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Tytuł :
César Augusto Restrepo Valencia, Consuelo Vélez Álvarez Abstract Objective. To evaluate the effectiveness of calcineurin ciclosporin and tacrolimus inhibitors to induce remission in patients with refractory lupus nephritis. Patients, materials and methods. Patients with lupus nephritis class IV-G who despite receiving therapy with high doses of steroid and with a cytostatic (cyclophosphamide or mycophenolate) for 3 months had not been able to induce some kind of remission.The exclusion criteria were creatinine levels greater than 3 mg / dl, pregnancy, previous history of exposure to calcineurin inhibitors, cancer, active infections, uncontrolled hypertension, and negligence with medication intake. The recommended dose of cyclosporine was 3 mg / kg / day and tacrolimus 0.1 mg / kg / day, in joint with prednisone 0.3 mg / kg / day, cyclophosphamide 1 mg / kg / day or mycophenolate mofetil 1 gram every 12 hours. The cyclophosphamide was administered only during 6 months, after which it was changed to azathioprine at doses of 1 mg / kg / day. Still, mycophenolate was continued at the same dose. All patients completed a minimum period of 12 months follow-up, it was considered that patients achieved partial remission when proteinuria decreased by 50% of the baseline value or its value decreased to less than 1 gram in 24 hours, decrease of leukocytes count and red blood cells in urine of 50%, and creatinine values were stable. A complete remission was considered when there was a reduction in proteinuria in a value less than 300 mg per 24 hours, urinary sediment with less than 3 red blood cells, less than 5 leukocyte for each high power microscopic field, and a creatinine value reduction by 50% or reaching a normal value. Results. Twelve patients met the inclusion criteria and initiated the calcineurin inhibitor protocol. Two presented accelerated deterioration in their function and required chronic dialysis therapy. Ten patients with active treatment completed 12 months of follow-up, of which 4 (40%) had partial remission (PR), 5 (50%) complete remission (RC). One patient had no significant modification to his baseline values. The following findings were made for all the patients with any significant degree of remission: their creatinine levels were reduced significantly from an average value of 1,34 +/-0,7 mg/dl to an average of 0,96 +/- 0,3 mg/dl and 0,97 +/- 0,24 mg/dl for measurements taken 6 and 12 months respectively after the start of the treatment (p<0,05). The protein levels in the urine in a timeframe of 24 hours changed from a baseline value of 2865 +/- 2586.7 milligrams to 824 +/- 981.9 milligrams at 6 months, and 488 +/- 697.7 milligrams at 12 months (p <0.05). On average, in both PR and CR patients, the C3 levels raised unlike the values for antinuclear antibodies that were diminished. No patients died, nor were there significant side effects triggered by medications. No patient presented relapses during the follow-up time. Conclusion. The calcineurin inhibitors at low doses are an important alternative to induce partial or complete remission in patients with refractory lupus nephritis compared to classic steroid and cytostatic treatment. It is required to do a long-term follow-up to establish its safety profile at low doses and relapse rate after suspension. Keywords Lupus nephritis, cyclosporine, tacrolimus. References Cameron J S. Lupus Nephritis. J Am Soc Nephrol 10:413-424. Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P, Mejía JC, Aydintug AO, Chwalinska-Sadowska H, de Ramón E, Fernández-Nebro A, Galeazzi M, Valen M, Mathieu A, Houssiau F, Caro N, Alba P, Ramos-Casals M, Ingelmo M, Hughes GR; European Working Party on Systemic Lupus Erythematosus. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore). 2003;82:299-308. Austin HA 3rd, Klippel JH, Balow JE, le Riche NG, Steinberg AD, Plotz PH, Decker JL. Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs. N Engl J Med. 1986 Mar 6;314(10):614-619. Boumpas DT, Austin HA 3rd, Vaughn EM, Klippel JH, Steinberg AD, Yarboro CH, Balow JE. Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Lancet. 1992;340:741- 45. Gourley MF, Austin HA 3rd, Scott D, Yarboro CH, Vaughan EM, Muir J, Boumpas DT, Klippel JH, Balow JE, Steinberg AD. Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized, controlled trial. Ann Intern Med. 1996;125:549-557. Walsh M, James M, Jayne D, Tonelli M, Manns BJ, Hemmelgarn BR. 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Copyright (c) User Username Password Remember me This journal follows the principles and procedures given by the Committee on Publication Ethics (COPE) www.publicationethics.org Instructions for authors How to submit an article How to upload a modified version Instructions for reviewers How to review an article Instructions for associate editors How to send it to reviewers How to send corrections to authors Language Select Language Journal Content Search Search Scope Browse By Issue By Author By Title About The Authors César Augusto Restrepo Valencia Facultad de Ciencias para la Salud, Departamento de Medicina Interna, Universidad de Caldas, Manizales, Colombia Colombia Consuelo Vélez Álvarez Grupo de Investigación Promoción de la Salud y revención de la enfermedad, Facultad de Ciencias para la Salud, Departamento de Salud Pública Colombia Font Size Make font size smaller Make font size default Make font size larger Information For Readers For Authors For Librarians Indexaciones JournalTOCs Notifications View Subscribe Keywords Adolescence Biocompatible peritoneal dialysis solutions Chronic renal disease Glucose degradation products (GDP) Rejection chronic renal insufficiency education. fatty acids folic acid graft biopsy inflammation, Polivinil chloride (PVC), phthalates kidney Transplant peritoneal dialysis proteins. renal protection residual renal function. scintigraphy survival transition transplant. zinc
Autorzy :
César Augusto Restrepo Valencia
Consuelo Vélez Álvarez
Pokaż więcej
Temat :
Lupus nephritis
cyclosporine
Internal medicine
RC31-1245
Diseases of the genitourinary system. Urology
RC870-923
Źródło :
Revista Colombiana de Nefrología, Vol 2, Iss 1, Pp 77-88 (2014)
Opis pliku :
electronic resource
Relacje :
http://www.revistanefrologia.org/index.php/rcn/article/view/179/pdf; https://doaj.org/toc/2389-7708; https://doaj.org/toc/2500-5006
Dostęp URL :
https://doaj.org/article/d5057296d78e4f559d54e4d243eaefc5
Czasopismo naukowe
Tytuł :
Nanoindentation of Calcified and Non-calcified Components of Atherosclerotic Tissues
Autorzy :
Cahalane, R. M.
Walsh, M. T.Aff1, Aff2
Pokaż więcej
Źródło :
Experimental Mechanics: An International Journal Integrating Experimental Methods with the Mechanical Behavior of Materials and Structures. :1-14
Czasopismo naukowe
Tytuł :
Walsh, M F, 217341
URL :
http://hdl.handle.net/11343/190190">http://hdl.handle.net/11343/190190
Series: [2016.0049] "MISSING, WOUNDED AND PRISONER OF WAR ENQUIRY CARDS"
Zasób elektroniczny
Tytuł :
Walsh, M J, 1734630
URL :
http://hdl.handle.net/11343/190191">http://hdl.handle.net/11343/190191
Series: [2016.0049] "MISSING, WOUNDED AND PRISONER OF WAR ENQUIRY CARDS"
Zasób elektroniczny
Tytuł :
Walsh, M M, VX40782
URL :
http://hdl.handle.net/11343/153678">http://hdl.handle.net/11343/153678
Series: [2016.0049] "MISSING, WOUNDED AND PRISONER OF WAR ENQUIRY CARDS"
Zasób elektroniczny
Tytuł :
Walsh, M F, 217341
URL :
http://hdl.handle.net/11343/190190">http://hdl.handle.net/11343/190190
Series: [2016.0049] "MISSING, WOUNDED AND PRISONER OF WAR ENQUIRY CARDS"
Zasób elektroniczny
Tytuł :
Walsh, M J, 1734630
URL :
http://hdl.handle.net/11343/190191">http://hdl.handle.net/11343/190191
Series: [2016.0049] "MISSING, WOUNDED AND PRISONER OF WAR ENQUIRY CARDS"
Zasób elektroniczny
Tytuł :
Walsh, M M, VX40782
URL :
http://hdl.handle.net/11343/153678">http://hdl.handle.net/11343/153678
Series: [2016.0049] "MISSING, WOUNDED AND PRISONER OF WAR ENQUIRY CARDS"
Zasób elektroniczny
Tytuł :
The Presence of a High Peak Feature Within Low-Average Shear Stimuli Induces Quiescence in Venous Endothelial Cells
Autorzy :
Franzoni, M.Aff1, Aff2
O’Connor, D. T.Aff1, Aff2
Marcar, L.
Power, D.Aff2, Aff3
Moloney, M. A.Aff2, Aff3
Kavanagh, E. G.Aff2, Aff3
Leask, R. L.
Nolan, J.Aff2, Aff5
Kiely, P. A.Aff2, Aff5
Walsh, M. T.Aff1, Aff2
Pokaż więcej
Źródło :
Annals of Biomedical Engineering: The Journal of the Biomedical Engineering Society. 48(2):582-594
Czasopismo naukowe

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