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Wyświetlanie 1-17 z 17
Tytuł :
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
Autorzy :
Lagnado A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Ruchaud-Sparagano MH; Translational Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Victorelli S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Hirsova P; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Ogrodnik M; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Collins AL; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Vizioli MG; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Habiballa L; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Saretzki G; Ageing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Evans SA; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Salmonowicz H; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Ageing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Hruby A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Geh D; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Pavelko KD; Department of Immunology and Immune Monitoring Core, Mayo Clinic, Rochester, MN, USA.
Dolan D; Computational Biology Unit, University of Bergen, Bergen, Norway.
Reeves HL; Newcastle University Translational and Clinical Research Institute, Liver Unit, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.
Grellscheid S; Computational Biology Unit, University of Bergen, Bergen, Norway.; Department of Biosciences, Durham University, Durham, UK.
Wilson CH; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Pandanaboyana S; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Doolittle M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
von Zglinicki T; Ageing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Gallage S; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Wilson CL; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Birch J; Ageing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Carroll B; School of Biochemistry, University of Bristol, Bristol, UK.
Chapman J; Ageing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Neretti N; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Masuda CA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Jurk D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Mann DA; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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Źródło :
The EMBO journal [EMBO J] 2021 May 03; Vol. 40 (9), pp. e106048. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Cytoplasmic chromatin fragments-from mechanisms to therapeutic potential.
Autorzy :
Miller KN; Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States.
Dasgupta N; Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States.
Liu T; Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States.
Adams PD; Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States.
Vizioli MG; Cancer Research United Kingdom Beatson Institute, Garscube Estate, Glasgow, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, United Kingdom.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, United States.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, United States.
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Źródło :
ELife [Elife] 2021 Jan 29; Vol. 10. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence.
Autorzy :
Vizioli MG; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Liu T; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Miller KN; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Robertson NA; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Gilroy K; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Lagnado AB; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.; Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom.
Perez-Garcia A; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Kiourtis C; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Dasgupta N; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Lei X; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Kruger PJ; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.
Nixon C; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
Clark W; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
Jurk D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.; Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom.
Bird TG; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH1 64TJ, United Kingdom.
Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.; Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom.
Berger SL; Epigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Dou Z; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Adams PD; Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
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Źródło :
Genes & development [Genes Dev] 2020 Mar 01; Vol. 34 (5-6), pp. 428-445. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Cell Nucleus/*pathology
Cellular Senescence/*physiology
Chromatin/*pathology
Cytoplasm/*pathology
Mitochondria/*pathology
Animals ; Cell Nucleus/physiology ; Gene Expression Regulation, Developmental/drug effects ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Inflammation/physiopathology ; MAP Kinase Signaling System/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/physiology ; Reactive Oxygen Species/metabolism ; Tumor Suppressor p53-Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism.
Autorzy :
Mazzoni M; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy.
Mauro G; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy.
Erreni M; Department of Immunology, IRCCS Humanitas Clinical and Research Center, Via Manzoni, 56, 20089, Rozzano, Milan, Italy. .
Romeo P; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy.
Minna E; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy.
Vizioli MG; Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.; Institute of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G61 1BD, UK.
Belgiovine C; Department of Immunology, IRCCS Humanitas Clinical and Research Center, Via Manzoni, 56, 20089, Rozzano, Milan, Italy.
Rizzetti MG; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy.
Pagliardini S; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy.
Avigni R; Department of Immunology, IRCCS Humanitas Clinical and Research Center, Via Manzoni, 56, 20089, Rozzano, Milan, Italy.
Anania MC; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy.
Allavena P; Department of Immunology, IRCCS Humanitas Clinical and Research Center, Via Manzoni, 56, 20089, Rozzano, Milan, Italy.
Borrello MG; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy.
Greco A; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G.A. Amadeo, 42, 20133, Milan, Italy. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 May 21; Vol. 38 (1), pp. 208. Date of Electronic Publication: 2019 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence/*drug effects
Cyclooxygenase 2/*genetics
Inflammation/*drug therapy
Thyroid Neoplasms/*drug therapy
Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Polarity/drug effects ; Cellular Senescence/genetics ; Chemokine CCL17/genetics ; Culture Media, Conditioned/chemistry ; Culture Media, Conditioned/pharmacology ; Cyclooxygenase 2 Inhibitors/pharmacology ; Flow Cytometry ; Gene Expression Regulation, Neoplastic ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Macrophages/drug effects ; Macrophages/pathology ; Monocytes/drug effects ; Signal Transduction/drug effects ; Thyroid Epithelial Cells/drug effects ; Thyroid Epithelial Cells/pathology ; Thyroid Gland/drug effects ; Thyroid Gland/pathology ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Cytoplasmic chromatin triggers inflammation in senescence and cancer.
Autorzy :
Dou Z; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Ghosh K; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Vizioli MG; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1BD, UK.
Zhu J; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Sen P; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Wangensteen KJ; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Simithy J; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Lan Y; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Lin Y; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Zhou Z; Biodynamic Optical Imaging Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University, Beijing 100871, China.
Capell BC; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Xu C; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Xu M; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Kieckhaefer JE; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Jiang T; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Shoshkes-Carmel M; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Tanim KMAA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Barber GN; Department of Cell Biology and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Seykora JT; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Millar SE; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Kaestner KH; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Garcia BA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Penn Epigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Adams PD; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1BD, UK.; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Berger SL; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Penn Epigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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Źródło :
Nature [Nature] 2017 Oct 19; Vol. 550 (7676), pp. 402-406. Date of Electronic Publication: 2017 Oct 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Cellular Senescence/*genetics
Chromatin/*metabolism
Cytoplasm/*genetics
Inflammation/*genetics
Inflammation/*pathology
Neoplasms/*genetics
Neoplasms/*immunology
Animals ; Cell Line, Tumor ; Chromatin/immunology ; Cytokines/immunology ; Cytokines/metabolism ; Cytoplasm/immunology ; Female ; Humans ; Inflammation/immunology ; Liver/metabolism ; Male ; Membrane Proteins/deficiency ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Neoplasms/pathology ; Nucleotidyltransferases/metabolism ; Oncogene Protein p21(ras)/genetics ; Oncogene Protein p21(ras)/immunology ; Radiation, Ionizing
Czasopismo naukowe
Tytuł :
Senescence Can Be BETter without the SASP?
Autorzy :
Vizioli MG; Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom. Institute of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Adams PD; Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom. Institute of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. .
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Źródło :
Cancer discovery [Cancer Discov] 2016 Jun; Vol. 6 (6), pp. 576-8.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Phenotype*
Cellular Senescence/*genetics
Chromatin ; Humans
Czasopismo naukowe
Tytuł :
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.
Autorzy :
Rai TS; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom; Institute of Biomedical and Environmental Health Research, University of West of Scotland, Paisley PA1 2BE, United Kingdom .
Cole JJ; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Nelson DM; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Dikovskaya D; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Faller WJ; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
Vizioli MG; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Hewitt RN; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Anannya O; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
McBryan T; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Manoharan I; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
van Tuyn J; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Morrice N; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
Pchelintsev NA; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Ivanov A; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Brock C; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Drotar ME; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom;
Nixon C; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
Clark W; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
Sansom OJ; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
Anderson KI; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
King A; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
Blyth K; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom;
Adams PD; Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom; .
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Źródło :
Genes & development [Genes Dev] 2014 Dec 15; Vol. 28 (24), pp. 2712-25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
Cellular Senescence/*physiology
Histone Chaperones/*metabolism
Transcription Factors/*metabolism
Animals ; Antineoplastic Agents, Hormonal/pharmacology ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Cell Cycle Proteins/genetics ; Cell Line ; Cell Proliferation ; Cellular Senescence/genetics ; Chromatin/metabolism ; Female ; Gene Expression Regulation/drug effects ; Genetic Markers ; Histone Chaperones/genetics ; Histones/genetics ; Histones/metabolism ; Humans ; Male ; Mice ; Papilloma/pathology ; Skin Neoplasms/pathology ; Tamoxifen/pharmacology ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved.
Autorzy :
Vizioli MG; Molecular Mechanism Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, UK.
Santos J; Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, UK.
Pilotti S; Laboratory of Molecular Pathology, Department of Pathology, IRCCS Foundation - Istituto Nazionale dei Tumori, Milan, Italy.
Mazzoni M; Molecular Mechanism Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Anania MC; Molecular Mechanism Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Miranda C; Molecular Mechanism Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Pagliardini S; Molecular Mechanism Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Pierotti MA; Scientific Directorate, IRCCS Foundation - Istituto Nazionale dei Tumori, Milan, Italy.
Gil J; Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, UK. Senior co-authors.
Greco A; Molecular Mechanism Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Senior co-authors.
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Źródło :
Oncotarget [Oncotarget] 2014 Sep 30; Vol. 5 (18), pp. 8270-83.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, ras*
Inflammation Mediators/*metabolism
Oncogene Protein p21(ras)/*metabolism
Thyroid Gland/*metabolism
Cell Proliferation ; Cell Shape ; Cells, Cultured ; Cellular Senescence ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Gene Expression Regulation ; Humans ; Interleukin-8/metabolism ; Oncogene Protein p21(ras)/genetics ; Primary Cell Culture ; RNA Interference ; Receptors, Interleukin-8B/genetics ; Receptors, Interleukin-8B/metabolism ; Signal Transduction ; Thyroid Gland/immunology ; Thyroid Gland/pathology ; Time Factors ; Transfection ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; beta-Galactosidase/metabolism
Czasopismo naukowe
Tytuł :
S100A11 overexpression contributes to the malignant phenotype of papillary thyroid carcinoma.
Autorzy :
Anania MC; PhD, Fondazione IRCCS, Istituto Nazionale dei Tumori, Via G. A. Amadeo, 42 20133 Milan, Italy. .
Miranda C
Vizioli MG
Mazzoni M
Cleris L
Pagliardini S
Manenti G
Borrello MG
Pierotti MA
Greco A
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2013 Oct; Vol. 98 (10), pp. E1591-600. Date of Electronic Publication: 2013 Aug 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Carcinoma, Papillary/*genetics
S100 Proteins/*genetics
Thyroid Neoplasms/*genetics
Adenocarcinoma, Follicular/genetics ; Adenocarcinoma, Follicular/pathology ; Animals ; Carcinoma, Papillary/pathology ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Thyroid Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Evidence of oncogene-induced senescence in thyroid carcinogenesis.
Autorzy :
Vizioli MG; Molecular Mechanisms Unit, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation-Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy.
Possik PA
Tarantino E
Meissl K
Borrello MG
Miranda C
Anania MC
Pagliardini S
Seregni E
Pierotti MA
Pilotti S
Peeper DS
Greco A
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Źródło :
Endocrine-related cancer [Endocr Relat Cancer] 2011 Dec 01; Vol. 18 (6), pp. 743-57. Date of Electronic Publication: 2011 Dec 01 (Print Publication: 2011).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
Proto-Oncogenes*/genetics
Thyroid Neoplasms/*metabolism
Adult ; Aged ; Carcinoma ; Carcinoma, Papillary ; Cells, Cultured ; Cyclin-Dependent Kinase Inhibitor p16/biosynthesis ; Cyclin-Dependent Kinase Inhibitor p21/biosynthesis ; Female ; HEK293 Cells ; Humans ; Insulin-Like Growth Factor Binding Proteins/biosynthesis ; Male ; Middle Aged ; Thyroid Cancer, Papillary ; Thyroid Carcinoma, Anaplastic ; Thyroid Gland/cytology ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
Role of STAT3 in in vitro transformation triggered by TRK oncogenes.
Autorzy :
Miranda C; Operative Unit Molecular Mechanisms, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation, Istituto Nazionale dei Tumori, Milan, Italy. />Fumagalli T
Anania MC
Vizioli MG
Pagliardini S
Pierotti MA
Greco A
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Źródło :
PloS one [PLoS One] 2010 Mar 03; Vol. 5 (3), pp. e9446. Date of Electronic Publication: 2010 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic*
Gene Expression Regulation, Neoplastic*
Oncogene Proteins/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; Cell Survival ; HeLa Cells ; Humans ; MAP Kinase Signaling System ; Mice ; NIH 3T3 Cells ; Oncogenes ; PC12 Cells ; Phosphorylation ; Rats
Czasopismo naukowe
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