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Wyszukujesz frazę ""Viral Proteins"" wg kryterium: Temat


Tytuł :
Comparative study of potyvirid NIa proteases and their cleavage sites.
Autorzy :
Palani SN; Madurai Kamaraj University, Madurai, Tamil Nadu, India.
Sankaranarayanan R; Madurai Kamaraj University, Madurai, Tamil Nadu, India.
Tennyson J; Madurai Kamaraj University, Madurai, Tamil Nadu, India. .
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Źródło :
Archives of virology [Arch Virol] 2021 Apr; Vol. 166 (4), pp. 1141-1149. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Endopeptidases/*metabolism
Potyviridae/*enzymology
Viral Proteins/*metabolism
Amino Acid Sequence ; Endopeptidases/chemistry ; Endopeptidases/genetics ; Genetic Variation ; Oligopeptides/chemistry ; Oligopeptides/metabolism ; Polyproteins/chemistry ; Polyproteins/metabolism ; Potyviridae/classification ; Potyviridae/genetics ; Protein Processing, Post-Translational ; Species Specificity ; Substrate Specificity ; Viral Proteins/chemistry ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Autorzy :
Almofti YA; Department of Molecular Biology and Bioinformatics, College of Veterinary Medicine, University of Bahri, Khartoum, Sudan. .
Abd-Elrahman KA; Department of Pharmaceutical Technology, College of Pharmacy, University of Medical Science and Technology (MUST), Khartoum, Sudan.
Eltilib EEM; Department of Molecular Biology and Bioinformatics, College of Veterinary Medicine, University of Bahri, Khartoum, Sudan.
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Źródło :
BMC immunology [BMC Immunol] 2021 Mar 25; Vol. 22 (1), pp. 22. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19 Vaccines*/chemistry
COVID-19 Vaccines*/genetics
COVID-19 Vaccines*/immunology
Epitopes, B-Lymphocyte*/chemistry
Epitopes, B-Lymphocyte*/genetics
Epitopes, B-Lymphocyte*/immunology
Epitopes, T-Lymphocyte*/chemistry
Epitopes, T-Lymphocyte*/genetics
Epitopes, T-Lymphocyte*/immunology
SARS-CoV-2*/chemistry
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/immunology
Viral Proteins*/chemistry
Viral Proteins*/genetics
Viral Proteins*/immunology
COVID-19/*immunology
B-Lymphocytes/immunology ; COVID-19/prevention & control ; Humans ; Polyproteins/chemistry ; Polyproteins/genetics ; Polyproteins/immunology ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
First insights into the structural features of Ebola virus methyltransferase activities.
Autorzy :
Valle C; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France.
Martin B; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France.
Ferron F; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France.
Roig-Zamboni V; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France.
Desmyter A; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France.
Debart F; IBMM, UMR 5247 CNRS, Université de Montpellier, ENSCM, Montpellier, France.
Vasseur JJ; IBMM, UMR 5247 CNRS, Université de Montpellier, ENSCM, Montpellier, France.
Canard B; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France.
Coutard B; Unité des Virus Émergents (UVE: Aix-Marseille Univ-IRD 190-Inserm, 1207-IHU Méditerranée Infection) Marseille, France.
Decroly E; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 22; Vol. 49 (3), pp. 1737-1748.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ebolavirus/*enzymology
Methyltransferases/*chemistry
Viral Proteins/*chemistry
Catalytic Domain ; Crystallography, X-Ray ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Models, Molecular ; Mutation ; Protein Conformation, alpha-Helical ; Single-Domain Antibodies/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase.
Autorzy :
Gregor J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.; First Faculty of Medicine, Charles University, Kateřinská 1660/32, 12108 Prague 2, Czech Republic.
Radilová K; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.; First Faculty of Medicine, Charles University, Kateřinská 1660/32, 12108 Prague 2, Czech Republic.
Brynda J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.
Fanfrlík J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.
Konvalinka J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.; Department of Biochemistry, Faculty of Science, Charles University, Hlavova 8, 12800 Prague 2, Czech Republic.
Kožíšek M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 14; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 14.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Viral/*drug effects
Influenza A virus/*enzymology
Protein Subunits/*antagonists & inhibitors
Pyridines/*chemistry
Pyridines/*pharmacology
Pyrimidines/*chemistry
Pyrimidines/*pharmacology
Pyrroles/*chemistry
Pyrroles/*pharmacology
RNA-Dependent RNA Polymerase/*metabolism
Viral Proteins/*antagonists & inhibitors
Crystallography, X-Ray ; Influenza A virus/drug effects ; Models, Molecular ; Mutant Proteins/metabolism ; Mutation/genetics ; Protein Domains ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Quantum Theory ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; RNA-Dependent RNA Polymerase/chemistry ; Thermodynamics ; Viral Proteins/chemistry ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structural and Functional Diversity among Five RING Finger Proteins from Carassius Auratus Herpesvirus (CaHV).
Autorzy :
Wang ZH; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; College of Modern Agriculture Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; The Innovation Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
Ke F; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; College of Modern Agriculture Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang QY; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; College of Modern Agriculture Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; The Innovation Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
Gui JF; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; College of Modern Agriculture Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; The Innovation Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
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Źródło :
Viruses [Viruses] 2021 Feb 07; Vol. 13 (2). Date of Electronic Publication: 2021 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Herpesviridae/*metabolism
Viral Proteins/*chemistry
Viral Proteins/*metabolism
Animals ; Fish Diseases/virology ; Goldfish/virology ; HEK293 Cells ; Herpesviridae/genetics ; Herpesviridae/physiology ; Herpesviridae Infections/veterinary ; Herpesviridae Infections/virology ; Host-Pathogen Interactions ; Humans ; Intracellular Space/metabolism ; Mutation ; RING Finger Domains/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Uncovering potential host proteins and pathways that may interact with eukaryotic short linear motifs in viral proteins of MERS, SARS and SARS2 coronaviruses that infect humans.
Autorzy :
Yang CW; Department of Microbiology, Center for Applied Artificial Intelligence Research, Soochow University, Taipei, Taiwan.
Shi ZL; Ocean School of Fuzhou University, Fuzhou University, Fuzhou, China.
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Źródło :
PloS one [PLoS One] 2021 Feb 03; Vol. 16 (2), pp. e0246150. Date of Electronic Publication: 2021 Feb 03 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Coronavirus Infections/*pathology
Middle East Respiratory Syndrome Coronavirus/*metabolism
SARS Virus/*metabolism
SARS-CoV-2/*metabolism
Viral Proteins/*metabolism
Amino Acid Motifs ; Coronavirus Infections/virology ; Databases, Protein ; Humans ; Middle East Respiratory Syndrome Coronavirus/isolation & purification ; Phylogeny ; Protein Interaction Domains and Motifs ; Proteins/chemistry ; Proteins/classification ; SARS Virus/isolation & purification ; SARS-CoV-2/isolation & purification ; Signal Transduction/genetics ; User-Computer Interface ; Viral Proteins/chemistry ; Viral Proteins/classification
Czasopismo naukowe
Tytuł :
The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta.
Autorzy :
Rashid F; Dermatology Hospital, Southern Medical University, Guangzhou, China. Electronic address: .
Dzakah EE; Dermatology Hospital, Southern Medical University, Guangzhou, China; Department of Molecular Biology and Biotechnology, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana. Electronic address: .
Wang H; Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: .
Tang S; Dermatology Hospital, Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Apr 15; Vol. 296, pp. 198350. Date of Electronic Publication: 2021 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
Immune Evasion*
Endoplasmic Reticulum Stress/*physiology
Interferon-beta/*antagonists & inhibitors
Viral Proteins/*physiology
Activating Transcription Factor 6/physiology ; Endoribonucleases/physiology ; HEK293 Cells ; Humans ; Interferon-beta/biosynthesis ; Protein-Serine-Threonine Kinases/physiology ; Sequence Alignment ; Signal Transduction/physiology ; Unfolded Protein Response ; Viral Proteins/chemistry ; X-Box Binding Protein 1/physiology ; eIF-2 Kinase/physiology
Czasopismo naukowe
Tytuł :
Platelets and viruses.
Autorzy :
Antoniak S; UNC Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Mackman N; UNC Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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Źródło :
Platelets [Platelets] 2021 Apr 03; Vol. 32 (3), pp. 325-330. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Blood Platelets/*immunology
COVID-19/*immunology
Host-Pathogen Interactions/*immunology
Neutrophils/*immunology
Receptors, Virus/*immunology
Viral Proteins/*immunology
Viruses/*immunology
Animals ; Blood Platelets/pathology ; Blood Platelets/virology ; COVID-19/genetics ; COVID-19/pathology ; COVID-19/virology ; Cell Communication/genetics ; Cell Communication/immunology ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Dendritic Cells/virology ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Humans ; Immunity, Innate ; Lymphocytes/immunology ; Lymphocytes/pathology ; Lymphocytes/virology ; Neutrophils/pathology ; Neutrophils/virology ; Platelet Activation/immunology ; Protein Binding ; Receptors, Virus/genetics ; Toll-Like Receptors/genetics ; Toll-Like Receptors/immunology ; Viral Proteins/genetics ; Viruses/pathogenicity
Czasopismo naukowe
Tytuł :
Current methods and prospects of coronavirus detection.
Autorzy :
Bu J; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China.
Deng Z; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China.
Liu H; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China.
Li J; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China.
Wang; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China.
Yang Y; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China. Electronic address: .
Zhong S; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China. Electronic address: .
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Źródło :
Talanta [Talanta] 2021 Apr 01; Vol. 225, pp. 121977. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Imprinting*
COVID-19/*diagnosis
Magnetite Nanoparticles/*chemistry
Polymers/*chemistry
SARS-CoV-2/*metabolism
Viral Proteins/*metabolism
COVID-19/virology ; Humans ; Microspheres ; Ovalbumin/chemistry ; Ovalbumin/metabolism ; SARS-CoV-2/physiology ; Sensitivity and Specificity ; Viral Proteins/chemistry
Czasopismo naukowe
Tytuł :
Effects of SARS-CoV-2 mutations on protein structures and intraviral protein-protein interactions.
Autorzy :
Wu S; College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China.; Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China.
Tian C; College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China.; Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China.
Liu P; College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China.; Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China.
Guo D; College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China.; Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China.
Zheng W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Huang X; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Zhang Y; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
Liu L; College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China.; Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Apr; Vol. 93 (4), pp. 2132-2140. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
COVID-19/*virology
SARS-CoV-2/*genetics
Viral Proteins/*genetics
Humans ; Mutation ; Open Reading Frames ; Protein Binding ; Protein Structure, Tertiary ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Sarbecovirus ORF6 proteins hamper induction of interferon signaling.
Autorzy :
Kimura I; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.
Konno Y; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.
Uriu K; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan; Graduate School of Medicine, The University of Tokyo, Tokyo 1130033, Japan.
Hopfensperger K; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen 72076, Germany.
Sauter D; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen 72076, Germany.
Nakagawa S; Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa 2591193, Japan; CREST, Japan Science and Technology Agency, Saitama 3220012, Japan.
Sato K; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan; CREST, Japan Science and Technology Agency, Saitama 3220012, Japan. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2021 Mar 30; Vol. 34 (13), pp. 108916. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*metabolism
Interferon Type I/*metabolism
Viral Proteins/*metabolism
Animals ; COVID-19/genetics ; Chlorocebus aethiops ; HEK293 Cells ; Humans ; Immunity, Innate/immunology ; SARS-CoV-2/isolation & purification ; Signal Transduction/immunology ; Vero Cells ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Production of ORF8 protein from SARS-CoV-2 using an inducible virus-mediated expression system in suspension-cultured tobacco BY-2 cells.
Autorzy :
Imamura T; Laboratory of Plant Gene Function, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, 308-1 Suematsu, Nonoichi, Ishikawa, 921-8836, Japan. .
Isozumi N; Center for Nano Materials and Technology (CNMT), Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan.
Higashimura Y; Department of Food Science, Ishikawa Prefectural University, 308-1 Suematsu, Nonoichi, Ishikawa, 921-8836, Japan.
Ohki S; Center for Nano Materials and Technology (CNMT), Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan. .
Mori M; Laboratory of Plant Gene Function, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, 308-1 Suematsu, Nonoichi, Ishikawa, 921-8836, Japan. .
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Źródło :
Plant cell reports [Plant Cell Rep] 2021 Mar; Vol. 40 (3), pp. 433-436. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*virology
SARS-CoV-2/*genetics
Tobacco/*metabolism
Viral Proteins/*metabolism
Cells, Cultured ; Humans ; Tobacco/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Mutational spectra of SARS-CoV-2 orf1ab polyprotein and signature mutations in the United States of America.
Autorzy :
Banerjee S; Environmental Epigenomics Lab, Department of Environmental Science, University of Calcutta, Kolkata, India.; UGC-DAE Consortium for Scientific Research Kolkata Centre, Kolkata, India.
Seal S; Environmental Epigenomics Lab, Department of Environmental Science, University of Calcutta, Kolkata, India.; Department of Zoology, Ramakrishna Mission Vidyamandira, Howrah, India.
Dey R; Environmental Epigenomics Lab, Department of Environmental Science, University of Calcutta, Kolkata, India.; Department of Zoology, Ramakrishna Mission Vidyamandira, Howrah, India.
Mondal KK; Environmental Epigenomics Lab, Department of Environmental Science, University of Calcutta, Kolkata, India.
Bhattacharjee P; Environmental Epigenomics Lab, Department of Environmental Science, University of Calcutta, Kolkata, India.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Mar; Vol. 93 (3), pp. 1428-1435. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
COVID-19/*virology
SARS-CoV-2/*genetics
Viral Proteins/*genetics
Amino Acid Substitution ; Coronavirus RNA-Dependent RNA Polymerase/chemistry ; Coronavirus RNA-Dependent RNA Polymerase/genetics ; Humans ; Polyproteins/chemistry ; Polyproteins/genetics ; Protein Conformation ; United States ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics ; Viral Proteins/chemistry
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.
Autorzy :
Kumar G; Department of Structural Biology, Memphis, TN 38105, USA.
Cuypers M; Department of Structural Biology, Memphis, TN 38105, USA.
Webby RR; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Webb TR; Wildflower Biopharma, Inc., 8650 Genesee Ave. STE 214, San Diego, CA 92122, USA.; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
White SW; Department of Structural Biology, Memphis, TN 38105, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 22; Vol. 49 (3), pp. 1609-1618.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Endoribonucleases/*chemistry
Influenza A Virus, H1N1 Subtype/*enzymology
Viral Proteins/*chemistry
Antiviral Agents/chemistry ; DNA/chemistry ; Dibenzothiepins/chemistry ; Endoribonucleases/metabolism ; Models, Molecular ; Morpholines/chemistry ; Pyridones/chemistry ; RNA/chemistry ; Substrate Specificity ; Triazines/chemistry ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.
Autorzy :
Shah M; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Taylor VL; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Bona D; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Tsao Y; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Stanley SY; Department of Molecular Genetics, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Pimentel-Elardo SM; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
McCallum M; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada; Program in Molecular Structure & Function, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Bondy-Denomy J; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Howell PL; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada; Program in Molecular Structure & Function, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Nodwell JR; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Davidson AR; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada; Department of Molecular Genetics, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Moraes TF; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada. Electronic address: .
Maxwell KL; Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 571-583.e6. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Quorum Sensing*
Bacterial Proteins/*metabolism
Bacteriophages/*metabolism
Pseudomonas aeruginosa/*metabolism
Trans-Activators/*metabolism
Viral Proteins/*metabolism
Bacterial Proteins/genetics ; Bacteriophages/genetics ; Bacteriophages/pathogenicity ; Fimbriae, Bacterial/metabolism ; Host-Pathogen Interactions ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/growth & development ; Pyocyanine/metabolism ; Trans-Activators/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
An insight into the interaction between α-ketoamide- based inhibitor and coronavirus main protease: A detailed in silico study.
Autorzy :
Banerjee S; Department of Chemistry, Government College of Engineering and Leather Technology, Salt Lake, Sector-3, Kolkata, PIN-700106, West Bengal, India. Electronic address: .
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Źródło :
Biophysical chemistry [Biophys Chem] 2021 Feb; Vol. 269, pp. 106510. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*chemistry
Coronavirus/*enzymology
Peptide Hydrolases/*chemistry
Protease Inhibitors/*chemistry
Viral Proteins/*antagonists & inhibitors
Amides/metabolism ; Binding Sites ; Catalytic Domain ; Coronavirus/isolation & purification ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Coronavirus M Proteins/antagonists & inhibitors ; Coronavirus M Proteins/metabolism ; Drug Design ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation ; Peptide Hydrolases/metabolism ; Protease Inhibitors/metabolism ; Quantum Theory ; Thermodynamics ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
DBCOVP: A database of coronavirus virulent glycoproteins.
Autorzy :
Sahoo S; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Mahapatra SR; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Parida BK; Informatics Lab, CSIR-Institute of Minerals and Materials Technology (CSIR-IMMT), Bhubaneswar, Odisha, India.
Rath S; Informatics Lab, CSIR-Institute of Minerals and Materials Technology (CSIR-IMMT), Bhubaneswar, Odisha, India.
Dehury B; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Raina V; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Mohakud NK; Department of Pediatrics, Kalinga Institute of Medical Sciences, KIIT Deemed to Be University, Bhubaneswar, Odisha, India.
Misra N; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India; KIIT-Technology Business Incubator (KIIT-TBI), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Suar M; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India; KIIT-Technology Business Incubator (KIIT-TBI), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India. Electronic address: .
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Źródło :
Computers in biology and medicine [Comput Biol Med] 2021 Feb; Vol. 129, pp. 104131. Date of Electronic Publication: 2020 Nov 21.
Typ publikacji :
Journal Article
MeSH Terms :
Databases, Protein*
COVID-19/*virology
Glycoproteins/*metabolism
SARS-CoV-2/*metabolism
Viral Proteins/*metabolism
Glycoproteins/chemistry ; Phylogeny ; SARS-CoV-2/pathogenicity ; Sequence Alignment ; Viral Proteins/chemistry ; Virulence
Czasopismo naukowe
Tytuł :
Development of Monoclonal Antibodies for Detection of Conserved and Variable Epitopes of Large Protein of Rabies Virus.
Autorzy :
Zhao W; Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Su J; Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Zhao N; Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Liu J; Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Su S; Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
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Źródło :
Viruses [Viruses] 2021 Jan 31; Vol. 13 (2). Date of Electronic Publication: 2021 Jan 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*analysis
DNA-Directed RNA Polymerases/*immunology
Epitopes/*immunology
Rabies/*virology
Rabies virus/*immunology
Viral Proteins/*immunology
Amino Acid Sequence ; Antibodies, Monoclonal/immunology ; DNA-Directed RNA Polymerases/chemistry ; DNA-Directed RNA Polymerases/genetics ; Epitope Mapping ; Epitopes/chemistry ; Epitopes/genetics ; Humans ; Phylogeny ; Rabies virus/chemistry ; Rabies virus/classification ; Rabies virus/genetics ; Sequence Alignment ; Viral Proteins/chemistry ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2.
Autorzy :
Zinzula L; Max-Planck Institute of Biochemistry, Department of Molecular Structural Biology, Am Klopferspitz 18, 82152, Martinsried, Germany. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 29; Vol. 538, pp. 116-124. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
SARS-CoV-2/*metabolism
Viral Proteins/*chemistry
Viral Proteins/*metabolism
Antiviral Agents/pharmacology ; Host-Pathogen Interactions/physiology ; Humans ; Immunity, Innate ; Mutation ; SARS-CoV-2/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics.
Autorzy :
Walsh MA; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, OX11 0FA, UK.
Grimes JM; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK; Division of Structural Biology, The Nuffield Department of Medicine, University of Oxford, Headington, Oxford, OX3 7BN, UK.
Stuart DI; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK; Division of Structural Biology, The Nuffield Department of Medicine, University of Oxford, Headington, Oxford, OX3 7BN, UK; Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, OX4 2JY, UK. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 29; Vol. 538, pp. 40-46. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Development*
Drug Discovery*
SARS-CoV-2*/genetics
SARS-CoV-2*/metabolism
Viral Proteins*/chemistry
Viral Proteins*/genetics
COVID-19/*drug therapy
Humans ; Protein Conformation
Czasopismo naukowe

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