Neuroblastoma/*genetics
Nuclear Proteins/*biosynthesis
Nuclear Proteins/*genetics
Oncogene Proteins/*biosynthesis
Oncogene Proteins/*genetics
Cell Line, Tumor ; Cluster Analysis ; Cohort Studies ; Humans ; N-Myc Proto-Oncogene Protein ; Nervous System Neoplasms/genetics ; Nervous System Neoplasms/metabolism ; Nucleic Acid Hybridization ; Reverse Transcriptase Polymerase Chain Reaction ; Sensitivity and Specificity ; Sequence Analysis, DNA ; Sympathetic Nervous System/pathology ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles.
Autorzy:
Hoebeeck J; Center for Medical Genetics, Ghent University Hospital, Belgium.
De Wilde B
Michels E
Combaret V
Yigit N
De Smet E
Van Roy N
Stanbridge E
Ru N
Laureys G
De Paepe A
Speleman F
Vandesompele J
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Źródło:
Cancer investigation [Cancer Invest] 2009 Oct; Vol. 27 (8), pp. 857-68.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosome Mapping*/methods
Chromosomes, Human, Pair 3*
Genes, Tumor Suppressor*
Loss of Heterozygosity*
Microsatellite Repeats*
Neuroblastoma/*genetics
Alleles ; Cell Line ; Gene Expression Regulation, Neoplastic ; Gene Transfer Techniques ; Genotype ; Humans ; Neuroblastoma/pathology ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23.
Autorzy:
Michels E; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium. Evi_ />Hoebeeck J
De Preter K
Schramm A
Brichard B
De Paepe A
Eggert A
Laureys G
Vandesompele J
Speleman F
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Źródło:
BMC cancer [BMC Cancer] 2008 Jun 17; Vol. 8, pp. 173. Date of Electronic Publication: 2008 Jun 17.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosomes, Human, Pair 11*
Immunoglobulins/*genetics
Membrane Proteins/*genetics
Neuroblastoma/*genetics
Tumor Suppressor Proteins/*genetics
Cell Adhesion Molecule-1 ; Cell Adhesion Molecules ; Cell Line, Tumor ; Chromosome Mapping ; Gene Dosage ; Gene Expression ; Humans ; Immunoglobulins/biosynthesis ; Membrane Proteins/biosynthesis ; Neuroblastoma/metabolism ; Nucleic Acid Hybridization ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Tumor Suppressor Proteins/biosynthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes.
Autorzy:
Vandepoele K; Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
Andries V
Van Roy N
Staes K
Vandesompele J
Laureys G
De Smet E
Berx G
Speleman F
van Roy F
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Źródło:
PloS one [PLoS One] 2008 May 21; Vol. 3 (5), pp. e2207. Date of Electronic Publication: 2008 May 21.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 17*
Translocation, Genetic*
Epithelial Sodium Channels/*genetics
Neoplasm Proteins/*genetics
Nerve Tissue Proteins/*genetics
Neuroblastoma/*genetics
Acid Sensing Ion Channels ; Base Sequence ; Cell Division/genetics ; Cell Line, Tumor ; DNA Primers ; Degenerin Sodium Channels ; Humans ; Hybrid Cells ; Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11.
Autorzy:
De Preter K; Center for Medical Genetics, Ghent University Hospital, MRB 2nd floor, De Pintelaan 185, B-9000 Ghent, Belgium. />Vandesompele J
Menten B
Carr P
Fiegler H
Edsjö A
Carter NP
Yigit N
Waelput W
Van Roy N
Bader S
Påhlman S
Speleman F
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Źródło:
BMC genomics [BMC Genomics] 2005 Jul 06; Vol. 6, pp. 97. Date of Electronic Publication: 2005 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Tumor Suppressor*
Chromosome Mapping/*methods
Chromosomes, Human, Pair 11/*ultrastructure
Neuroblastoma/*genetics
Neuroblastoma/*pathology
Alleles ; Cell Differentiation ; Cell Line ; Chromosome Deletion ; Chromosomes, Artificial, Bacterial/genetics ; Gene Deletion ; Heterozygote ; Humans ; In Situ Hybridization, Fluorescence ; Microsatellite Repeats ; Neuroblastoma/metabolism ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis ; Phalloidine/pharmacology ; Phenotype ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
No evidence for involvement of SDHD in neuroblastoma pathogenesis.
Autorzy:
De Preter K; Center for Medical Genetics, Ghent University Hospital, K5, De Pintelaan 185, B-9000 Ghent, Belgium. />Vandesompele J
Hoebeeck J
Vandenbroecke C
Smet J
Nuyts A
Laureys G
Combaret V
Van Roy N
Roels F
Van Coster R
Praet M
De Paepe A
Speleman F
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Źródło:
BMC cancer [BMC Cancer] 2004 Aug 24; Vol. 4, pp. 55. Date of Electronic Publication: 2004 Aug 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosomes, Human, Pair 11/*genetics
Membrane Proteins/*metabolism
Neuroblastoma/*genetics
Neuroblastoma/*ultrastructure
Base Sequence ; Cell Line, Tumor ; DNA, Neoplasm/isolation & purification ; Humans ; Membrane Proteins/genetics ; Methylation ; Mitochondria/ultrastructure ; Molecular Sequence Data ; Mutation ; Neuroblastoma/metabolism ; RNA, Messenger/isolation & purification ; RNA, Neoplasm/isolation & purification ; Succinate Dehydrogenase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 80

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