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Tytuł :
Laparoscopic hepatectomy enhances recovery for small hepatocellular carcinoma with liver cirrhosis by postoperative inflammatory response attenuation: a propensity score matching analysis with a conventional open approach.
Autorzy :
Fu XT; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.
Tang Z; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.
Chen JF; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.
Shi YH; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.
Liu WR; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.
Gao Q; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.
Ding GY; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.
Song K; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.
Wang XY; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China. wang..
Zhou J; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China.; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, China.
Fan J; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China. .; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, China. .
Ding ZB; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032, China. .
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Źródło :
Surgical endoscopy [Surg Endosc] 2021 Feb; Vol. 35 (2), pp. 910-920. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*surgery
Hepatectomy/*methods
Laparoscopy/*methods
Liver Cirrhosis/*surgery
Liver Neoplasms/*surgery
Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Propensity Score ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Laparoscopic Versus Open Left Lateral Segmentectomy for Large Hepatocellular Carcinoma: A Propensity Score-Matched Analysis.
Autorzy :
Fu XT; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Tang Z; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Shi YH; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Zhou J; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, China.
Liu WR; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Gao Q; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Ding GY; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Chen JF; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Song K; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Wang XY; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
Fan J; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, China.
Ding ZB; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.
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Źródło :
Surgical laparoscopy, endoscopy & percutaneous techniques [Surg Laparosc Endosc Percutan Tech] 2019 Dec; Vol. 29 (6), pp. 513-519.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasm Staging*
Propensity Score*
Carcinoma, Hepatocellular/*surgery
Hepatectomy/*methods
Laparoscopy/*methods
Liver Neoplasms/*surgery
Postoperative Complications/*epidemiology
Adult ; Aged ; Carcinoma, Hepatocellular/diagnosis ; China/epidemiology ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Incidence ; Length of Stay/trends ; Liver Neoplasms/diagnosis ; Male ; Middle Aged ; Operative Time ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression.
Autorzy :
Yang X; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Miao BS; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Wei CY; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Dong RZ; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Gao PT; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Zhang XY; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Lu JC; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Gao C; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Wang XY; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Sun HC; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Zhou J; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Fan J; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Ke AW; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Shi GM; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Cai JB; Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
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Źródło :
Cancer science [Cancer Sci] 2019 Jul; Vol. 110 (7), pp. 2133-2144. Date of Electronic Publication: 2019 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Carcinoma, Hepatocellular/*pathology
Chromosomal Proteins, Non-Histone/*genetics
DNA Helicases/*metabolism
Liver Neoplasms/*pathology
Microfilament Proteins/*genetics
Aged ; Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Mice ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Prognosis ; Sequence Analysis, RNA ; Survival Analysis ; Tissue Array Analysis ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Activated and Exhausted MAIT Cells Foster Disease Progression and Indicate Poor Outcome in Hepatocellular Carcinoma.
Autorzy :
Duan M; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Goswami S; Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Shi JY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Wu LJ; School of Mathematical Sciences, Peking University, Beijing, China.
Wang XY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Ma JQ; Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Zhang Z; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Shi Y; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Ma LJ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Zhang S; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Xi RB; School of Mathematical Sciences, Peking University, Beijing, China.; Center for Statistical Sciences, Peking University, Beijing, China.
Cao Y; Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.
Zhou J; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.; Institute of Biomedical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
Fan J; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China. .; Institute of Biomedical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
Zhang XM; Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China. .
Gao Q; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China. .; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Jun 01; Vol. 25 (11), pp. 3304-3316. Date of Electronic Publication: 2019 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*
Liver Neoplasms/*immunology
Mucosal-Associated Invariant T Cells/*immunology
Disease Progression ; Hepatitis A Virus Cellular Receptor 2 ; Humans ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
CCL15 Recruits Suppressive Monocytes to Facilitate Immune Escape and Disease Progression in Hepatocellular Carcinoma.
Autorzy :
Liu LZ; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Zhang Z; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Zheng BH; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Shi Y; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Duan M; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Ma LJ; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Wang ZC; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Dong LQ; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Dong PP; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shi JY; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Zhang S; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Ding ZB; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Ke AW; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Cao Y; Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.
Zhang XM; Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Xi R; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Zhou J; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.; Institute of Biomedical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
Fan J; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.; Institute of Biomedical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
Wang XY; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Gao Q; Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2019 Jan; Vol. 69 (1), pp. 143-159. Date of Electronic Publication: 2018 Dec 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Carcinoma, Hepatocellular/*immunology
Chemokines, CC/*physiology
Liver Neoplasms/*immunology
Macrophage Inflammatory Proteins/*physiology
Monocytes/*physiology
Tumor Escape/*physiology
Carcinoma, Hepatocellular/pathology ; Humans ; Liver Neoplasms/pathology ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Radiomics score: a potential prognostic imaging feature for postoperative survival of solitary HCC patients.
Autorzy :
Zheng BH; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Liu LZ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Zhang ZZ; Department of Hematology, Shanghai Jiao Tong University School of Medicine Affiliated Tongren Hospital, Shanghai, China.
Shi JY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Dong LQ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Tian LY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Ding ZB; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Ji Y; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Rao SX; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhou J; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Fan J; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.; Institute of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Wang XY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. wang..
Gao Q; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. .; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, People's Republic of China. .
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Źródło :
BMC cancer [BMC Cancer] 2018 Nov 21; Vol. 18 (1), pp. 1148. Date of Electronic Publication: 2018 Nov 21.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*diagnostic imaging
Hepatectomy/*methods
Liver Neoplasms/*diagnostic imaging
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Cohort Studies ; Diagnostic Imaging/methods ; Diagnostic Imaging/standards ; Diagnostic Imaging/statistics & numerical data ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Nomograms ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/statistics & numerical data ; Postoperative Period ; Prognosis ; Proportional Hazards Models ; Young Adult
Czasopismo naukowe
Tytuł :
Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinoma.
Autorzy :
Ma LJ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Feng FL; Department of Biliary Surgery, Eastern Hepatobiliary Surgical Hospital, Naval Military Medical University, Shanghai 200082, China.
Dong LQ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Zhang Z; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Duan M; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Liu LZ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Shi JY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Yang LX; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Wang ZC; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Zhang S; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Ding ZB; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Ke AW; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Cao Y; Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China.
Zhang XM; Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200032, China.
Zhou J; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Fan J; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Wang XY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Gao Q; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200433, China.
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Źródło :
Theranostics [Theranostics] 2018 Nov 10; Vol. 8 (20), pp. 5690-5702. Date of Electronic Publication: 2018 Nov 10 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Amplification*
B7-H1 Antigen/*genetics
Carcinoma, Hepatocellular/*genetics
Carcinoma, Hepatocellular/*pathology
Programmed Cell Death 1 Ligand 2 Protein/*genetics
Programmed Cell Death 1 Receptor/*genetics
Fluorescent Antibody Technique ; Gene Expression Profiling ; Humans ; In Situ Hybridization, Fluorescence ; Microarray Analysis ; Real-Time Polymerase Chain Reaction ; Tissue Array Analysis
Czasopismo naukowe
Tytuł :
MicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma.
Autorzy :
Fu XT; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: .
Shi YH; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: .
Zhou J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China; Institute of Biomedical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Peng YF; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: .
Liu WR; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: .
Shi GM; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: .
Gao Q; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: .
Wang XY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: wang..
Song K; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: .
Fan J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China; Institute of Biomedical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Ding ZB; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2018 Jan 01; Vol. 412, pp. 108-117. Date of Electronic Publication: 2017 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Anoikis*
Autophagy/*physiology
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
MicroRNAs/*physiology
Adult ; Aged ; Animals ; Autophagy-Related Protein 5/physiology ; Cell Line, Tumor ; Female ; Humans ; Lung Neoplasms/secondary ; Male ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local
Czasopismo naukowe
Tytuł :
Telomere length variation in tumor cells and cancer-associated fibroblasts: potential biomarker for hepatocellular carcinoma.
Autorzy :
Ma LJ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Wang XY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Duan M; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Liu LZ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Shi JY; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Dong LQ; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Yang LX; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Wang ZC; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Ding ZB; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Ke AW; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Cao Y; Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, PR China.
Zhang XM; Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, PR China.
Zhou J; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Fan J; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.
Gao Q; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, PR China.; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, PR China.
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Źródło :
The Journal of pathology [J Pathol] 2017 Dec; Vol. 243 (4), pp. 407-417. Date of Electronic Publication: 2017 Oct 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Telomere Homeostasis*
Telomere Shortening*
Cancer-Associated Fibroblasts/*metabolism
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
Telomere/*metabolism
Cancer-Associated Fibroblasts/pathology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Cell Line, Tumor ; Chi-Square Distribution ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Kaplan-Meier Estimate ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Multivariate Analysis ; Mutation ; Neoplasm Recurrence, Local ; Promoter Regions, Genetic ; Proportional Hazards Models ; Real-Time Polymerase Chain Reaction ; Telomerase/genetics ; Telomerase/metabolism ; Telomere/genetics ; Telomere/pathology ; Treatment Outcome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway.
Autorzy :
Shi JY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Ma LJ; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Zhang JW; Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Duan M; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Ding ZB; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Yang LX; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Cao Y; Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.
Zhou J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.; Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
Fan J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.; Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
Zhang X; Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Zhao YJ; Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Wang XY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. wang..
Gao Q; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. .
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Źródło :
BMC cancer [BMC Cancer] 2017 Sep 13; Vol. 17 (1), pp. 648. Date of Electronic Publication: 2017 Sep 13.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*genetics
Forkhead Transcription Factors/*genetics
Liver Neoplasms/*genetics
Transforming Growth Factor beta/*genetics
Aged ; Animals ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/pathology ; Male ; Mice ; Middle Aged ; Signal Transduction/genetics ; Smad2 Protein/genetics ; Smad3 Protein/genetics ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Predictive value of microRNA-143 in evaluating the prognosis of patients with hepatocellular carcinoma.
Autorzy :
Zhang J; Department of Infectious Diseases, The Central Hospital of Linyi City, Linyi 276400, Shandong, China.
Lin H; Department of Gastroenterology, The Central Hospital of Linyi City, Liny 276400, Shandong, China.
Wang XY; Department of Infectious Diseases, The Central Hospital of Linyi City, Linyi 276400, Shandong, China.
Zhang DQ; Department of Infectious Diseases, The Central Hospital of Linyi City, Linyi 276400, Shandong, China.
Chen JX; Department of Reproduction, The Central Hospital of Linyi City, Liny 276400, Shandong, China.
Zhuang Y; Department of Nephrology, The Central Hospital of Linyi City, Liny 276400, Shandong, China.
Zheng XL; Department of Infectious Diseases, The Central Hospital of Linyi City, Linyi 276400, Shandong, China.; Department of Infectious Diseases, Qujing Medical College, Qujing 655000, Yunnan, China.
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Źródło :
Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2017 Jul 04; Vol. 19 (3), pp. 257-262.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*genetics
Liver Neoplasms/*genetics
MicroRNAs/*metabolism
Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Female ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; MicroRNAs/genetics ; Middle Aged ; Predictive Value of Tests ; Prognosis
Czasopismo naukowe
Tytuł :
Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents.
Autorzy :
Gao Q; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Wang ZC; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Duan M; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Lin YH; Institute of Precision Medicine, 3D Medicines Inc., Shanghai, China.
Zhou XY; Department of Psychiatry, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Worthley DL; Cancer Theme, South Australian Health and Medical Research Institute and Department of Medicine, University of Adelaide, Adelaide, Australia.
Wang XY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Niu G; Institute of Precision Medicine, 3D Medicines Inc., Shanghai, China.
Xia Y; School of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing, China.
Deng M; School of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing, China.
Liu LZ; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Shi JY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Yang LX; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Zhang S; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Ding ZB; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Zhou J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China; Cancer Center, Institute of Biomedical Sciences, Fudan University, Shanghai, China.
Liang CM; Department of Anatomy and Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai, China.
Cao Y; Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.
Xiong L; Institute of Precision Medicine, 3D Medicines Inc., Shanghai, China.
Xi R; School of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing, China.
Shi YY; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. Electronic address: .
Fan J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China; Cancer Center, Institute of Biomedical Sciences, Fudan University, Shanghai, China. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2017 Jan; Vol. 152 (1), pp. 232-242.e4. Date of Electronic Publication: 2016 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Pharmacogenomic Variants*
Carcinoma, Hepatocellular/*genetics
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*genetics
Liver Neoplasms/*pathology
RNA, Messenger/*metabolism
Antineoplastic Agents/pharmacology ; Azepines/pharmacology ; Base Sequence ; Carcinoma, Hepatocellular/drug therapy ; Cell Line, Tumor ; Clonal Evolution ; DNA Copy Number Variations ; DNA Mutational Analysis ; Drug Resistance, Neoplasm/genetics ; Drug Screening Assays, Antitumor ; Exome ; Fibroblast Growth Factors/genetics ; Gene Amplification ; Humans ; Indazoles/pharmacology ; Liver Neoplasms/drug therapy ; Mutation, Missense ; Phylogeny ; Primary Cell Culture ; Receptor, Fibroblast Growth Factor, Type 4/antagonists & inhibitors ; Sequence Deletion ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Lamp2a is required for tumor growth and promotes tumor recurrence of hepatocellular carcinoma.
Autorzy :
Ding ZB; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Fu XT; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Shi YH; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Zhou J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Peng YF; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Liu WR; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Shi GM; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Gao Q; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Wang XY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Song K; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Jin L; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Tian MX; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Shen YH; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
Fan J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P.R. China.
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Źródło :
International journal of oncology [Int J Oncol] 2016 Dec; Vol. 49 (6), pp. 2367-2376. Date of Electronic Publication: 2016 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*genetics
Carcinoma, Hepatocellular/*pathology
Cell Proliferation/*genetics
Heterografts/*growth & development
Liver Neoplasms/*pathology
Lysosomal-Associated Membrane Protein 2/*genetics
Lysosomal-Associated Membrane Protein 2/*metabolism
Animals ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Survival/genetics ; Hep G2 Cells ; Humans ; Mice ; Mice, Nude ; Neoplasm Recurrence, Local/genetics ; Neoplasm Transplantation ; RNA Interference ; RNA, Small Interfering/genetics ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Naive Treg-like CCR7(+) mononuclear cells indicate unfavorable prognosis in hepatocellular carcinoma.
Autorzy :
Shi JY; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Duan M; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Sun QM; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Yang L; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Wang ZC; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Mynbaev OA; Department of ObGyn and Reproductive Medicine, Moscow State University of Medicine & Dentistry, Moscow, Russia.; Moscow Institute of Physics and Technology (State University), Moscow, Russia.
He YF; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Wang LY; Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Zhou J; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.; Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
Tang QQ; Key Laboratory of Molecular Medicine, the Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, People's Republic of China.
Cao Y; Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.
Fan J; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.; Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
Wang XY; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China. .; Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. .
Gao Q; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China. .; Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. .; Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. .
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Źródło :
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2016 Jul; Vol. 37 (7), pp. 9909-17. Date of Electronic Publication: 2016 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Carcinoma, Hepatocellular/*immunology
Liver Neoplasms/*immunology
Neoplasm Recurrence, Local/*immunology
Receptors, CCR/*metabolism
Receptors, CCR7/*metabolism
T-Lymphocytes, Regulatory/*immunology
Apoptosis ; Blotting, Western ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation ; Chemokine CCL19/metabolism ; Chemokine CCL21/metabolism ; Cohort Studies ; Flow Cytometry ; Fluorescent Antibody Technique ; Follow-Up Studies ; Humans ; Immunoenzyme Techniques ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Prognosis ; Transforming Growth Factor beta1/metabolism ; Tumor Cells, Cultured ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity.
Autorzy :
Shi JY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.
Xing Q; School of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing, P. R. China.
Duan M; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.
Wang ZC; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.
Yang LX; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.
Zhao YJ; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shangai, P. R. China.
Wang XY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.
Liu Y; School of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing, P. R. China.
Deng M; School of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing, P. R. China.
Ding ZB; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.
Ke AW; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.
Zhou J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.; Institute of Biomedical Sciences, Fudan University, Shanghai, P. R. China.
Fan J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.; Institute of Biomedical Sciences, Fudan University, Shanghai, P. R. China.
Cao Y; Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, P. R. China.
Wang J; Division of Surgical Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xi R; School of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing, P. R. China.
Gao Q; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China.
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Źródło :
Oncotarget [Oncotarget] 2016 Jan 19; Vol. 7 (3), pp. 2867-77.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cadherins/*genetics
Carcinoma, Hepatocellular/*genetics
Cholangiocarcinoma/*genetics
Liver Neoplasms/*genetics
Neoplasms, Multiple Primary/*genetics
Tumor Suppressor Proteins/*genetics
Aged ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/secondary ; Cholangiocarcinoma/pathology ; DNA Copy Number Variations ; DNA Mutational Analysis ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Male ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Neoplasms, Multiple Primary/pathology
Czasopismo naukowe
Tytuł :
Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition.
Autorzy :
Wang ZC; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Gao Q; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Shi JY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Guo WJ; Shanghai Medical College, Fudan University, Shanghai, China.
Yang LX; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Liu XY; Fudan University Shanghai Cancer Center, and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Liu LZ; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Ma LJ; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Duan M; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Zhao YJ; Fudan University Shanghai Cancer Center, and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Wu YN; Department of General Surgery, the First Hospital of Lanzhou University, Lanzhou, China.
Gao DM; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Wang XY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Shi GM; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Ding ZB; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Ke AW; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.
Tang QQ; Key Laboratory of Molecular Medicine, the Ministry of Education; Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China.
Cao Y; Cancer Research Institute, Key Laboratory of Chinese Ministry of Education, Xiangya School of Medicine, Central South University, Changsha, China.
Zhou J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.; Institute of Biomedical Sciences, Fudan University, Shanghai, China.
Fan J; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.; Institute of Biomedical Sciences, Fudan University, Shanghai, China.
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2015 Oct; Vol. 62 (4), pp. 1201-14. Date of Electronic Publication: 2015 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Epithelial-Mesenchymal Transition*
Neoplasm Metastasis*
Carcinoma, Hepatocellular/*secondary
ErbB Receptors/*physiology
Liver Neoplasms/*pathology
Receptor-Like Protein Tyrosine Phosphatases, Class 2/*physiology
Humans ; Receptors, Growth Factor ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma.
Autorzy :
Wang ZC; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Liu LZ; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Liu XY; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Hu JJ; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Wu YN; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Shi JY; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Yang LX; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Duan M; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Wang XY; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Zhou J; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.; Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
Fan J; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.; Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
Gao Q; Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China. .; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China. .
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Źródło :
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2015 Sep; Vol. 36 (9), pp. 7007-15. Date of Electronic Publication: 2015 Apr 12.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*genetics
Drug Resistance, Multiple/*genetics
Liver Neoplasms/*genetics
ATP Binding Cassette Transporter, Subfamily B/genetics ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Ethnic Groups ; Genetic Predisposition to Disease ; Genotype ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Polymorphism, Single Nucleotide ; Risk Factors
Czasopismo naukowe
Tytuł :
TREM-1, an inflammatory modulator, is expressed in hepatocellular carcinoma cells and significantly promotes tumor progression.
Autorzy :
Duan M; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Wang ZC
Wang XY
Shi JY
Yang LX
Ding ZB
Gao Q
Zhou J
Fan J
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Źródło :
Annals of surgical oncology [Ann Surg Oncol] 2015 Sep; Vol. 22 (9), pp. 3121-9. Date of Electronic Publication: 2014 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Carcinoma, Hepatocellular/*pathology
Inflammation/*pathology
Inflammation Mediators/*metabolism
Liver Neoplasms/*pathology
Membrane Glycoproteins/*metabolism
Neoplasm Recurrence, Local/*pathology
Receptors, Immunologic/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Blotting, Western ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/mortality ; Cell Movement ; Cells, Cultured ; Female ; Fluorescent Antibody Technique ; Follow-Up Studies ; Humans ; Immunoenzyme Techniques ; Inflammation/metabolism ; Inflammation/mortality ; Liver Neoplasms/metabolism ; Liver Neoplasms/mortality ; Male ; Membrane Glycoproteins/genetics ; Middle Aged ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/mortality ; Neoplasm Staging ; Prognosis ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Receptors, Immunologic/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Survival Rate ; Triggering Receptor Expressed on Myeloid Cells-1
Czasopismo naukowe
Tytuł :
Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression.
Autorzy :
Cai JB; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai, China.
Shi GM
Dong ZR
Ke AW
Ma HH
Gao Q
Shen ZZ
Huang XY
Chen H
Yu DD
Liu LX
Zhang PF
Zhang C
Hu MY
Yang LX
Shi YH
Wang XY
Ding ZB
Qiu SJ
Sun HC
Zhou J
Shi YG
Fan J
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2015 May; Vol. 61 (5), pp. 1603-14. Date of Electronic Publication: 2015 Feb 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Carrier Proteins/*metabolism
Liver Neoplasms/*metabolism
Tumor Suppressor Protein p14ARF/*metabolism
Ubiquitin Thiolesterase/*physiology
Ubiquitin-Protein Ligases/*metabolism
Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Ubiquitin-Specific Peptidase 7
Czasopismo naukowe
Tytuł :
CC chemokine receptor-like 1 functions as a tumour suppressor by impairing CCR7-related chemotaxis in hepatocellular carcinoma.
Autorzy :
Shi JY; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
Yang LX
Wang ZC
Wang LY
Zhou J
Wang XY
Shi GM
Ding ZB
Ke AW
Dai Z
Qiu SJ
Tang QQ
Gao Q
Fan J
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Źródło :
The Journal of pathology [J Pathol] 2015 Mar; Vol. 235 (4), pp. 546-58. Date of Electronic Publication: 2014 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemotaxis*
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
Receptors, CCR/*metabolism
Receptors, CCR7/*metabolism
Tumor Suppressor Proteins/*metabolism
Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/therapy ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Knockdown Techniques ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/genetics ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Phenotype ; Proportional Hazards Models ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference ; RNA, Messenger/metabolism ; Receptors, CCR/genetics ; Receptors, CCR7/genetics ; Signal Transduction ; Time Factors ; Transfection ; Treatment Outcome ; Tumor Microenvironment ; Tumor Suppressor Proteins/genetics ; beta Catenin/metabolism
Czasopismo naukowe

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