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Tytuł:
Comparative analysis of effectiveness for phage cocktail development against multiple Salmonella serovars and its biofilm control activity.
Autorzy:
Ribeiro JM; Laboratory of Basic and Applied Bacteriology, State University of Londrina, Londrina, PR, Brazil.
Pereira GN; Laboratory of Basic and Applied Bacteriology, State University of Londrina, Londrina, PR, Brazil.
Durli Junior I; Laboratory of Bioinformatics, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Teixeira GM; Laboratory of Microbe Biotechnology, State University of Londrina, Londrina, PR, Brazil.
Bertozzi MM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, State University of Londrina, Londrina, PR, Brazil.
Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, State University of Londrina, Londrina, PR, Brazil.
Kobayashi RKT; Laboratory of Basic and Applied Bacteriology, State University of Londrina, Londrina, PR, Brazil.
Nakazato G; Laboratory of Basic and Applied Bacteriology, State University of Londrina, Londrina, PR, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2023 Aug 11; Vol. 13 (1), pp. 13054. Date of Electronic Publication: 2023 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Salmonella*
Bacteriophages*
Animals ; Humans ; Serogroup ; Host Specificity ; Biofilms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Specialized Pro-Resolving Lipid Mediators: Endogenous Roles and Pharmacological Activities in Infections.
Autorzy:
Rasquel-Oliveira FS; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Silva MDVD; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Martelossi-Cebinelli G; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Fattori V; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Casagrande R; Department of Pharmaceutical Sciences, Center of Health Science, Londrina State University, Londrina 86038-440, Paraná, Brazil.
Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jun 27; Vol. 28 (13). Date of Electronic Publication: 2023 Jun 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Fatty Acids, Omega-3*/pharmacology
Fatty Acids, Omega-3*/metabolism
Parasitic Diseases*
Animals ; Inflammation/metabolism ; Eicosanoids ; Cytokines ; Inflammation Mediators/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Standard of care drugs do not modulate activity of senescent primary human lung fibroblasts.
Autorzy:
Badaro-Garcia S; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, USA.; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Brazil.
Hohmann MS; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, USA.
Coelho AL; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, USA.
Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Brazil.
Hogaboam CM; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 04; Vol. 13 (1), pp. 3654. Date of Electronic Publication: 2023 Mar 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Standard of Care*
Idiopathic Pulmonary Fibrosis*
Humans ; Fibroblasts ; Apoptosis ; Lung
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Behavioral Voluntary and Social Bioassays Enabling Identification of Complex and Sex-Dependent Pain-(-Related) Phenotypes in Rats with Bone Cancer.
Autorzy:
Segelcke D; Department of Anesthesiology Intensive Care and Pain Medicine, University Hospital Münster, 48149 Münster, Germany.
Linnemann J; Department of Anesthesiology Intensive Care and Pain Medicine, University Hospital Münster, 48149 Münster, Germany.
Pradier B; Department of Anesthesiology Intensive Care and Pain Medicine, University Hospital Münster, 48149 Münster, Germany.; Department of Clinical Radiology, Translational Research Imaging Center, University Hospital Münster, 48149 Münster, Germany.
Kronenberg D; Institute for Musculoskeletal Medicine, University Hospital Münster, 48149 Münster, Germany.
Stange R; Institute for Musculoskeletal Medicine, University Hospital Münster, 48149 Münster, Germany.
Richter SH; Department of Behavioural Biology, University of Münster, 48149 Münster, Germany.
Görlich D; Institute of Biostatistics and Clinical Research, University of Münster, 48149 Münster, Germany.
Baldini N; Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.; Biomedical Science and Technologies and Nanobiotechnologies Laboratory, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Di Pompo G; Biomedical Science and Technologies and Nanobiotechnologies Laboratory, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Verri WA Jr; Centro de Ciências Biológicas, Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.
Avnet S; Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.
Pogatzki-Zahn EM; Department of Anesthesiology Intensive Care and Pain Medicine, University Hospital Münster, 48149 Münster, Germany.
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Źródło:
Cancers [Cancers (Basel)] 2023 Mar 02; Vol. 15 (5). Date of Electronic Publication: 2023 Mar 02.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice.
Autorzy:
Zaninelli TH; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Fattori V; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.; Vascular Biology Program, Department of Surgery, Boston Children's Hospital-Harvard Medical School, Boston, Massachusetts, USA.
Saraiva-Santos T; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Badaro-Garcia S; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Staurengo-Ferrari L; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Andrade KC; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Artero NA; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Ferraz CR; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Bertozzi MM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Rasquel-Oliveira F; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Manchope MF; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Amaral FA; Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Teixeira MM; Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Borghi SM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
Rogers MS; Vascular Biology Program, Department of Surgery, Boston Children's Hospital-Harvard Medical School, Boston, Massachusetts, USA.
Casagrande R; Laboratory of Antioxidants and Inflammation, Department of Pharmaceutical Sciences, Centre of Health Sciences, Londrina State University, Londrina, Paraná, Brazil.
Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Sep; Vol. 179 (18), pp. 4500-4515. Date of Electronic Publication: 2022 Jul 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arthritis, Gouty*/chemically induced
Arthritis, Gouty*/drug therapy
Animals ; Calcitonin Gene-Related Peptide ; Docosahexaenoic Acids ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Inflammation/metabolism ; Macrophage Activation ; Male ; Mice ; Neuroimmunomodulation ; Neurons ; Nociceptors/metabolism ; Pain ; Uric Acid/chemistry ; Uric Acid/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association between IL-10 systemic low level and highest pain score in patients during symptomatic SARS-CoV-2 infection.
Autorzy:
Bussmann AJC; Department of Pathology, Biological Sciences Center, Londrina State University, Londrina, Brazil.
Ferraz CR; Department of Pathology, Biological Sciences Center, Londrina State University, Londrina, Brazil.
Lima AVA; Universitary Hospital, Londrina State University, Londrina, Brazil.
Castro JGS; Universitary Hospital, Londrina State University, Londrina, Brazil.
Ritter PD; Departament of Pharmaceutical Sciences, Health Sciences Center, Londrina State University, Londrina, Brazil.
Zaninelli TH; Department of Pathology, Biological Sciences Center, Londrina State University, Londrina, Brazil.
Saraiva-Santos T; Department of Pathology, Biological Sciences Center, Londrina State University, Londrina, Brazil.
Verri WA Jr; Department of Pathology, Biological Sciences Center, Londrina State University, Londrina, Brazil.
Borghi SM; Department of Pathology, Biological Sciences Center, Londrina State University, Londrina, Brazil.; Center for Research in Health Sciences, University of Northern Paraná, Londrina, Brazil.
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Źródło:
Pain practice : the official journal of World Institute of Pain [Pain Pract] 2022 Apr; Vol. 22 (4), pp. 453-462. Date of Electronic Publication: 2022 Feb 04.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/complications
Interleukin-10/*blood
Cytokines ; Female ; Humans ; Leptin ; Male ; Pain ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hydroethanolic Extract of Grape Peel from Vitis labrusca Winemaking Waste: Antinociceptive and Anti-Inflammatory Activities.
Autorzy:
Silva CFG; Department of Chemistry, State University of Londrina, Rod. Celso Garcia Cid, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
Fattori V; Department of Pathology, State University of Londrina, Rod. Celso Garcia Cid, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
Tonetti CR; Department of Chemistry, State University of Londrina, Rod. Celso Garcia Cid, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
Ribeiro MAS; Department of Exact Sciences, Federal University of Paraná, R. Dr. João Maxímiano 426, Vila Operária, 86900-000 Jandaia do Sul, PR, Brazil.
Matos RLN; Department of Pharmaceutical Sciences, State University of Londrina, Av. Robert Koch 60, Operária, 86038-440 Londrina, PR, Brazil.
Carra JB; Department of Chemistry, State University of Londrina, Rod. Celso Garcia Cid, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
Meurer EC; Department of Exact Sciences, Federal University of Paraná, R. Dr. João Maxímiano 426, Vila Operária, 86900-000 Jandaia do Sul, PR, Brazil.
Hirooka EY; Department of Food Science and Technology, State University of Londrina, Rod. Celso Garcia Cid, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
Rafael JA; Pharmaceutical Science Course, Filadelfia University Center, Av. Juscelino Kubitschek 1626, Centro, 86020-000 Londrina, PR, Brazil.
Georgetti SR; Department of Pharmaceutical Sciences, State University of Londrina, Av. Robert Koch 60, Operária, 86038-440 Londrina, PR, Brazil.
Baracat MM; Department of Pharmaceutical Sciences, State University of Londrina, Av. Robert Koch 60, Operária, 86038-440 Londrina, PR, Brazil.
Verri WA Jr; Department of Pathology, State University of Londrina, Rod. Celso Garcia Cid, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
Arakawa NS; Department of Chemistry, State University of Londrina, Rod. Celso Garcia Cid, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.; Department of Pharmaceutical Sciences, State University of Londrina, Av. Robert Koch 60, Operária, 86038-440 Londrina, PR, Brazil.
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Źródło:
Food technology and biotechnology [Food Technol Biotechnol] 2022 Mar; Vol. 60 (1), pp. 21-28.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cognition-immune interactions between executive function and working memory, tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and sTNFR2) in bipolar disorder.
Autorzy:
Zazula R; Federal University for Latin American Integration, Foz do Iguacu, Brazil.; Londrina State University, Health Sciences Graduate Program, Londrina, Brazil.; Deakin University, iMPACT, the Institute for Mental and Physical Health and Clinical Translation, Barwon Health, Geelong, Australia.
Dodd S; Deakin University, iMPACT, the Institute for Mental and Physical Health and Clinical Translation, Barwon Health, Geelong, Australia.; Centre of Youth Mental Health, University of Melbourne, Parkville, Australia.; Department of Psychiatry, University of Melbourne, Parkville, Australia.
Dean OM; Deakin University, iMPACT, the Institute for Mental and Physical Health and Clinical Translation, Barwon Health, Geelong, Australia.; Centre of Youth Mental Health, University of Melbourne, Parkville, Australia.; Department of Psychiatry, University of Melbourne, Parkville, Australia.; Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Australia.
Berk M; Deakin University, iMPACT, the Institute for Mental and Physical Health and Clinical Translation, Barwon Health, Geelong, Australia.; Centre of Youth Mental Health, University of Melbourne, Parkville, Australia.; Department of Psychiatry, University of Melbourne, Parkville, Australia.; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.; Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Australia.
Bortolasci CC; Deakin University, iMPACT, the Institute for Mental and Physical Health and Clinical Translation, Barwon Health, Geelong, Australia.
Verri WA Jr; Department of Pathology, Londrina State University, Londrina, Brazil.
Vargas HO; Londrina State University, Health Sciences Graduate Program, Londrina, Brazil.
Nunes SOV; Londrina State University, Health Sciences Graduate Program, Londrina, Brazil.
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Źródło:
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2022 Jan; Vol. 23 (1), pp. 67-77. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bipolar Disorder*/immunology
Executive Function*
Memory, Short-Term*
Tumor Necrosis Factor-alpha*
Cognition ; Humans ; Receptors, Tumor Necrosis Factor, Type I ; Receptors, Tumor Necrosis Factor, Type II
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Topical Administration of 15-Deoxy- Δ -Prostaglandin J 2 Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice.
Autorzy:
Kumagai CM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Martinez RM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Colombo BB; Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 80, PR445, Cx. Postal 10.011, 86057-970 Londrina, Brazil.
Saito P; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Pinto IC; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Rodrigues CCA; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Vale DL; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Matos RLN; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Bracarense APFRL; Laboratório de Patologia Animal, Universidade Estadual de Londrina, Campus Universitário, Rodovia Celso Garcia Cid, Km 380, Londrina Paraná 86057-970, Brazil.
Baracat MM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Georgetti SR; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
Clemente-Napimoga JT; Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Laboratory of Neuro-Immune Interface of Pain Research, R. José Rocha Junqueira, 13, Campinas, São Paulo 13045-755, Brazil.
Napimoga MH; Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Laboratory of Neuro-Immune Interface of Pain Research, R. José Rocha Junqueira, 13, Campinas, São Paulo 13045-755, Brazil.
Fattori V; Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 80, PR445, Cx. Postal 10.011, 86057-970 Londrina, Brazil.; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
Verri WA Jr; Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 80, PR445, Cx. Postal 10.011, 86057-970 Londrina, Brazil.
Casagrande R; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina Paraná, Brazil.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2021 Nov 02; Vol. 2021, pp. 9330596. Date of Electronic Publication: 2021 Nov 02 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Oxidative Stress*
Prostaglandins*/metabolism
Administration, Topical ; Animals ; Mice ; Mice, Hairless ; Skin/metabolism ; Ultraviolet Rays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A topical formulation containing quercetin-loaded microcapsules protects against oxidative and inflammatory skin alterations triggered by UVB irradiation: enhancement of activity by microencapsulation.
Autorzy:
Vale DL; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, Londrina, Brazil.
Martinez RM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, Londrina, Brazil.
Medeiros DC; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina-UEL, Londrina, Brazil.
da Rocha C; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, Londrina, Brazil.
Sfeir N; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, Londrina, Brazil.
Lopez RFV; Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto, Brazil.
Vicentini FTMC; Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto, Brazil.
Verri WA Jr; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina-UEL, Londrina, Brazil.
Georgetti SR; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, Londrina, Brazil.
Baracat MM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, Londrina, Brazil.
Casagrande R; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, Londrina, Brazil.
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Źródło:
Journal of drug targeting [J Drug Target] 2021 Nov; Vol. 29 (9), pp. 983-997. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antioxidants/*pharmacology
Inflammation/*drug therapy
Oxidative Stress/*drug effects
Quercetin/*pharmacology
Skin/*drug effects
Administration, Cutaneous ; Animals ; Antioxidants/administration & dosage ; Antioxidants/metabolism ; Capsules ; Disease Models, Animal ; Female ; Inflammation/etiology ; Male ; Mice ; Mice, Hairless ; Quercetin/administration & dosage ; Skin/pathology ; Ultraviolet Rays/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Redox interactions of immune cells and muscle in the regulation of exercise-induced pain and analgesia: implications on the modulation of muscle nociceptor sensory neurons.
Autorzy:
Bussulo SKD; Center for Research in Health Sciences, University of Northern Paraná, Londrina, Brazil.
Ferraz CR; Department of Pathology, Biological Sciences Center, Rodovia Celso Garcia Cid, State University of Londrina, Londrina, Brazil.
Carvalho TT; Department of Pathology, Biological Sciences Center, Rodovia Celso Garcia Cid, State University of Londrina, Londrina, Brazil.
Verri WA Jr; Department of Pathology, Biological Sciences Center, Rodovia Celso Garcia Cid, State University of Londrina, Londrina, Brazil.
Borghi SM; Center for Research in Health Sciences, University of Northern Paraná, Londrina, Brazil.; Department of Pathology, Biological Sciences Center, Rodovia Celso Garcia Cid, State University of Londrina, Londrina, Brazil.
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Źródło:
Free radical research [Free Radic Res] 2021 Jul; Vol. 55 (7), pp. 757-775. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Exercise*
Oxidative Stress*
Analgesia/*adverse effects
Muscle, Skeletal/*pathology
Nociceptors/*pathology
Pain/*pathology
Sensory Receptor Cells/*pathology
Humans ; Muscle, Skeletal/metabolism ; Nociceptors/immunology ; Nociceptors/metabolism ; Oxidation-Reduction ; Pain/etiology ; Pain/metabolism ; Sensory Receptor Cells/immunology ; Sensory Receptor Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Diethyldithiocarbamate encapsulation reduces toxicity and promotes leishmanicidal effect through apoptosis-like mechanism in promastigote and ROS production by macrophage.
Autorzy:
Assolini JP; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Tomiotto-Pellissier F; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.; Biosciences and Biotechnology Postgraduate Program, Carlos Chagas Institute (ICC), Curitiba, PR, Brazil.
da Silva Bortoleti BT; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.; Biosciences and Biotechnology Postgraduate Program, Carlos Chagas Institute (ICC), Curitiba, PR, Brazil.
Gonçalves MD; Department of Chemical, Center of Exact Sciences, State University of Londrina, Londrina, PR, Brazil.
Sahd CS; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Carloto ACM; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Feuser PE; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Cordeiro AP; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Borghi SM; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Verri WA Jr; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Sayer C; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Hermes de Araújo PH; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Costa IN; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Conchon-Costa I; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Miranda-Sapla MM; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Pavanelli WR; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.; Biosciences and Biotechnology Postgraduate Program, Carlos Chagas Institute (ICC), Curitiba, PR, Brazil.
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Źródło:
Journal of drug targeting [J Drug Target] 2020 Dec; Vol. 28 (10), pp. 1110-1123. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ditiocarb/*pharmacology
Leishmania/*drug effects
Macrophages/*drug effects
Nanoparticles/*chemistry
Reactive Oxygen Species/*metabolism
Animals ; Apoptosis/drug effects ; Ditiocarb/administration & dosage ; Mice, Inbred BALB C ; Plant Preparations/chemistry ; Surface Properties ; Waxes/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
N-acetylcysteine as an adjunctive treatment for smoking cessation: a randomized clinical trial.
Autorzy:
Machado RCBR; Centro de Referência de Abordagem e Tratamento do Tabagismo, Hospital Universitário, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.; Programa de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.
Vargas HO; Centro de Referência de Abordagem e Tratamento do Tabagismo, Hospital Universitário, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.; Departamento de Medicina Clínica, Unidade de Psiquiatria, Hospital Universitário, CCS, UEL, Londrina, PR, Brazil.
Baracat MM; Programa de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.
Urbano MR; Programa de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.; Departamento de Estatística, Centro de Ciências Exatas, UEL, Londrina, PR, Brazil.
Verri WA Jr; Programa de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.; Departamento de Patologia, Centro de Ciências Biológicas, UEL, Londrina, PR, Brazil.
Porcu M; Centro de Referência de Abordagem e Tratamento do Tabagismo, Hospital Universitário, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.; Programa de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.
Nunes SOV; Centro de Referência de Abordagem e Tratamento do Tabagismo, Hospital Universitário, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.; Programa de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.; Departamento de Medicina Clínica, Unidade de Psiquiatria, Hospital Universitário, CCS, UEL, Londrina, PR, Brazil.
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Źródło:
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2020 Sep-Oct; Vol. 42 (5), pp. 519-526.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Smoking Cessation*
Tobacco Use Disorder*
Acetylcysteine/therapeutic use ; Double-Blind Method ; Humans ; Nicotine ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Lipoxin Receptor/FPR2 Agonist BML-111 Protects Mouse Skin Against Ultraviolet B Radiation.
Autorzy:
Martinez RM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
Fattori V; Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, Londrina 86057-970, Paraná, Brazil.
Saito P; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
Pinto IC; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
Rodrigues CCA; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
Melo CPB; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
Bussmann AJC; Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, Londrina 86057-970, Paraná, Brazil.
Staurengo-Ferrari L; Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, Londrina 86057-970, Paraná, Brazil.
Bezerra JR; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
Vignoli JA; Departamento de Bioquímica e Biotecnologia, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, Londrina 86057-970, Paraná, Brazil.
Baracat MM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
Georgetti SR; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
Verri WA Jr; Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, Londrina 86057-970, Paraná, Brazil.
Casagrande R; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, Londrina 86038-350, Paraná, Brazil.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Jun 26; Vol. 25 (12). Date of Electronic Publication: 2020 Jun 26.
Typ publikacji:
Journal Article
MeSH Terms:
Dermatitis/*prevention & control
Heptanoic Acids/*administration & dosage
Radiation-Protective Agents/*administration & dosage
Receptors, Lipoxin/*antagonists & inhibitors
Animals ; CD59 Antigens/metabolism ; Dermatitis/etiology ; Dermatitis/metabolism ; Disease Models, Animal ; Docosahexaenoic Acids/metabolism ; Dose-Response Relationship, Drug ; Heptanoic Acids/pharmacology ; Lipoxins/metabolism ; Mice ; Mice, Hairless ; Radiation-Protective Agents/pharmacology ; Ultraviolet Rays/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development.
Autorzy:
Ferraz CR; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Carvalho TT; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Manchope MF; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Artero NA; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Rasquel-Oliveira FS; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Fattori V; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Casagrande R; Departament of Pharmaceutical Sciences, Center of Health Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Verri WA Jr; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Feb 10; Vol. 25 (3). Date of Electronic Publication: 2020 Feb 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Analgesics/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Flavonoids/*chemistry
Flavonoids/*pharmacology
Analgesics/chemistry ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Drug Delivery Systems ; Drug Evaluation, Preclinical ; Humans ; Inflammation/drug therapy ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Metabolic syndrome agravates cardiovascular, oxidative and inflammatory dysfunction during the acute phase of Trypanosoma cruzi infection in mice.
Autorzy:
Lucchetti BFC; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.; Department of Physiotherapy, University Center of Araguaia Valley, Barra do Garças, MT, Brazil.
Boaretto N; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Lopes FNC; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Malvezi AD; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Lovo-Martins MI; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Tatakihara VLH; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Fattori V; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Pereira RS; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Verri WA Jr; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
de Almeida Araujo EJ; Department of Histology, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Pinge-Filho P; Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
Martins-Pinge MC; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2019 Dec 11; Vol. 9 (1), pp. 18885. Date of Electronic Publication: 2019 Dec 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adipose Tissue/*metabolism
Chagas Disease/*metabolism
Inflammation/*metabolism
Liver/*metabolism
Metabolic Syndrome/*metabolism
Myocardium/*metabolism
Oxidative Stress/*physiology
Adipose Tissue/pathology ; Animals ; Chagas Disease/complications ; Chagas Disease/pathology ; Cytokines/blood ; Disease Models, Animal ; Fatty Liver/metabolism ; Fatty Liver/pathology ; Inflammation/complications ; Inflammation/pathology ; Insulin Resistance/physiology ; Liver/pathology ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/pathology ; Mice ; Myocardium/pathology ; Trypanosoma cruzi
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The specialised pro-resolving lipid mediator maresin 1 reduces inflammatory pain with a long-lasting analgesic effect.
Autorzy:
Fattori V; Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Brazil.
Pinho-Ribeiro FA; Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Brazil.
Staurengo-Ferrari L; Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Brazil.
Borghi SM; Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Brazil.
Rossaneis AC; Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Brazil.
Casagrande R; Department of Pharmaceutical Sciences, Centre of Health Science, Londrina State University, Londrina, Brazil.
Verri WA Jr; Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Brazil.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2019 Jun; Vol. 176 (11), pp. 1728-1744. Date of Electronic Publication: 2019 Apr 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Analgesics/*therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Docosahexaenoic Acids/*therapeutic use
Hyperalgesia/*drug therapy
Pain/*drug therapy
Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Calcitonin Gene-Related Peptide/metabolism ; Carrageenan ; Docosahexaenoic Acids/pharmacology ; Freund's Adjuvant ; Ganglia, Spinal/drug effects ; Hot Temperature ; Hyperalgesia/genetics ; Hyperalgesia/metabolism ; Interleukin-1beta/metabolism ; Male ; Mice ; NAV1.8 Voltage-Gated Sodium Channel/genetics ; NF-kappa B/metabolism ; Neurons/drug effects ; Pain/genetics ; Pain/metabolism ; Physical Stimulation ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; TRPV Cation Channels/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice.
Autorzy:
Borghi SM; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.; Center for Research in Health Sciences, University of Northern Paraná - Unopar, Rua Marselha, 591, Jardim Piza, Londrina, Paraná, 86041-140, Brazil.
Fattori V; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Pinho-Ribeiro FA; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Domiciano TP; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Miranda-Sapla MM; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Zaninelli TH; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Casagrande R; Departament of Pharmaceutical Sciences, Health Sciences Center, University Hospital, Londrina State University, Avenida Robert Koch, 60, Londrina, Paraná, 86038-350, Brazil.
Pinge-Filho P; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Pavanelli WR; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Alves-Filho JC; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Cunha FQ; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Cunha TM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Verri WA Jr; Departament of Pathology, Biological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, Pr 445, Km 380 Cx. Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2019 May 28; Vol. 16 (1), pp. 113. Date of Electronic Publication: 2019 May 28.
Typ publikacji:
Journal Article
MeSH Terms:
Edema/*pathology
Hyperalgesia/*pathology
Leishmaniasis/*pathology
Neuroglia/*pathology
Pain/*pathology
Spinal Cord/*pathology
Animals ; Edema/microbiology ; Hyperalgesia/microbiology ; Leishmania ; Male ; Mice ; Mice, Inbred BALB C ; Neuroglia/microbiology ; Pain/microbiology ; Spinal Cord/microbiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation.
Autorzy:
Lourenco-Gonzalez Y; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid km 480 PR 445, Londrina, Paraná, Brazil.
Fattori V; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid km 480 PR 445, Londrina, Paraná, Brazil.
Domiciano TP; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, Brazil.
Rossaneis AC; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid km 480 PR 445, Londrina, Paraná, Brazil.
Borghi SM; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid km 480 PR 445, Londrina, Paraná, Brazil.
Zaninelli TH; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid km 480 PR 445, Londrina, Paraná, Brazil.
Bernardy CCF; Departmento de Enfermagem, Centro de Ciências da Saúde, Universidade Estadual de Londrina, Av. Robert Koch 60, Londrina, PR, Brazil.
Alves-Filho JC; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, Brazil.
Cunha TM; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, Brazil.
Cunha FQ; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, Brazil.
Casagrande R; Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Estadual de Londrina, Av. Robert Koch 60, Londrina, Paraná, Brazil.
Verri WA Jr; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid km 480 PR 445, Londrina, Paraná, Brazil.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2019 Mar 31; Vol. 2019, pp. 6481812. Date of Electronic Publication: 2019 Mar 31 (Print Publication: 2019).
Typ publikacji:
Journal Article
MeSH Terms:
Analgesics/*therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Drug Repositioning/*methods
Inflammation/*drug therapy
Inflammation/*metabolism
Nootropic Agents/*therapeutic use
Superoxides/*toxicity
Vinca Alkaloids/*therapeutic use
Animals ; Cytokines/metabolism ; Disease Models, Animal ; Edema/drug therapy ; Edema/metabolism ; Heme Oxygenase-1 ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Male ; Membrane Proteins ; Mice ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Treatment with maresin 1, a docosahexaenoic acid-derived pro-resolution lipid, protects skin from inflammation and oxidative stress caused by UVB irradiation.
Autorzy:
Cezar TLC; Laboratory of Oxidative Stress and Inflammation, Department of Pharmaceutical Sciences, Londrina State University, Londrina, PR, Brazil.
Martinez RM; Laboratory of Oxidative Stress and Inflammation, Department of Pharmaceutical Sciences, Londrina State University, Londrina, PR, Brazil.
Rocha CD; Laboratory of Oxidative Stress and Inflammation, Department of Pharmaceutical Sciences, Londrina State University, Londrina, PR, Brazil.
Melo CPB; Laboratory of Oxidative Stress and Inflammation, Department of Pharmaceutical Sciences, Londrina State University, Londrina, PR, Brazil.
Vale DL; Laboratory of Oxidative Stress and Inflammation, Department of Pharmaceutical Sciences, Londrina State University, Londrina, PR, Brazil.
Borghi SM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil.
Fattori V; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil.
Vignoli JA; Department of Biochemistry and Biotechnology, Londrina State University, Londrina, PR, Brazil.
Camilios-Neto D; Department of Biochemistry and Biotechnology, Londrina State University, Londrina, PR, Brazil.
Baracat MM; Laboratory of Oxidative Stress and Inflammation, Department of Pharmaceutical Sciences, Londrina State University, Londrina, PR, Brazil.
Georgetti SR; Laboratory of Oxidative Stress and Inflammation, Department of Pharmaceutical Sciences, Londrina State University, Londrina, PR, Brazil.
Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil.
Casagrande R; Laboratory of Oxidative Stress and Inflammation, Department of Pharmaceutical Sciences, Londrina State University, Londrina, PR, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2019 Feb 28; Vol. 9 (1), pp. 3062. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents/*therapeutic use
Antioxidants/*therapeutic use
Docosahexaenoic Acids/*therapeutic use
Inflammation/*prevention & control
Oxidative Stress/*drug effects
Ultraviolet Rays/*adverse effects
Animals ; Mice ; Mice, Hairless ; Mice, Inbred C57BL ; Oxidative Stress/radiation effects ; Skin/drug effects ; Skin/radiation effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 54

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