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Wyświetlanie 1-20 z 36
Tytuł:
Altered Tau Kinase Activity in rTg4510 Mice after a Single Interfaced CHIMERA Traumatic Brain Injury.
Autorzy:
Cheng WH; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Cheung H; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Kang A; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Fan J; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Cooper J; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Anwer M; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Barron C; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Wilkinson A; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Hu G; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Yue J; Department of Chemistry, Simon Fraser University, Vancouver, BC V5A 1S6, Canada.
Cripton PA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; International Collaboration on Repair Discoveries, Vancouver, BC V5Z 1M9, Canada.
Vocadlo DJ; Department of Chemistry, Simon Fraser University, Vancouver, BC V5A 1S6, Canada.
Wellington CL; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; International Collaboration on Repair Discoveries, Vancouver, BC V5Z 1M9, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 29; Vol. 24 (11). Date of Electronic Publication: 2023 May 29.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Injuries, Traumatic*/genetics
Head Injuries, Closed*
Tauopathies*/genetics
Mice ; Male ; Animals ; Glycogen Synthase Kinase 3 beta/genetics ; Brain/metabolism ; Disease Models, Animal ; Acceleration ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In Situ Imaging of O-Linked β-N-Acetylglucosamine Using On-Tissue Hydrolysis and MALDI Mass Spectrometry.
Autorzy:
Escobar EE; Department of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Seeley EH; Department of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Serrano-Negrón JE; Department of Molecular Biology and Biochemistry, Burnaby, BC V5A 1S6, Canada.
Vocadlo DJ; Department of Molecular Biology and Biochemistry, Burnaby, BC V5A 1S6, Canada.; Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Brodbelt JS; Department of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
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Źródło:
Cancers [Cancers (Basel)] 2023 Feb 15; Vol. 15 (4). Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
sp -Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease.
Autorzy:
González-Cuesta M; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain.
Herrera-González I; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain.
García-Moreno MI; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain.
Ashmus RA; Department of Chemistry and Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
Vocadlo DJ; Department of Chemistry and Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
García Fernández JM; Instituto de Investigaciones Químicas (IIQ), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Sevilla, Sevilla, Spain.
Nanba E; Organization for Research Initiative and Promotion, Tottori University, Yonago, Japan.
Higaki K; Organization for Research Initiative and Promotion, Tottori University, Yonago, Japan.
Ortiz Mellet C; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, Spain.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1364-1374.
Typ publikacji:
Journal Article
MeSH Terms:
Tay-Sachs Disease*/drug therapy
Tay-Sachs Disease*/genetics
Hexosaminidase A/genetics ; Humans ; Lysosomes ; Piperidines ; beta-N-Acetylhexosaminidases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity.
Autorzy:
Meek RW; Department of Chemistry. University of York, York, United Kingdom.
Brockerman J; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Fordwour OB; Department of Chemistry, Irving K. Barber Faculty of Science, University of British Columbia, Kelowna, British Columbia, Canada.
Zandberg WF; Department of Chemistry, Irving K. Barber Faculty of Science, University of British Columbia, Kelowna, British Columbia, Canada.
Davies GJ; Department of Chemistry. University of York, York, United Kingdom.
Vocadlo DJ; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
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Źródło:
PLoS biology [PLoS Biol] 2022 Sep 21; Vol. 20 (9), pp. e3001764. Date of Electronic Publication: 2022 Sep 21 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Diseases*/genetics
Brain Diseases*/metabolism
Glycoside Hydrolases*/genetics
Animals ; Brain/metabolism ; Humans ; Ligands ; Mammals/metabolism ; Muscle Development ; Pedigree ; Substrate Specificity ; alpha-Galactosidase/genetics ; alpha-Galactosidase/metabolism ; alpha-Glucosidases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 36

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