Autor: "Viveiros, M" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Genomic epidemiology of Mycobacterium tuberculosis in Santa Catarina, Southern Brazil.
Autorzy:: Verza M; Programa Acadêmico de Tuberculose da Faculdade de Medicina e Complexo Hospitalar HUCFF-IDT, Universidade Federal do Rio de Janeiro (UFRJ), Rua Prof. Rodolpho Paulo Rocco, 255, Ilha do Fundão, Rio de Janeiro, RJ, 21941-590, Brazil. .; Laboratório de Biologia Molecular, Microbiologia e Sorologia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil. .
Scheffer MC; Laboratório de Biologia Molecular, Microbiologia e Sorologia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
Salvato RS; Programa de Pós-graduação em Biologia Celular e Molecular, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. .; Centro de Desenvolvimento Científico e Tecnológico (CDCT), Centro Estadual de Vigilância em Saúde, Secretaria Estadual da Saúde do Rio Grande do Sul, Av. Ipiranga, 5400, Porto Alegre, RS, 90610-000, Brazil. .
Schorner MA; Laboratório de Biologia Molecular, Microbiologia e Sorologia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
Barazzetti FH; Laboratório de Biologia Molecular, Microbiologia e Sorologia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
Machado HM; Laboratório de Biologia Molecular, Microbiologia e Sorologia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
Medeiros TF; Laboratório de Biologia Molecular, Microbiologia e Sorologia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
Rovaris DB; Setor de Bacteriologia da Tuberculose, Laboratório Central do Estado de Santa Catarina (LACEN-SC), Florianópolis, Santa Catarina, Brazil.
Portugal I; iMed.Ulisboa-Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Viveiros M; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal.
Perdigão J; iMed.Ulisboa-Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Kritski A; Programa Acadêmico de Tuberculose da Faculdade de Medicina e Complexo Hospitalar HUCFF-IDT, Universidade Federal do Rio de Janeiro (UFRJ), Rua Prof. Rodolpho Paulo Rocco, 255, Ilha do Fundão, Rio de Janeiro, RJ, 21941-590, Brazil.
Bazzo ML; Laboratório de Biologia Molecular, Microbiologia e Sorologia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jul 30; Vol. 10 (1), pp. 12891. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji:: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/pathogenicity
Phylogeny*
Tuberculosis, Multidrug-Resistant*/epidemiology
Tuberculosis, Multidrug-Resistant*/genetics
Tuberculosis, Multidrug-Resistant*/transmission
Adult ; Antitubercular Agents/pharmacology ; Brazil/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; Whole Genome Sequencing

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Skocz do pozycji: 2.

Tytuł:: Using genomics to understand the origin and dispersion of multidrug and extensively drug resistant tuberculosis in Portugal.
Autorzy:: Perdigão J; Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal. .
Gomes P; Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Miranda A; Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Porto, Portugal.
Maltez F; Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.; Serviço de Doenças Infecciosas, Hospital de Curry Cabral, Lisboa, Portugal.
Machado D; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Silva C; Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Phelan JE; London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.
Brum L; SYNLAB Portugal, Lisboa, Portugal.
Campino S; London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.
Couto I; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Viveiros M; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Clark TG; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.; London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.
Portugal I; Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Feb 13; Vol. 10 (1), pp. 2600. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genome, Bacterial*
Extensively Drug-Resistant Tuberculosis/*epidemiology
Extensively Drug-Resistant Tuberculosis/*microbiology
Mycobacterium tuberculosis/*genetics
Genetic Variation ; Humans ; Mycobacterium tuberculosis/isolation & purification ; Phylogeny ; Polymorphism, Single Nucleotide ; Portugal/epidemiology ; Whole Genome Sequencing

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Skocz do pozycji: 3.

Tytuł:: Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.
Autorzy:: Phelan JE; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
O'Sullivan DM; Molecular Biology, LGC Ltd, Queens Road, Teddington, Middlesex, TW11 0LY, UK.
Machado D; Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisbon, Portugal.
Ramos J; Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisbon, Portugal.
Oppong YEA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Campino S; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
O'Grady J; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
McNerney R; Department of Medicine, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Hibberd ML; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Viveiros M; Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisbon, Portugal.
Huggett JF; Molecular Biology, LGC Ltd, Queens Road, Teddington, Middlesex, TW11 0LY, UK.; School of Biosciences & Medicine, Faculty of Health & Medical Science, University of Surrey, Guildford, GU2 7XH, UK.
Clark TG; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK. .; Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisbon, Portugal. .; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK. .; Pokaż więcej
Źródło:: Genome medicine [Genome Med] 2019 Jun 24; Vol. 11 (1), pp. 41. Date of Electronic Publication: 2019 Jun 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Resistance, Microbial*
Software*
Molecular Diagnostic Techniques/*methods
Mycobacterium tuberculosis/*genetics
Tuberculosis, Multidrug-Resistant/*microbiology
Whole Genome Sequencing/*methods
Antitubercular Agents/pharmacology ; Genome, Bacterial ; Humans ; Mycobacterium tuberculosis/drug effects ; Point-of-Care Testing ; Tuberculosis, Multidrug-Resistant/diagnosis

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Skocz do pozycji: 4.

Tytuł:: Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance.
Autorzy:: Oppong YEA; Pathogen Molecular Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. .
Phelan J; Pathogen Molecular Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Perdigão J; iMed.ULisboa - Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.
Machado D; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, UNL, Lisbon, Portugal.
Miranda A; National Mycobacterium Reference Laboratory, Porto, Portugal.
Portugal I; iMed.ULisboa - Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.
Viveiros M; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, UNL, Lisbon, Portugal.
Clark TG; Pathogen Molecular Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.; Faculty of Epidemiology and Population Health, LSHTM, London, UK.
Hibberd ML; Pathogen Molecular Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2019 Mar 29; Vol. 20 (1), pp. 252. Date of Electronic Publication: 2019 Mar 29.
Typ publikacji:: Journal Article
MeSH Terms:: Polymorphism, Genetic*
Tuberculosis, Multidrug-Resistant*
Genome-Wide Association Study/*methods
Mycobacterium tuberculosis/*genetics
Bacterial Proteins/genetics ; Drug Resistance, Multiple, Bacterial ; Evolution, Molecular ; Gene Transfer, Horizontal ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Whole Genome Sequencing

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Skocz do pozycji: 5.

Tytuł:: Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data.
Autorzy:: Sobkowiak B; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. .
Glynn JR; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Houben RMGJ; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.; TB Modelling Group, TB Centre, London School of Hygiene and Tropical Medicine, London, UK.
Mallard K; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Phelan JE; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Guerra-Assunção JA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.; Bill Lyons Informatics Centre, University College London, London, UK.
Banda L; Karonga Prevention Study, Chilumba, Malawi.
Mzembe T; Karonga Prevention Study, Chilumba, Malawi.
Viveiros M; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
McNerney R; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Parkhill J; Wellcome Trust Sanger Institute, Hinxton, UK.
Crampin AC; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.; Karonga Prevention Study, Chilumba, Malawi.
Clark TG; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2018 Aug 14; Vol. 19 (1), pp. 613. Date of Electronic Publication: 2018 Aug 14.
Typ publikacji:: Journal Article
MeSH Terms:: Mycobacterium tuberculosis/*classification
Mycobacterium tuberculosis/*genetics
Sequence Analysis, DNA/*methods
Tuberculosis/*diagnosis
Whole Genome Sequencing/*methods
Adolescent ; Adult ; Bayes Theorem ; DNA, Bacterial ; Female ; Genome, Bacterial ; Humans ; Male ; Middle Aged ; Mycobacterium tuberculosis/isolation & purification ; Polymorphism, Single Nucleotide ; Tuberculosis/genetics ; Tuberculosis/microbiology ; Young Adult

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Skocz do pozycji: 6.

Tytuł:: Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola.
Autorzy:: Perdigão J; iMed.ULisboa - Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Clemente S; Hospital da Divina Providência, Serviço de Doenças Infecciosas, Luanda, Angola.
Ramos J; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Masakidi P; Hospital da Divina Providência, Serviço de Doenças Infecciosas, Luanda, Angola.
Machado D; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Silva C; iMed.ULisboa - Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Couto I; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Viveiros M; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Taveira N; iMed.ULisboa - Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.; Centro de Investigação Interdisciplinar Egas Moniz, Instituto Superior de Ciências da Saúde Egas Moniz, Monte de Caparica, Portugal.
Portugal I; iMed.ULisboa - Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2017 Feb 23; Vol. 7, pp. 42814. Date of Electronic Publication: 2017 Feb 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Resistance, Multiple, Bacterial*
Genetic Variation*
DNA, Bacterial/*genetics
Mycobacterium tuberculosis/*classification
Tuberculosis, Multidrug-Resistant/*transmission
Angola/epidemiology ; Anti-Bacterial Agents/pharmacology ; Antitubercular Agents/pharmacology ; Evolution, Molecular ; Female ; Genotyping Techniques ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Phylogeny

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Skocz do pozycji: 7.

Tytuł:: The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs.
Autorzy:: Phelan J; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK.
O'Sullivan DM; Molecular Biology, LGC Ltd, Queens Road, Teddington, Middlesex, TW11 0LY, UK.
Machado D; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisbon, Portugal.
Ramos J; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisbon, Portugal.
Whale AS; Molecular Biology, LGC Ltd, Queens Road, Teddington, Middlesex, TW11 0LY, UK.
O'Grady J; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Dheda K; Division of Pulmonary Medicine and UCT Lung Institute, Lung Infection and Immunity Unit, University of Cape Town, Groote Schuur Hospital, Observatory, 7925, Cape Town, South Africa.
Campino S; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK.
McNerney R; Division of Pulmonary Medicine and UCT Lung Institute, Lung Infection and Immunity Unit, University of Cape Town, Groote Schuur Hospital, Observatory, 7925, Cape Town, South Africa.
Viveiros M; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisbon, Portugal.
Huggett JF; Molecular Biology, LGC Ltd, Queens Road, Teddington, Middlesex, TW11 0LY, UK.; School of Biosciences & Medicine, Faculty of Health & Medical Science, University of Surrey, Guildford, GU2 7XH, UK.
Clark TG; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, WC1E 7HT, London, UK. .; Pokaż więcej
Źródło:: Genome medicine [Genome Med] 2016 Dec 22; Vol. 8 (1), pp. 132. Date of Electronic Publication: 2016 Dec 22.
Typ publikacji:: Journal Article
MeSH Terms:: Antitubercular Agents*
Genome, Bacterial*
High-Throughput Nucleotide Sequencing*
Drug Resistance, Bacterial/*genetics
Mycobacterium tuberculosis/*genetics
Sequence Analysis, DNA/*methods
Humans

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Skocz do pozycji: 8.

Tytuł:: Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages.
Autorzy:: Phelan JE; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .
Coll F; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .
Bergval I; KIT Biomedical Research, Royal Tropical Institute, Amsterdam, Netherlands. .
Anthony RM; KIT Biomedical Research, Royal Tropical Institute, Amsterdam, Netherlands. .
Warren R; Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. .
Sampson SL; Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. .
Gey van Pittius NC; Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. .
Glynn JR; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, WC1E 7HT, London, UK. .
Crampin AC; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, WC1E 7HT, London, UK. .; Karonga Prevention Study, Lilongwe, Malawi. .
Alves A; National Mycobacterium Reference Laboratory, Porto, Portugal. .
Bessa TB; Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz Bahia R, Salvador, Bahia, Brazil. .
Campino S; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .
Dheda K; Department of Medicine, Lung Infection and Immunity Unit, Division of Pulmonology & UCT Lung Institute, University of Cape Town, Cape Town, Western Cape, South Africa. .; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, Western Cape, South Africa. .
Grandjean L; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .; Laboratorio de Enfermedades Infecciosas, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru. .
Hasan R; Department of Pathology and Laboratory Medicine, The Aga Khan University, Stadium Road, Karachi, Pakistan. .
Hasan Z; Department of Pathology and Laboratory Medicine, The Aga Khan University, Stadium Road, Karachi, Pakistan. .
Miranda A; National Mycobacterium Reference Laboratory, Porto, Portugal. .
Moore D; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .
Panaiotov S; National Center of Infectious and Parasitic Diseases, 1504, Sofia, Bulgaria. .
Perdigao J; Universidade de Lisboa, Lisbon, Portugal. .
Portugal I; Universidade de Lisboa, Lisbon, Portugal. .
Sheen P; Laboratorio de Enfermedades Infecciosas, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru. .
de Oliveira Sousa E; Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz Bahia R, Salvador, Bahia, Brazil. .
Streicher EM; Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. .
van Helden PD; Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. .
Viveiros M; Grupo de Micobactérias, Unidade de Microbiologia Médica, Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa (IHMT/UNL), Lisbon, Portugal. .
Hibberd ML; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .
Pain A; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia. .
McNerney R; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .
Clark TG; Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK. .; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, WC1E 7HT, London, UK. .; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2016 Feb 29; Vol. 17, pp. 151. Date of Electronic Publication: 2016 Feb 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genes, Bacterial*
Multigene Family*
Polymorphism, Single Nucleotide*
Recombination, Genetic*
Mycobacterium tuberculosis/*genetics
DNA, Bacterial/genetics ; Evolution, Molecular ; Genome, Bacterial ; Genomics/methods ; Genotype ; Mutation ; Phylogeny ; Selection, Genetic ; Sequence Analysis, DNA

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Skocz do pozycji: 9.

Tytuł:: Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.
Autorzy:: Machado D; Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.; Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Pires D; iMed.ULisboa - Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Perdigão J; iMed.ULisboa - Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Couto I; Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.; Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Portugal I; iMed.ULisboa - Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Martins M; UCD Centre for Food Safety, School of Public Health, Physiotherapy and Sports Science, UCD Centre for Molecular Innovation and Drug Discovery, University College Dublin, Belfield, Dublin, Ireland.
Amaral L; Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.
Anes E; iMed.ULisboa - Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Viveiros M; Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.; Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2016 Feb 26; Vol. 11 (2), pp. e0149326. Date of Electronic Publication: 2016 Feb 26 (Print Publication: 2016).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Resistance, Bacterial*/genetics
Anti-Infective Agents/*pharmacology
Cytotoxicity, Immunologic/*drug effects
Ion Channels/*antagonists & inhibitors
Macrophages/*immunology
Macrophages/*microbiology
Mycobacterium tuberculosis/*drug effects
Mycobacterium tuberculosis/*immunology
Adenosine Triphosphate/metabolism ; Antitubercular Agents/pharmacology ; Drug Synergism ; Gene Expression Regulation, Bacterial/drug effects ; Humans ; Macrophages/metabolism ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Microbial Viability/immunology ; Mutation ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; Phagocytosis/immunology ; Phagosomes/immunology ; Phagosomes/metabolism ; Phagosomes/microbiology

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Skocz do pozycji: 10.

Tytuł:: Direct Detection by the Xpert MTB/RIF Assay and Characterization of Multi and Poly Drug-Resistant Tuberculosis in Guinea-Bissau, West Africa.
Autorzy:: Rabna P; Instituto Nacional de Saúde Pública/Projecto de Saúde de Bandim (INASA/PSB), Bissau, Guiné-Bissau.
Ramos J; Grupo de Micobactérias, Unidade de Microbiologia Médica, Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa (IHMT, UNL), Lisboa, Portugal.
Ponce G; Unidade de Clínica Tropical, Instituto de Higiene e Medicina Tropical de Lisboa/Universidade NOVA de Lisboa (IHMT/UNL), Lisboa, Portugal.
Sanca L; Instituto Nacional de Saúde Pública/Projecto de Saúde de Bandim (INASA/PSB), Bissau, Guiné-Bissau.
Mané M; Instituto Nacional de Saúde Pública/Projecto de Saúde de Bandim (INASA/PSB), Bissau, Guiné-Bissau.
Armada A; Grupo de Micobactérias, Unidade de Microbiologia Médica, Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa (IHMT, UNL), Lisboa, Portugal; Centro de Malária e Outras Doenças Tropicais (CMDT), Instituto de Higiene e Medicina Tropical de Lisboa/Universidade NOVA de Lisboa (IHMT/UNL), Lisboa, Portugal.
Machado D; Grupo de Micobactérias, Unidade de Microbiologia Médica, Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa (IHMT, UNL), Lisboa, Portugal.
Vieira F; Hospital Raoul Follereau, Bissau, Guiné-Bissau.
Gomes VF; Ministério da Saúde/Programa Nacional de Luta contra a Tuberculose, Bissau, Guiné-Bissau.
Martins E; Hospital Raoul Follereau, Bissau, Guiné-Bissau.
Colombatti R; Aid, Health and Development-Onlus-Ahead-Onlus, Rome, Italy.
Riccardi F; Aid, Health and Development-Onlus-Ahead-Onlus, Rome, Italy.
Perdigão J; Centro de Patogénese Molecular, URIA, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Sotero J; Centro de Patogénese Molecular, URIA, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Portugal I; Centro de Patogénese Molecular, URIA, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Couto I; Grupo de Micobactérias, Unidade de Microbiologia Médica, Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa (IHMT, UNL), Lisboa, Portugal.
Atouguia J; Unidade de Clínica Tropical, Instituto de Higiene e Medicina Tropical de Lisboa/Universidade NOVA de Lisboa (IHMT/UNL), Lisboa, Portugal; Centro de Malária e Outras Doenças Tropicais (CMDT), Instituto de Higiene e Medicina Tropical de Lisboa/Universidade NOVA de Lisboa (IHMT/UNL), Lisboa, Portugal.
Rodrigues A; Instituto Nacional de Saúde Pública/Projecto de Saúde de Bandim (INASA/PSB), Bissau, Guiné-Bissau.
Viveiros M; Grupo de Micobactérias, Unidade de Microbiologia Médica, Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa (IHMT, UNL), Lisboa, Portugal; Centro de Malária e Outras Doenças Tropicais (CMDT), Instituto de Higiene e Medicina Tropical de Lisboa/Universidade NOVA de Lisboa (IHMT/UNL), Lisboa, Portugal.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 May 27; Vol. 10 (5), pp. e0127536. Date of Electronic Publication: 2015 May 27 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antitubercular Agents/*pharmacology
Mycobacterium tuberculosis/*isolation & purification
Rifampin/*pharmacology
Tuberculosis, Multidrug-Resistant/*microbiology
Adult ; Antitubercular Agents/therapeutic use ; Cross-Sectional Studies ; Female ; Genotype ; Guinea-Bissau/epidemiology ; Humans ; Male ; Molecular Typing ; Mutation ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/physiology ; Patient Selection ; Rifampin/therapeutic use ; Risk ; Time Factors ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology

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Skocz do pozycji: 11.

Tytuł:: Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.
Autorzy:: Perdigão J
Silva H
Machado D
Macedo R
Maltez F
Silva C
Jordao L
Couto I
Mallard K
Coll F
Hill-Cawthorne GA
McNerney R
Pain A
Clark TG
Viveiros M
Portugal I; Centro de Patogénese Molecular, URIA, Faculdade de Farmácia da Universidade de Lisboa, Av, Prof, Gama Pinto, 1649-003 Lisboa, Portugal. .; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2014 Nov 18; Vol. 15, pp. 991. Date of Electronic Publication: 2014 Nov 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Evolution, Molecular*
Genetic Variation*
Genome, Bacterial*
Drug Resistance, Multiple, Bacterial/*genetics
Mycobacterium tuberculosis/*drug effects
Mycobacterium tuberculosis/*genetics
Antitubercular Agents/pharmacology ; Bacterial Proteins/genetics ; Chromosome Mapping ; Computational Biology ; Genetic Loci ; Genomic Instability ; Genomics ; Genotype ; Humans ; INDEL Mutation ; Microbial Sensitivity Tests ; Minisatellite Repeats ; Phylogeny ; Polymorphism, Single Nucleotide ; Portugal/epidemiology ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/microbiology

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Skocz do pozycji: 12.

Tytuł:: GidB mutation as a phylogenetic marker for Q1 cluster Mycobacterium tuberculosis isolates and intermediate-level streptomycin resistance determinant in Lisbon, Portugal.
Autorzy:: Perdigão J; Faculdade de Farmácia, Centro de Patogénese Molecular, URIA, Universidade de Lisboa, Lisboa, Portugal.
Macedo R
Machado D
Silva C
Jordão L
Couto I
Viveiros M
Portugal I; Pokaż więcej
Źródło:: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2014 May; Vol. 20 (5), pp. O278-84. Date of Electronic Publication: 2013 Nov 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Resistance, Bacterial/*genetics
Mycobacterium tuberculosis/*drug effects
Streptomycin/*pharmacology
Biomarkers ; DNA Mutational Analysis ; Genotype ; Humans ; Microbial Sensitivity Tests ; Mutation, Missense ; Mycobacterium tuberculosis/genetics ; Phylogeny ; Portugal ; Tuberculosis, Pulmonary/microbiology

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Skocz do pozycji: 13.

Tytuł:: Assessment of the BD MGIT TBc identification test for the detection of Mycobacterium tuberculosis complex in a network of mycobacteriology laboratories.
Autorzy:: Machado D; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisboa, Portugal.
Ramos J; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisboa, Portugal.
Couto I; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisboa, Portugal ; Centro de Recursos Microbiológicos (CREM), UNL, 2829-516 Caparica, Portugal.
Cadir N; Instituto Nacional de Saúde, Ministério da Saúde de Moçambique, 264 Cidade de Maputo, Mozambique.
Narciso I; Instituto Nacional de Saúde, Ministério da Saúde de Moçambique, 264 Cidade de Maputo, Mozambique.
Coelho E; Programa Nacional de Controlo da Tuberculose, Ministério da Saúde de Moçambique, 264 Cidade de Maputo, Mozambique.
Viegas S; Instituto Nacional de Saúde, Ministério da Saúde de Moçambique, 264 Cidade de Maputo, Mozambique.
Viveiros M; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisboa, Portugal ; Centro de Malária e Outras Doenças Tropicais/LA, IHMT/UNL, Rua da Junqueira 100, 1349-008 Lisboa, Portugal.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 398108. Date of Electronic Publication: 2014 Jan 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Reagent Kits, Diagnostic*
Bacteriological Techniques/*methods
Clinical Laboratory Techniques/*methods
Mycobacterium tuberculosis/*isolation & purification
Culture Media ; Humans

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Skocz do pozycji: 14.

Tytuł:: Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis.
Autorzy:: Veigas B; , Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica 2829-516, Caparica, Portugal. .
Pedrosa P
Couto I
Viveiros M
Baptista PV; Pokaż więcej
Źródło:: Journal of nanobiotechnology [J Nanobiotechnology] 2013 Nov 25; Vol. 11, pp. 38. Date of Electronic Publication: 2013 Nov 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mutation*
DNA, Bacterial/*isolation & purification
Gold/*chemistry
Metal Nanoparticles/*chemistry
Mycobacterium tuberculosis/*isolation & purification
Nucleic Acid Amplification Techniques/*methods
Antibiotics, Antitubercular/therapeutic use ; Bacterial Proteins/genetics ; DNA Probes/chemistry ; DNA, Bacterial/genetics ; DNA-Directed RNA Polymerases ; Drug Resistance, Multiple, Bacterial/genetics ; Humans ; Mycobacterium tuberculosis/genetics ; Nucleic Acid Amplification Techniques/economics ; Rifampin/therapeutic use ; Sensitivity and Specificity ; Tuberculosis, Multidrug-Resistant/diagnosis ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/microbiology

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Skocz do pozycji: 15.

Tytuł:: Enhanced detection of tuberculous mycobacteria in animal tissues using a semi-nested probe-based real-time PCR.
Autorzy:: Costa P; Unidade Estratégica de Investigação e Serviços em Produção e Saúde Animal, Instituto Nacional de Investigação Agrária e Veterinária, I.P., (INIAV, I.P.), Lisboa, Portugal ; Grupo de Micobactérias, Unidade de Ensino e Investigação de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal.
Ferreira AS
Amaro A
Albuquerque T
Botelho A
Couto I
Cunha MV
Viveiros M
Inácio J; Pokaż więcej
Źródło:: PloS one [PLoS One] 2013 Nov 21; Vol. 8 (11), pp. e81337. Date of Electronic Publication: 2013 Nov 21 (Print Publication: 2013).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Polymerase Chain Reaction*/methods
Animal Diseases/*diagnosis
Mycobacterium tuberculosis/*genetics
Tuberculosis, Bovine/*diagnosis
Animal Diseases/microbiology ; Animals ; Antigens, Bacterial/chemistry ; Antigens, Bacterial/genetics ; Cattle ; DNA, Bacterial ; Deer ; Foxes ; Mycobacterium tuberculosis/isolation & purification ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; Sensitivity and Specificity ; Sus scrofa ; Tuberculosis/veterinary

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Skocz do pozycji: 16.

Tytuł:: Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.
Autorzy:: Machado D; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Lisboa, Portugal.
Couto I
Perdigão J
Rodrigues L
Portugal I
Baptista P
Veigas B
Amaral L
Viveiros M; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (4), pp. e34538. Date of Electronic Publication: 2012 Apr 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mycobacterium tuberculosis*/drug effects
Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/metabolism
Antitubercular Agents/*pharmacology
Carrier Proteins/*antagonists & inhibitors
Drug Resistance, Multiple, Bacterial/*drug effects
Isoniazid/*pharmacology
Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/genetics ; Biological Transport, Active ; Carrier Proteins/genetics ; Catalase/antagonists & inhibitors ; Catalase/genetics ; Chlorpromazine/pharmacology ; DNA-Directed RNA Polymerases ; Gene Expression ; Humans ; Microbial Sensitivity Tests ; Mutation ; Rifampin/pharmacology ; Thioridazine/pharmacology ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology ; Verapamil/pharmacology

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Skocz do pozycji: 17.

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Skocz do pozycji: 18.

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Skocz do pozycji: 19.

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Skocz do pozycji: 20.

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