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Tytuł:
Cullin-3 proteins be a novel biomarkers and therapeutic targets for hyperchloremia induced by oral poisoning.
Autorzy:
Duan H; Department of Emergency Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Li N; Department of Vascular Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Qi J; Department of Hematology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Li X; Department of Ophthalmology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Zhou K; Department of Physical Examination Center, Taihe Hospital, Hubei University of Medicine, Shiyan, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 13; Vol. 14 (1), pp. 8597. Date of Electronic Publication: 2024 Apr 13.
Typ publikacji:
Journal Article
MeSH Terms:
Chlorides*/adverse effects
Chlorides*/toxicity
Cullin Proteins*/metabolism
Humans ; Acidosis ; Biomarkers ; Halogens ; Molecular Docking Simulation ; Protein Serine-Threonine Kinases/metabolism ; WNK Lysine-Deficient Protein Kinase 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A missense mutation of the WNK1 gene affects cold tolerance in Chinese domestic cattle.
Autorzy:
Liu X; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Chen J; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xu X; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Liu J; Yunnan Academy of Grassland and Animal Science, Kunming, China.
Zhang J; Yunnan Academy of Grassland and Animal Science, Kunming, China.
Cheng H; Shandong Key Lab of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China.
Ahmed Z; Faculty of Veterinary and Animal Sciences, University of Poonch Rawalakot Azad Jammu and Kashmir Pakistan, Rawalakot, Pakistan.
Huang B; Yunnan Academy of Grassland and Animal Science, Kunming, China.
Lei C; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
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Źródło:
Animal biotechnology [Anim Biotechnol] 2023 Dec; Vol. 34 (9), pp. 4803-4808. Date of Electronic Publication: 2023 Apr 20.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Serine-Threonine Kinases*/genetics
Protein Serine-Threonine Kinases*/metabolism
Mutation, Missense*
Humans ; Cattle/genetics ; Animals ; WNK Lysine-Deficient Protein Kinase 1/genetics ; Minor Histocompatibility Antigens/genetics ; China
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway.
Autorzy:
Shimizu M; Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, 113-8510, Japan.
Shibuya H; Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, 113-8510, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Sep 23; Vol. 12 (1), pp. 15858. Date of Electronic Publication: 2022 Sep 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hereditary Sensory and Autonomic Neuropathies*
Neuronal Outgrowth*
Protein Serine-Threonine Kinases*/genetics
WNK Lysine-Deficient Protein Kinase 1*/genetics
Alanine ; Cholinergic Agents ; Glycogen Synthase Kinase 3 beta/genetics ; Humans ; LIM-Homeodomain Proteins ; Proline ; Transcription Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unanticipated domain requirements for Drosophila Wnk kinase in vivo.
Autorzy:
Yarikipati P; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America.
Jonusaite S; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America.
Pleinis JM; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America.
Dominicci Cotto C; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America.
Sanchez-Hernandez D; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America.
Morrison DE; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America.
Goyal S; Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern, Dallas, Texas, United States of America.
Schellinger J; Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern, Dallas, Texas, United States of America.
Pénalva C; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America.
Curtiss J; Department of Cell & Developmental Biology, New Mexico State University, Las Cruces, New Mexico, United States of America.
Rodan AR; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America.; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, Utah, United States of America.; Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America.; Medical Service, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah, United States of America.
Jenny A; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America.; Department of Genetics, Albert Einstein College of Medicine, New York, New York, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2023 Oct 11; Vol. 19 (10), pp. e1010975. Date of Electronic Publication: 2023 Oct 11 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Protein Serine-Threonine Kinases*/metabolism
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
Animals ; Humans ; Drosophila/metabolism ; Zebrafish/metabolism ; Homeostasis ; WNK Lysine-Deficient Protein Kinase 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elucidating specificity of an allosteric inhibitor WNK476 among With-No-Lysine kinase isoforms using molecular dynamic simulations.
Autorzy:
Amarnath Jonniya N; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.
Sk MF; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.
Kar P; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2021 Sep; Vol. 98 (3), pp. 405-420. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Dynamics Simulation*
Protein Kinase Inhibitors/*chemistry
WNK Lysine-Deficient Protein Kinase 1/*antagonists & inhibitors
Allosteric Site ; Binding Sites ; Humans ; Hydrogen Bonding ; Principal Component Analysis ; Protein Binding ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Protein Kinase Inhibitors/metabolism ; Thermodynamics ; WNK Lysine-Deficient Protein Kinase 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The WNK1-ERK5 route plays a pathophysiological role in ovarian cancer and limits therapeutic efficacy of trametinib.
Autorzy:
Sánchez-Fdez A; Instituto de Biología Molecular y Celular del Cáncer-CSIC, Salamanca, Spain.; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Matilla-Almazán S; Instituto de Biología Molecular y Celular del Cáncer-CSIC, Salamanca, Spain.; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain.
Montero JC; Instituto de Biología Molecular y Celular del Cáncer-CSIC, Salamanca, Spain.; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain.; Department of Pathology, University Hospital of Salamanca, Salamanca, Spain.
Del Carmen S; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.; Department of Pathology, University Hospital of Salamanca, Salamanca, Spain.
Abad M; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.; Department of Pathology, University Hospital of Salamanca, Salamanca, Spain.
García-Alonso S; Instituto de Biología Molecular y Celular del Cáncer-CSIC, Salamanca, Spain.; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain.
Bhattacharya S; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota, USA.
Calar K; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota, USA.
de la Puente P; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota, USA.; Department of Surgery, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA.
Ocaña A; Experimental Therapeutics Unit CRIS-Cancer, Hospital Clínico San Carlos and CIBERONC, Madrid, Spain.; Universidad de Castilla La Mancha, Castilla La Mancha, Albacete, Spain.
Pandiella A; Instituto de Biología Molecular y Celular del Cáncer-CSIC, Salamanca, Spain.; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain.
Esparís-Ogando A; Instituto de Biología Molecular y Celular del Cáncer-CSIC, Salamanca, Spain.; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Apr; Vol. 13 (4), pp. e1217.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
MAP Kinase Kinase 5*/genetics
MAP Kinase Kinase 5*/metabolism
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Humans ; Animals ; Mice ; Female ; MAP Kinase Signaling System ; Signal Transduction ; WNK Lysine-Deficient Protein Kinase 1/genetics ; WNK Lysine-Deficient Protein Kinase 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID.
Autorzy:
Sato A; Department of Molecular Cell Biology, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, 113-8510, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0032, Japan.
Shimizu M; Department of Molecular Cell Biology, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, 113-8510, Japan.; Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Bunkyo-ku, Tokyo, 113-8602, Japan.
Goto T; Department of Molecular Cell Biology, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, 113-8510, Japan.
Masuno H; Institute of Biomaterials and Bioengineering, TMDU, Bunkyo-ku, Tokyo, 113-8510, Japan.
Kagechika H; Institute of Biomaterials and Bioengineering, TMDU, Bunkyo-ku, Tokyo, 113-8510, Japan.
Tanaka N; Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Bunkyo-ku, Tokyo, 113-8602, Japan.
Shibuya H; Department of Molecular Cell Biology, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, 113-8510, Japan. .
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Źródło:
Communications biology [Commun Biol] 2020 Nov 12; Vol. 3 (1), pp. 666. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
WNK Lysine-Deficient Protein Kinase 1*/genetics
WNK Lysine-Deficient Protein Kinase 1*/metabolism
Wnt Signaling Pathway/*physiology
beta Catenin/*metabolism
Animals ; Cell Line, Tumor ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Ubiquitin-Protein Ligase Complexes/metabolism ; Ubiquitination/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Loss of WNK1 Suppressed the Malignant Behaviors of Hepatocellular Carcinoma Cells by Promoting Autophagy and Activating AMPK Pathway.
Autorzy:
Wang F; College of Life Science, Shandong Normal University, Jinan, 250014 Shandong, China.; Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033 Shandong, China.
Yan X; Clinical Laboratory of Shandong Mental Health Center, China.
Shi G; Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033 Shandong, China.
Zhang L; College of Life Science, Shandong Normal University, Jinan, 250014 Shandong, China.; Microbiome-X, National Institute of Health Data Science of China & Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan, 250002 Shandong, China.; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250002 Shandong, China.
Jing X; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 65 Stockholm, Sweden.
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Źródło:
Disease markers [Dis Markers] 2022 Dec 30; Vol. 2022, pp. 6831224. Date of Electronic Publication: 2022 Dec 30 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Humans ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Cell Line, Tumor ; Autophagy ; Cell Proliferation/genetics ; Cell Movement/genetics ; WNK Lysine-Deficient Protein Kinase 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy.
Autorzy:
Hou CY; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.
Ma CY; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.
Lin YJ; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.
Huang CL; Division of Nephrology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Wang HD; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.; Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu 300044, Taiwan.; Department of Life Science, National Tsing Hua University, Hsinchu 300044, Taiwan.
Yuh CH; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300044, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.; Ph.D. Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 11; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 11.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/drug therapy
Liver Neoplasms*/genetics
Animals ; Humans ; WNK Lysine-Deficient Protein Kinase 1/genetics ; WNK Lysine-Deficient Protein Kinase 1/metabolism ; Protein Serine-Threonine Kinases/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Zebrafish/metabolism ; Rafoxanide ; Protein Phosphatase 2/metabolism ; Lysine ; Tumor Suppressor Protein p53 ; Minor Histocompatibility Antigens ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/genetics ; Human Umbilical Vein Endothelial Cells/metabolism ; Transcription Factors/metabolism ; beta-Galactosidase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RNA-sequencing reveals that STRN, ZNF484 and WNK1 add to the value of mitochondrial MT-COI and COX10 as markers of unstable coronary artery disease.
Autorzy:
Holvoet P; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Klocke B; Intrexon Bioinformatics Germany, Munich, Germany.
Vanhaverbeke M; Department of Clinical Cardiology, UZ Leuven, Leuven, Belgium.
Menten R; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Sinnaeve P; Department of Clinical Cardiology, UZ Leuven, Leuven, Belgium.
Raitoharju E; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Life Sciences University of Tampere, Tampere, Finland.
Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Life Sciences University of Tampere, Tampere, Finland.
Oksala N; Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, Tampere, Finland.
Zinser C; Intrexon Bioinformatics Germany, Munich, Germany.
Janssens S; Department of Clinical Cardiology, UZ Leuven, Leuven, Belgium.
Sipido K; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Lyytikainen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Life Sciences University of Tampere, Tampere, Finland.
Cagnin S; Department of Biology, CRIBI Biotechnology Centre, Padova, Italy.; CIR-Myo Myology Centre, University of Padova, Padova, Italy.
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Źródło:
PloS one [PLoS One] 2019 Dec 10; Vol. 14 (12), pp. e0225621. Date of Electronic Publication: 2019 Dec 10 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acute Coronary Syndrome/*diagnosis
Calmodulin-Binding Proteins/*metabolism
Coronary Artery Disease/*diagnosis
Membrane Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Plaque, Atherosclerotic/*pathology
WNK Lysine-Deficient Protein Kinase 1/*metabolism
Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/pathology ; Aged ; Alkyl and Aryl Transferases/blood ; Alkyl and Aryl Transferases/metabolism ; Biomarkers/blood ; Biomarkers/metabolism ; Calmodulin-Binding Proteins/blood ; Cholesterol/blood ; Coronary Angiography ; Coronary Artery Disease/blood ; Coronary Artery Disease/pathology ; Diagnosis, Differential ; Electron Transport Complex IV/blood ; Electron Transport Complex IV/metabolism ; Female ; Follow-Up Studies ; Humans ; Male ; Membrane Proteins/blood ; Middle Aged ; Mitochondria/metabolism ; Monocytes/cytology ; Monocytes/metabolism ; Nerve Tissue Proteins/blood ; Plaque, Atherosclerotic/blood ; Prospective Studies ; RNA-Seq ; WNK Lysine-Deficient Protein Kinase 1/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The coexistence of a novel WNK1 variant and a copy number variation causes hereditary sensory and autonomic neuropathy type IIA.
Autorzy:
Wang JJ; Division of Cardiology, Departments of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Yu B; Division of Cardiology, Departments of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Li Z; Division of Cardiology, Departments of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. .; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Huazhong University of Science and Technology, Wuhan, China. .
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Źródło:
BMC medical genetics [BMC Med Genet] 2019 May 27; Vol. 20 (1), pp. 91. Date of Electronic Publication: 2019 May 27.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Codon, Nonsense*
DNA Copy Number Variations*
Hereditary Sensory and Autonomic Neuropathies/*genetics
WNK Lysine-Deficient Protein Kinase 1/*genetics
Amino Acid Sequence ; Base Sequence ; DNA Mutational Analysis ; Family Health ; Female ; Hereditary Sensory and Autonomic Neuropathies/metabolism ; Hereditary Sensory and Autonomic Neuropathies/pathology ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Male ; Pedigree ; Sequence Homology, Amino Acid ; WNK Lysine-Deficient Protein Kinase 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway.
Autorzy:
Sato A; Department of Molecular Cell Biology and Joint Usage/Research Center for Intractable Diseases, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
Shibuya H; Department of Molecular Cell Biology and Joint Usage/Research Center for Intractable Diseases, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2018 Mar 01; Vol. 13 (3), pp. e0193204. Date of Electronic Publication: 2018 Mar 01 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drosophila Proteins/*metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
Signal Transduction/*physiology
WNK Lysine-Deficient Protein Kinase 1/*metabolism
Animals ; Cell Line, Tumor ; Drosophila/metabolism ; Drosophila Proteins/antagonists & inhibitors ; Drosophila Proteins/genetics ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Glycogen Synthase Kinase 3 beta/genetics ; Immunoprecipitation ; LIM-Homeodomain Proteins/metabolism ; Mice ; Phosphorylation ; Protein Binding ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Transcription Factors/metabolism ; WNK Lysine-Deficient Protein Kinase 1/antagonists & inhibitors ; WNK Lysine-Deficient Protein Kinase 1/genetics ; Wings, Animal/metabolism ; Wings, Animal/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
With-No-Lysine Kinase 1 (WNK1) Augments TRPV4 Function in the Aldosterone-Sensitive Distal Nephron.
Autorzy:
Tomilin VN; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
Pyrshev K; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
Khayyat NH; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
Zaika O; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
Pochynyuk O; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
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Źródło:
Cells [Cells] 2021 Jun 12; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Kidney Tubules, Distal/*metabolism
TRPV Cation Channels/*metabolism
WNK Lysine-Deficient Protein Kinase 1/*metabolism
Aldosterone/metabolism ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Mice ; Potassium/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke.
Autorzy:
Josiah SS; Hatherly Laboratories, Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Exeter EX4 4PS, UK.
Meor Azlan NF; Hatherly Laboratories, Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Exeter EX4 4PS, UK.
Zhang J; Hatherly Laboratories, Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Exeter EX4 4PS, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 27; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Protein Serine-Threonine Kinases/*metabolism
Sodium Potassium Chloride Symporter Inhibitors/*pharmacology
Sodium-Potassium-Chloride Symporters/*metabolism
Stroke/*metabolism
Symporters/*metabolism
WNK Lysine-Deficient Protein Kinase 1/*metabolism
Homeostasis ; Humans ; Neurons/metabolism ; Neurons/pathology ; Phosphorylation ; Signal Transduction ; Sodium Potassium Chloride Symporter Inhibitors/therapeutic use ; Sodium-Potassium-Chloride Symporters/genetics ; Stroke/physiopathology ; Symporters/genetics ; K Cl- Cotransporters
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.
Autorzy:
Zhang J; Hatherly Laboratories, Medical School, College of Medicine and Health, Institute of Biomedical and Clinical Sciences, University of Exeter, Exeter, United Kingdom.; Xiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, China.
Cordshagen A; Division of Neurogenetics, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Medina I; INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de la Méditerranée), Aix-Marseille University UMR 1249, Marseille, France.
Nothwang HG; Division of Neurogenetics, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.; Research Center for Neurosensory Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.; Center of Excellence Hearing4all, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Wisniewski JR; Department of Proteomics and Signal Transduction, Biochemical Proteomics Group, Max-Planck-Institute of Biochemistry, Martinsried, Germany.
Winklhofer M; Research Center for Neurosensory Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.; Institute for Biology and Environmental Sciences IBU, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.
Hartmann AM; Division of Neurogenetics, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.; Research Center for Neurosensory Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
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Źródło:
PloS one [PLoS One] 2020 May 15; Vol. 15 (5), pp. e0232967. Date of Electronic Publication: 2020 May 15 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ethylmaleimide/*pharmacology
Neurons/*drug effects
Neurons/*metabolism
Solute Carrier Family 12, Member 2/*metabolism
Staurosporine/*pharmacology
Symporters/*metabolism
Animals ; Binding Sites ; Cells, Cultured ; HEK293 Cells ; Hippocampus/cytology ; Hippocampus/metabolism ; Humans ; Phosphorylation/drug effects ; Protein Kinases/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Rats ; Recombinant Proteins/metabolism ; Signal Transduction/drug effects ; Transfection ; WNK Lysine-Deficient Protein Kinase 1/metabolism ; K Cl- Cotransporters
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Claudin-7 Modulates Cl Homeostasis and WNK4 Expression in Renal Collecting Duct Cells.
Autorzy:
Fan J; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Tatum R; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Hoggard J; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Chen YH; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. .; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Aug 03; Vol. 20 (15). Date of Electronic Publication: 2019 Aug 03.
Typ publikacji:
Journal Article
MeSH Terms:
Claudins/*genetics
Epithelial Sodium Channels/*genetics
Hypertension/*genetics
Protein Serine-Threonine Kinases/*genetics
Animals ; Cell Membrane Permeability ; Chlorides/metabolism ; Disease Models, Animal ; Gene Expression Regulation/genetics ; Humans ; Hypertension/metabolism ; Hypertension/pathology ; Kidney/metabolism ; Kidney/pathology ; Kidney Tubules, Collecting/metabolism ; Kidney Tubules, Collecting/pathology ; Mice ; Mice, Knockout ; Sodium/metabolism ; Transendothelial and Transepithelial Migration ; WNK Lysine-Deficient Protein Kinase 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A novel nonsense mutation in WNK1/HSN2 associated with sensory neuropathy and limb destruction in four siblings of a large Iranian pedigree.
Autorzy:
Rahmani B; Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fekrmandi F; Department of Radiation Oncology, University Health Network, Princess Margaret Cancer Centre, Toronto, Canada.
Ahadi K; Department of Orthopaedic Surgery, Milad Hospital, Tehran, Iran.
Ahadi T; Neuromusculoskeletal Research Centre, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.
Alavi A; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Ahmadiani A; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asadi S; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
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Źródło:
BMC neurology [BMC Neurol] 2018 Nov 29; Vol. 18 (1), pp. 195. Date of Electronic Publication: 2018 Nov 29.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Hereditary Sensory and Autonomic Neuropathies/*genetics
WNK Lysine-Deficient Protein Kinase 1/*genetics
Codon, Nonsense ; Female ; Humans ; Iran ; Male ; Pedigree ; Siblings
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases.
Autorzy:
Selvan LDN; L&T Opthalmic Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu 600 006, India. .
Danda R; L&T Opthalmic Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu 600 006, India. .; Centre for Nanotechnology and Advanced Biomaterials, Shanmugha Arts, Science, Technology and Research Academy University, Tanjore, Tamil Nadu 613 401, India. .
Madugundu AK; Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560 066, India. .
Puttamallesh VN; Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560 066, India. .
Sathe GJ; Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560 066, India. .; Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576 104, India. .
Krishnan UM; Centre for Nanotechnology and Advanced Biomaterials, Shanmugha Arts, Science, Technology and Research Academy University, Tanjore, Tamil Nadu 613 401, India. .
Khetan V; Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu 600 006, India. .
Rishi P; Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu 600 006, India. .
Prasad TSK; Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560 066, India. .; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka 575 108, India. .
Pandey A; Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560 066, India. .; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. .; Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. .
Krishnakumar S; L&T Opthalmic Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu 600 006, India. .
Gowda H; Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560 066, India. .
Elchuri SV; Department of Nanotechnology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu 600 006, India. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2018 Jun 15; Vol. 23 (6). Date of Electronic Publication: 2018 Jun 15.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphoproteins/*metabolism
Protein Kinases/*metabolism
Proteomics/*methods
Retinoblastoma/*metabolism
Adult ; CDC2 Protein Kinase/metabolism ; Cell Cycle Proteins ; Gene Regulatory Networks ; Histones/chemistry ; Histones/metabolism ; Humans ; Nuclear Proteins/metabolism ; Pilot Projects ; Serine/chemistry ; Sirtuin 1/chemistry ; Sirtuin 1/metabolism ; Transcription Factors/metabolism ; WNK Lysine-Deficient Protein Kinase 1/metabolism ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells.
Autorzy:
Pio GM; Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western University, London, ON, Canada.
Xia Y; London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.
Piaseczny MM; Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western University, London, ON, Canada.
Chu JE; Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western University, London, ON, Canada.
Allan AL; Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western University, London, ON, Canada.; London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.; Department of Oncology, Schulich School of Medicine & Dentistry, University of Western University, London, ON, Canada.; Cancer Research Laboratories, Lawson Health Research Institute; London, ON, Canada.
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Źródło:
PloS one [PLoS One] 2017 May 12; Vol. 12 (5), pp. e0177640. Date of Electronic Publication: 2017 May 12 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms/*metabolism
Cell Movement/*physiology
Osteopontin/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Aldehyde Dehydrogenase/genetics ; Aldehyde Dehydrogenase/metabolism ; Animals ; Breast Neoplasms/genetics ; CD24 Antigen/genetics ; CD24 Antigen/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Female ; Flow Cytometry ; Humans ; Hyaluronan Receptors/genetics ; Hyaluronan Receptors/metabolism ; Immunoblotting ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice, Nude/genetics ; Mice, Nude/physiology ; Minor Histocompatibility Antigens/genetics ; Minor Histocompatibility Antigens/metabolism ; Osteopontin/genetics ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; WNK Lysine-Deficient Protein Kinase 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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