- Tytuł:
-
Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers
apoptosis via mitochondrial pathway. - Autorzy:
- Źródło:
- Chemical biology & drug design [Chem Biol Drug Des] 2019 Apr; Vol. 93 (4), pp. 617-627. Date of Electronic Publication: 2019 Jan 11.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Antineoplastic Agents/*pharmacology
Apoptosis /*drug effects
Mitochondria/*metabolism
Quinoxalines/*chemistry
Reactive Oxygen Species/*metabolism
Tubulin/*chemistry
Tubulin Modulators/*chemical synthesis
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Binding Sites ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Dose-Response Relationship, Drug ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Quinoxalines/metabolism ; Quinoxalines/pharmacology ; Structure-Activity Relationship ; Tubulin/metabolism ; Tubulin Modulators/metabolism ; Tubulin Modulators/pharmacology ; Up-Regulation/drug effects
Czasopismo naukowe