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Wyświetlanie 1-20 z 20
Tytuł :
Small Extracellular Vesicles in Pre-Therapy Plasma Predict Clinical Outcome in Non-Small-Cell Lung Cancer Patients.
Autorzy :
Vetsika EK; School of Medicine, University of Crete, 71003 Heraklion, Greece.; School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Sharma P; Cancer Center, Department of Pathology, University of Pittsburgh School of Medicine and UPMC Hillman, Pittsburgh, PA 15213, USA.
Samaras I; Department of Medical Oncology, University General Hospital of Larissa, 41334 Larissa, Greece.
Markou A; Department of Medical Oncology, University General Hospital of Larissa, 41334 Larissa, Greece.
Georgoulias V; School of Medicine, University of Crete, 71003 Heraklion, Greece.
Whiteside TL; Cancer Center, Department of Pathology, University of Pittsburgh School of Medicine and UPMC Hillman, Pittsburgh, PA 15213, USA.
Kotsakis A; Department of Medical Oncology, University General Hospital of Larissa, 41334 Larissa, Greece.; Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.
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Źródło :
Cancers [Cancers (Basel)] 2021 Apr 23; Vol. 13 (9). Date of Electronic Publication: 2021 Apr 23.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Epithelial-to-mesenchymal Transition Heterogeneity of Circulating Tumor Cells and Their Correlation With MDSCs and Tregs in HER2-negative Metastatic Breast Cancer Patients.
Autorzy :
Papadaki MA; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Aggouraki D; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Vetsika EK; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Xenidis N; Department of Medical Oncology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.; Hellenic Oncology Research Group (HORG), Athens, Greece.
Kallergi G; Hellenic Oncology Research Group (HORG), Athens, Greece.; Department of Biology, University of Patras, Patras, Greece.
Kotsakis A; Hellenic Oncology Research Group (HORG), Athens, Greece.; Department of Medical Oncology, University Hospital of Larissa & Laboratory of Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Georgoulias V; Hellenic Oncology Research Group (HORG), Athens, Greece; .; School of Medicine, University of Crete, Heraklion, Greece.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 661-670.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Tumor Escape*
Breast Neoplasms/*immunology
Myeloid-Derived Suppressor Cells/*immunology
Neoplastic Cells, Circulating/*immunology
Neoplastic Stem Cells/*immunology
T-Lymphocytes, Regulatory/*immunology
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Breast Neoplasms/blood ; Breast Neoplasms/pathology ; Case-Control Studies ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Middle Aged ; Myeloid-Derived Suppressor Cells/metabolism ; Neoplastic Cells, Circulating/metabolism ; Neoplastic Cells, Circulating/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phenotype ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial.
Autorzy :
Gridelli C; S.G. Moscati Hospital, Avellino, Italy. .
Ciuleanu T; Institutui, Oncologic I. Chircuta, Cluz-Napoca, Romania.
Domine M; Fundacion Jimenez Diaz, Madrid, Spain.
Szczesna A; Mazowieckie Centrum, Otwock, Poland.
Bover I; Son Llatzer Hospital, Palma de Mallorca, Spain.
Cobo M; Hospital Regional Universitario Málaga, Instituto de Investigaciones Biomédicas (IBIMA), Málaga, Spain.
Kentepozidis N; 251 General Airforce Hospital, Athens, Greece.
Zarogoulidis K; Papanikolaou General Hospital, Exohi, Greece.
Kalofonos C; University Hospital of Patras, Rio, Greece.
Kazarnowisz A; Oddzial Onkologiiz Pododdziatem, Olsztyn, Poland.
Korozan M; Hospicjum Dutkiewicza SAC, Gdansk, Poland.
de Las Penas R; Hospital Provincial de Castellon, Castellon, Spain.
Majem M; Hospital de la Santa Creui Sant Pau, Barcelona, Spain.
Chella A; A.O.U. di Pisa Hospital, Pisa, Italy.
Griesinger F; Pius Hospital, Oldenburg, Germany.
Bournakis E; University Hospital 'Aretaieion', Athens, Greece.
Sadjadian P; Johannes Wesling Klinikum, Minden, Germany.
Kotsakis A; Dpt of Medical Oncology, University General Hospital of Larissa, Larissa, Greece.
Chinet T; Hopital Ambroise Paré, Boulogne-Billancourt, France.
Syrigos KN; General Hospital of Thoracic Diseases ''Sotiria', Athens, Greece.
Correale P; University Hospital of Siena, Siena, Italy.
Gallou C; Vaxon-Biotech, Paris, France.
Jamet JM; Vaxon-Biotech, Paris, France.
Vetsika EK; University General Hospital of Heraklion, Heraklion, Crete, Greece.
Kosmatopoulos K; Vaxon-Biotech, Paris, France.
Georgoulias V; University General Hospital of Heraklion, Heraklion, Crete, Greece.
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Corporate Authors :
Vx-001-201 trial team
Źródło :
British journal of cancer [Br J Cancer] 2020 May; Vol. 122 (10), pp. 1461-1466. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Cancer Vaccines/*administration & dosage
Carcinoma, Non-Small-Cell Lung/*therapy
Immunity/*drug effects
Telomerase/*administration & dosage
Aged ; CD8-Positive T-Lymphocytes/immunology ; Cancer Vaccines/immunology ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Female ; Humans ; Immunotherapy/adverse effects ; Maintenance Chemotherapy/methods ; Male ; Middle Aged ; Neoplasm Staging ; Placebo Effect ; Telomerase/antagonists & inhibitors ; Telomerase/genetics ; Telomerase/immunology
Czasopismo naukowe
Tytuł :
Myeloid-Derived Suppressor Cells: Major Figures that Shape the Immunosuppressive and Angiogenic Network in Cancer.
Autorzy :
Vetsika EK; Department of Medicine, pMEDgr, School of Health Sciences, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Koukos A; Laboratory of Translational Oncology, School of Medicine, University of Crete, P.O. Box 2208, 71003 Heraklion, Greece.
Kotsakis A; Department of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.; Department of Medical Oncology, University General Hospital of Larissa, 41334 Larissa, Greece.
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Źródło :
Cells [Cells] 2019 Dec 15; Vol. 8 (12). Date of Electronic Publication: 2019 Dec 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Myeloid-Derived Suppressor Cells/*metabolism
Myeloid-Derived Suppressor Cells/*pathology
Neoplasms/*pathology
Histone Deacetylase Inhibitors ; Humans ; Immune Tolerance ; Immunosuppression ; Killer Cells, Natural/immunology ; Myeloid Cells/physiology ; Neoplasms/metabolism ; Neovascularization, Physiologic/physiology ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Signal Transduction ; T-Lymphocytes/immunology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Characterization of DLL3-positive circulating tumor cells (CTCs) in patients with small cell lung cancer (SCLC) and evaluation of their clinical relevance during front-line treatment.
Autorzy :
Messaritakis I; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Greece.
Nikolaou M; Department of Internal Medicine, Medical Oncology Unit, 'Marika Iliadi' Hospital of Athens, Greece.
Koinis F; Department of Medical Oncology, University General Hospital of Larissa, Thessaly, Greece.
Politaki E; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Greece.
Koutsopoulos A; Department of Pathology, University General Hospital of Heraklion, Greece.
Lagoudaki E; Department of Pathology, University General Hospital of Heraklion, Greece.
Vetsika EK; Department of Medical Oncology, University General Hospital of Larissa, Thessaly, Greece.
Georgoulias V; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Greece; First Department of Medical Oncology, IASO General Hospital of Athens, Greece.
Kotsakis A; Department of Medical Oncology, University General Hospital of Larissa, Thessaly, Greece. Electronic address: .
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Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2019 Sep; Vol. 135, pp. 33-39. Date of Electronic Publication: 2019 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Intracellular Signaling Peptides and Proteins/*metabolism
Lung Neoplasms/*metabolism
Membrane Proteins/*metabolism
Neoplastic Cells, Circulating/*metabolism
Small Cell Lung Carcinoma/*metabolism
Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers ; Biomarkers, Tumor ; Cell Line, Tumor ; Disease Management ; Female ; Fluorescent Antibody Technique ; Gene Expression ; Humans ; Immunophenotyping ; Intracellular Signaling Peptides and Proteins/genetics ; Leukocytes, Mononuclear ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy ; Male ; Membrane Proteins/genetics ; Neoplasm Staging ; Proportional Hazards Models ; Small Cell Lung Carcinoma/diagnosis ; Small Cell Lung Carcinoma/genetics ; Small Cell Lung Carcinoma/therapy ; Vimentin/genetics ; Vimentin/metabolism
Czasopismo naukowe
Tytuł :
CD8 circulating tumor cells in chemotherapy-naïve non-small cell lung cancer: towards their clinical relevance?
Autorzy :
Kotsakis A; School of Medical Sciences, University of Thessaly, GR-41334, Larissa, Thessaly, Greece.
Kallergi G; Laboratory Tumor Cell Biology, University of Crete, Medical School, Heraklion, Crete, Greece.
Aggouraki D; Hellenic Society of Immuno-Oncology, Athens, Greece.
Lyristi Z; Laboratory Tumor Cell Biology, University of Crete, Medical School, Heraklion, Crete, Greece.
Koinis F; Department of Medical Oncology, University General Hospital of Larissa, Thessaly, Greece.
Lagoudaki E; Hellenic Society of Immuno-Oncology, Athens, Greece.
Koutsopoulos A; Hellenic Society of Immuno-Oncology, Athens, Greece.
Georgoulias V; Laboratory Tumor Cell Biology, University of Crete, Medical School, Heraklion, Crete, Greece.
Vetsika EK; School of Medical Sciences, University of Thessaly, Larissa, Thessaly, Greece.
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Źródło :
Therapeutic advances in medical oncology [Ther Adv Med Oncol] 2019 Jun 12; Vol. 11, pp. 1758835919853193. Date of Electronic Publication: 2019 Jun 12 (Print Publication: 2019).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Evaluation of PD-L1/PD-1 on circulating tumor cells in patients with advanced non-small cell lung cancer.
Autorzy :
Kallergi G; Department of Biochemistry, University of Crete Medical School, Heraklion, Crete, Greece and Hellenic Oncology Research Group (HORG).
Vetsika EK; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion Greece and Hellenic Oncology Research Group (HORG).
Aggouraki D; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion Greece and Hellenic Oncology Research Group (HORG).
Lagoudaki E; Department of Pathology, University General Hospital of Heraklion, Crete, Greece.
Koutsopoulos A; Department of Pathology, University General Hospital of Heraklion, Crete, Greece.
Koinis F; Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece.
Katsarlinos P; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion Greece and Hellenic Oncology Research Group (HORG).
Trypaki M; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion Greece and Hellenic Oncology Research Group (HORG).
Messaritakis I; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion Greece and Hellenic Oncology Research Group (HORG).
Stournaras C; Department of Biochemistry, University of Crete Medical School, Heraklion, Crete, Greece.
Georgoulias V; School of Medicine, University of Crete, Crete, Greece; Hellenic Oncology Research Group (HORG).
Kotsakis A; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion Greece.
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Źródło :
Therapeutic advances in medical oncology [Ther Adv Med Oncol] 2018 Jan 15; Vol. 10, pp. 1758834017750121. Date of Electronic Publication: 2018 Jan 15 (Print Publication: 2018).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Expression of insulin-like growth factor-1 receptor in circulating tumor cells of patients with breast cancer is associated with patient outcomes.
Autorzy :
Spiliotaki M; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Mavroudis D; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.; Department of Medical Oncology, University General Hospital of Heraklion, Greece.
Kokotsaki M; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Vetsika EK; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Stoupis I; Department of Medical Oncology, University General Hospital of Heraklion, Greece.
Matikas A; Department of Medical Oncology, University General Hospital of Heraklion, Greece.
Kallergi G; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Georgoulias V; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Agelaki S; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.; Department of Medical Oncology, University General Hospital of Heraklion, Greece.
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Źródło :
Molecular oncology [Mol Oncol] 2018 Jan; Vol. 12 (1), pp. 21-32. Date of Electronic Publication: 2017 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*blood
Neoplastic Cells, Circulating/*pathology
Receptors, Somatomedin/*blood
Adult ; Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Cadherins/blood ; Female ; Humans ; MCF-7 Cells ; Middle Aged ; Neoplasm Invasiveness ; Prognosis ; Receptor, IGF Type 1 ; Statistics, Nonparametric
Czasopismo naukowe
Tytuł :
Prognostic value of circulating regulatory T cell subsets in untreated non-small cell lung cancer patients.
Autorzy :
Kotsakis A; Laboratory of Translational Oncology, School of Medicine, University of Crete, Voutes, GR-71110, Heraklion, Crete, Greece.; Department of Medical Oncology, University Hospital of Heraklion, Voutes, GR-71110, Heraklion, Crete, Greece.; Hellenic Society of Immuno-Oncology, 55 Lombardou str., 11474, Athens, Greece.
Koinis F; Laboratory of Translational Oncology, School of Medicine, University of Crete, Voutes, GR-71110, Heraklion, Crete, Greece.; Department of Medical Oncology, University Hospital of Heraklion, Voutes, GR-71110, Heraklion, Crete, Greece.; Hellenic Society of Immuno-Oncology, 55 Lombardou str., 11474, Athens, Greece.
Katsarou A; Laboratory of Translational Oncology, School of Medicine, University of Crete, Voutes, GR-71110, Heraklion, Crete, Greece.; Hellenic Society of Immuno-Oncology, 55 Lombardou str., 11474, Athens, Greece.
Gioulbasani M; Laboratory of Translational Oncology, School of Medicine, University of Crete, Voutes, GR-71110, Heraklion, Crete, Greece.; Hellenic Society of Immuno-Oncology, 55 Lombardou str., 11474, Athens, Greece.
Aggouraki D; Laboratory of Translational Oncology, School of Medicine, University of Crete, Voutes, GR-71110, Heraklion, Crete, Greece.; Hellenic Society of Immuno-Oncology, 55 Lombardou str., 11474, Athens, Greece.
Kentepozidis N; Hellenic Society of Immuno-Oncology, 55 Lombardou str., 11474, Athens, Greece.; Department of Medical Oncology, 251 Air Force Hospital, Leof. P. Kanellopoulou, 115 25, Athens, Greece.
Georgoulias V; Laboratory of Translational Oncology, School of Medicine, University of Crete, Voutes, GR-71110, Heraklion, Crete, Greece.; Department of Medical Oncology, University Hospital of Heraklion, Voutes, GR-71110, Heraklion, Crete, Greece.; Hellenic Society of Immuno-Oncology, 55 Lombardou str., 11474, Athens, Greece.
Vetsika EK; Laboratory of Translational Oncology, School of Medicine, University of Crete, Voutes, GR-71110, Heraklion, Crete, Greece.; Hellenic Society of Immuno-Oncology, 55 Lombardou str., 11474, Athens, Greece.
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Źródło :
Scientific reports [Sci Rep] 2016 Dec 15; Vol. 6, pp. 39247. Date of Electronic Publication: 2016 Dec 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*pathology
Lung Neoplasms/*pathology
T-Lymphocytes, Regulatory/*immunology
Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; CD4 Antigens/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/mortality ; Case-Control Studies ; Disease-Free Survival ; Female ; Humans ; Interleukin-10/metabolism ; Kaplan-Meier Estimate ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Effect of First-Line Treatment on Myeloid-Derived Suppressor Cells' Subpopulations in the Peripheral Blood of Patients with Non-Small Cell Lung Cancer.
Autorzy :
Koinis F; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece; Department of Medical Oncology, University General Hospital of Heraklion, Voutes, Crete, Greece; Hellenic Oncology Research Group, Athens, Greece.
Vetsika EK; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Aggouraki D; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Skalidaki E; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Koutoulaki A; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Gkioulmpasani M; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece.
Georgoulias V; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece; Department of Medical Oncology, University General Hospital of Heraklion, Voutes, Crete, Greece; Hellenic Oncology Research Group, Athens, Greece.
Kotsakis A; Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Greece; Department of Medical Oncology, University General Hospital of Heraklion, Voutes, Crete, Greece; Hellenic Oncology Research Group, Athens, Greece. Electronic address: .
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Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2016 Aug; Vol. 11 (8), pp. 1263-1272. Date of Electronic Publication: 2016 May 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Myeloid-Derived Suppressor Cells/*drug effects
Aged ; Aged, 80 and over ; Bevacizumab/therapeutic use ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/mortality ; Female ; Humans ; Immunosuppressive Agents ; Lewis X Antigen/analysis ; Lipopolysaccharide Receptors/analysis ; Lung Neoplasms/immunology ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Distinct features of circulating microparticles and their relationship with disease activity in inflammatory bowel disease.
Autorzy :
Voudoukis E; Department of Gastroenterology, Venizelion General Hospital (Evangelos Voudoukis, Konstantina Giannakopoulou, Konstantinos Karmiris, Angeliki Theodoropoulou, Gregorios A. Paspatis), Crete, Greece.
Vetsika EK; Laboratory of Tumor Biology, School of Medicine, University of Crete (Eleni-Kyriaki Vetsika, Vassilis Georgoulias), Crete, Greece.
Giannakopoulou K; Department of Gastroenterology, Venizelion General Hospital (Evangelos Voudoukis, Konstantina Giannakopoulou, Konstantinos Karmiris, Angeliki Theodoropoulou, Gregorios A. Paspatis), Crete, Greece.
Karmiris K; Department of Gastroenterology, Venizelion General Hospital (Evangelos Voudoukis, Konstantina Giannakopoulou, Konstantinos Karmiris, Angeliki Theodoropoulou, Gregorios A. Paspatis), Crete, Greece.
Theodoropoulou A; Department of Gastroenterology, Venizelion General Hospital (Evangelos Voudoukis, Konstantina Giannakopoulou, Konstantinos Karmiris, Angeliki Theodoropoulou, Gregorios A. Paspatis), Crete, Greece.
Sfiridaki A; Blood Bank, Venizelion General Hospital (Aekaterini Sfiridaki), Crete, Greece.
Georgoulias V; Laboratory of Tumor Biology, School of Medicine, University of Crete (Eleni-Kyriaki Vetsika, Vassilis Georgoulias), Crete, Greece.
Paspatis GA; Department of Gastroenterology, Venizelion General Hospital (Evangelos Voudoukis, Konstantina Giannakopoulou, Konstantinos Karmiris, Angeliki Theodoropoulou, Gregorios A. Paspatis), Crete, Greece.
Koutroubakis IE; Department of Gastroenterology, University Hospital, Heraklion (Ioannis E. Koutroubakis), Crete, Greece.
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Źródło :
Annals of gastroenterology [Ann Gastroenterol] 2016 Apr-Jun; Vol. 29 (2), pp. 180-7.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Sequential administration of vinorelbine plus cisplatin and bevacizumab followed by docetaxel plus gemcitabine and bevacizumab compared to docetaxel plus cisplatin and bevacizumab regimen as first-line therapy for advanced or metastatic non-squamous non-small cell lung cancer: A multicenter randomized phase II trial of the Hellenic Oncology Research Group (HORG).
Autorzy :
Kotsakis A; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece. Electronic address: .
Kentepozidis N; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Emmanouilidis Ch; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Polyzos A; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Agelidou A; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Vaslamatzis M; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Chandrinos V; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Agelaki S; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Vamvakas L; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Kalbakis K; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Katsaounis P; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Stoltidis D; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Nintos G; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Hatzidaki D; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Vetsika EK; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Mavroudis D; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
Georgoulias V; On behalf of the Lung Cancer Working Group of the Hellenic Oncology Research Group (HORG), 55 Lomvardou Street, 11471, Athens, Greece.
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Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2015 Apr; Vol. 88 (1), pp. 57-62. Date of Electronic Publication: 2015 Jan 23.
Typ publikacji :
Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Adult ; Aged ; Bevacizumab/administration & dosage ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/secondary ; Cisplatin/administration & dosage ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Disease-Free Survival ; Docetaxel ; Drug Administration Schedule ; Female ; Humans ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Taxoids/administration & dosage ; Treatment Outcome ; Vinblastine/administration & dosage ; Vinblastine/analogs & derivatives ; Vinorelbine
Czasopismo naukowe
Tytuł :
A phase II trial evaluating the clinical and immunologic response of HLA-A2(+) non-small cell lung cancer patients vaccinated with an hTERT cryptic peptide.
Autorzy :
Kotsakis A; Department of Medical Oncology, University General Hospital of Heraklion, Greece; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece. Electronic address: .
Papadimitraki E; Department of Medical Oncology, University General Hospital of Heraklion, Greece; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece.
Vetsika EK; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece.
Aggouraki D; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece.
Dermitzaki EK; Department of Medical Oncology, University General Hospital of Heraklion, Greece.
Hatzidaki D; Department of Medical Oncology, University General Hospital of Heraklion, Greece.
Kentepozidis N; Department of Medical Oncology, 251 Air Force General Hospital, Athens, Greece.
Mavroudis D; Department of Medical Oncology, University General Hospital of Heraklion, Greece; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece.
Georgoulias V; Department of Medical Oncology, University General Hospital of Heraklion, Greece; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece.
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Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2014 Oct; Vol. 86 (1), pp. 59-66. Date of Electronic Publication: 2014 Aug 05.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cancer Vaccines/*immunology
Carcinoma, Non-Small-Cell Lung/*immunology
Carcinoma, Non-Small-Cell Lung/*therapy
HLA-A2 Antigen/*immunology
Lung Neoplasms/*immunology
Lung Neoplasms/*therapy
Peptide Fragments/*immunology
Telomerase/*immunology
Adult ; Aged ; Aged, 80 and over ; Cancer Vaccines/administration & dosage ; Cancer Vaccines/adverse effects ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Chemotherapy, Adjuvant ; Disease Progression ; Female ; Humans ; Immunotherapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Radiotherapy, Adjuvant ; Telomerase/chemistry ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients.
Autorzy :
Vetsika EK; Laboratory of Cancer Cell Biology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece.
Koinis F; Department of Medical Oncology, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
Gioulbasani M; Laboratory of Cancer Cell Biology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece.
Aggouraki D; Laboratory of Cancer Cell Biology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece.
Koutoulaki A; Laboratory of Cancer Cell Biology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece.
Skalidaki E; Laboratory of Cancer Cell Biology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece.
Mavroudis D; Laboratory of Cancer Cell Biology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece ; Department of Medical Oncology, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
Georgoulias V; Laboratory of Cancer Cell Biology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece ; Department of Medical Oncology, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
Kotsakis A; Laboratory of Cancer Cell Biology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece ; Department of Medical Oncology, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
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Źródło :
Journal of immunology research [J Immunol Res] 2014; Vol. 2014, pp. 659294. Date of Electronic Publication: 2014 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*immunology
Lung Neoplasms/*immunology
Monocytes/*immunology
Myeloid Cells/*immunology
Aged ; Aged, 80 and over ; CD11b Antigen/immunology ; CD11b Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Disease-Free Survival ; Female ; Flow Cytometry ; HLA-DR Antigens/immunology ; HLA-DR Antigens/metabolism ; Humans ; Immunophenotyping ; Lewis X Antigen/immunology ; Lewis X Antigen/metabolism ; Lipopolysaccharide Receptors/immunology ; Lipopolysaccharide Receptors/metabolism ; Lung Neoplasms/blood ; Lung Neoplasms/drug therapy ; Male ; Middle Aged ; Monocytes/metabolism ; Multivariate Analysis ; Myeloid Cells/metabolism ; Nitric Oxide Synthase Type II/immunology ; Nitric Oxide Synthase Type II/metabolism ; Prognosis ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Sialic Acid Binding Ig-like Lectin 3/immunology ; Sialic Acid Binding Ig-like Lectin 3/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Immunological responses in cancer patients after vaccination with the therapeutic telomerase-specific vaccine Vx-001.
Autorzy :
Vetsika EK; Laboratory of Tumor Biology, Medical School, University of Crete, Voutes, 71110, Heraklion, Crete, Greece. vetsika@edu.med.uoc.gr.
Konsolakis G; Laboratory of Tumor Biology, Medical School, University of Crete, Voutes, 71110, Heraklion, Crete, Greece.
Aggouraki D; Laboratory of Tumor Biology, Medical School, University of Crete, Voutes, 71110, Heraklion, Crete, Greece.
Kotsakis A; Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece.
Papadimitraki E; Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece.
Christou S; Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece.
Menez-Jamet J; Vaxon Biotech, Paris, France.
Kosmatopoulos K; Vaxon Biotech, Paris, France.
Georgoulias V; Laboratory of Tumor Biology, Medical School, University of Crete, Voutes, 71110, Heraklion, Crete, Greece.; Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece.; Department of Medical Oncology, 'IASO' General Hospital of Athens, Athens, Greece.
Mavroudis D; Laboratory of Tumor Biology, Medical School, University of Crete, Voutes, 71110, Heraklion, Crete, Greece.; Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2012 Feb; Vol. 61 (2), pp. 157-168. Date of Electronic Publication: 2011 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cancer Vaccines*
Immunotherapy*
CD8-Positive T-Lymphocytes/*metabolism
Carcinoma, Non-Small-Cell Lung/*immunology
Lung Neoplasms/*immunology
Adult ; Aged ; Aged, 80 and over ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Cytotoxicity, Immunologic ; Enzyme-Linked Immunospot Assay ; Female ; HLA-A2 Antigen/immunology ; HLA-A2 Antigen/metabolism ; Humans ; Interferon-gamma/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Survival Analysis ; Telomerase ; Vaccination
Czasopismo naukowe
Tytuł :
Clinical outcome of patients with various advanced cancer types vaccinated with an optimized cryptic human telomerase reverse transcriptase (TERT) peptide: results of an expanded phase II study.
Autorzy :
Kotsakis A; Department of Medical Oncology, University Hospital of Heraklion, Crete, Greece.
Vetsika EK
Christou S
Hatzidaki D
Vardakis N
Aggouraki D
Konsolakis G
Georgoulias V
Christophyllakis Ch
Cordopatis P
Kosmatopoulos K
Mavroudis D
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Źródło :
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2012 Feb; Vol. 23 (2), pp. 442-9. Date of Electronic Publication: 2011 Aug 25.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cancer Vaccines/*administration & dosage
Neoplasms/*immunology
Neoplasms/*therapy
Telomerase/*administration & dosage
Adult ; Aged ; Aged, 80 and over ; Cancer Vaccines/immunology ; Female ; HLA-A2 Antigen/immunology ; Humans ; Injections, Subcutaneous ; Male ; Middle Aged ; Neoplasms/pathology ; Telomerase/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Sequential administration of the native TERT572 cryptic peptide enhances the immune response initiated by its optimized variant TERT(572Y) in cancer patients.
Autorzy :
Vetsika EK; Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Greece. vetsika@edu.med.uoc.gr
Papadimitraki E
Aggouraki D
Konsolakis G
Mela ME
Kotsakis A
Christou S
Patramani S
Alefantinou M
Kaskara A
Christophyllakis C
Kosmatopoulos K
Georgoulias V
Mavroudis D
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Źródło :
Journal of immunotherapy (Hagerstown, Md. : 1997) [J Immunother] 2011 Nov-Dec; Vol. 34 (9), pp. 641-50.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Neoplasm/*immunology
Neoplasms/*drug therapy
Peptide Fragments/*immunology
T-Lymphocytes/*metabolism
Telomerase/*immunology
Aged ; Aged, 80 and over ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Cells, Cultured ; Clinical Protocols ; Drug Resistance, Neoplasm ; Enzyme-Linked Immunospot Assay ; Epitopes, T-Lymphocyte/metabolism ; Female ; HLA-A2 Antigen/metabolism ; Humans ; Interferon-gamma/metabolism ; Lymphocyte Activation ; Male ; Middle Aged ; Mutation/genetics ; Neoplasms/immunology ; Neoplasms/mortality ; Neoplasms/pathology ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Survival Analysis ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Telomerase/genetics ; Telomerase/metabolism ; Vaccination
Czasopismo naukowe
Tytuł :
Infectious mononucleosis and Epstein-Barr virus.
Autorzy :
Vetsika EK; Division of Medicine, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK. e.k.vetsika@imperial.ac.uk
Callan M
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Źródło :
Expert reviews in molecular medicine [Expert Rev Mol Med] 2004 Nov 05; Vol. 6 (23), pp. 1-16. Date of Electronic Publication: 2004 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Herpesvirus 4, Human/*pathogenicity
Infectious Mononucleosis/*virology
Adolescent ; Adult ; B-Lymphocytes/virology ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; Child ; Child, Preschool ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/prevention & control ; Female ; Herpesvirus 4, Human/immunology ; Herpesvirus 4, Human/physiology ; Humans ; Infant ; Infectious Mononucleosis/immunology ; Male ; T-Lymphocyte Subsets/immunology ; Viral Vaccines ; Virus Activation ; Virus Latency
Czasopismo naukowe
Tytuł :
The effects of CSF blockage in early-onset hydrocephalus on the activity of the germinal epithelium.
Autorzy :
Vetsika EK; Department of Biomolecular Sciences, University of Manchester Institute of Science & Technology, UK.
Bannister CM
Buckle AM
Miyan JA
Pokaż więcej
Źródło :
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie [Eur J Pediatr Surg] 1999 Dec; Vol. 9 Suppl 1, pp. 43-4.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Aqueduct*
Intracranial Pressure*
Cerebrospinal Fluid/*physiology
Hydrocephalus/*physiopathology
Age Factors ; Animals ; Animals, Newborn ; Brain/pathology ; Disease Models, Animal ; Epithelium/pathology ; Hydrocephalus/genetics ; Hydrocephalus/pathology ; Rats ; Rats, Inbred Strains
Czasopismo naukowe
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