Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([ F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression.
Autorzy:
Verbeek J; 1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands. Eriksson J; 1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.; 3Present Address: Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. Syvänen S; 2Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.; 3Present Address: Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. Huisman M; 1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands. Schuit RC; 1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands. Molthoff CFM; 1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands. VoskuylRA; 2Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.; 4Stichting Epilepsie Instellingen Nederland, SEIN, Heemstede, The Netherlands. de Lange EC; 2Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands. Lammertsma AA; 1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands. Windhorst AD; 1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.
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Źródło:
EJNMMI radiopharmacy and chemistry [EJNMMI Radiopharm Chem] 2018 Sep 21; Vol. 3, pp. 11. Date of Electronic Publication: 2018 Sep 21 (Print Publication: 2018).
MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.
Autorzy:
Schouten M; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH, Amsterdam, The Netherlands. Fratantoni SA; Oncoproteomics Laboratory, Cancer Center, Free University Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands. Hubens CJ; 1] Division of Pharmacology, LACDR, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands [2] Foundation of Epilepsy Institutes of The Netherlands (SEIN), Achterweg 5, 2103 SW, Heemstede, The Netherlands. Piersma SR; Oncoproteomics Laboratory, Cancer Center, Free University Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands. Pham TV; Oncoproteomics Laboratory, Cancer Center, Free University Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands. Bielefeld P; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH, Amsterdam, The Netherlands. VoskuylRA; 1] Division of Pharmacology, LACDR, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands [2] Foundation of Epilepsy Institutes of The Netherlands (SEIN), Achterweg 5, 2103 SW, Heemstede, The Netherlands. Lucassen PJ; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH, Amsterdam, The Netherlands. Jimenez CR; Oncoproteomics Laboratory, Cancer Center, Free University Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands. Fitzsimons CP; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH, Amsterdam, The Netherlands.
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Źródło:
Scientific reports [Sci Rep] 2015 Jul 24; Vol. 5, pp. 12448. Date of Electronic Publication: 2015 Jul 24.
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