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Tytuł :
Human umbilical cord mesenchymal stem cells attenuate podocyte injury under high glucose via TLR2 and TLR4 signaling.
Autorzy :
Wang Y; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong 250012, China.
Liu J; Graduate School of Arts and Sciences, Columbia University, USA.
Zhang Q; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong 250012, China.
Wang W; Zibo Central Hospital, Shandong, China.
Liu Q; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China.
Liu S; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China.
Song Y; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China.
Wang X; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China.
Zhang Y; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China.
Li S; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong 250012, China.
Yang X; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong 250012, China.
Lv S; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China. Electronic address: .
Liu G; Nephrology Research Institute of Shandong University, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong 250012, China. Electronic address: .
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Źródło :
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2021 Mar; Vol. 173, pp. 108702. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Fetal Blood/*metabolism
Glucose/*metabolism
Mesenchymal Stem Cells/*metabolism
Podocytes/*metabolism
Toll-Like Receptor 2/*metabolism
Toll-Like Receptor 4/*metabolism
Animals ; Disease Models, Animal ; Humans ; Inflammation/metabolism ; Male ; Mice ; Signal Transduction
Czasopismo naukowe
Tytuł :
Coaxial electrospinning of PEEU/gelatin to fiber meshes with enhanced mesenchymal stem cell attachment and proliferation.
Autorzy :
Tung WT; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; University of Potsdam, Potsdam, Germany.
Zou J; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Sun X; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; University of Potsdam, Potsdam, Germany.
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Gould OEC; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Kratz K; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; University of Potsdam, Potsdam, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2020; Vol. 74 (1), pp. 53-66.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation/*physiology
Gelatin/*chemistry
Mesenchymal Stem Cells/*metabolism
Polyesters/*chemistry
Polymers/*metabolism
Tissue Engineering/*methods
Humans ; Tissue Scaffolds/chemistry
Czasopismo naukowe
Tytuł :
Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.
Autorzy :
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Li Z; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Kratz K; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials for Medicine', Teltow, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials for Medicine', Teltow, Germany.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials for Medicine', Teltow, Germany.; Institute of Chemistry, University of Potsdam, Potsdam, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2019; Vol. 71 (2), pp. 277-289.
Typ publikacji :
Journal Article
MeSH Terms :
Acrylates/*therapeutic use
Arteries/*drug effects
Mesenchymal Stem Cells/*metabolism
Polymers/*therapeutic use
Vascular Endothelial Growth Factor A/*metabolism
Acrylates/pharmacology ; Elasticity ; Humans ; Mesenchymal Stem Cells/cytology ; Polymers/pharmacology
Czasopismo naukowe
Tytuł :
Microscale roughness regulates laminin-5 secretion of bone marrow mesenchymal stem cells.
Autorzy :
Zou J; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Nie Y; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.; Institute of Chemistry, University of Potsdam, Potsdam, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2019; Vol. 73 (1), pp. 237-247.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Marrow Cells/*metabolism
Cell Adhesion Molecules/*metabolism
Mesenchymal Stem Cells/*metabolism
Bone Marrow Cells/cytology ; Cell Differentiation ; Cells, Cultured ; Humans
Czasopismo naukowe
Tytuł :
The effect of stiffness variation of electrospun fiber meshes of multiblock copolymers on the osteogenic differentiation of human mesenchymal stem cells.
Autorzy :
Sun X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.
Tung W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Zou J; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.
Gould OEC; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Kratz K; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2019; Vol. 73 (1), pp. 219-228.
Typ publikacji :
Journal Article
MeSH Terms :
Mesenchymal Stem Cells/*metabolism
Nanofibers/*chemistry
Osteogenesis/*genetics
Polymers/*metabolism
Cell Differentiation ; Humans
Czasopismo naukowe
Tytuł :
Evaluation of human mesenchymal stem cell senescence, differentiation and secretion behavior cultured on polycarbonate cell culture inserts.
Autorzy :
Zou J
Wang W
Kratz K
Xu X
Nie Y
Ma N
Lendlein A
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2018; Vol. 70 (4), pp. 573-583.
Typ publikacji :
Journal Article
MeSH Terms :
Mesenchymal Stem Cells/*metabolism
Polycarboxylate Cement/*metabolism
Cell Culture Techniques ; Cell Differentiation ; Cell Proliferation ; Humans
Czasopismo naukowe
Tytuł :
Biological Membrane-Packed Mesenchymal Stem Cells Treat Acute Kidney Disease by Ameliorating Mitochondrial-Related Apoptosis.
Autorzy :
Geng X; Department of Nephrology, PLA General Hospital, Institute of Nephrology, Beijing Key Laboratory of Kidney Disease, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing 100853, China.
Hong Q; Department of Nephrology, PLA General Hospital, Institute of Nephrology, Beijing Key Laboratory of Kidney Disease, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing 100853, China.
Wang W; Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China.
Zheng W; Department of Nephrology, PLA General Hospital, Institute of Nephrology, Beijing Key Laboratory of Kidney Disease, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing 100853, China.
Li O; Department of Nephrology, PLA General Hospital, Institute of Nephrology, Beijing Key Laboratory of Kidney Disease, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing 100853, China.
Cai G; Department of Nephrology, PLA General Hospital, Institute of Nephrology, Beijing Key Laboratory of Kidney Disease, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing 100853, China.
Chen X; Department of Nephrology, PLA General Hospital, Institute of Nephrology, Beijing Key Laboratory of Kidney Disease, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing 100853, China.
Wu D; Department of Nephrology, PLA General Hospital, Institute of Nephrology, Beijing Key Laboratory of Kidney Disease, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing 100853, China.
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Źródło :
Scientific reports [Sci Rep] 2017 Jan 24; Vol. 7, pp. 41136. Date of Electronic Publication: 2017 Jan 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Acute Kidney Injury/*therapy
Cell Membrane/*metabolism
Mesenchymal Stem Cells/*metabolism
Mitochondria/*metabolism
Rhabdomyolysis/*metabolism
Acute Kidney Injury/chemically induced ; Acute Kidney Injury/metabolism ; Animals ; Cadherins/metabolism ; Cell Line ; Cell Survival ; Cell- and Tissue-Based Therapy/methods ; Glycerol/administration & dosage ; Humans ; Male ; Mice, Inbred C57BL ; Rhabdomyolysis/therapy
Czasopismo naukowe
Tytuł :
Functional Nanoparticles and their Interactions with Mesenchymal Stem Cells.
Autorzy :
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, KantstraBe 55, 14513 Teltow. Germany.
Deng Z; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, KantstraBe 55, 14513 Teltow. Germany.
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, KantstraBe 55, 14513 Teltow. Germany.
Li Z; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, KantstraBe 55, 14513 Teltow. Germany.
Jung F; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, KantstraBe 55, 14513 Teltow. Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz- Zentrum Geesthacht, KantstraBe 55, 14513 Teltow. Germany.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz- Zentrum Geesthacht, KantstraBe 55, 14513 Teltow. Germany.
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Źródło :
Current pharmaceutical design [Curr Pharm Des] 2017; Vol. 23 (26), pp. 3814-3832.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mesenchymal Stem Cells/*metabolism
Nanoparticles/*metabolism
Animals ; Cell Survival/drug effects ; Cell Survival/physiology ; Endocytosis/drug effects ; Endocytosis/physiology ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cell Transplantation/trends ; Mesenchymal Stem Cells/drug effects ; Nanoparticles/administration & dosage ; Surface Properties
Czasopismo naukowe
Tytuł :
Adipogenic differentiation of human adipose derived mesenchymal stem cells in 3D architectured gelatin based hydrogels (ArcGel).
Autorzy :
Zou J; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität, Berlin, Germany.
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Neffe AT; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials in Medicine', Teltow, Germany.
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität, Berlin, Germany.
Li Z; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität, Berlin, Germany.
Deng Z; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität, Berlin, Germany.
Sun X; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Biochemistry and Biology, Universität Potsdam, Potsdam, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität, Berlin, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials in Medicine', Teltow, Germany.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität, Berlin, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials in Medicine', Teltow, Germany.; Institute of Biochemistry and Biology, Universität Potsdam, Potsdam, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2017; Vol. 67 (3-4), pp. 297-307.
Typ publikacji :
Journal Article
MeSH Terms :
Adipose Tissue/*metabolism
Gelatin/*chemistry
Hydrogels/*metabolism
Mesenchymal Stem Cells/*metabolism
Tissue Scaffolds/*chemistry
Adipose Tissue/cytology ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Humans ; Mesenchymal Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Modulation of the mesenchymal stem cell migration capacity via preconditioning with topographic microstructure.
Autorzy :
Li Z; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Kratz K; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials in Medicine', Teltow, Germany.
Sun X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Biochemistry and Biology, Universität Potsdam, Potsdam, Germany.
Zou J; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Deng Z; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Jung F; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials in Medicine', Teltow, Germany.
Gossen M; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials in Medicine', Teltow, Germany.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.; Institute of Biochemistry and Biology, Universität Potsdam, Potsdam, Germany.; Helmholtz Virtual Institute 'Multifunctional Biomaterials in Medicine', Teltow, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2017; Vol. 67 (3-4), pp. 267-278.
Typ publikacji :
Journal Article
MeSH Terms :
Mesenchymal Stem Cells/*metabolism
Animals ; Humans ; Immunohistochemistry ; Mesenchymal Stem Cells/cytology ; Rats
Czasopismo naukowe
Tytuł :
Folate receptor mediated genetic modification of human mesenchymal stem cells via folic acid-polyethylenimine-grafted poly(N-3-hydroxypropyl)aspartamide.
Autorzy :
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, University of Rostock, Rostock, Germany.
Li W; Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, University of Rostock, Rostock, Germany.
Wang J; Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou, P. R. China.
Hu Q; Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou, P. R. China.
Balk M; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Bieback K; Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden-Württemberg-Hessen, Heidelberg University, Mannheim, Germany.
Stamm C; Charité - Universitätsmedizin Berlin, Deutsches Herzzentrum Berlin, Berlin-Brandenburg Center for Regenerative Therapies, Germany.
Jung F; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Tang G; Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou, P. R. China.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Free University of Berlin, Berlin, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Free University of Berlin, Berlin, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2017; Vol. 67 (3-4), pp. 279-295.
Typ publikacji :
Journal Article
MeSH Terms :
Folic Acid/*metabolism
Mesenchymal Stem Cells/*metabolism
Polyethyleneimine/*metabolism
Polymers/*metabolism
Humans
Czasopismo naukowe
Tytuł :
Perichondrium mesenchymal stem cells inhibit the growth of breast cancer cells via the DKK-1/Wnt/β-catenin signaling pathway.
Autorzy :
Li M; The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Cai H; Department of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Yang Y; The Third Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.
Zhang J; The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Sun K; Department of Medical Oncology, The Second Hospital of Lanzhou, Lanzhou, Gansu 730000, P.R. China.
Yan Y; The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Qu H; The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Wang W; Department of Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing 400016, P.R. China.
Wang J; The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Duan X; Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2016 Aug; Vol. 36 (2), pp. 936-44. Date of Electronic Publication: 2016 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
Cell Proliferation/*genetics
Intercellular Signaling Peptides and Proteins/*genetics
Mesenchymal Stem Cells/*pathology
Wnt Signaling Pathway/*genetics
Animals ; Breast Neoplasms/metabolism ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Culture Media, Conditioned/metabolism ; Down-Regulation/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Mesenchymal Stem Cells/metabolism ; Neoplasm Invasiveness/genetics ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
[IFN-γ up-regulates PD-L1 expression in human placenta mesenchymal stem cells and enhances cell ability to induce the differentiation of IL-10+ T cells from cord blood- and peripheral blood-derived T cells].
Autorzy :
Wang W; Department of Immunology, Binzhou Medical University, Yantai 264003, China.
Li H; Department of Immunology, Binzhou Medical University, Yantai 264003, China.
Xu F; Department of Immunology, Binzhou Medical University, Yantai 264003, China.
DU H; Department of Gynecology and Obstetrics, Laishan First People's Hospital, Yantai 264003, China.
Li X; Yantai Center Blood Station, Yantai 264003, China.
Yi J; Department of Immunology, Binzhou Medical University, Yantai 264003, China.
Wang G; Department of Laboratory Medicine, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264003, China.
Luan X; Department of Immunology, Binzhou Medical University, Yantai 264003, China. *Corresponding author, E-mail: xyluan@ sohu.com.
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2016 Feb; Vol. 32 (2), pp. 191-5.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
Cell Differentiation/*drug effects
Interferon-gamma/*pharmacology
Mesenchymal Stem Cells/*drug effects
T-Lymphocytes/*drug effects
Adult ; Animals ; B7-H1 Antigen/genetics ; Cells, Cultured ; Coculture Techniques ; Female ; Fetal Blood/cytology ; Flow Cytometry ; Gene Expression/drug effects ; Humans ; Interleukin-10/metabolism ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Placenta/cytology ; Pregnancy ; Reverse Transcriptase Polymerase Chain Reaction ; Sheep ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
MiR-214 Attenuates Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1.
Autorzy :
Yang L; Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ge D
Cao X
Ge Y
Chen H
Wang W
Zhang H
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2016; Vol. 38 (2), pp. 809-20. Date of Electronic Publication: 2016 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Mesenchymal Stem Cells/*cytology
MicroRNAs/*genetics
Osteoblasts/*cytology
Osteoporosis, Postmenopausal/*genetics
Receptor, Fibroblast Growth Factor, Type 1/*genetics
Animals ; Cell Differentiation ; Cells, Cultured ; Down-Regulation ; Female ; Humans ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/pathology ; Mice ; Mice, Inbred C57BL ; Osteoblasts/metabolism ; Osteoblasts/pathology ; Osteogenesis ; Osteoporosis, Postmenopausal/physiopathology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma.
Autorzy :
Wang W; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Zhong W; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Yuan J; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Yan C; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Hu S; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Tong Y; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Mao Y; Department of Basic Medicine, Medical College of Xiamen University, Xiamen 361102, China.
Hu T; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Zhang B; Department of Basic Medicine, Medical College of Xiamen University, Xiamen 361102, China.
Song G; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
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Źródło :
Oncotarget [Oncotarget] 2015 Dec 08; Vol. 6 (39), pp. 42276-89.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bile Duct Neoplasms/*genetics
Cholangiocarcinoma/*genetics
Mesenchymal Stem Cells/*metabolism
Wnt Signaling Pathway/*genetics
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/metabolism ; Blotting, Western ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cells, Cultured ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/metabolism ; Culture Media, Conditioned/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic ; Ginsenosides/pharmacology ; Humans ; Male ; Mesenchymal Stem Cells/cytology ; Mice, Inbred BALB C ; Mice, Nude ; Microscopy, Confocal ; Neoplasm Metastasis ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Burden/drug effects ; Tumor Burden/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Spray- and laser-assisted biomaterial processing for fast and efficient autologous cell-plus-matrix tissue engineering.
Autorzy :
Klopsch C; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Gäbel R; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Kaminski A; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Mark P; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Wang W; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Toelk A; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Delyagina E; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Kleiner G; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Koch L; Laser Zentrum Hannover, Germany.
Chichkov B; Laser Zentrum Hannover, Germany.
Mela P; Department of Tissue Engineering and Textile Implants, AME-Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Germany.
Jockenhoevel S; Department of Tissue Engineering and Textile Implants, AME-Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Germany.
Ma N; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
Steinhoff G; Reference and Translation Centre for Cardiac Stem Cell Therapy, University of Rostock, Germany.; Department of Cardiac Surgery, Medical Faculty, University of Rostock, Germany.
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Źródło :
Journal of tissue engineering and regenerative medicine [J Tissue Eng Regen Med] 2015 Dec; Vol. 9 (12), pp. E177-90. Date of Electronic Publication: 2012 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Extracellular Matrix/*chemistry
Human Umbilical Vein Endothelial Cells/*metabolism
Mesenchymal Stem Cells/*metabolism
Polyesters/*chemistry
Tissue Engineering/*methods
Female ; Human Umbilical Vein Endothelial Cells/cytology ; Humans ; Male ; Mesenchymal Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Interferon-γ and tumor necrosis factor-α promote the ability of human placenta-derived mesenchymal stromal cells to express programmed death ligand-2 and induce the differentiation of CD4(+)interleukin-10(+) and CD8(+)interleukin-10(+)Treg subsets.
Autorzy :
Li H; Department of Immunology, Binzhou Medical University, Shandong Province, Yantai, People's Republic of China.
Wang W; Department of Immunology, Binzhou Medical University, Shandong Province, Yantai, People's Republic of China.
Wang G; Department of Laboratory, Affiliated Yantai Hospital of Binzhou Medical University, Yantai, People's Republic of China.
Hou Y; Department of Histology and Embryology, Binzhou Medical University, Shandong Province, Yantai, People's Republic of China.
Xu F; Department of Immunology, Binzhou Medical University, Shandong Province, Yantai, People's Republic of China.
Liu R; Department of Reproductive Medicine, Affiliated Yantai Hospital of Binzhou Medical University, Yantai, People's Republic of China.
Wang F; Department of Anesthesiology, Affiliated Yantai Hospital of Binzhou Medical University, Yantai, People's Republic of China.
Xue J; Department of Immunology, Binzhou Medical University, Shandong Province, Yantai, People's Republic of China.
Hu T; Department of Immunology, Binzhou Medical University, Shandong Province, Yantai, People's Republic of China.
Luan X; Department of Immunology, Binzhou Medical University, Shandong Province, Yantai, People's Republic of China. Electronic address: .
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Źródło :
Cytotherapy [Cytotherapy] 2015 Nov; Vol. 17 (11), pp. 1560-71.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon-gamma/*metabolism
Interleukin-10/*metabolism
Mesenchymal Stem Cells/*physiology
Placenta/*cytology
Programmed Cell Death 1 Ligand 2 Protein/*metabolism
T-Lymphocytes, Regulatory/*metabolism
Tumor Necrosis Factor-alpha/*metabolism
CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/metabolism ; CD8 Antigens/metabolism ; Cell Differentiation/drug effects ; Coculture Techniques ; Female ; Humans ; Interferon-gamma/immunology ; Interferon-gamma/pharmacology ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Pregnancy ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
The interaction of adipose-derived human mesenchymal stem cells and polyether ether ketone.
Autorzy :
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Kratz K; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Helmholtz Virtual Institute - Multifunctional Materials in Medicine, Berlin and Teltow, Teltow, Germany.
Behl M; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Yan W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry, University of Potsdam, Potsdam, Germany.
Liu Y; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry, University of Potsdam, Potsdam, Germany.
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Baudis S; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Li Z; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Kurtz A; Berlin-Brandenburg Center for Regenerative Therapies, Charité - University Medicine Berlin, Berlin, Germany.; College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Gwangk-ro 1, Gwanak-gu, Seoul, Korea.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Helmholtz Virtual Institute - Multifunctional Materials in Medicine, Berlin and Teltow, Teltow, Germany.; Institute of Chemistry, University of Potsdam, Potsdam, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.; Helmholtz Virtual Institute - Multifunctional Materials in Medicine, Berlin and Teltow, Teltow, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2015; Vol. 61 (2), pp. 301-21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipose Tissue/*cytology
Biocompatible Materials/*pharmacology
Ketones/*pharmacology
Mesenchymal Stem Cells/*cytology
Osseointegration/*physiology
Polyethylene Glycols/*pharmacology
Adipose Tissue/physiology ; Cells, Cultured ; Humans ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/physiology ; Osseointegration/drug effects ; Prostheses and Implants ; Tissue Scaffolds
Czasopismo naukowe
Tytuł :
Controlling major cellular processes of human mesenchymal stem cells using microwell structures.
Autorzy :
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstraße 55, 14513, Teltow, Germany; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Wang W
Kratz K
Fang L
Li Z
Kurtz A
Ma N
Lendlein A
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Źródło :
Advanced healthcare materials [Adv Healthc Mater] 2014 Dec; Vol. 3 (12), pp. 1991-2003. Date of Electronic Publication: 2014 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Physiological Phenomena*/drug effects
Cell Physiological Phenomena*/physiology
Mesenchymal Stem Cells*/cytology
Mesenchymal Stem Cells*/drug effects
Mesenchymal Stem Cells*/physiology
Cell Culture Techniques/*methods
Adipose Tissue/cytology ; Biocompatible Materials/pharmacology ; Cells, Cultured ; Humans ; Vitronectin/pharmacology ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Genetic engineering of mesenchymal stem cells by non-viral gene delivery.
Autorzy :
Wang W; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Xu X; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Li Z; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Lendlein A; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany Helmholtz Virtual Institute - Multifunctional Materials in Medicine, Berlin and Teltow, Germany.
Ma N; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany Helmholtz Virtual Institute - Multifunctional Materials in Medicine, Berlin and Teltow, Germany Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
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Źródło :
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2014; Vol. 58 (1), pp. 19-48.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Transfer Techniques*
Genetic Engineering/*methods
Mesenchymal Stem Cells/*cytology
Animals ; Bone Marrow Cells/cytology ; Cell Differentiation ; Cell Lineage ; DNA/chemistry ; Electroporation ; Humans ; Microscopy, Phase-Contrast ; Nanoparticles/chemistry ; Nanotechnology/methods ; RNA, Messenger/metabolism ; RNA, Small Interfering/metabolism ; Tissue Engineering/methods ; Transfection
Czasopismo naukowe

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