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Tytuł:
Endothelin-1 potentiates TRPV1-mediated vasoconstriction of human adipose arterioles in a protein kinase C-dependent manner.
Autorzy:
Korishettar AM; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Medicine - Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Nishijima Y; Department of Medicine - Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Wang Z; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Geriatrics, The First Hospital of Jilin University, Changchun, China.
Xie Y; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Fang J; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.; Children's Research Institute, The Children's Hospital of Wisconsin, Milwaukee, WI, USA.
Wilcox DA; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.; Children's Research Institute, The Children's Hospital of Wisconsin, Milwaukee, WI, USA.
Zhang DX; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Medicine - Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2021 Feb; Vol. 178 (3), pp. 709-725. Date of Electronic Publication: 2020 Dec 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelin-1*
Vasoconstriction*
Adipose Tissue ; Arterioles ; Capsaicin/pharmacology ; Humans ; Protein Kinase C ; TRPV Cation Channels
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1.
Autorzy:
Morris GE; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Denniff MJ; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Karamanavi E; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Andrews SA; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Kostogrys RB; Department of Human Nutrition, Faculty of Food Technology, University of Agriculture in Krakow, Krakow, Poland.
Bountziouka V; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Ghaderi-Najafabadi M; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Shamkhi N; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
McConnell G; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Kaiser MA; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Carleton L; Horizon Discovery Ltd., Cambridge, UK.
Schofield C; Horizon Discovery Ltd., Cambridge, UK.
Kessler T; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany.; German Centre of Cardiovascular Research (DZHK e. V.), Partner Site Munich Heart Alliance, Munich, Germany.
Rainbow RD; Department of Cardiovascular and Metabolic Medicine & Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.
Samani NJ; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Webb TR; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Nov; Vol. 179 (21), pp. 4958-4973. Date of Electronic Publication: 2022 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Induced Pluripotent Stem Cells*
Integrin alpha4beta1*
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid ; Animals ; Calcium/metabolism ; Cell Adhesion Molecules ; Humans ; Integrins/genetics ; Integrins/metabolism ; Ligands ; Mice ; Vasoconstriction ; Vasoconstrictor Agents ; rho-Associated Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights.
Autorzy:
Leo CH; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.
Ng HH; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.; Heart Failure Pharmacology, Baker Heart & Diabetes Institute, Melbourne, VIC, Australia.
Marshall SA; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.
Jelinic M; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.
Rupasinghe T; Metabolomics Australia, School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.
Qin C; Heart Failure Pharmacology, Baker Heart & Diabetes Institute, Melbourne, VIC, Australia.; Department of Pharmacology & Therapeutics, The University of Melbourne, Parkville, VIC, Australia.
Roessner U; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.; Metabolomics Australia, School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.
Ritchie RH; Heart Failure Pharmacology, Baker Heart & Diabetes Institute, Melbourne, VIC, Australia.; Department of Diabetes, Monash University, Clayton, VIC, Australia.
Tare M; Monash Rural Health, Monash University, Churchill, VIC, Australia.; Department of Physiology, Monash University, Clayton, VIC, Australia.
Parry LJ; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2020 Jan; Vol. 177 (1), pp. 217-233. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelium, Vascular/*drug effects
Endothelium, Vascular/*metabolism
Hypertension/*drug therapy
Hypertension/*metabolism
Relaxin/*therapeutic use
Vasoconstriction/*drug effects
Animals ; Dose-Response Relationship, Drug ; Male ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Relaxin/pharmacology ; Vasoconstriction/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances K v 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries.
Autorzy:
Khammy MM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Kim S; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Bentzen BH; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lee S; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.
Choi I; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.
Aalkjaer C; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Jepps TA; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2018 Feb; Vol. 175 (3), pp. 501-516. Date of Electronic Publication: 2018 Jan 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
4-Aminopyridine/*pharmacology
KCNQ Potassium Channels/*physiology
Mesenteric Arteries/*physiology
Norepinephrine/*pharmacology
Potassium Channel Blockers/*pharmacology
Vasoconstriction/*physiology
Animals ; Dose-Response Relationship, Drug ; Female ; HEK293 Cells ; Humans ; KCNQ Potassium Channels/antagonists & inhibitors ; Male ; Mesenteric Arteries/drug effects ; Norepinephrine/antagonists & inhibitors ; Organ Culture Techniques ; Rats ; Rats, Wistar ; Vasoconstriction/drug effects ; Xenopus laevis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
NO-mediated signal transmission in bladder vasculature as a therapeutic target of PDE5 inhibitors. Rodent model studies.
Autorzy:
Tanaka H; Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Mitsui R; Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Oishi M; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Passlick S; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Jabs R; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Steinhäuser C; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Tanaka KF; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Hashitani H; Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2021 Mar; Vol. 178 (5), pp. 1073-1094. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Phosphodiesterase 5 Inhibitors*
Urinary Bladder*
Animals ; Arterioles ; Mice ; Rats ; Rodentia ; Vasoconstriction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protons modulate perivascular axo-axonal neurotransmission in the rat mesenteric artery.
Autorzy:
Takatori S; Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Ehime, Japan; Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Hirai K
Ozaki S
Tangsucharit P
Fukushima-Miyashita S
Goda M
Hashikawa-Hobara N
Ono N
Kawasaki H
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2014 Dec; Vol. 171 (24), pp. 5743-56.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protons*
Adrenergic Neurons/*metabolism
Axons/*metabolism
Calcitonin Gene-Related Peptide/*metabolism
Mesenteric Arteries/*innervation
Synaptic Transmission/*physiology
Vasoconstriction/*physiology
Vasodilation/*physiology
Acetylcholine/pharmacology ; Adrenergic Neurons/drug effects ; Animals ; Atropine/pharmacology ; Axons/drug effects ; Calcitonin Gene-Related Peptide/drug effects ; Capsaicin/analogs & derivatives ; Capsaicin/pharmacology ; Cholinergic Agonists/pharmacology ; Guanethidine/pharmacology ; Hydrogen-Ion Concentration/drug effects ; Mecamylamine/pharmacology ; Muscarinic Antagonists/pharmacology ; Nicotinic Antagonists/pharmacology ; Rats ; Ruthenium Red/pharmacology ; Sympatholytics/pharmacology ; Synaptic Transmission/drug effects ; Vasoconstriction/drug effects ; Vasodilation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The α₁B -adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium.
Autorzy:
Böhmer T; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
Manicam C
Steege A
Michel MC
Pfeiffer N
Gericke A
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2014 Aug; Vol. 171 (16), pp. 3858-67.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arterioles/*physiopathology
Endothelium, Vascular/*physiopathology
Receptors, Adrenergic, alpha-1/*physiology
Retinal Vessels/*physiopathology
Vasoconstriction/*physiology
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Adrenergic alpha-1 Receptor Agonists/pharmacology ; Animals ; Arterioles/drug effects ; Endothelium, Vascular/drug effects ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Phenylephrine/pharmacology ; Receptors, Adrenergic, alpha-1/genetics ; Retinal Vessels/drug effects ; Vasoconstriction/drug effects ; Vasoconstrictor Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways.
Autorzy:
El-Daly M; Libin Cardiovascular Institute of Alberta and the Snyder Institute for Chronic Diseases, Calgary, AB, Canada; Department of Physiology and Pharmacology, The University of Calgary Faculty of Medicine, Calgary, AB, Canada.
Saifeddine M
Mihara K
Ramachandran R
Triggle CR
Hollenberg MD
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2014 May; Vol. 171 (9), pp. 2413-25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Coronary Vessels/*enzymology
Protein-Tyrosine Kinases/*physiology
Receptor, PAR-1/*physiology
Receptor, PAR-2/*physiology
Vasoconstriction/*physiology
Animals ; Coronary Vessels/drug effects ; Organ Culture Techniques ; Protein Kinase Inhibitors/pharmacology ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Swine ; Vasoconstriction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Erucin exhibits vasorelaxing effects and antihypertensive activity by H 2 S-releasing properties.
Autorzy:
Martelli A; Department of Pharmacy, University of Pisa, Pisa, Italy.; Interdepartmental Research Centre 'Nutraceuticals and Food for Health (NUTRAFOOD)', University of Pisa, Pisa, Italy.
Piragine E; Department of Pharmacy, University of Pisa, Pisa, Italy.
Citi V; Department of Pharmacy, University of Pisa, Pisa, Italy.
Testai L; Department of Pharmacy, University of Pisa, Pisa, Italy.; Interdepartmental Research Centre 'Nutraceuticals and Food for Health (NUTRAFOOD)', University of Pisa, Pisa, Italy.
Pagnotta E; Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, Bologna, Italy.
Ugolini L; Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, Bologna, Italy.
Lazzeri L; Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, Bologna, Italy.
Di Cesare Mannelli L; Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Section of Pharmacology and Toxicology, Florence, Italy.
Manzo OL; Department of Pharmacy, University of Naples 'Federico II', Naples, Italy.
Bucci M; Department of Pharmacy, University of Naples 'Federico II', Naples, Italy.
Ghelardini C; Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Section of Pharmacology and Toxicology, Florence, Italy.
Breschi MC; Department of Pharmacy, University of Pisa, Pisa, Italy.
Calderone V; Department of Pharmacy, University of Pisa, Pisa, Italy.; Interdepartmental Research Centre 'Nutraceuticals and Food for Health (NUTRAFOOD)', University of Pisa, Pisa, Italy.; Interdepartmental Research Centre of Ageing Biology and Pathology, University of Pisa, Pisa, Italy.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2020 Feb; Vol. 177 (4), pp. 824-835. Date of Electronic Publication: 2019 Apr 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antihypertensive Agents*/pharmacology
Sulfides*/pharmacology
Animals ; Endothelium, Vascular ; Rats ; Thiocyanates/pharmacology ; Vasoconstriction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of binding, functional activity, and contractile responses of the selective 5-HT 1F receptor agonist lasmiditan.
Autorzy:
Rubio-Beltrán E; Division of Pharmacology, Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Labastida-Ramírez A; Division of Pharmacology, Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Haanes KA; Division of Pharmacology, Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.
van den Bogaerdt A; Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Bogers AJJC; Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Zanelli E; Research and Development, Déclion Pharmaceuticals, Inc., Marblehead, Massachusetts.
Meeus L; Euroscreen Fast Services Unit, Epics Therapeutics SA, Gosselies, Belgium.
Danser AHJ; Division of Pharmacology, Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Gralinski MR; CorDynamics, Inc., Chicago, Illinois.
Senese PB; CorDynamics, Inc., Chicago, Illinois.
Johnson KW; Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana.
Kovalchin J; Research and Development, CoLucid Pharmaceuticals, Inc., Cambridge, Massachusetts.
Villalón CM; Pharmacobiology, Cinvestav-Coapa, Mexico City, Mexico.
MaassenVanDenBrink A; Division of Pharmacology, Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2019 Dec; Vol. 176 (24), pp. 4681-4695. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzamides/*pharmacology
Coronary Vessels/*drug effects
Meningeal Arteries/*drug effects
Muscle Contraction/*drug effects
Piperidines/*pharmacology
Pyridines/*pharmacology
Receptors, Serotonin/*metabolism
Serotonin Receptor Agonists/*pharmacology
Vasoconstriction/*drug effects
Animals ; Binding, Competitive ; CHO Cells ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Coronary Vessels/metabolism ; Coronary Vessels/physiopathology ; Cricetulus ; Dogs ; Dose-Response Relationship, Drug ; Female ; Humans ; In Vitro Techniques ; Male ; Meningeal Arteries/metabolism ; Meningeal Arteries/physiopathology ; Protein Binding ; Radioligand Assay ; Sumatriptan/pharmacology ; Receptor, Serotonin, 5-HT1F
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Properties of submucosal venules in the rat distal colon.
Autorzy:
Mitsui R; Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Miyamoto S
Takano H
Hashitani H
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2013 Nov; Vol. 170 (5), pp. 968-77.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Vasoconstriction*/drug effects
Vasodilation*/drug effects
Colon/*blood supply
Enteric Nervous System/*metabolism
Animals ; Calcitonin Gene-Related Peptide/metabolism ; Calcium Signaling ; Electric Stimulation ; Enteric Nervous System/drug effects ; Fluorescent Antibody Technique ; Male ; Microscopy, Fluorescence ; Microscopy, Video ; Rats ; Rats, Wistar ; Substance P/metabolism ; Vasodilator Agents/pharmacology ; Venules/drug effects ; Venules/innervation ; Venules/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery.
Autorzy:
Craig J; College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, UK.
Martin W
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2012 Oct; Vol. 167 (3), pp. 527-36.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carotid Arteries/*metabolism
Regional Blood Flow/*physiology
Vasoconstriction/*physiology
Vasodilation/*physiology
Animals ; Biological Factors/metabolism ; Carotid Arteries/drug effects ; Cerebrovascular Circulation/physiology ; Female ; Myography ; Nitric Oxide/metabolism ; Rats ; Rats, Wistar ; Regional Blood Flow/drug effects ; Vasoconstriction/drug effects ; Vasodilation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A Ca²⁺-dependent chloride current and Ca²⁺ influx via Ca(v)1.2 ion channels play major roles in P2Y receptor-mediated pulmonary vasoconstriction.
Autorzy:
Mitchell C; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Syed NI
Gurney AM
Kennedy C
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2012 Jun; Vol. 166 (4), pp. 1503-12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Signaling*/drug effects
Membrane Potentials*/drug effects
Vasoconstriction*/drug effects
Calcium Channels, L-Type/*metabolism
Chloride Channels/*metabolism
Pulmonary Artery/*metabolism
Receptors, Purinergic P2Y/*metabolism
Adenosine Triphosphate/metabolism ; Animals ; Chloride Channels/antagonists & inhibitors ; Endothelium, Vascular/physiology ; In Vitro Techniques ; Kinetics ; Male ; Membrane Transport Modulators/pharmacology ; Myography ; Pulmonary Artery/drug effects ; Purinergic Antagonists/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P2X1/metabolism ; Uridine Diphosphate/metabolism ; Uridine Triphosphate/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
α1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor.
Autorzy:
Ulu N; Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands. />Gurdal H
Landheer SW
Duin M
Guc MO
Buikema H
Henning RH
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2010 Nov; Vol. 161 (6), pp. 1301-10.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aorta, Thoracic/*physiology
ErbB Receptors/*metabolism
Receptors, Adrenergic, alpha-1/*physiology
Transcriptional Activation/*physiology
Vasoconstriction/*physiology
Animals ; Aorta, Thoracic/drug effects ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Male ; Quinazolines ; Random Allocation ; Rats ; Rats, Wistar ; Transcriptional Activation/drug effects ; Tyrphostins/pharmacology ; Vasoconstriction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats.
Autorzy:
Sánchez A; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Contreras C
Villalba N
Martínez P
Martínez AC
Bríones A
Salaíces M
García-Sacristán A
Hernández M
Prieto D
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2010 Feb 01; Vol. 159 (3), pp. 604-16. Date of Electronic Publication: 2010 Jan 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Obesity*/metabolism
Obesity*/physiopathology
Arteries/*physiology
Arteries/*physiopathology
Vasoconstriction/*physiology
Vasodilation/*physiology
Acetylcholine/metabolism ; Acetylcholine/pharmacology ; Animals ; Arachidonic Acid/metabolism ; Arachidonic Acid/pharmacology ; Arteries/metabolism ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 1/pharmacology ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2/pharmacology ; Hyperemia/metabolism ; Hyperemia/physiopathology ; Insulin Resistance ; Male ; Nitric Oxide Synthase Type III ; Norepinephrine/metabolism ; Norepinephrine/pharmacology ; Penis/metabolism ; Penis/physiopathology ; Prediabetic State/metabolism ; Prediabetic State/physiopathology ; Rats ; Rats, Zucker ; Vasoconstriction/drug effects ; Vasoconstrictor Agents/metabolism ; Vasoconstrictor Agents/pharmacology ; Vasodilation/drug effects ; Vasodilator Agents/metabolism ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries.
Autorzy:
Maki J; Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Hirano M
Hoka S
Kanaide H
Hirano K
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2010 Feb; Vol. 159 (4), pp. 919-27. Date of Electronic Publication: 2010 Jan 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Signaling*/drug effects
Vasoconstriction*/drug effects
Actin Cytoskeleton/*metabolism
Muscle, Smooth, Vascular/*metabolism
Receptor, PAR-1/*metabolism
Thrombin/*metabolism
Actin Cytoskeleton/drug effects ; Animals ; Cattle ; Dose-Response Relationship, Drug ; Endothelium, Vascular/metabolism ; In Vitro Techniques ; Membrane Potentials ; Muscle, Smooth, Vascular/drug effects ; Myosin Light Chains/metabolism ; Phosphorylation ; Potassium/metabolism ; Protease Inhibitors/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Pulmonary Artery/metabolism ; Receptor, PAR-1/drug effects ; Swine ; Vasodilation ; rho-Associated Kinases/antagonists & inhibitors ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction.
Autorzy:
Yin A; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.
Yamada A; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.; Clinical Pharmacology PKMS Group, Astellas Pharma Inc., Tokyo, Japan.
Stam WB; Dutch Ministry of Health and Sports, Den Haag, The Netherlands.
van Hasselt JGC; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
van der Graaf PH; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.; Certara QSP, Canterbury, UK.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2018 Aug; Vol. 175 (16), pp. 3394-3406. Date of Electronic Publication: 2018 Jul 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Arginine Vasopressin/*pharmacology
Norepinephrine/*pharmacology
Vasoconstriction/*drug effects
Adrenergic alpha-Antagonists/pharmacology ; Animals ; Drug Interactions ; Humans ; Male ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/physiology ; Phenoxybenzamine/pharmacology ; Rats, Wistar ; Renal Artery/drug effects ; Renal Artery/physiology ; Systems Biology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2.
Autorzy:
Rorsman NJG; Department of Pharmacology, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK.
Ta CM; Department of Pharmacology, University of Oxford, Oxford, UK.
Garnett H; Department of Pharmacology, University of Oxford, Oxford, UK.
Swietach P; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Tammaro P; Department of Pharmacology, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2018 Jun; Vol. 175 (11), pp. 2028-2045. Date of Electronic Publication: 2018 Apr 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Optogenetics*
Channelrhodopsins/*metabolism
Myocytes, Smooth Muscle/*metabolism
Animals ; Electrophysiology ; Hydrogen-Ion Concentration ; Ions/metabolism ; Mice ; Mice, Transgenic ; Myocytes, Smooth Muscle/cytology ; Optical Imaging ; Vasoconstriction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Myoendothelial coupling in the mesenteric arterial bed; segmental differences and interplay between nitric oxide and endothelin-1.
Autorzy:
Hilgers RH; Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands.
De Mey JG
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 Apr; Vol. 156 (8), pp. 1239-47. Date of Electronic Publication: 2009 Mar 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Paracrine Communication*/drug effects
Vasoconstriction*/drug effects
Endothelin-1/*metabolism
Endothelium, Vascular/*metabolism
Gap Junctions/*metabolism
Muscle, Smooth, Vascular/*metabolism
Nitric Oxide/*metabolism
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology ; Animals ; Bosentan ; Calcium Channel Agonists/pharmacology ; Dose-Response Relationship, Drug ; Electric Stimulation ; Endothelin Receptor Antagonists ; Endothelium, Vascular/drug effects ; Enzyme Inhibitors/pharmacology ; Gap Junctions/drug effects ; Hydroxyeicosatetraenoic Acids/metabolism ; In Vitro Techniques ; Mesenteric Arteries/metabolism ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/innervation ; Myography ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide Donors/pharmacology ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/metabolism ; Nitroprusside/pharmacology ; Phenylephrine/pharmacology ; Rats ; Rats, Inbred WKY ; Receptors, Endothelin/metabolism ; Sulfonamides/pharmacology ; Sympathetic Nervous System/physiology ; Vasoconstrictor Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 676

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