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    Wyświetlanie 1-2 z 2
    Tytuł:
    Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types.
    Autorzy:
    Mead BE; Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. .; Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA. .; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA. .; Harvard Stem Cell Institute, Cambridge, MA, USA. .; Broad Institute of Harvard and MIT, Cambridge, MA, USA. .
    Ordovas-Montanes J; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemistry, MIT, Cambridge, MA, USA.; Divisions of Infectious Diseases and Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
    Braun AP; Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
    Levy LE; Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.
    Bhargava P; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.
    Szucs MJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
    Ammendolia DA; Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.
    MacMullan MA; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
    Yin X; Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.
    Hughes TK; Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemistry, MIT, Cambridge, MA, USA.
    Wadsworth MH 2nd; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemistry, MIT, Cambridge, MA, USA.
    Ahmad R; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
    Rakoff-Nahoum S; Divisions of Infectious Diseases and Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
    Carr SA; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
    Langer R; Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Department of Chemical Engineering, MIT, Cambridge, MA,, USA.
    Collins JJ; Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Department of Biological Engineering, MIT, Cambridge, MA, USA.; Synthetic Biology Center, MIT, Cambridge, MA, USA.; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.
    Shalek AK; Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
    Karp JM; Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. .; Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA. .; Harvard Stem Cell Institute, Cambridge, MA, USA. .; Broad Institute of Harvard and MIT, Cambridge, MA, USA. .
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    Źródło:
    BMC biology [BMC Biol] 2018 Jun 05; Vol. 16 (1), pp. 62. Date of Electronic Publication: 2018 Jun 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Genomics/*methods
    Organoids/*cytology
    Paneth Cells/*cytology
    Single-Cell Analysis/*methods
    Humans ; Models, Biological ; Proteomics ; Sequence Analysis, RNA ; Stem Cell Niche
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
    Autorzy:
    Tirosh I; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Izar B; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA. _.
    Prakadan SM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemistry, MIT, Cambridge, MA 02142, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA.
    Wadsworth MH 2nd; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemistry, MIT, Cambridge, MA 02142, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA.
    Treacy D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Trombetta JJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Rotem A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
    Rodman C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Lian C; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
    Murphy G; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
    Fallahi-Sichani M; Program in Therapeutic Sciences, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
    Dutton-Regester K; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    Lin JR; HMS LINCS Center and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
    Cohen O; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Shah P; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
    Lu D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Genshaft AS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemistry, MIT, Cambridge, MA 02142, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA.
    Hughes TK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA. Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
    Ziegler CG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA. Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
    Kazer SW; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemistry, MIT, Cambridge, MA 02142, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA.
    Gaillard A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemistry, MIT, Cambridge, MA 02142, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA.
    Kolb KE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemistry, MIT, Cambridge, MA 02142, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA.
    Villani AC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Johannessen CM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Andreev AY; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Van Allen EM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
    Bertagnolli M; Department of Surgical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Department of Surgical Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
    Sorger PK; Program in Therapeutic Sciences, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. HMS LINCS Center and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Ludwig Center at Harvard, Boston, MA 02215, USA.
    Sullivan RJ; Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
    Flaherty KT; Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
    Frederick DT; Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
    Jané-Valbuena J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Yoon CH; Department of Surgical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Department of Surgical Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
    Rozenblatt-Rosen O; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemistry, MIT, Cambridge, MA 02142, USA. Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA. Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA. Department of Immunology, Massachusetts General Hospital, Boston, MA 02114, USA.
    Regev A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Department of Biology and Koch Institute, MIT, Boston, MA 02142, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. _.
    Garraway LA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. _.
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2016 Apr 08; Vol. 352 (6282), pp. 189-96.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Tumor Microenvironment*
    Melanoma/*genetics
    Melanoma/*secondary
    Skin Neoplasms/*pathology
    Base Sequence ; Cell Communication ; Cell Cycle ; Drug Resistance, Neoplasm/genetics ; Endothelial Cells/pathology ; Genomics ; Humans ; Immunotherapy ; Lymphocyte Activation ; Melanoma/therapy ; Microphthalmia-Associated Transcription Factor/metabolism ; Neoplasm Metastasis ; RNA/genetics ; Sequence Analysis, RNA ; Single-Cell Analysis ; Stromal Cells/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Transcriptome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-2 z 2

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