Autor: "Wagner MCE" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia.
Autorzy:: Dos Reis RS; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Sant S; Department of Pharmaceutical Sciences, School of Pharmacy, McGowan Institute for Regenerative Medicine, UPMC Hillman Cancer Center, Pittsburgh, PA, 15261, USA. .; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .
Keeney H; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Wagner MCE; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Ayyavoo V; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Sep 16; Vol. 10 (1), pp. 15209. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*cytology
HIV Infections/*complications
HIV-1/*pathogenicity
Neurocognitive Disorders/*pathology
Organoids/*cytology
Brain/metabolism ; Brain/pathology ; Brain/virology ; Cell Differentiation ; Culture Media/chemistry ; HEK293 Cells ; HIV Infections/metabolism ; HIV Infections/pathology ; Humans ; Interleukin-1beta/metabolism ; Models, Anatomic ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neural Stem Cells/pathology ; Neural Stem Cells/virology ; Neurocognitive Disorders/etiology ; Neurocognitive Disorders/metabolism ; Organ Culture Techniques ; Organoids/metabolism ; Organoids/pathology ; Organoids/virology ; Tumor Necrosis Factor-alpha/metabolism ; Virus Replication

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Tytuł:: Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury.
Autorzy:: Guha D; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 2117 Pitt Public Health, 130 DeSoto Street, Pittsburgh, PA, 15261, USA.
Wagner MCE; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 2117 Pitt Public Health, 130 DeSoto Street, Pittsburgh, PA, 15261, USA.
Ayyavoo V; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 2117 Pitt Public Health, 130 DeSoto Street, Pittsburgh, PA, 15261, USA. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2018 Apr 27; Vol. 15 (1), pp. 126. Date of Electronic Publication: 2018 Apr 27.
Typ publikacji:: Journal Article
MeSH Terms:: HIV-1*
AIDS Dementia Complex/*metabolism
Dendrites/*metabolism
Frontal Lobe/*metabolism
Neurogranin/*biosynthesis
Synapses/*metabolism
AIDS Dementia Complex/pathology ; Adult ; Aged ; Dendrites/pathology ; Female ; Frontal Lobe/pathology ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Middle Aged ; Synapses/pathology

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