Temat: "Verapamil" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms.
Autorzy:: Clark AP; Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Wei S; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, New York, USA.
Kalola D; Computational Biology Summer Program, Weill Cornell Medicine & Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Krogh-Madsen T; Department of Physiology & Biophysics, Weill Cornell Medicine, New York, New York, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York, USA.
Christini DJ; Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.; Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, New York, USA.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2022 Oct; Vol. 179 (20), pp. 4829-4843. Date of Electronic Publication: 2022 Jul 24.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Cardiotoxicity*/metabolism
Induced Pluripotent Stem Cells*
Action Potentials ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/metabolism ; Cisapride ; Drug Evaluation, Preclinical/methods ; HEK293 Cells ; Humans ; Ion Channels/metabolism ; Myocytes, Cardiac/metabolism ; Quinidine/pharmacology ; Quinine ; Verapamil

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Skocz do pozycji: 2.

Tytuł:: Assessing Potential Drug-Drug Interactions Between Dabigatran Etexilate and a P-Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling.
Autorzy:: Doki K; Department of Pharmaceutical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Neuhoff S; Simcyp Division, Certara UK Ltd., Sheffield, UK.
Rostami-Hodjegan A; Simcyp Division, Certara UK Ltd., Sheffield, UK.; Division of Pharmacy & Optometry, Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Homma M; Department of Pharmaceutical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2019 Feb; Vol. 8 (2), pp. 118-126.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Dabigatran/*pharmacokinetics
Kidney Diseases/*complications
Verapamil/*administration & dosage
ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors ; Dabigatran/administration & dosage ; Drug Dosage Calculations ; Drug Interactions ; Humans ; Models, Theoretical ; Prodrugs/administration & dosage ; Prodrugs/pharmacokinetics ; Verapamil/pharmacokinetics

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Skocz do pozycji: 3.

Tytuł:: The Effect of Verapamil, a P-Glycoprotein Inhibitor, on the Pharmacokinetics of Peficitinib, an Orally Administered, Once-Daily JAK Inhibitor.
Autorzy:: Zhu T; Astellas Pharma Global Development Inc., Northbrook, IL, USA.
Howieson C; Astellas Pharma Global Development Inc., Northbrook, IL, USA.
Wojtkowski T; Astellas Pharma Global Development Inc., Northbrook, IL, USA.
Garg JP; Astellas Pharma Global Development Inc., Northbrook, IL, USA.
Han D; California Clinical Trials, PAREXEL International, Glendale, CA, USA.
Fisniku O; Astellas Research Institute of America LLC, Skokie, IL, USA.
Keirns J; Astellas Pharma Global Development Inc., Northbrook, IL, USA.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2017 Nov; Vol. 6 (6), pp. 548-555. Date of Electronic Publication: 2017 Mar 16.
Typ publikacji:: Clinical Trial; Journal Article
MeSH Terms:: ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
Adamantane/*analogs & derivatives
Janus Kinase Inhibitors/*pharmacokinetics
Niacinamide/*analogs & derivatives
Verapamil/*pharmacology
Adamantane/administration & dosage ; Adamantane/adverse effects ; Adamantane/pharmacokinetics ; Administration, Oral ; Adult ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/pharmacology ; Area Under Curve ; Cross-Over Studies ; Drug Interactions ; Female ; Humans ; Janus Kinase Inhibitors/administration & dosage ; Janus Kinase Inhibitors/adverse effects ; Male ; Middle Aged ; Niacinamide/administration & dosage ; Niacinamide/adverse effects ; Niacinamide/pharmacokinetics ; Verapamil/administration & dosage ; Verapamil/adverse effects ; Young Adult

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Skocz do pozycji: 4.

Tytuł:: Physiologically-based pharmacokinetic modeling to evaluate in vitro-to-in vivo extrapolation for intestinal P-glycoprotein inhibition.
Autorzy:: Yamazaki S; Drug Metabolism & Pharmacokinetics, Janssen Research & Development, LLC, San Diego, California, USA.
Evers R; Drug Metabolism & Pharmacokinetics, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
De Zwart L; Drug Metabolism & Pharmacokinetics, Janssen Research & Development, Beerse, Belgium.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2022 Jan; Vol. 11 (1), pp. 55-67. Date of Electronic Publication: 2021 Nov 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
Dabigatran/*pharmacokinetics
Digoxin/*pharmacokinetics
Intestines/*metabolism
Quinidine/*pharmacokinetics
Adult ; Area Under Curve ; Computer Simulation ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Humans ; Itraconazole/pharmacology ; Male ; Metabolic Clearance Rate ; Middle Aged ; Models, Biological ; Verapamil/pharmacology ; Young Adult

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Skocz do pozycji: 5.

Tytuł:: In Silico Predictions and In Vivo Results of Drug-Drug Interactions by Ketoconazole and Verapamil on AZD1305, a Combined Ion Channel Blocker and a Sensitive CYP3A4 Substrate.
Autorzy:: Johansson S; AstraZeneca R&D, Mölndal, Sweden. .
Löfberg B; AstraZeneca R&D, Mölndal, Sweden.
Aunes M; AstraZeneca R&D, Mölndal, Sweden.
Lunde H; AstraZeneca R&D, Mölndal, Sweden.
Frison L; AstraZeneca R&D, Mölndal, Sweden.
Edvardsson N; Sahlgrenska Academy at Sahlgrenska University Hospital, Göteborg, Sweden.
Cullberg M; AstraZeneca R&D, Mölndal, Sweden.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2016 Sep; Vol. 5 (5), pp. 364-73. Date of Electronic Publication: 2016 Mar 23.
Typ publikacji:: Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms:: Azabicyclo Compounds/*pharmacokinetics
Carbamates/*pharmacokinetics
Cytochrome P-450 CYP3A Inhibitors/*pharmacology
Ketoconazole/*pharmacology
Verapamil/*pharmacology
Adult ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/pharmacokinetics ; Area Under Curve ; Azabicyclo Compounds/administration & dosage ; Carbamates/administration & dosage ; Computer Simulation ; Cross-Over Studies ; Cytochrome P-450 CYP3A Inhibitors/administration & dosage ; Drug Interactions ; Humans ; Ketoconazole/administration & dosage ; Male ; Middle Aged ; Verapamil/administration & dosage ; Young Adult

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Skocz do pozycji: 6.

Tytuł:: A Physiologically Based Pharmacokinetic Model to Predict Potential Drug-Drug Interactions and Inform Dosing of Acumapimod, an Oral p38 MAPK Inhibitor.
Autorzy:: Agyemang A; Barts and The London School of Medicine and Dentistry, London, UK.
Farrell C; ICON Clinical Research, Marlow, UK.
Moore W; Mereo BioPharma Group plc, London, UK.
Parkin J; Mereo BioPharma Group plc, London, UK.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Jan; Vol. 10 (1), pp. 30-39. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Models, Biological*
ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
Benzamides/*administration & dosage
Cytochrome P-450 CYP3A Inhibitors/*administration & dosage
Protein Kinase Inhibitors/*administration & dosage
Pyrazoles/*administration & dosage
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Administration, Oral ; Adult ; Anti-Bacterial Agents/administration & dosage ; Azithromycin/administration & dosage ; Benzamides/adverse effects ; Benzamides/blood ; Benzamides/pharmacokinetics ; Cross-Over Studies ; Cytochrome P-450 CYP3A Inhibitors/adverse effects ; Drug Interactions ; Humans ; Itraconazole/administration & dosage ; Itraconazole/adverse effects ; Male ; Middle Aged ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/blood ; Protein Kinase Inhibitors/pharmacokinetics ; Pyrazoles/adverse effects ; Pyrazoles/blood ; Pyrazoles/pharmacokinetics ; Verapamil/administration & dosage

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Skocz do pozycji: 7.

Tytuł:: A case of pediatric palpitations
Autorzy:: Lauren Icken
Alexander Bracey
Benjamin Biddix
H. Pendell Meyers
Christopher Malabanan; Pokaż więcej
Temat:: Belhassen
fascicular ventricular tachycardia
ventricular tachycardia
verapamil
Medical emergencies. Critical care. Intensive care. First aid
RC86-88.9
Źródło:: Journal of the American College of Emergency Physicians Open, Vol 5, Iss 1, Pp n/a-n/a (2024)
Opis pliku:: electronic resource
Relacje:: https://doaj.org/toc/2688-1152
Dostęp URL:: https://doaj.org/article/4c9c109362894eef98534985f653f398 Link otwiera się w nowym oknie

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Szczegóły

Skocz do pozycji: 8.

Tytuł:: Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.
Autorzy:: Wanek T; Health & Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
Mairinger S
Langer O; Pokaż więcej
Źródło:: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2013 Mar-Apr; Vol. 56 (3-4), pp. 68-77.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: ATP-Binding Cassette Transporters/*antagonists & inhibitors
Acridines/*chemical synthesis
Blood-Brain Barrier/*diagnostic imaging
Quinolines/*chemical synthesis
Radiopharmaceuticals/*chemical synthesis
Tetrahydroisoquinolines/*chemical synthesis
Verapamil/*chemical synthesis
ATP-Binding Cassette Transporters/metabolism ; Acridines/pharmacology ; Animals ; Carbon Radioisotopes/chemistry ; Humans ; Isotope Labeling ; Quinolines/pharmacology ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacology ; Tetrahydroisoquinolines/pharmacology ; Verapamil/pharmacology

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Skocz do pozycji: 9.

Tytuł:: Contact dermatitis caused by diltiazem cream and cross-reactivity with other calcium channel blockers.
Autorzy:: Forkel S; Department of Dermatology, Venereology and Allergology, University Medical Centre Göttingen, Göttingen, Germany.
Baltzer AB; Department of Dermatology, Venereology and Allergology, University Medical Centre Göttingen, Göttingen, Germany.
Geier J; Information Network of Departments of Dermatology (IVDK), University Medical Centre Göttingen, Göttingen, Germany.
Buhl T; Department of Dermatology, Venereology and Allergology, University Medical Centre Göttingen, Göttingen, Germany.; Pokaż więcej
Źródło:: Contact dermatitis [Contact Dermatitis] 2018 Oct; Vol. 79 (4), pp. 244-246. Date of Electronic Publication: 2018 May 31.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Calcium Channel Blockers/*adverse effects
Dermatitis, Allergic Contact/*etiology
Diltiazem/*adverse effects
Fissure in Ano/*drug therapy
Cross Reactions ; Humans ; Male ; Middle Aged ; Nifedipine/adverse effects ; Skin Cream ; Verapamil/adverse effects

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Skocz do pozycji: 10.

Tytuł:: Blockade of I(Ca) suppresses early afterdepolarizations and reduces transmural dispersion of repolarization in a whole heart model of chronic heart failure.
Autorzy:: Milberg P; Division of Experimental and Clinical Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Münster, Germany. />Fink M
Pott C
Frommeyer G
Biertz J
Osada N
Stypmann J
Mönnig G
Koopmann M
Breithardt G
Eckardt L; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2012 May; Vol. 166 (2), pp. 557-68.
Typ publikacji:: Journal Article
MeSH Terms:: Calcium Channel Blockers/*therapeutic use
Heart Failure/*drug therapy
Tachycardia, Ventricular/*drug therapy
Verapamil/*therapeutic use
Action Potentials/drug effects ; Animals ; Calcium/physiology ; Calcium Channel Blockers/pharmacology ; Erythromycin/pharmacology ; Female ; Heart/drug effects ; Heart/physiology ; Heart Failure/physiopathology ; Models, Biological ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/physiology ; Potassium Channel Blockers/pharmacology ; Rabbits ; Tachycardia, Ventricular/physiopathology ; Verapamil/pharmacology

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Skocz do pozycji: 11.

Tytuł:: Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
Autorzy:: Oros A; Department of Medical Physiology, Division Heart & Lungs, UMC Utrecht, the Netherlands.
Houtman MJ
Neco P
Gomez AM
Rajamani S
Oosterhoff P
Attevelt NJ
Beekman JD
van der Heyden MA
Ver Donck L
Belardinelli L
Richard S
Antoons G
Vos MA; Pokaż więcej
Corporate Authors:: CONTICA investigators
Źródło:: British journal of pharmacology [Br J Pharmacol] 2010 Sep; Vol. 161 (1), pp. 162-75.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-Arrhythmia Agents/*therapeutic use
Flunarizine/*therapeutic use
Phenethylamines/*toxicity
Sulfonamides/*toxicity
Torsades de Pointes/*chemically induced
Torsades de Pointes/*drug therapy
Verapamil/*therapeutic use
Animals ; Calcium Signaling/drug effects ; Cell Line ; Dogs ; Humans ; Lidocaine/administration & dosage ; Lidocaine/therapeutic use ; Mice ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/physiology ; Verapamil/administration & dosage

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Skocz do pozycji: 12.

Tytuł:: Effect of K+ and Rb+ on the action of verapamil on a voltage-gated K+ channel, hKv1.3: implications for a second open state?
Autorzy:: Kuras Z; Institute of Applied Physiology, Ulm University, Ulm, Germany.
Grissmer S; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2009 Jul; Vol. 157 (5), pp. 757-68. Date of Electronic Publication: 2009 Apr 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ion Channel Gating/*drug effects
Kv1.3 Potassium Channel/*drug effects
Potassium/*metabolism
Potassium Channel Blockers/*pharmacology
Rubidium/*metabolism
Verapamil/*pharmacology
Animals ; Binding Sites ; COS Cells ; Chlorocebus aethiops ; Dose-Response Relationship, Drug ; Humans ; Kv1.3 Potassium Channel/genetics ; Kv1.3 Potassium Channel/metabolism ; Membrane Potentials ; Models, Biological ; Mutation ; Patch-Clamp Techniques ; Potassium Channel Blockers/metabolism ; Protein Conformation ; Time Factors ; Transfection ; Verapamil/metabolism

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Skocz do pozycji: 13.

Tytuł:: Actions of R- and S-verapamil and nifedipine on rat vascular and intestinal smooth muscle.
Autorzy:: Cleary L; Department of Physiology, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
Vandeputte C
Kelly JG
Docherty JR; Pokaż więcej
Źródło:: Autonomic & autacoid pharmacology [Auton Autacoid Pharmacol] 2004 Jul; Vol. 24 (3), pp. 63-7.
Typ publikacji:: Journal Article
MeSH Terms:: Calcium Channel Blockers/*pharmacology
Muscle, Smooth/*drug effects
Muscle, Smooth, Vascular/*drug effects
Nifedipine/*pharmacology
Verapamil/*pharmacology
Adrenergic alpha-1 Receptor Antagonists ; Animals ; Aorta, Thoracic/drug effects ; Calcium Channel Blockers/chemistry ; Colon/drug effects ; Electric Stimulation ; In Vitro Techniques ; Male ; Rats ; Rats, Wistar ; Stereoisomerism ; Vas Deferens/drug effects ; Verapamil/chemistry

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Skocz do pozycji: 14.

Tytuł:: A comparison of Ca2+ channel blocking mode between gabapentin and verapamil: implication for protection against hypoxic injury in rat cerebrocortical slices.
Autorzy:: Oka M; Department of Biochemical Pharmacology, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.
Itoh Y
Wada M
Yamamoto A
Fujita T; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2003 May; Vol. 139 (2), pp. 435-43.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Amines*
Cyclohexanecarboxylic Acids*
gamma-Aminobutyric Acid*
Acetates/*pharmacology
Calcium Channel Blockers/*pharmacology
Cerebral Cortex/*drug effects
Hypoxia, Brain/*prevention & control
Verapamil/*pharmacology
Acetates/therapeutic use ; Animals ; Calcium Channel Blockers/therapeutic use ; Calcium Channels, N-Type/biosynthesis ; Calcium Channels, N-Type/drug effects ; Calcium Channels, P-Type/biosynthesis ; Calcium Channels, P-Type/drug effects ; Calcium Channels, Q-Type/biosynthesis ; Calcium Channels, Q-Type/drug effects ; Cells, Cultured ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Fetus ; Gabapentin ; Hypoxia, Brain/metabolism ; Nitric Oxide/biosynthesis ; Potassium Chloride/pharmacology ; RNA, Messenger/biosynthesis ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Verapamil/therapeutic use ; omega-Agatoxin IVA/pharmacology ; omega-Conotoxin GVIA/pharmacology

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Skocz do pozycji: 15.

Tytuł:: Cutaneous leukocytoclastic vasculitis associated with verapamil and atorvastatin: A case report
Autorzy:: Yi Tong Vincent Aw
Jonathan Thomas McGuane; Pokaż więcej
Temat:: atorvastatin
cryoglobulinemia
leukocytoclastic
Sjogren's
vasculitis
verapamil
Medicine
Medicine (General)
R5-920
Źródło:: Clinical Case Reports, Vol 11, Iss 7, Pp n/a-n/a (2023)
Opis pliku:: electronic resource
Relacje:: https://doaj.org/toc/2050-0904
Dostęp URL:: https://doaj.org/article/7bfd77c274934b86aae1b1cbab540d69 Link otwiera się w nowym oknie

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Skocz do pozycji: 16.

Tytuł:: Clinical evaluation of nebulized verapamil in out‐patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease
Autorzy:: Fanak Fahimi
Guitti Pourdowlat
Neda Behzadnia
Sahar Sadigh Mostofi
Aida Sefidani Forough
Omid Parto
Ayda Esmaeili; Pokaż więcej
Temat:: calcium channel blocker
COPD
inhaled verapamil
nebulization
pulmonary function test
pulmonary hypertension
Diseases of the respiratory system
RC705-779
Źródło:: The Clinical Respiratory Journal, Vol 16, Iss 12, Pp 802-811 (2022)
Opis pliku:: electronic resource
Relacje:: https://doaj.org/toc/1752-6981; https://doaj.org/toc/1752-699X
Dostęp URL:: https://doaj.org/article/88cbe6da00eb4a2a8e4cd83fe5f875b2 Link otwiera się w nowym oknie

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Skocz do pozycji: 17.

Tytuł:: The intestinal nematode inhibits T-cell reactivity by targeting P-GP activity.
Autorzy:: Donskow-Łysoniewska K; Faculty of Biology, Department of Parasitology, Institute of Zoology, University of Warsaw, Warsaw, Poland.
Krawczak K; Faculty of Biology, Department of Parasitology, Institute of Zoology, University of Warsaw, Warsaw, Poland.
Kozłowska E; Faculty of Biology, Department of Immunology, Institute of Zoology, University of Warsaw, Warsaw, Poland.
Doligalska M; Faculty of Biology, Department of Parasitology, Institute of Zoology, University of Warsaw, Warsaw, Poland.; Pokaż więcej
Źródło:: Parasite immunology [Parasite Immunol] 2017 Dec; Vol. 39 (12).
Typ publikacji:: Journal Article
MeSH Terms:: ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Nematospiroides dubius/*immunology
Strongylida Infections/*immunology
T-Lymphocyte Subsets/*immunology
ATP Binding Cassette Transporter, Subfamily B, Member 1/immunology ; Animals ; Cell Proliferation/drug effects ; Cells, Cultured ; Cyclosporine/pharmacology ; Host-Parasite Interactions/immunology ; Interleukin-4/immunology ; Interleukin-4/metabolism ; Lymphocyte Activation/immunology ; Male ; Mice ; Mice, Inbred BALB C ; NF-kappa B/biosynthesis ; Quinolines/pharmacology ; Strongylida Infections/parasitology ; Verapamil/pharmacology

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Skocz do pozycji: 18.

Tytuł:: Predicting QRS and PR interval prolongations in humans using nonclinical data.
Autorzy:: Bergenholm L; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, UK.; Drug Metabolism and Pharmacokinetics, Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden.
Parkinson J; Early Clinical Development, Quantitative Clinical Pharmacology, Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden.
Mettetal J; Safety and ADME Translational Sciences, Drug Safety and Metabolism, Innovative Medicines and Early Development, AstraZeneca, Cambridge, UK.
Evans ND; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, UK.
Chappell MJ; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, UK.
Collins T; Safety and ADME Translational Sciences, Drug Safety and Metabolism, Innovative Medicines and Early Development, AstraZeneca, Cambridge, UK.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2017 Oct; Vol. 174 (19), pp. 3268-3283. Date of Electronic Publication: 2017 Aug 24.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
MeSH Terms:: Models, Biological*
Anti-Arrhythmia Agents/*pharmacology
Heart Rate/*drug effects
Animals ; Azabicyclo Compounds/pharmacology ; Carbamates/pharmacology ; Dogs ; Drug Evaluation, Preclinical ; Electrocardiography ; Flecainide/pharmacology ; Guinea Pigs ; Heart/drug effects ; Heart/physiology ; Humans ; Long QT Syndrome/chemically induced ; Male ; Quinidine/pharmacology ; Verapamil/pharmacology

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Skocz do pozycji: 19.

Tytuł:: Efficacy and Safety of Local Intracoronary Drug Delivery in Treatment of No-Reflow Phenomenon: A Pilot Study.
Autorzy:: Abu Arab T; Department of Cardiology, Ain Shams University Hospitals, Cairo, Egypt. .
Rafik R; Department of Cardiology, Ain Shams University Hospitals, Cairo, Egypt.
El Etriby A; Department of Cardiology, Ain Shams University Hospitals, Cairo, Egypt.; Pokaż więcej
Źródło:: Journal of interventional cardiology [J Interv Cardiol] 2016 Oct; Vol. 29 (5), pp. 496-504. Date of Electronic Publication: 2016 Jul 27.
Typ publikacji:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Angioplasty, Balloon, Coronary*/adverse effects
Angioplasty, Balloon, Coronary*/methods
Coronary Vessels*/diagnostic imaging
Coronary Vessels*/drug effects
Epinephrine/*administration & dosage
Injections, Intra-Arterial/*methods
No-Reflow Phenomenon/*therapy
Verapamil/*administration & dosage
Aged ; Cardiovascular Agents/administration & dosage ; Coronary Angiography/methods ; Female ; Humans ; Male ; Middle Aged ; Myocardial Reperfusion/methods ; No-Reflow Phenomenon/diagnosis ; No-Reflow Phenomenon/etiology ; Pilot Projects ; Treatment Outcome

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Skocz do pozycji: 20.

Tytuł:: Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.
Autorzy:: Chapy H; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.; Faculté de Pharmacie, Université Paris Descartes, UMR-S 1144, Paris, France.; Université Paris Diderot, UMR-S 1144, Paris, France.
Saubaméa B; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.; Faculté de Pharmacie, Université Paris Descartes, UMR-S 1144, Paris, France.; Université Paris Diderot, UMR-S 1144, Paris, France.
Tournier N; INSERM, CEA, Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France.
Bourasset F; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.; Faculté de Pharmacie, Université Paris Descartes, UMR-S 1144, Paris, France.; Université Paris Diderot, UMR-S 1144, Paris, France.
Behar-Cohen F; Université Paris Descartes, UMR-S 1138, Paris, France.; Physiopathologies des Maladies Oculaires, INSERM U1138, Paris, France.
Declèves X; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.; Faculté de Pharmacie, Université Paris Descartes, UMR-S 1144, Paris, France.; Université Paris Diderot, UMR-S 1144, Paris, France.; Assistance Publique des Hôpitaux de Paris - AP-HP, Paris, France.
Scherrmann JM; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.; Faculté de Pharmacie, Université Paris Descartes, UMR-S 1144, Paris, France.; Université Paris Diderot, UMR-S 1144, Paris, France.; Assistance Publique des Hôpitaux de Paris - AP-HP, Paris, France.
Cisternino S; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.; Faculté de Pharmacie, Université Paris Descartes, UMR-S 1144, Paris, France.; Université Paris Diderot, UMR-S 1144, Paris, France.; Assistance Publique des Hôpitaux de Paris - AP-HP, Paris, France.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2016 Feb; Vol. 173 (3), pp. 497-510. Date of Electronic Publication: 2016 Jan 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: ATP-Binding Cassette Transporters/*metabolism
Blood-Brain Barrier/*metabolism
Blood-Retinal Barrier/*metabolism
Verapamil/*pharmacology
ATP-Binding Cassette Transporters/genetics ; Animals ; Biological Transport ; Male ; Mice, Knockout ; Mitoxantrone/pharmacology ; Zidovudine/pharmacology

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