The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.
Correlations in sleeping patterns and circadian preference between spouses.
Autorzy:
Richmond RC; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. .; Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, UK. . Howe LJ; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, UK. Heilbron K; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA. Jones S; Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland. Liu J; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, UK.; Oxford Population Health, Nuffield Department of Population Health, University of Oxford, Oxford, UK. Wang X; 23andMe, Inc., 223 N Mathilda Avenue, Sunnyvale, CA, USA. WeedonMN; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. Rutter MK; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UK. Lawlor DA; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, UK.; National Institute of Health Research Biomedical Research Centre, University of Bristol, Bristol, UK. Davey Smith G; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, UK.; National Institute of Health Research Biomedical Research Centre, University of Bristol, Bristol, UK. Vetter C; Circadian and Sleep Epidemiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records.
Autorzy:
Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK. . Beaumont RN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK. Locke JM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK. Tyrrell J; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK. Crandall CJ; Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA, 90024, USA. Hawkes G; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK. Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK. Prague JK; Exeter Centre of Excellence for Diabetes Research, University of Exeter, Exeter, EX2 5DW, UK.; Macleod Diabetes and Endocrinology Centre, Royal Devon and Exeter National Health Service Foundation Trust, Exeter, EX2 5DW, UK. Patel KA; Exeter Centre of Excellence for Diabetes Research, University of Exeter, Exeter, EX2 5DW, UK.; Macleod Diabetes and Endocrinology Centre, Royal Devon and Exeter National Health Service Foundation Trust, Exeter, EX2 5DW, UK. Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK. WeedonMN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK. Murray A; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
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BMC medical genomics [BMC Med Genomics] 2023 Oct 02; Vol. 16 (1), pp. 231. Date of Electronic Publication: 2023 Oct 02.
Identification and analysis of individuals who deviate from their genetically-predicted phenotype.
Autorzy:
Hawkes G; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Yengo L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. Vedantam S; Endocrinology, Boston Children's Hospital, Sharon, Massachusetts, United States of America. Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, United Kingdom. Beaumont RN; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Tyrrell J; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. WeedonMN; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Hirschhorn J; Boston Children's Hospital/Broad Institute, Boston, Massachusetts, United States of America. Frayling TM; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Wood AR; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom.
The impact of Mendelian sleep and circadian genetic variants in a population setting.
Autorzy:
WeedonMN; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Jones SE; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. Lane JM; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America. Lee J; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. Ollila HM; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California, United States of America. Dawes A; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Tyrrell J; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Beaumont RN; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Partonen T; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland. Merikanto I; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; SleepWell Research Program Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Rich SS; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America. Rotter JI; Institute for Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Torrance, California, United States of America.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, United States of America. Frayling TM; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom. Rutter MK; Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom.; Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom. Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. Sofer T; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. Saxena R; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Broad Institute, Cambridge, Massachusetts, United States of America.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America. Wood AR; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom.
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Źródło:
PLoS genetics [PLoS Genet] 2022 Sep 22; Vol. 18 (9), pp. e1010356. Date of Electronic Publication: 2022 Sep 22 (Print Publication: 2022).
SavvyCNV: Genome-wide CNV calling from off-target reads.
Autorzy:
Laver TW; Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom. De Franco E; Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom. Johnson MB; Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom. Patel KA; Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom. Ellard S; Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom. WeedonMN; Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom. Flanagan SE; Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom. Wakeling MN; Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2022 Mar 16; Vol. 18 (3), pp. e1009940. Date of Electronic Publication: 2022 Mar 16 (Print Publication: 2022).
A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor.
Autorzy:
Green HD; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Jones A; Shoulder Unit, Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter Hospital, Exeter, United Kingdom. Evans JP; Shoulder Unit, Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter Hospital, Exeter, United Kingdom. Wood AR; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Beaumont RN; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Tyrrell J; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Smith C; Shoulder Unit, Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter Hospital, Exeter, United Kingdom. WeedonMN; Shoulder Unit, Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter Hospital, Exeter, United Kingdom.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Jun 10; Vol. 17 (6), pp. e1009577. Date of Electronic Publication: 2021 Jun 10 (Print Publication: 2021).
Sleep classification from wrist-worn accelerometer data using random forests.
Autorzy:
Sundararajan K; Netherlands eScience Center, Amsterdam, The Netherlands. Georgievska S; Netherlands eScience Center, Amsterdam, The Netherlands. Te Lindert BHW; Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. Gehrman PR; Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. Ramautar J; Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. Mazzotti DR; Divison of Medical Informatics, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA. Sabia S; Inserm U1153, EpiAgeing, Université de Paris, Paris, France.; Department of Epidemiology and Public Health, University College London, London, UK. WeedonMN; University of Exeter, Exeter, UK. van Someren EJW; Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. Ridder L; Netherlands eScience Center, Amsterdam, The Netherlands. Wang J; Eli Lilly and Company Ltd, Lilly Research Laboratories Neuroscience, Indianapolis, IN, 46285, USA. van Hees VT; Netherlands eScience Center, Amsterdam, The Netherlands. .; Accelting, Almere, The Netherlands. .
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Scientific reports [Sci Rep] 2021 Jan 08; Vol. 11 (1), pp. 24. Date of Electronic Publication: 2021 Jan 08.
Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment.
Autorzy:
Lin S; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK.; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Green HD; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK. Hendy P; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK.; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Heerasing NM; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK.; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Chanchlani N; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK. Hamilton B; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK. Walker GJ; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK.; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Heap GA; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK.; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Hobart J; Department of Neurology, University Hospitals Plymouth, Plymouth, UK. Martin RJ; Department of Neurology, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK. Coles AJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. Silverberg MS; Mount Sinai Hospital Inflammatory Bowel Disease Centre, University of Toronto, Toronto, ON, Canada. Irving PM; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK. Chung-Faye G; Department of Gastroenterology, King's College Hospital, London, UK. Silber E; Department of Neurology, King's College Hospital, London, UK. Cummings JRF; Department of Gastroenterology, Southampton General Hospital, Southampton, UK. Lytvyak E; Department of Medicine, University of Alberta, Edmonton, AB, Canada. Andersen V; Focussed Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Soenderjylland, University Hospital of Southern Denmark, Odense, Denmark. Wood AR; University of Exeter, Medical School, Exeter, UK. Tyrrell J; University of Exeter, Medical School, Exeter, UK. Beaumont RN; University of Exeter, Medical School, Exeter, UK. WeedonMN; University of Exeter, Medical School, Exeter, UK. Kennedy NA; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK.; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Spiers A; Department of Radiology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Harrower T; Department of Neurology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Goodhand JR; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK.; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK. Ahmad T; IBD Pharmacogenetics Group, University of Exeter, Exeter, UK.; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK.
A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care.
Autorzy:
Sharp SA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. Jones SE; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. Kimmitt RA; Royal Devon & Exeter, NHS Foundation Trust, Exeter, UK. WeedonMN; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. Halpin AM; Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada. Wood AR; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. Beaumont RN; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. King S; Faculty of Medicine and Dentistry, Pediatrics, University of Alberta, Edmonton, AB, Canada. van Heel DA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Campbell PM; Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada. Hagopian WA; Pacific Northwest Research Institute, Seattle, WA, USA. Turner JM; Faculty of Medicine and Dentistry, Pediatrics, University of Alberta, Edmonton, AB, Canada. Oram RA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.; Royal Devon & Exeter, NHS Foundation Trust, Exeter, UK.
Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India.
Autorzy:
Harrison JW; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK. Tallapragada DSP; Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Uppal Road, Hyderabad, 500 007, India. Baptist A; KEM Hospital, 489 Rasta Peth, Sardar Moodaliar Road, Pune, 411011, India. Sharp SA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK. Bhaskar S; Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Uppal Road, Hyderabad, 500 007, India. Jog KS; KEM Hospital, 489 Rasta Peth, Sardar Moodaliar Road, Pune, 411011, India. Patel KA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK.; National Institute for Health Research Exeter, Clinical Research Facility, Exeter, UK. WeedonMN; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK. Chandak GR; Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Uppal Road, Hyderabad, 500 007, India. . Yajnik CS; KEM Hospital, 489 Rasta Peth, Sardar Moodaliar Road, Pune, 411011, India. . Oram RA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK. .; National Institute for Health Research Exeter, Clinical Research Facility, Exeter, UK. .
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Scientific reports [Sci Rep] 2020 Jun 11; Vol. 10 (1), pp. 9450. Date of Electronic Publication: 2020 Jun 11.
Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis.
Autorzy:
Green HD; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.; IBD Pharmacogenetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Beaumont RN; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. Thomas A; IBD Pharmacogenetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Hamilton B; IBD Pharmacogenetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Wood AR; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. Sharp S; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. Jones SE; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. Tyrrell J; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. Walker G; IBD Pharmacogenetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Goodhand J; IBD Pharmacogenetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Kennedy NA; IBD Pharmacogenetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Ahmad T; IBD Pharmacogenetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. WeedonMN; Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans.
Autorzy:
Chang AM; Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania, 16802, USA. .; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA. .; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA. .; Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA. . Duffy JF; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA. Buxton OM; Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania, 16802, USA.; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Department of Social and Behavioral Sciences, Harvard Chan School of Public Health, Boston, Massachusetts, 02115, USA. Lane JM; Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA.; Department of Anesthesia, Critical Care and Pain Medicine and Center for Genomic Medicine; Massachusetts General Hospital, Boston, Massachusetts, 02114, USA. Aeschbach D; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Department of Sleep and Human Factors Research, Institute of Aerospace Medicine, German Aerospace Center, Cologne, 51147, Germany. Anderson C; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC, Australia. Bjonnes AC; Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA.; Department of Anesthesia, Critical Care and Pain Medicine and Center for Genomic Medicine; Massachusetts General Hospital, Boston, Massachusetts, 02114, USA. Cain SW; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC, Australia. Cohen DA; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA. Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Gooley JJ; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, Singapore, Singapore. Jones SE; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Klerman EB; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA. Lockley SW; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA. Munch M; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Sleep/Wake Research Centre, College of Health, Massey University, Wellington, New Zealand. Rajaratnam SMW; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC, Australia. Rueger M; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA. Rutter MK; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Santhi N; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Surrey Sleep Research Centre, University of Surrey, Guildford, UK. Scheuermaier K; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Wits Sleep Laboratory, Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Van Reen E; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA. WeedonMN; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Czeisler CA; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA. Scheer FAJL; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA. .; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA. . Saxena R; Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA.; Department of Anesthesia, Critical Care and Pain Medicine and Center for Genomic Medicine; Massachusetts General Hospital, Boston, Massachusetts, 02114, USA.
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Źródło:
Scientific reports [Sci Rep] 2019 Mar 29; Vol. 9 (1), pp. 5350. Date of Electronic Publication: 2019 Mar 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Estimating sleep parameters using an accelerometer without sleep diary.
Autorzy:
van Hees VT; Netherlands eScience Center, Amsterdam, The Netherlands. . Sabia S; INSERM U1018, Centre for Research in Epidemiology and Population Health, Université Paris-Saclay, Paris, France.; Department of Epidemiology & Public Health, University College London (UCL), London, UK. Jones SE; University of Exeter Medical School, Genetics of Complex Traits, Exeter, UK. Wood AR; University of Exeter Medical School, Genetics of Complex Traits, Exeter, UK. Anderson KN; Regional Sleep Service, Freeman Hospital, Newcastle-upon-Tyne, UK. Kivimäki M; Department of Epidemiology & Public Health, University College London (UCL), London, UK. Frayling TM; University of Exeter Medical School, Genetics of Complex Traits, Exeter, UK. Pack AI; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Bucan M; Department of Genetics, Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Trenell MI; Movelab, Newcastle University, Newcastle-upon-Tyne, UK. Mazzotti DR; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Gehrman PR; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Singh-Manoux BA; INSERM U1018, Centre for Research in Epidemiology and Population Health, Université Paris-Saclay, Paris, France.; Department of Epidemiology & Public Health, University College London (UCL), London, UK. WeedonMN; University of Exeter Medical School, Genetics of Complex Traits, Exeter, UK.
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Źródło:
Scientific reports [Sci Rep] 2018 Aug 28; Vol. 8 (1), pp. 12975. Date of Electronic Publication: 2018 Aug 28.
Typ publikacji:
Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.
Autorzy:
Bonifacio E; DFG-Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. Beyerlein A; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany. Hippich M; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany. Winkler C; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany. Vehik K; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America. WeedonMN; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom. Laimighofer M; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany. Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom. Krumsiek J; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany. Frohnert BI; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, United States of America. Steck AK; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, United States of America. Hagopian WA; Pacific Northwest Diabetes Research Institute, Seattle, Washington, United States of America. Krischer JP; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America. Lernmark Å; Department of Clinical Sciences, Clinical Research Centre, Skåne University Hospital, Lund University, Malmo, Sweden. Rewers MJ; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, United States of America. She JX; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, United States of America. Toppari J; Department of Pediatrics, Turku University Hospital, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland. Akolkar B; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America. Oram RA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.; Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.; National Institute for Health Research, Exeter Clinical Research Facility, Exeter, United Kingdom. Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America. Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany.
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