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Wyszukujesz frazę ""Virus Replication"" wg kryterium: Temat


Tytuł :
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network.
Autorzy :
Delattre H; School of Life Sciences, University of Warwick, UK.
Sasidharan K; School of Life Sciences, University of Warwick, UK.; Bio-Electrical Engineering Innovation Hub, University of Warwick, UK.
Soyer OS; School of Life Sciences, University of Warwick, UK .; Bio-Electrical Engineering Innovation Hub, University of Warwick, UK.
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Źródło :
Life science alliance [Life Sci Alliance] 2020 Nov 24; Vol. 4 (1). Date of Electronic Publication: 2020 Nov 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Host-Pathogen Interactions*/drug effects
Host-Pathogen Interactions*/physiology
Lung*/cytology
Lung*/metabolism
SARS-CoV-2*/drug effects
SARS-CoV-2*/metabolism
SARS-CoV-2*/pathogenicity
Virus Replication*/drug effects
Virus Replication*/physiology
Antiviral Agents/pharmacology ; Biomass ; COVID-19/prevention & control ; COVID-19/virology ; Cells, Cultured ; Culture Media/chemistry ; Culture Media/metabolism ; Glycolysis/physiology ; Humans ; Metabolic Flux Analysis ; Models, Biological ; Systems Biology
Czasopismo naukowe
Tytuł :
S6K1 inhibits HBV replication through inhibiting AMPK-ULK1 pathway and disrupting acetylation modification of H3K27.
Autorzy :
Wang Y; Peking University Ditan Teaching Hospital, Beijing 100015, China; Institiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Han M; Institiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Liu S; Institiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Yuan X; Institiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Zhao J; Institiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China; Department of Gastroenterology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Lu H; Beijing Pan-Asia Tongze Institute of Biomedicine Co, Ltd, Beijing 100103, China.
Han K; Institiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Liang P; Institiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Cheng J; Peking University Ditan Teaching Hospital, Beijing 100015, China; Institiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118848. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy-Related Protein-1 Homolog/*metabolism
Hepatitis B virus/*physiology
Histones/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Ribosomal Protein S6 Kinases, 70-kDa/*metabolism
Virus Replication/*physiology
AMP-Activated Protein Kinases/metabolism ; Acetylation ; Autophagy/physiology ; Cell Line, Tumor ; Hep G2 Cells ; Hepatitis B virus/genetics ; Humans ; Signal Transduction/physiology ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient.
Autorzy :
Baang JH; Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.
Smith C; Division of Hospital Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Mirabelli C; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Valesano AL; Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Manthei DM; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Bachman MA; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Wobus CE; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Adams M; Division of Hospital Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Washer L; Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.
Martin ET; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Lauring AS; Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2021 Jan 04; Vol. 223 (1), pp. 23-27.
Typ publikacji :
Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Virus Replication*
COVID-19/*virology
SARS-CoV-2/*physiology
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antibodies, Viral/blood ; COVID-19/diagnosis ; Hospitalization ; Humans ; Immunity, Humoral ; Immunocompromised Host ; Lymphoma, Mantle-Cell/complications ; Male ; Middle Aged ; Primary Immunodeficiency Diseases/complications ; Seroconversion
Czasopismo naukowe
Tytuł :
SARS-CoV-2 replicates in respiratory ex vivo organ cultures of domestic ruminant species.
Autorzy :
Di Teodoro G; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Valleriani F; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Puglia I; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Monaco F; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Di Pancrazio C; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Luciani M; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Krasteva I; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Petrini A; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Marcacci M; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy; Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.
D'Alterio N; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Curini V; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Iorio M; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Migliorati G; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Di Domenico M; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Morelli D; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Calistri P; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Savini G; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy.
Decaro N; Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.
Holmes EC; Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
Lorusso A; Istituto Zooprofilattico Sperimentale dell' Abruzzo e Molise, Teramo, Italy. Electronic address: .
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Źródło :
Veterinary microbiology [Vet Microbiol] 2021 Jan; Vol. 252, pp. 108933. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article
MeSH Terms :
Organ Culture Techniques*
Viral Tropism*
Virus Replication*
Respiratory System/*virology
Ruminants/*virology
SARS-CoV-2/*physiology
Angiotensin-Converting Enzyme 2/genetics ; Animals ; Cattle/virology ; Host Specificity ; SARS-CoV-2/genetics ; Sheep/virology ; Swine/virology
Czasopismo naukowe
Tytuł :
SARS-COV-2 (COVID-19): Cellular and biochemical properties and pharmacological insights into new therapeutic developments.
Autorzy :
Parlakpinar H; Department of Medical Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey.
Gunata M; Department of Medical Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey.
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Źródło :
Cell biochemistry and function [Cell Biochem Funct] 2021 Jan; Vol. 39 (1), pp. 10-28. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19*/drug therapy
COVID-19*/epidemiology
COVID-19*/genetics
COVID-19*/metabolism
Pandemics*
SARS-CoV-2*/pathogenicity
SARS-CoV-2*/physiology
Virus Replication*
Antiviral Agents/*therapeutic use
Age Factors ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Humans
Czasopismo naukowe
Tytuł :
SARS-CoV-2 Spike Alterations Enhance Pseudoparticle Titers and Replication-Competent VSV-SARS-CoV-2 Virus.
Autorzy :
Havranek KE; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Jimenez AR; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Acciani MD; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Lay Mendoza MF; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Reyes Ballista JM; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Diaz DA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Brindley MA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
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Źródło :
Viruses [Viruses] 2020 Dec 18; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Replication*
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*genetics
Vesicular stomatitis Indiana virus/*genetics
Viral Envelope Proteins/*genetics
Animals ; Cell Line ; Cells, Cultured ; Chlorocebus aethiops ; Fluorescent Antibody Technique ; Gene Expression ; Genes, Reporter ; Genetic Engineering ; Giant Cells ; Humans ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Vero Cells ; Vesicular stomatitis Indiana virus/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł :
Sea Lice ( Lepeophtheirus salmonis ) Infestation Reduces the Ability of Peripheral Blood Monocytic Cells (PBMCs) to Respond to and Control Replication of Salmonid Alphavirus in Atlantic Salmon ( Salmo salar L.).
Autorzy :
Gamil AAA; Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.O. Box 369, 0102 Oslo, Norway.
Gadan K; Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.O. Box 369, 0102 Oslo, Norway.
Gislefoss E; Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.O. Box 369, 0102 Oslo, Norway.
Evensen Ø; Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.O. Box 369, 0102 Oslo, Norway.
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Źródło :
Viruses [Viruses] 2020 Dec 16; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Alphavirus/*physiology
Ectoparasitic Infestations/*veterinary
Fish Diseases/*immunology
Host-Parasite Interactions/*immunology
Monocytes/*immunology
Salmo salar/*virology
Animals ; Cells, Cultured ; Ectoparasitic Infestations/immunology ; Salmo salar/immunology
Czasopismo naukowe
Tytuł :
mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2.
Autorzy :
Hassert M; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Geerling E; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Stone ET; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Steffen TL; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Feldman MS; Department of Biomedical Engineering, Saint Louis University, St. Louis, Missouri, United States of America.
Dickson AL; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Class J; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, United States of America.
Richner JM; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, United States of America.
Brien JD; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
Pinto AK; Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Dec 16; Vol. 16 (12), pp. e1009163. Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Adaptive Immunity/*immunology
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*immunology
RNA, Messenger/*metabolism
SARS-CoV-2/*immunology
T-Lymphocytes/*immunology
Angiotensin-Converting Enzyme 2/genetics ; Animals ; COVID-19/metabolism ; COVID-19/virology ; Chlorocebus aethiops ; Epitopes, T-Lymphocyte/immunology ; Humans ; Mice ; Mice, Knockout ; Mice, Transgenic ; RNA, Messenger/genetics ; Receptor, Interferon alpha-beta/physiology ; T-Lymphocytes/virology ; Vero Cells
Czasopismo naukowe
Tytuł :
DEFA1B inhibits ZIKV replication and retards cell cycle progression through interaction with ORC1.
Autorzy :
Li S; Provincial Key Laboratory for Transfusion-Transmitted Infectious Diseases, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan 610052, China. Electronic address: .
Zhu A; Provincial Key Laboratory for Transfusion-Transmitted Infectious Diseases, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan 610052, China.
Ren K; Provincial Key Laboratory for Transfusion-Transmitted Infectious Diseases, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan 610052, China.
Li S; Provincial Key Laboratory for Transfusion-Transmitted Infectious Diseases, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan 610052, China.
Chen L; Provincial Key Laboratory for Transfusion-Transmitted Infectious Diseases, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan 610052, China; Toronto General Research Institute, University of Toronto, ON M5G 1L6, Canada. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Dec 15; Vol. 263, pp. 118564. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle*
Virus Replication*
Exosomes/*virology
Origin Recognition Complex/*metabolism
Zika Virus/*physiology
Zika Virus Infection/*prevention & control
alpha-Defensins/*metabolism
A549 Cells ; Antiviral Agents/pharmacology ; Cytopathogenic Effect, Viral ; Exosomes/genetics ; Exosomes/metabolism ; Gene Expression Profiling ; High-Throughput Screening Assays ; Host-Pathogen Interactions ; Humans ; Immunity, Innate/immunology ; Origin Recognition Complex/genetics ; Zika Virus/isolation & purification ; Zika Virus Infection/metabolism ; Zika Virus Infection/pathology ; Zika Virus Infection/virology ; alpha-Defensins/genetics
Czasopismo naukowe
Tytuł :
Disentangling the dynamical underpinnings of differences in SARS-CoV-2 pathology using within-host ecological models.
Autorzy :
Metcalf CJE; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.; Princeton School of Public and International Affairs, Princeton University, New Jersey, United States of America.
Grenfell BT; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.; Princeton School of Public and International Affairs, Princeton University, New Jersey, United States of America.
Graham AL; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Dec 11; Vol. 16 (12), pp. e1009105. Date of Electronic Publication: 2020 Dec 11 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Host-Pathogen Interactions*
Models, Biological*
Virus Replication*
COVID-19/*metabolism
SARS-CoV-2/*physiology
Humans
Czasopismo naukowe
Tytuł :
The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans.
Autorzy :
Pancer K; Department of Virology, National Institute of Public Health-National Institute of Hygiene; Warsaw, Poland.
Milewska A; Małopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland, Europe.; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University; Krakow, Poland.
Owczarek K; Małopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland, Europe.
Dabrowska A; Małopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland, Europe.; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University; Krakow, Poland.
Kowalski M; Małopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland, Europe.
Łabaj PP; Małopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland, Europe.
Branicki W; Małopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland, Europe.
Sanak M; Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College; Kraków, Poland.
Pyrc K; Małopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland, Europe.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Dec 10; Vol. 16 (12), pp. e1008959. Date of Electronic Publication: 2020 Dec 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
Mutation*
Virus Replication*
COVID-19/*virology
Open Reading Frames/*genetics
SARS-CoV-2/*genetics
Viral Proteins/*genetics
Adult ; COVID-19/epidemiology ; COVID-19/genetics ; Codon, Nonsense ; Female ; Humans ; In Vitro Techniques ; Male ; Middle Aged ; Poland/epidemiology ; SARS-CoV-2/isolation & purification ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Viral replication of SARS-CoV-2 could be self-limitative - The role of the renin-angiotensin system on COVID-19 pathophysiology.
Autorzy :
Novaes Rocha V; Laboratory of Pathology and Veterinary Histology, Department of Veterinary Medicine, Faculty of Medicine, Federal University of Juiz de Fora, Brazil. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2020 Dec; Vol. 145, pp. 110330. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Renin-Angiotensin System*
Virus Replication*
COVID-19/*virology
SARS-CoV-2/*physiology
Adult ; Animals ; Antiviral Agents/therapeutic use ; Asymptomatic Infections ; COVID-19/drug therapy ; COVID-19/physiopathology ; Child ; Comorbidity ; CpG Islands ; Dogs ; Humans ; Inflammation ; Models, Theoretical ; Pandemics ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Membrane heist: Coronavirus host membrane remodeling during replication.
Autorzy :
Zhang J; Artemis One Health Research Foundation, Delft, the Netherlands.
Lan Y; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Sanyal S; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2020 Dec; Vol. 179, pp. 229-236. Date of Electronic Publication: 2020 Oct 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Host Microbial Interactions*
Virus Replication*
Cell Membrane/*metabolism
Coronavirus/*physiology
Cell Membrane/virology ; Humans ; Molecular Targeted Therapy
Czasopismo naukowe
Tytuł :
Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation.
Autorzy :
Zhang X; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Chu H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Wen L; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Shuai H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Yang D; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Wang Y; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Hou Y; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Zhu Z; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Yuan S; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Yin F; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, People's Republic of China, and The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Pathogen Biology, Hainan Medical University, Haikou, People's Republic of China.; Key Laboratory of Translational Tropical Medicine of Ministry of Education, Hainan Medical University, Haikou, People's Republic of China.
Chan JF; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, People's Republic of China, and The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.
Yuen KY; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.; The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 733-746.
Typ publikacji :
Journal Article
MeSH Terms :
Virus Replication*
MicroRNAs/*metabolism
Middle East Respiratory Syndrome Coronavirus/*physiology
RNA, Circular/*metabolism
RNA, Messenger/*metabolism
Cell Line, Tumor ; Gene Expression ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; MicroRNAs/genetics ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; RNA Interference ; RNA, Circular/genetics ; RNA, Messenger/genetics ; RNA, Small Interfering ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication.
Autorzy :
Alexandersen S; Geelong Centre for Emerging Infectious Diseases, Geelong, VIC, 3220, Australia. .; Deakin University, Geelong, VIC, 3220, Australia. .; Barwon Health, University Hospital Geelong, Geelong, VIC, 3220, Australia. .
Chamings A; Geelong Centre for Emerging Infectious Diseases, Geelong, VIC, 3220, Australia.; Deakin University, Geelong, VIC, 3220, Australia.
Bhatta TR; Geelong Centre for Emerging Infectious Diseases, Geelong, VIC, 3220, Australia.; Deakin University, Geelong, VIC, 3220, Australia.
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Źródło :
Nature communications [Nat Commun] 2020 Nov 27; Vol. 11 (1), pp. 6059. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
Virus Replication*
COVID-19/*diagnosis
COVID-19 Testing/*methods
RNA, Viral/*isolation & purification
SARS-CoV-2/*genetics
Adult ; COVID-19/virology ; Cytoplasm/virology ; Female ; High-Throughput Nucleotide Sequencing ; Host-Pathogen Interactions/genetics ; Humans ; Male ; Middle Aged ; Nasopharynx/cytology ; Nasopharynx/virology ; Oropharynx/cytology ; Oropharynx/virology ; Polymerase Chain Reaction ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/pathogenicity ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Architecture of a SARS-CoV-2 mini replication and transcription complex.
Autorzy :
Yan L; MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China.
Zhang Y; School of Life Sciences, Tsinghua University, Beijing, China.
Ge J; School of Life Sciences, Tsinghua University, Beijing, China.
Zheng L; School of Life Sciences, Tsinghua University, Beijing, China.
Gao Y; MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China.; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Wang T; MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China.
Jia Z; Research Centre of Microbiome, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Wang H; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Huang Y; MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China.
Li M; MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China.
Wang Q; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Rao Z; MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China. .; School of Life Sciences, Tsinghua University, Beijing, China. .; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China. .
Lou Z; MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 18; Vol. 11 (1), pp. 5874. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Betacoronavirus/*chemistry
Betacoronavirus/*physiology
Betacoronavirus/genetics ; Betacoronavirus/metabolism ; Binding Sites ; Cryoelectron Microscopy ; Humans ; Methyltransferases/chemistry ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Models, Molecular ; Mutation ; Protein Binding ; Protein Conformation ; RNA Helicases/chemistry ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA, Viral/metabolism ; SARS-CoV-2 ; Structure-Activity Relationship ; Transcription, Genetic ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography.
Autorzy :
Klein S; Schaller Research Groups, Department of Infectious Diseases-Virology, Heidelberg University, Heidelberg, Germany.; Research Group 'Membrane Biology of Viral Infection,' Department of Infectious Diseases-Virology, Heidelberg University, Heidelberg, Germany.
Cortese M; Department of Infectious Diseases-Molecular Virology, Heidelberg University, Heidelberg, Germany.
Winter SL; Schaller Research Groups, Department of Infectious Diseases-Virology, Heidelberg University, Heidelberg, Germany.; Research Group 'Membrane Biology of Viral Infection,' Department of Infectious Diseases-Virology, Heidelberg University, Heidelberg, Germany.
Wachsmuth-Melm M; Schaller Research Groups, Department of Infectious Diseases-Virology, Heidelberg University, Heidelberg, Germany.; Research Group 'Membrane Biology of Viral Infection,' Department of Infectious Diseases-Virology, Heidelberg University, Heidelberg, Germany.
Neufeldt CJ; Department of Infectious Diseases-Molecular Virology, Heidelberg University, Heidelberg, Germany.
Cerikan B; Department of Infectious Diseases-Molecular Virology, Heidelberg University, Heidelberg, Germany.
Stanifer ML; Department of Infectious Diseases-Molecular Virology, Heidelberg University, Heidelberg, Germany.
Boulant S; Research Group 'Host/Pathogen Interactions at Intestinal Epithelial Surfaces,' Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany.
Bartenschlager R; Department of Infectious Diseases-Molecular Virology, Heidelberg University, Heidelberg, Germany. .; Division Virus-Associated Carcinogenesis, German Cancer Research Center, Heidelberg, Germany. .; German Center for Infection Research (DZIF), (Heidelberg Partner Site), Heidelberg, Germany. .
Chlanda P; Schaller Research Groups, Department of Infectious Diseases-Virology, Heidelberg University, Heidelberg, Germany. .; Research Group 'Membrane Biology of Viral Infection,' Department of Infectious Diseases-Virology, Heidelberg University, Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 18; Vol. 11 (1), pp. 5885. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Betacoronavirus/*chemistry
Betacoronavirus/*physiology
A549 Cells ; Animals ; COVID-19 ; Cell Line ; Chlorocebus aethiops ; Coronavirus Infections/virology ; Cryoelectron Microscopy ; Cytoplasmic Vesicles/virology ; Electron Microscope Tomography ; Endoplasmic Reticulum/virology ; Humans ; Pandemics ; Pneumonia, Viral/virology ; RNA, Viral/chemistry ; RNA, Viral/metabolism ; SARS-CoV-2 ; Vero Cells ; Virion/chemistry ; Virion/metabolism ; Virus Assembly
Czasopismo naukowe
Tytuł :
Paradoxical modulation of influenza by intranasal administration of non-replicating adenovirus particles.
Autorzy :
Tang DC; VaxDome Inc., Commercialization Program, University of North Texas Health Science Center, Fort Worth, Texas, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Nov 12; Vol. 15 (11), pp. e0241266. Date of Electronic Publication: 2020 Nov 12 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Adenoviridae/*physiology
Influenza, Human/*immunology
Orthomyxoviridae Infections/*immunology
Orthomyxoviridae Infections/*virology
Virion/*physiology
Administration, Intranasal ; Animals ; Antibodies, Viral/immunology ; Disease Progression ; Dogs ; HEK293 Cells ; Humans ; Madin Darby Canine Kidney Cells ; Mice, Inbred C57BL ; Time Factors
Czasopismo naukowe
Tytuł :
Chikungunya virus superinfection exclusion is mediated by a block in viral replication and does not rely on non-structural protein 2.
Autorzy :
Boussier J; Immubiology of Dendritic Cells unit, Institut Pasteur, Paris, France.; Inserm U1223, Institut Pasteur, Paris, France.; École doctorale Frontières du Vivant, Université Paris Diderot, Paris, France.
Levi L; Viral Population and Pathogenesis Unit, Institut Pasteur, Paris, France.
Weger-Lucarelli J; Viral Population and Pathogenesis Unit, Institut Pasteur, Paris, France.; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, United States of America.
Poirier EZ; Viral Population and Pathogenesis Unit, Institut Pasteur, Paris, France.; Immunobiology Laboratory, The Francis Crick Institute, London, United Kingdom.
Vignuzzi M; Viral Population and Pathogenesis Unit, Institut Pasteur, Paris, France.
Albert ML; Immubiology of Dendritic Cells unit, Institut Pasteur, Paris, France.; Insitro, South San Francisco, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Nov 12; Vol. 15 (11), pp. e0241592. Date of Electronic Publication: 2020 Nov 12 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Virus Replication*
Chikungunya Fever/*virology
Chikungunya virus/*physiology
Superinfection/*virology
Viral Nonstructural Proteins/*metabolism
Animals ; Cells, Cultured ; Chikungunya virus/genetics ; Chikungunya virus/pathogenicity ; Chlorocebus aethiops ; Genome, Viral ; Influenza A virus/pathogenicity ; Mice ; Sindbis Virus/pathogenicity ; Vero Cells ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe

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