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Wyszukujesz frazę ""Velazquez, Francisco"" wg kryterium: Autor


Wyświetlanie 1-10 z 10
Tytuł :
Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.
Autorzy :
Venkatraman S; Merck Research Laboratories, Mail Stop RY121E-28, 126 East Lincoln Avenue, Rahway, NJ 07065-0900, USA. />Velazquez F
Gavalas S
Wu W
Chen KX
Nair AG
Bennett F
Huang Y
Pinto P
Jiang Y
Selyutin O
Vibulbhan B
Zeng Q
Lesburg C
Duca J
Huang HC
Agrawal S
Jiang CK
Ferrari E
Li C
Kozlowski J
Rosenblum S
Shih NY
Njoroge FG
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2013 Apr 01; Vol. 21 (7), pp. 2007-17. Date of Electronic Publication: 2013 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Hepacivirus/*enzymology
Indoles/*chemistry
Indoles/*pharmacology
RNA-Dependent RNA Polymerase/*antagonists & inhibitors
Binding Sites ; Crystallography, X-Ray ; Hepacivirus/chemistry ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans ; Molecular Docking Simulation ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.
Autorzy :
Verma VA; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. />Rossman R
Bennett F
Chen L
Gavalas S
Girijavallabhan V
Huang Y
Kim SH
Kosinski A
Pinto P
Rizvi R
Shankar B
Tong L
Velazquez F
Venkatraman S
Kozlowski J
MacCoss M
Kwong CD
Bansal N
Kezar HS 3rd
Reynolds RC
Maddry JA
Ananthan S
Secrist JA 3rd
Li C
Chase R
Curry S
Huang HC
Tong X
Njoroge FG
Arasappan A
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Nov 15; Vol. 22 (22), pp. 6967-73. Date of Electronic Publication: 2012 Sep 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemical synthesis
Carbohydrates/*chemistry
Pyrimidines/*chemistry
Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Biological Availability ; Dogs ; Half-Life ; Haplorhini ; Hepacivirus/drug effects ; Hepacivirus/metabolism ; Pyrimidines/chemical synthesis ; Pyrimidines/pharmacokinetics ; Rats ; Structure-Activity Relationship ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Autorzy :
Arasappan A; Merck Research Laboratories, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. />Bennett F
Girijavallabhan V
Huang Y
Huelgas R
Alvarez C
Chen L
Gavalas S
Kim SH
Kosinski A
Pinto P
Rizvi R
Rossman R
Shankar B
Tong L
Velazquez F
Venkatraman S
Verma VA
Kozlowski J
Shih NY
Piwinski JJ
MacCoss M
Kwong CD
Clark JL
Fowler AT
Geng F
Kezar HS 3rd
Roychowdhury A
Reynolds RC
Maddry JA
Ananthan S
Secrist JA 3rd
Li C
Chase R
Curry S
Huang HC
Tong X
Njoroge FG
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 May 01; Vol. 22 (9), pp. 3229-34. Date of Electronic Publication: 2012 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Benzothiazoles/*chemistry
Hepacivirus/*drug effects
Pyrimidines/*chemistry
Virus Replication/*drug effects
Animals ; Dogs ; Haplorhini ; Hepacivirus/physiology ; Methylation ; Rodentia ; Species Specificity
Czasopismo naukowe
Tytuł :
Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.
Autorzy :
Chen KX; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States. />Vibulbhan B
Yang W
Sannigrahi M
Velazquez F
Chan TY
Venkatraman S
Anilkumar GN
Zeng Q
Bennet F
Jiang Y
Lesburg CA
Duca J
Pinto P
Gavalas S
Huang Y
Wu W
Selyutin O
Agrawal S
Feld B
Huang HC
Li C
Cheng KC
Shih NY
Kozlowski JA
Rosenblum SB
Njoroge FG
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2012 Jan 26; Vol. 55 (2), pp. 754-65. Date of Electronic Publication: 2012 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemical synthesis
Hepacivirus/*enzymology
Indoles/*chemical synthesis
Sulfonamides/*chemical synthesis
Viral Nonstructural Proteins/*antagonists & inhibitors
Administration, Oral ; Animals ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Caco-2 Cells ; Crystallography, X-Ray ; Dogs ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Humans ; Indoles/chemistry ; Indoles/pharmacokinetics ; Indoles/pharmacology ; Models, Molecular ; Molecular Structure ; Permeability ; Rats ; Replicon ; Structure-Activity Relationship ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
II. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides.
Autorzy :
Anilkumar GN; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. />Selyutin O
Rosenblum SB
Zeng Q
Jiang Y
Chan TY
Pu H
Wang L
Bennett F
Chen KX
Lesburg CA
Duca J
Gavalas S
Huang Y
Pinto P
Sannigrahi M
Velazquez F
Venkatraman S
Vibulbhan B
Agrawal S
Ferrari E
Jiang CK
Huang HC
Shih NY
George Njoroge F
Kozlowski JA
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 01; Vol. 22 (1), pp. 713-7. Date of Electronic Publication: 2011 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Indoles/*chemistry
Viral Nonstructural Proteins/*antagonists & inhibitors
Chemistry, Pharmaceutical/methods ; Crystallography, X-Ray/methods ; Drug Design ; Humans ; Hydrogen Bonding ; Inhibitory Concentration 50 ; Models, Chemical ; Models, Molecular ; Molecular Conformation ; Structure-Activity Relationship ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Autorzy :
Bennett F; Schering-Plough Research Institute, K-15-A-3545, Kenilworth, NJ 07033, USA. />Huang Y
Hendrata S
Lovey R
Bogen SL
Pan W
Guo Z
Prongay A
Chen KX
Arasappan A
Venkatraman S
Velazquez F
Nair L
Sannigrahi M
Tong X
Pichardo J
Cheng KC
Girijavallabhan VM
Saksena AK
Njoroge FG
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Apr 15; Vol. 20 (8), pp. 2617-21. Date of Electronic Publication: 2010 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Proline/*analogs & derivatives
Protease Inhibitors/*chemistry
Viral Nonstructural Proteins/*antagonists & inhibitors
Animals ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Area Under Curve ; Biological Availability ; Crystallography, X-Ray ; Haplorhini ; Models, Molecular ; Proline/chemistry ; Proline/pharmacokinetics ; Proline/pharmacology ; Protease Inhibitors/pharmacokinetics ; Protease Inhibitors/pharmacology ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups.
Autorzy :
Venkatraman S; Schering Plough Research Institute, K15-MS 3545, 2015, Galloping Hill Road, Kenilworth, NJ 07033, United States. />Velazquez F
Wu W
Blackman M
Madison V
Njoroge FG
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Apr 01; Vol. 20 (7), pp. 2151-5. Date of Electronic Publication: 2010 Feb 14.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*pharmacology
Antiviral Agents/*pharmacology
Hepacivirus/*enzymology
Hepatitis C/*drug therapy
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Nonstructural Proteins/*metabolism
Amides/chemistry ; Antiviral Agents/chemistry ; Humans ; Proline/analogs & derivatives ; Proline/pharmacology ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.
Autorzy :
Bogen SL; Department of Medicinal Chemistry, Merck Research Labs, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. />Arasappan A
Velazquez F
Blackman M
Huelgas R
Pan W
Siegel E
Nair LG
Venkatraman S
Guo Z
Doll R
Shih NY
Njoroge FG
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 Mar 01; Vol. 18 (5), pp. 1854-65. Date of Electronic Publication: 2010 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*chemistry
Antiviral Agents/*chemistry
Serine Proteinase Inhibitors/*chemistry
Sulfonamides/*chemistry
Urea/*analogs & derivatives
Viral Nonstructural Proteins/*antagonists & inhibitors
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacokinetics ; Binding Sites ; Computer Simulation ; Dogs ; Drug Evaluation, Preclinical ; Escherichia coli Proteins ; Haplorhini ; Humans ; Membrane Proteins ; Models, Molecular ; Rats ; Serine Proteinase Inhibitors/chemical synthesis ; Serine Proteinase Inhibitors/pharmacokinetics ; Sulfonamides/chemical synthesis ; Sulfonamides/pharmacokinetics ; Urea/chemical synthesis ; Urea/chemistry ; Urea/pharmacokinetics ; Viral Nonstructural Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
    Wyświetlanie 1-10 z 10

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