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    Wyświetlanie 1-15 z 15
    Tytuł:
    Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.
    Autorzy:
    Zhou Y; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK.
    Peskett TR; Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 7HX, UK.; Department of Biology, Institute of Biochemistry, ETH Zurich, Otto-Stern-Weg 3, 8093, Zurich, Switzerland.
    Landles C; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK.
    Warner JB; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
    Sathasivam K; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK.
    Smith EJ; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK.
    Chen S; Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 7HX, UK.
    Wetzel R; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, USA.
    Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
    Bates GP; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK. .
    Saibil HR; Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 7HX, UK.
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Apr 14; Vol. 9 (1), pp. 70. Date of Electronic Publication: 2021 Apr 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Endosomes/*pathology
    Huntington Disease/*pathology
    Inclusion Bodies/*ultrastructure
    Lysosomes/*pathology
    Neurons/*pathology
    Animals ; Brain/metabolism ; Brain/pathology ; Brain/ultrastructure ; Endosomes/metabolism ; Endosomes/ultrastructure ; Gene Knock-In Techniques ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Huntington Disease/metabolism ; Inclusion Bodies/metabolism ; Inclusion Bodies/pathology ; Lysosomes/metabolism ; Lysosomes/ultrastructure ; Mice ; Microscopy, Electron, Transmission ; Microscopy, Fluorescence ; Mutation ; Neurons/metabolism ; Neurons/ultrastructure
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Ileum Gene Expression in Response to Acute Systemic Inflammation in Mice Chronically Fed Ethanol: Beneficial Effects of Elevated Tissue n-3 PUFAs.
    Autorzy:
    Hardesty JE; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
    Warner JB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
    Song YL; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
    Rouchka EC; Department of Computer Science and Engineering, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USA.
    McClain CJ; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.; University of Louisville Alcohol Center, School of Medicine, University of Louisville, Louisville, KY 40292, USA.; University of Louisville Hepatology and Toxicology Center, School of Medicine, University of Louisville, Louisville, KY 40292, USA.; Robley Rex Veterans Medical Center, Louisville, KY 40206, USA.
    Warner DR; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
    Kirpich IA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.; University of Louisville Alcohol Center, School of Medicine, University of Louisville, Louisville, KY 40292, USA.; University of Louisville Hepatology and Toxicology Center, School of Medicine, University of Louisville, Louisville, KY 40292, USA.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2021 Feb 04; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 04.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Ethanol/*toxicity
    Fatty Acid Desaturases/*physiology
    Fatty Acids, Omega-3/*pharmacology
    Gene Expression Regulation/*drug effects
    Ileum/*metabolism
    Inflammation/*metabolism
    Animals ; Central Nervous System Depressants/toxicity ; Gene Expression Profiling ; Humans ; Ileum/drug effects ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/genetics ; Male ; Mice ; Mice, Transgenic
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Transcriptional signatures of the small intestinal mucosa in response to ethanol in transgenic mice rich in endogenous n3 fatty acids.
    Autorzy:
    Hardesty JE; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, 505 Hancock St., Louisville, KY, 40202, USA.; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA.
    Warner JB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, 505 Hancock St., Louisville, KY, 40202, USA.; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA.
    Song YL; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, 505 Hancock St., Louisville, KY, 40202, USA.
    Rouchka EC; Department of Computer Science and Engineering, Speed School of Engineering, University of Louisville, Louisville, KY, USA.
    Chen CY; Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Kang JX; Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    McClain CJ; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, 505 Hancock St., Louisville, KY, 40202, USA.; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA.; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY, USA.; University of Louisville Hepatobiology and Toxicology Center, University of Louisville School of Medicine, Louisville, KY, USA.; Robley Rex Veterans Medical Center, Louisville, KY, USA.
    Warner DR; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, 505 Hancock St., Louisville, KY, 40202, USA.
    Kirpich IA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, 505 Hancock St., Louisville, KY, 40202, USA. .; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA. .; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY, USA. .; University of Louisville Hepatobiology and Toxicology Center, University of Louisville School of Medicine, Louisville, KY, USA. .
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    Źródło:
    Scientific reports [Sci Rep] 2020 Nov 16; Vol. 10 (1), pp. 19930. Date of Electronic Publication: 2020 Nov 16.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Gene Expression Profiling*
    Cadherins/*physiology
    Dietary Fats/*administration & dosage
    Ethanol/*pharmacology
    Fatty Acids, Omega-3/*metabolism
    Gene Expression Regulation/*drug effects
    Intestinal Mucosa/*metabolism
    Animals ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/growth & development ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease.
    Autorzy:
    Warner DR; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America.
    Liu H; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America.; College of Life Science, Jilin University, Changchun, China.
    Ghosh Dastidar S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America.
    Warner JB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America.; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.
    Prodhan MAI; Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America.
    Yin X; Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America.
    Zhang X; Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America.; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.; Hepatobiology & Toxicology Program, University of Louisville, Louisville, Kentucky, United States of America.
    Feldstein AE; Division of Gastroenterology, Department of Pediatrics, University of California San Diego, San Diego, California, United States of America.
    Gao B; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America.
    Prough RA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America.; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.; Hepatobiology & Toxicology Program, University of Louisville, Louisville, Kentucky, United States of America.
    McClain CJ; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America.; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.; Hepatobiology & Toxicology Program, University of Louisville, Louisville, Kentucky, United States of America.; Robley Rex Veterans Medical Center, Louisville, Kentucky, United States of America.
    Kirpich IA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America.; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.; Hepatobiology & Toxicology Program, University of Louisville, Louisville, Kentucky, United States of America.
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    Źródło:
    PloS one [PLoS One] 2018 Sep 26; Vol. 13 (9), pp. e0204119. Date of Electronic Publication: 2018 Sep 26 (Print Publication: 2018).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Dietary Fats/*adverse effects
    Ethanol/*adverse effects
    Fatty Acids, Omega-3/*metabolism
    Fatty Acids, Omega-6/*metabolism
    Liver/*metabolism
    Liver Diseases, Alcoholic/*metabolism
    Oxylipins/*metabolism
    Animals ; Binge Drinking/metabolism ; Dietary Fats/administration & dosage ; Disease Models, Animal ; Ethanol/administration & dosage ; Gene Expression Regulation ; Lipid Metabolism/genetics ; Liver/injuries ; Liver/pathology ; Liver Diseases, Alcoholic/pathology ; Male ; Metabolome ; Mice, Inbred C57BL ; Models, Biological ; Oxidation-Reduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Rodent Models of Alcoholic Liver Disease: Role of Binge Ethanol Administration.
    Autorzy:
    Ghosh Dastidar S; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA. .
    Warner JB; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA. .
    Warner DR; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA. dennis.warner@louisville.edu.
    McClain CJ; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA. .; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA. .; Robley Rex Veterans Medical Center, Louisville, KY 40202, USA. .; University of Louisville Alcohol Research Center and Hepatobiology & Toxicology COBRE, University of Louisville, Louisville, KY 40202, USA. .
    Kirpich IA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA. .; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA. .; University of Louisville Alcohol Research Center and Hepatobiology & Toxicology COBRE, University of Louisville, Louisville, KY 40202, USA. .
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    Źródło:
    Biomolecules [Biomolecules] 2018 Jan 13; Vol. 8 (1). Date of Electronic Publication: 2018 Jan 13.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
    MeSH Terms:
    Disease Models, Animal*
    Binge Drinking/*complications
    Ethanol/*administration & dosage
    Liver Diseases, Alcoholic/*etiology
    Animals ; Binge Drinking/pathology ; Ethanol/toxicity ; Liver Diseases, Alcoholic/pathology ; Mice ; Rats
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Synthetic biology: Two-for-one designer labels.
    Autorzy:
    Petersson EJ; Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.
    Warner JB; Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.
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    Źródło:
    Nature chemistry [Nat Chem] 2014 May; Vol. 6 (5), pp. 379-81.
    Typ publikacji:
    Journal Article; Comment
    MeSH Terms:
    Fluorescence Resonance Energy Transfer*
    Lysine/*analogs & derivatives
    Proteins/*metabolism
    Staining and Labeling/*methods
    Lysine/biosynthesis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Microdroplet-based PCR enrichment for large-scale targeted sequencing.
    Autorzy:
    Tewhey R; Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California, USA.
    Warner JB
    Nakano M
    Libby B
    Medkova M
    David PH
    Kotsopoulos SK
    Samuels ML
    Hutchison JB
    Larson JW
    Topol EJ
    Weiner MP
    Harismendy O
    Olson J
    Link DR
    Frazer KA
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    Źródło:
    Nature biotechnology [Nat Biotechnol] 2009 Nov; Vol. 27 (11), pp. 1025-31. Date of Electronic Publication: 2009 Nov 01.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Microfluidics/*methods
    Polymerase Chain Reaction/*methods
    Sequence Analysis, DNA/*methods
    Base Sequence ; Humans ; Mutation/genetics ; Reproducibility of Results ; Sequence Analysis, DNA/instrumentation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways.
    Autorzy:
    Estep PW 3rd; Longenity Inc, Lincoln, MA, USA. />Warner JB
    Bulyk ML
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    Źródło:
    PloS one [PLoS One] 2009; Vol. 4 (4), pp. e5242. Date of Electronic Publication: 2009 Apr 16.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Caloric Restriction*
    Gene Expression Regulation*
    Longevity*
    Aging/*metabolism
    Aging/genetics ; Animals ; Apoptosis/physiology ; Carrier Proteins/metabolism ; Cell Cycle/physiology ; Female ; Gene Expression Profiling ; Hormones/physiology ; Liver/metabolism ; Male ; Mice ; Nitrosamines/metabolism ; Phosphorylation ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Sex Factors ; Signal Transduction/physiology ; Sirtuins/metabolism ; TOR Serine-Threonine Kinases ; Transcription Factors/metabolism ; Tyramine/analogs & derivatives ; Tyramine/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Systematic identification of mammalian regulatory motifs' target genes and functions.
    Autorzy:
    Warner JB; Division of Genetics, Department of Medicine, Harvard Medical School, Harvard Medical School New Research Building, Room 466D, 77 Ave. Louis Pasteur, Boston, Massachusetts 02115, USA.
    Philippakis AA
    Jaeger SA
    He FS
    Lin J
    Bulyk ML
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    Źródło:
    Nature methods [Nat Methods] 2008 Apr; Vol. 5 (4), pp. 347-53. Date of Electronic Publication: 2008 Mar 02.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Computational Biology/*methods
    DNA/*genetics
    Regulatory Elements, Transcriptional/*genetics
    Regulatory Sequences, Nucleic Acid/*genetics
    Algorithms ; Animals ; Genome ; Humans ; Molecular Sequence Data ; Species Specificity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-15 z 15

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