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Tytuł :
Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors.
Autorzy :
Cui J; School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address: .
Jia J; School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 05; Vol. 225, pp. 113789. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*drug therapy
Naphthoquinones/*chemistry
Protease Inhibitors/*therapeutic use
SARS-CoV-2/*enzymology
Viral Matrix Proteins/*antagonists & inhibitors
Animals ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Catalytic Domain ; Cell Survival/drug effects ; Chlorocebus aethiops ; Drug Design ; Drug Evaluation, Preclinical ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation ; Naphthoquinones/metabolism ; Naphthoquinones/pharmacology ; Naphthoquinones/therapeutic use ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protease Inhibitors/pharmacology ; SARS-CoV-2/isolation & purification ; Structure-Activity Relationship ; Vero Cells ; Viral Matrix Proteins/metabolism
Czasopismo naukowe
Tytuł :
Susceptibility of livestock to SARS-CoV-2 infection.
Autorzy :
Bosco-Lauth AM; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Walker A; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Guilbert L; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Porter S; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Hartwig A; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
McVicker E; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Bielefeldt-Ohmann H; School of Chemistry & Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Australia.
Bowen RA; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 2199-2201.
Typ publikacji :
Comparative Study; Letter
MeSH Terms :
Host Specificity*/immunology
COVID-19/*veterinary
Livestock/*virology
SARS-CoV-2/*pathogenicity
Animals ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/virology ; Camelids, New World/virology ; Cattle/virology ; Chlorocebus aethiops ; Disease Reservoirs/virology ; Goats/virology ; Horses/virology ; Humans ; Nasal Cavity/virology ; RNA, Viral/analysis ; Rabbits/virology ; Rectum/virology ; Respiratory System/virology ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Sheep/virology ; Species Specificity ; Vero Cells ; Virus Shedding ; Viscera/virology
Raport
Tytuł :
Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat spike protein RBD protects mice against COVID-19.
Autorzy :
Xu K; Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, People's Republic of China.; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People's Republic of China.
An Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Li Q; Chengdu Kanghua Biological Products Co., Ltd, Chengdu, People's Republic of China.
Huang W; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Han Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Zheng T; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People's Republic of China.
Fang F; Chengdu Kanghua Biological Products Co., Ltd, Chengdu, People's Republic of China.
Liu H; Chengdu Kanghua Biological Products Co., Ltd, Chengdu, People's Republic of China.
Liu C; Laboratory of Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, People's Republic of China.
Gao P; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People's Republic of China.
Xu S; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People's Republic of China.
Liu X; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Zhang R; Laboratory of Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, People's Republic of China.
Zhao X; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.; CAS Center for Influenza Research and Early-Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, People's Republic of China.
Liu WJ; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Bi Y; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.; CAS Center for Influenza Research and Early-Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, People's Republic of China.
Wang Y; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Zhou D; Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, People's Republic of China.
Wang Q; Chengdu Kanghua Biological Products Co., Ltd, Chengdu, People's Republic of China.
Hou W; Chengdu Kanghua Biological Products Co., Ltd, Chengdu, People's Republic of China.
Xia Q; Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, People's Republic of China.
Gao GF; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People's Republic of China.; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Dai L; Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, People's Republic of China.; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 1574-1588.
Typ publikacji :
Journal Article
MeSH Terms :
Adenoviridae/*genetics
Antibodies, Viral/*blood
COVID-19 Vaccines/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Administration, Intranasal ; Animals ; Antibodies, Neutralizing/blood ; COVID-19 ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/genetics ; Chlorocebus aethiops ; Female ; Genetic Vectors/genetics ; HEK293 Cells ; Humans ; Immunogenicity, Vaccine ; Injections, Intramuscular ; Mice ; Mice, Inbred BALB C ; Pan troglodytes/virology ; Protein Binding ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/administration & dosage ; Spike Glycoprotein, Coronavirus/genetics ; Vaccination ; Vero Cells
Czasopismo naukowe
Tytuł :
An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facility.
Autorzy :
Das A; Gene and Protein Engineering Laboratory, National Institute of Animal Biotechnology, Hyderabad, India.
Dutta S; Gene and Protein Engineering Laboratory, National Institute of Animal Biotechnology, Hyderabad, India.
Sharma D; Gene and Protein Engineering Laboratory, National Institute of Animal Biotechnology, Hyderabad, India.
Pal A; Gene and Protein Engineering Laboratory, National Institute of Animal Biotechnology, Hyderabad, India.
Ganguli N; Gene and Protein Engineering Laboratory, National Institute of Animal Biotechnology, Hyderabad, India.
Majumdar SS; Gene and Protein Engineering Laboratory, National Institute of Animal Biotechnology, Hyderabad, India.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 4407-4419.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*pharmacology
Containment of Biohazards/*methods
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*antagonists & inhibitors
Viral Matrix Proteins/*antagonists & inhibitors
Virus Internalization/*drug effects
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Chlorocebus aethiops ; Embryo, Mammalian ; Fibroblasts/drug effects ; Fibroblasts/virology ; Gene Expression ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; MCF-7 Cells ; Mice ; Molecular Mimicry ; Plasmids/chemistry ; Plasmids/metabolism ; Primary Cell Culture ; Protein Binding ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Transfection ; Vero Cells ; Viral Matrix Proteins/genetics ; Viral Matrix Proteins/metabolism
Czasopismo naukowe
Tytuł :
Experimental re-infected cats do not transmit SARS-CoV-2.
Autorzy :
Gaudreault NN; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Carossino M; Louisiana Animal Disease Diagnostic Laboratory and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
Morozov I; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Trujillo JD; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Meekins DA; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Madden DW; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Cool K; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Artiaga BL; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
McDowell C; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Bold D; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Balaraman V; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Kwon T; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Ma W; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.; Department of Veterinary Pathobiology and Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, USA.
Henningson J; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Wilson DW; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Wilson WC; Arthropod Borne Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture, Manhattan, KS, USA.
Balasuriya UBR; Louisiana Animal Disease Diagnostic Laboratory and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Richt JA; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 638-650.
Typ publikacji :
Journal Article
MeSH Terms :
Virus Shedding*
Antibodies, Viral/*blood
COVID-19/*transmission
Disease Susceptibility/*immunology
Reinfection/*veterinary
Animals ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/veterinary ; Cats ; Cell Line ; Chlorocebus aethiops ; RNA, Viral/isolation & purification ; Reinfection/immunology ; Reinfection/virology ; SARS-CoV-2/immunology ; Vero Cells ; Viral Load
Czasopismo naukowe
Tytuł :
STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells.
Autorzy :
Yang D; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Chu H; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Lu G; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, People's Republic of China.; Hainan-Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, Hainan, People's Republic of China, and the The University of Hong Kong, Pokfulam, People's Republic of China.; Department of Pathogen Biology, Hainan Medical University, Haikou, Hainan, People's Republic of China.
Shuai H; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Wang Y; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Hou Y; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Zhang X; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Huang X; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Hu B; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Chai Y; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Yuen TT; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Zhao X; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Lee AC; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Ye Z; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Li C; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Chik KK; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Zhang AJ; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Zhou J; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Yuan S; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.
Chan JF; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam, People's Republic of China.; Hainan-Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, Hainan, People's Republic of China, and the The University of Hong Kong, Pokfulam, People's Republic of China.; Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People's Republic of China.; Department of Microbiology, Queen Mary Hospital, Pokfulam, People's Republic of China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 1024-1037.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Dendritic Cells/*virology
Macrophages/*virology
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Zika Virus/*physiology
Animals ; Cell Line ; Chlorocebus aethiops ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Gene Knockout Techniques ; Humans ; Interferon Type I/pharmacology ; Macrophages/drug effects ; Macrophages/metabolism ; Phosphorylation ; STAT1 Transcription Factor/genetics ; STAT2 Transcription Factor/genetics ; Vero Cells ; Virus Replication ; Zika Virus Infection/metabolism
Czasopismo naukowe
Tytuł :
Extracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract.
Autorzy :
Varese A; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
Dantas E; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
Paletta A; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
Fitzgerald W; Section on Intercellular Interaction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Di Diego García F; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
Cabrerizo G; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
Erra Diaz F; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
Defelipe LA; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Ciudad de Buenos Aires, Argentina.
Pallares H; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina.
Dodes Traian M; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Ciudad de Buenos Aires, Argentina.
Gamarnik A; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina.
Geffner J; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
Remes Lenicov F; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
Margolis L; Section on Intercellular Interaction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Ceballos A; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 1169-1179.
Typ publikacji :
Journal Article
MeSH Terms :
Cervix Uteri/*chemistry
Vagina/*chemistry
Zika Virus/*pathogenicity
Zika Virus Infection/*transmission
Acidosis ; Animals ; Cell Line ; Cervix Uteri/virology ; Chlorocebus aethiops ; Female ; Heparitin Sulfate/metabolism ; Humans ; Hydrogen-Ion Concentration ; Microscopy, Fluorescence ; Vagina/virology ; Vero Cells ; Zika Virus/genetics
Czasopismo naukowe
Tytuł :
The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.
Autorzy :
Shi Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, People's Republic of China.
Shuai L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China.
Wen Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China.
Wang C; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China.
Yan Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, People's Republic of China.
Jiao Z; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, People's Republic of China.
Guo F; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, People's Republic of China.
Fu ZF; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, People's Republic of China.
Chen H; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, People's Republic of China.
Bu Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China.; National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin, People's Republic of China.
Peng G; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 481-492.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Coronavirus RNA-Dependent RNA Polymerase/*antagonists & inhibitors
Respiratory System/*virology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Cell Proliferation/drug effects ; Chlorocebus aethiops ; Drug Therapy, Combination ; Female ; Mice ; Mice, Inbred BALB C ; Prodrugs/pharmacology ; Rats ; Rats, Sprague-Dawley ; Vero Cells
Czasopismo naukowe
Tytuł :
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate.
Autorzy :
Prieto-Fernández E; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Egia-Mendikute L; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Vila-Vecilla L; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Bosch A; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Barreira-Manrique A; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Lee SY; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
García-Del Río A; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Antoñana-Vildosola A; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Jiménez-Lasheras B; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Moreno-Cugnon L; Cancer Cell Signaling and Metabolism Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.
Jiménez-Barbero J; Chemical Glycobiology Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, Derio, Spain.; Department of Organic Chemistry II, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Berra E; Cancer Cell Signaling and Metabolism Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.; CIBERONC (Centro de Investigación Biomédica en Red de Cáncer), Madrid, Spain.
Ereño-Orbea J; Chemical Glycobiology Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Palazon A; Cancer Immunology and Immunotherapy Lab, Centre for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 1065-1076.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Cell Hypoxia/*physiology
Heparitin Sulfate/*metabolism
Neuropilin-1/*metabolism
Spike Glycoprotein, Coronavirus/*physiology
Syndecan-1/*metabolism
Angiotensin-Converting Enzyme 2/genetics ; Animals ; Chlorocebus aethiops ; Gene Expression Regulation/drug effects ; Heparitin Sulfate/genetics ; Humans ; Neuropilin-1/genetics ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/chemistry ; Syndecan-1/genetics ; Vero Cells ; Virus Attachment/drug effects
Czasopismo naukowe
Tytuł :
In vitro effects of bufotenine against RNA and DNA viruses.
Autorzy :
Barboza CM; Instituto Pasteur, Av. Paulista, São Paulo, 393, Brazil. .; Universidade Federal Do ABC, Santo André, Brazil. .
Pimenta DC; Laboratório de Bioquímica E Biofísica, Instituto Butantan, São Paulo, SP, Brazil.
Vigerelli H; Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.
de Cássia Rodrigues da Silva A; Instituto Pasteur, Av. Paulista, São Paulo, 393, Brazil.
Garcia JG; Instituto Pasteur, Av. Paulista, São Paulo, 393, Brazil.; Universidade Federal Do ABC, Santo André, Brazil.
Zamudio RM; Instituto Pasteur, Av. Paulista, São Paulo, 393, Brazil.; Universidade Federal Do ABC, Santo André, Brazil.
Castilho JG; Instituto Pasteur, Av. Paulista, São Paulo, 393, Brazil.
Montanha JA; Departamento de Produção E Matéria-Prima - Faculdade de Farmácia da Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Roehe PM; Instituto de Ciências Básicas da Saúde/Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
de Carvalho Ruthner Batista HB; Instituto Pasteur, Av. Paulista, São Paulo, 393, Brazil.; Universidade Federal Do ABC, Santo André, Brazil.
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Źródło :
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2021 Dec; Vol. 52 (4), pp. 2475-2482. Date of Electronic Publication: 2021 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/pharmacology
Bufotenin*/pharmacology
DNA Viruses/*drug effects
RNA Viruses/*drug effects
Animals ; Chlorocebus aethiops ; Cricetinae ; Vero Cells
Czasopismo naukowe
Tytuł :
A real-time and high-throughput neutralization test based on SARS-CoV-2 pseudovirus containing monomeric infrared fluorescent protein as reporter.
Autorzy :
Tsai WY; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Pacific Center for Emerging Infectious Diseases, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
Ching LL; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Pacific Center for Emerging Infectious Diseases, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
Hsieh SC; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Pacific Center for Emerging Infectious Diseases, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
Melish ME; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Pacific Center for Emerging Infectious Diseases, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Kapi'olani Medical Center for Women and Children, Honolulu, HI, USA.; Department of Pediatrics, John A. Burns School of Medicine, Honolulu, HI, USA.
Nerurkar VR; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Pacific Center for Emerging Infectious Diseases, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
Wang WK; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Pacific Center for Emerging Infectious Diseases, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 894-904.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Viral/*blood
COVID-19/*immunology
Neutralization Tests/*methods
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Ammonium Chloride/pharmacology ; Animals ; Antigen-Antibody Reactions ; Blotting, Western ; COVID-19/blood ; Chlorocebus aethiops ; Convalescence ; Defective Viruses/genetics ; Genes, Reporter ; Genetic Vectors/immunology ; HEK293 Cells ; HIV-1/genetics ; Humans ; Immunoglobulin G/immunology ; Lentivirus/genetics ; Mutagenesis, Site-Directed ; Pandemics ; Point Mutation ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
Critical role of neutralizing antibody for SARS-CoV-2 reinfection and transmission.
Autorzy :
Kim YI; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Korea.
Kim SM; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Korea.
Park SJ; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Korea.; Division of Applied Life Science and Research Institute of Life Sciences, Gyeongsang National University, Jinju, Korea.
Kim EH; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Korea.
Yu KM; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Korea.
Chang JH; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Kim EJ; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Casel MAB; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Korea.
Rollon R; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Jang SG; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Um J; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
Song MS; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Korea.
Jeong HW; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Kim EG; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Kim Y; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
Kim SY; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
Park JS; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
Park MS; Div. of Public Health Research, Sejong Institute of Health & Environment, Sejong City, Republic of Korea.
Kwon GY; Sejong Public Health Center, Sejong City, Republic of Korea.
Yeo SG; Div. of Public Health Research, Sejong Institute of Health & Environment, Sejong City, Republic of Korea.
Lee SA; Department of Cancer Biology and Center for Global and Emerging Pathogen Research, Lerner Research Institute, Cleveland, OH, USA.
Choi YJ; Department of Cancer Biology and Center for Global and Emerging Pathogen Research, Lerner Research Institute, Cleveland, OH, USA.
Jung JU; Department of Cancer Biology and Center for Global and Emerging Pathogen Research, Lerner Research Institute, Cleveland, OH, USA.
Choi YK; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Korea.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 152-160.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Neutralizing/*blood
Antibodies, Viral/*blood
COVID-19/*immunology
COVID-19/*transmission
Reinfection/*immunology
SARS-CoV-2/*immunology
Animals ; COVID-19/virology ; Chlorocebus aethiops ; Ferrets ; Vero Cells
Czasopismo naukowe
Tytuł :
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.
Autorzy :
Hou W; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
Kang W; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
Li Y; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
Shan Y; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
Wang S; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.; Computational Optics Laboratory, Jiangnan University , Wuxi, Jiangsu, China.
Liu F; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
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Źródło :
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 615-629.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dyneins/*metabolism
Kinesin/*metabolism
Microtubules/*metabolism
Porcine epidemic diarrhea virus/*physiology
Animals ; Biological Transport ; Chlorocebus aethiops ; Cytoplasm/metabolism ; Dyneins/antagonists & inhibitors ; Kinesin/genetics ; Membrane Fusion ; Microscopy, Fluorescence ; RNA, Small Interfering ; Vero Cells
Czasopismo naukowe
Tytuł :
SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling.
Autorzy :
Li F; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Li J; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Wang PH; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yang N; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Huang J; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Ou J; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Xu T; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Zhao X; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Liu T; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Huang X; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Wang Q; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Li M; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Yang L; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Lin Y; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Cai Y; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Chen H; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Zhang Q; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China; Institute of Sun Yat-sen University in Shenzhen, Shenzhen, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2021 Dec 01; Vol. 1867 (12), pp. 166260. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*metabolism
Inflammation/*metabolism
Spike Glycoprotein, Coronavirus/*immunology
Animals ; Apoptosis/immunology ; Autophagy/physiology ; Cell Line ; Chlorocebus aethiops ; Endothelial Cells/metabolism ; HEK293 Cells ; Humans ; Inflammation/immunology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Reactive Oxygen Species/metabolism ; SARS-CoV-2/pathogenicity ; Signal Transduction/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Vero Cells
Czasopismo naukowe
Tytuł :
A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity.
Autorzy :
Sirakanyan S; Scientific Technological Center of Organic and Pharmaceutical Chemistry of NAS, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan, Armenia.
Arabyan E; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Hakobyan A; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Hakobyan T; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Chilingaryan G; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Sahakyan H; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Sargsyan A; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Arakelov G; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Nazaryan K; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.; Russian-Armenian University, Yerevan, Armenia.
Izmailyan R; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Abroyan L; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Karalyan Z; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.; Department of Medical Biology, Yerevan State Medical University, Yerevan, Armenia.
Arakelova E; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Hakobyan E; Scientific Technological Center of Organic and Pharmaceutical Chemistry of NAS, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan, Armenia.
Hovakimyan A; Scientific Technological Center of Organic and Pharmaceutical Chemistry of NAS, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan, Armenia.
Serobian A; Advanced Solutions Center, Foundation for Armenian Science and Technology, Yerevan, Armenia.
Neves M; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Ferreira J; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Ferreira F; Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal.
Zakaryan H; Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.; Denovo Sciences, Yerevan, Armenia.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 783-796.
Typ publikacji :
Journal Article
MeSH Terms :
African Swine Fever/*virology
African Swine Fever Virus/*drug effects
Antiviral Agents/*pharmacology
Tubulin/*metabolism
African Swine Fever/drug therapy ; African Swine Fever/metabolism ; African Swine Fever Virus/genetics ; African Swine Fever Virus/physiology ; Animals ; Chlorocebus aethiops ; Microtubules/chemistry ; Microtubules/genetics ; Microtubules/metabolism ; Protein Stability ; Swine ; Tubulin/chemistry ; Tubulin/genetics ; Vero Cells ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission.
Autorzy :
Morozov I; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Monath TP; Bioprotection Systems, Inc, a subsidiary of NewLink Genetics Corp, Ames, IA, USA.
Meekins DA; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Trujillo JD; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Sunwoo SY; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Urbaniak K; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Kim IJ; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Narayanan SK; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Indran SV; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Ma W; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Wilson WC; Center for Grain and Animal Health Research, Arthropod-Borne Animal Diseases Research Unit, Agricultural Research Service, United States Department of Agriculture, Manhattan, KS, USA.
O'Connor C; Battelle Memorial Institute, Columbus, OH, USA.
Dubey S; Merck & Co, Inc., Kenilworth, NJ, USA.
Troth SP; Merck & Co, Inc., Kenilworth, NJ, USA.
Coller BA; Merck & Co, Inc., Kenilworth, NJ, USA.
Nichols R; Bioprotection Systems, Inc, a subsidiary of NewLink Genetics Corp, Ames, IA, USA.
Martin BK; Bioprotection Systems, Inc, a subsidiary of NewLink Genetics Corp, Ames, IA, USA.
Feldmann H; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Richt JA; Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 651-663.
Typ publikacji :
Journal Article
MeSH Terms :
Ebola Vaccines/*adverse effects
Ebola Vaccines/*immunology
Ebolavirus/*immunology
Vesicular Stomatitis/*transmission
Vesicular Stomatitis/*virology
Vesicular stomatitis Indiana virus/*immunology
Vesiculovirus/*immunology
Africa ; Animals ; Chlorocebus aethiops ; Ebolavirus/genetics ; Female ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Male ; Models, Animal ; RNA, Viral ; Swine ; Vaccination/methods ; Vaccines, Synthetic/adverse effects ; Vaccines, Synthetic/immunology ; Vero Cells ; Vesiculovirus/genetics
Czasopismo naukowe
Tytuł :
UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates.
Autorzy :
Rosenke K; Laboratory of Virology, Hamilton, MT, USA.
Feldmann F; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Okumura A; Laboratory of Virology, Hamilton, MT, USA.
Hansen F; Laboratory of Virology, Hamilton, MT, USA.
Tang-Huau TL; Laboratory of Virology, Hamilton, MT, USA.
Meade-White K; Laboratory of Virology, Hamilton, MT, USA.
Kaza B; Laboratory of Virology, Hamilton, MT, USA.
Callison J; Laboratory of Virology, Hamilton, MT, USA.
Lewis MC; Laboratory of Virology, Hamilton, MT, USA.
Smith BJ; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Hanley PW; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Lovaglio J; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Jarvis MA; Laboratory of Virology, Hamilton, MT, USA.; University of Plymouth, Plymouth, UK.; The Vaccine Group Ltd, Plymouth, UK.
Shaia C; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Feldmann H; Laboratory of Virology, Hamilton, MT, USA.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 2173-2182.
Typ publikacji :
Journal Article
MeSH Terms :
Virus Replication*
Virus Shedding*
COVID-19/*virology
Chlorocebus aethiops/*virology
Respiratory System/*virology
Administration, Intranasal ; Animals ; COVID-19/epidemiology ; Gastrointestinal Tract/virology ; Host Specificity ; Polymorphism, Single Nucleotide ; RNA, Viral/isolation & purification ; Random Allocation ; Rectum/virology ; United Kingdom/epidemiology ; Vero Cells ; Viral Load
Czasopismo naukowe
Tytuł :
Molecular diagnosis of SARS-CoV-2 in seminal fluid.
Autorzy :
Paoli D; Laboratory of Seminology-Sperm Bank 'Loredana Gandini', Department of Experimental Medicine, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. .
Pallotti F; Laboratory of Seminology-Sperm Bank 'Loredana Gandini', Department of Experimental Medicine, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Nigro G; Laboratory of Seminology-Sperm Bank 'Loredana Gandini', Department of Experimental Medicine, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Mazzuti L; Laboratory of Virology, Department of Molecular Medicine, 'Sapienza' University of Rome, Rome, Italy.
Hirsch MN; Laboratory of Seminology-Sperm Bank 'Loredana Gandini', Department of Experimental Medicine, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Valli MB; National Institute for Infectious Diseases, INMI (Istituto Nazionale Per Le Malattie Infettive), 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
Colangelo S; Laboratory of Seminology-Sperm Bank 'Loredana Gandini', Department of Experimental Medicine, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Mastroianni CM; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, Rome, Italy.
Antonelli G; Laboratory of Virology, Department of Molecular Medicine, 'Sapienza' University of Rome, Rome, Italy.
Lenzi A; Laboratory of Seminology-Sperm Bank 'Loredana Gandini', Department of Experimental Medicine, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Turriziani O; Laboratory of Virology, Department of Molecular Medicine, 'Sapienza' University of Rome, Rome, Italy.
Lombardo F; Laboratory of Seminology-Sperm Bank 'Loredana Gandini', Department of Experimental Medicine, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
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Źródło :
Journal of endocrinological investigation [J Endocrinol Invest] 2021 Dec; Vol. 44 (12), pp. 2675-2684. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*diagnosis
Pathology, Molecular/*methods
Semen/*virology
Adult ; Animals ; Chlorocebus aethiops ; Feasibility Studies ; Humans ; Male ; RNA, Messenger/chemistry ; RNA, Viral/chemistry ; Real-Time Polymerase Chain Reaction ; Reproductive Techniques ; Vero Cells
Czasopismo naukowe
Tytuł :
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro .
Autorzy :
Liu H; BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Ye F; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Sun Q; BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Liang H; BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Li C; Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Li S; Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Lu R; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Huang B; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Tan W; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Lai L; BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.; Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 497-503.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Coronavirus 3C Proteases/*antagonists & inhibitors
Flavanones/*pharmacology
Plant Extracts/*pharmacology
Protease Inhibitors/*pharmacology
SARS-CoV-2/*drug effects
Virus Replication/*drug effects
Animals ; COVID-19/enzymology ; COVID-19/virology ; Chlorocebus aethiops ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Humans ; In Vitro Techniques ; Models, Molecular ; SARS-CoV-2/enzymology ; Vero Cells
Czasopismo naukowe
Tytuł :
Evaluation of in vitro activity of copper gluconate against SARS-CoV-2 using confocal microscopy-based high content screening.
Autorzy :
Rodriguez K; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France.
Saunier F; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France; Infectious Diseases Department, University Hospital of St-Etienne, France.
Rigaill J; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France; Department of Infectious Agents and Hygiene, University Hospital of St-Etienne, France.
Audoux E; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France.
Botelho-Nevers E; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France; Infectious Diseases Department, University Hospital of St-Etienne, France.
Prier A; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France.
Dickerscheit Y; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France.
Pillet S; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France; Department of Infectious Agents and Hygiene, University Hospital of St-Etienne, France.
Pozzetto B; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France; Department of Infectious Agents and Hygiene, University Hospital of St-Etienne, France.
Bourlet T; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France; Department of Infectious Agents and Hygiene, University Hospital of St-Etienne, France.
Verhoeven PO; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, University of Lyon, University of St-Etienne, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, St-Etienne, France; Department of Infectious Agents and Hygiene, University Hospital of St-Etienne, France. Electronic address: .
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Źródło :
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2021 Dec; Vol. 68, pp. 126818. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Microscopy, Confocal*
Gluconates/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/pharmacology ; COVID-19/pathology ; COVID-19/virology ; Cell Survival/drug effects ; Chlorocebus aethiops ; Green Fluorescent Proteins/metabolism ; Vero Cells
Czasopismo naukowe

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