Autor: "Wainger BJ" - OpacWWW

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Tytuł:: Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic.
Autorzy:: DuBreuil DM; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; Genomic Medicine Unit, Sanofi, Waltham, MA, USA.
Lai X; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhu K; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Chahyadinata G; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Perner C; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, 2348Universitätsmedizin Greifswald, Germany.
Chiang BM; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Battenberg A; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Sokol CL; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; 2348Broad Institute of Harvard University and MIT, Cambridge, MA, USA.
Wainger BJ; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; 2348Broad Institute of Harvard University and MIT, Cambridge, MA, USA.; Department of Anesthesiology, Critical Care and Pain Medicine, 2348Massachusetts General Hospital, Boston MA, USA.; Pokaż więcej
Źródło:: Molecular pain [Mol Pain] 2023 Jan-Dec; Vol. 19, pp. 17448069221148351.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Nociceptors*/metabolism
Silymarin*/metabolism
Silymarin*/pharmacology
Mice ; Animals ; Calcium/metabolism ; Pain/metabolism ; Sensory Receptor Cells/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Ganglia, Spinal/metabolism

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Tytuł:: Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
Autorzy:: Wainger BJ; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [2] Department of Anesthesia, Critical Care and Pain Medicine and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
Buttermore ED; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
Oliveira JT; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [2] Laboratório de Neurodegeneração e Reparo, Departamento de Patologia, Faculdade de Medicina, Universidade Federal Do Rio De Janeiro, Rio de Janeiro, Brazil.
Mellin C; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
Lee S; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
Saber WA; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
Wang AJ; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
Ichida JK; 1] Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA. [2] Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, California, USA.
Chiu IM; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
Barrett L; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
Huebner EA; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
Bilgin C; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
Tsujimoto N; Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Brenneis C; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
Kapur K; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
Rubin LL; Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Eggan K; 1] Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA. [2] The Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA.
Woolf CJ; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.; Pokaż więcej
Źródło:: Nature neuroscience [Nat Neurosci] 2015 Jan; Vol. 18 (1), pp. 17-24. Date of Electronic Publication: 2014 Nov 24.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Fibroblasts*
Models, Neurological*
Nociceptors*
Sensory Receptor Cells*
Pain/*physiopathology
Animals ; Dysautonomia, Familial/pathology ; Electrophysiological Phenomena/physiology ; Humans ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Peripheral Nervous System Diseases/pathology ; Transcription Factors

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Skocz do pozycji: 5.

Tytuł:: A three-dimensional human neural cell culture model of Alzheimer's disease.
Autorzy:: Choi SH; 1] Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA [2].
Kim YH; 1] Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA [2] Division of Mass Spectrometry Research, Korea Basic Science Institute, Cheongju-si, Chungbuk 363-883, South Korea [3].
Hebisch M; 1] Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA [2] Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, 53127 Bonn, Germany.
Sliwinski C; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Lee S; FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA.
D'Avanzo C; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Chen H; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Hooli B; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Asselin C; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Muffat J; The Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
Klee JB; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Zhang C; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Wainger BJ; FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA.
Peitz M; Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, 53127 Bonn, Germany.
Kovacs DM; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Woolf CJ; FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA.
Wagner SL; Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA.
Tanzi RE; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Kim DY; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Pokaż więcej
Źródło:: Nature [Nature] 2014 Nov 13; Vol. 515 (7526), pp. 274-8. Date of Electronic Publication: 2014 Oct 12.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Models, Biological*
Alzheimer Disease/*metabolism
Alzheimer Disease/*pathology
Cell Culture Techniques/*methods
Neural Stem Cells/*metabolism
Alzheimer Disease/genetics ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Cell Differentiation ; Drug Evaluation, Preclinical/methods ; Extracellular Space/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Humans ; Microtubule-Associated Proteins/metabolism ; Neural Stem Cells/pathology ; Neurites/metabolism ; Phosphorylation ; Presenilin-1/metabolism ; Protein Aggregation, Pathological ; Reproducibility of Results ; tau Proteins/chemistry ; tau Proteins/metabolism